start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=2 article-no= start-page=797 end-page=799 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600130 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The Influences of γ-Amino-β-hydroxybutyric Acid (GABOB) On the Mouse Brain Water Content kn-title=脳含水量におよぼすγ-アミノ-β-ハイドロオキシ酪酸の影響に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The influences of GABOB on water content of CF-1 pure strain mouse cerebral cortex having artificaly increased water content in cerebral cortex and non treated one as the control were investigated, and it was clarfied that GABOB has no effect on the water content of the brain in both cases. en-copyright= kn-copyright= en-aut-name=HigashiTohru en-aut-sei=Higashi en-aut-mei=Tohru kn-aut-name=東徹 kn-aut-sei=東 kn-aut-mei=徹 aut-affil-num=1 ORCID= en-aut-name=MoriAkitane en-aut-sei=Mori en-aut-mei=Akitane kn-aut-name=森昭胤 kn-aut-sei=森 kn-aut-mei=昭胤 aut-affil-num=2 ORCID= en-aut-name=YoshikawaTamotsu en-aut-sei=Yoshikawa en-aut-mei=Tamotsu kn-aut-name=吉川全 kn-aut-sei=吉川 kn-aut-mei=全 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第1（陣内）外科教室 affil-num=2 en-affil= kn-affil=岡山大学医学部第1（陣内）外科教室 affil-num=3 en-affil= kn-affil=岡山大学医学部第1（陣内）外科教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=2 article-no= start-page=781 end-page=796 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600130 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the Disturbance in Blood Clotting Following Massive Transfusion of Preserved Blood Part U. Clinical and Experimental Studies on the Prophylaxis and Therapy of Impaired Blood Clotting Following Massive Transfusion of Preserved Blood kn-title=保存血大量輸血に伴う血液凝固障害に関する研究 第2編 血液凝固障害発生の予防とその治療について en-subtitle= kn-subtitle= en-abstract= kn-abstract=For the impaired blood clotting due to massive blood transfusion prophylaxis is to be the best treatment, for measures after its occurreance are often very difficult.　As prophylactic treatment, continuous drip infusion of a large amount of hydrocortisone, alternated transfusion of fresh and preserved blood, administration of tissue thromboplastin preparation and ACTH were effective. As thrapy for hemorrhagic tendency, massive infusion of hydrocortisone, administration of tissue thromboplastin preparation, transions of fressh blood or platelets were proved to be effective. For decreased clotting factors in case fibrinolysis. intravenous ε-aminocapronic acid and hydrocortisone were efficacious to depress the fibrinolysis. en-copyright= kn-copyright= en-aut-name=ShimizuHiroshi en-aut-sei=Shimizu en-aut-mei=Hiroshi kn-aut-name=志水浩 kn-aut-sei=志水 kn-aut-mei=浩 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部砂田外科教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=2 article-no= start-page=763 end-page=779 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600130 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the Disturbance in Blood Clotting Following Massive Transfusion of Preserved Blood Part I. Experimental Investigation on the Mechanism of Disturbed Blood Clotting Following Massive Transfusion of Preserved Blood kn-title=保存血大量輸血に伴う血液凝固障害に関する研究 第1編 血液凝固障害発現の成因に関する実験的研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Influences of operative stress, shock, anoxia and/or liver damage upon the disturbances in blood clotting following massive transfusion of preserved blood were investigated experimentally. None of coagulation factors were so disturbed to invite a hemorrhagic tendency only by one of them. Qualitative and quantitative decrease in platelets and decrease in AHG level were thought to be caused by massive preserved blood transfusion itself. Decreases in prothrombin and labile factor following preserved blood transfusion were much intensive in case of accompanying with operative stress, shock, anoxia or liver damage. It was surmized that the occurrence of fibrinolysis had an imptortant part to cause the decrease in clotting factors. en-copyright= kn-copyright= en-aut-name=ShimizuHiroshi en-aut-sei=Shimizu en-aut-mei=Hiroshi kn-aut-name=志水浩 kn-aut-sei=志水 kn-aut-mei=浩 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部砂田外科教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=2 article-no= start-page=757 end-page=761 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600130 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Experimental Studies on the Relation Between Tumor and Hormone Report 5. On the Effect of Sex Hormones on the Growth and Immunity of Tumor kn-title=腫瘍とホルモンに関する実験的研究 第5報 腫瘍免疫並びに増殖に及ぼす性ホルモンの影響について en-subtitle= kn-subtitle= en-abstract= kn-abstract=Formerly, concerning the relation between hormone and heterotransplantation, the author reported that, while teststerone inhibited heterotransplantation, estrogen and testectomy acceralate it. In this experiment, mice of R(3) strain were used. All mice were transplanted of mammary carcinoma from the R(3) strain of female mouse. The conclusions of this experiment are as follows; 1) Testaterone inhibited the homotransplantation and growth of tumor. 2) Estrogen and testectomy acceraiate the homotransplantation and growth of tumor. en-copyright= kn-copyright= en-aut-name=KiyamaTakashi en-aut-sei=Kiyama en-aut-mei=Takashi kn-aut-name=木山敞 kn-aut-sei=木山 kn-aut-mei=敞 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二外科教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=2 article-no= start-page=745 end-page=755 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600130 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Experimental Studies on the Influences of Spleen on the Hematopoietic Function of Bone Marrow Part 3. Influences of Homoioplastic Transplatation of Spleen and Spleen extract on the Production of Platelet in the Guinea-pig Bone Marrow kn-title=脾臓の骨髄造血機能に及ぼず影響に関する実験的研究 第3編 脾他家移植及び脾エキスが海?骨髄栓球系造血に及ぼす影響に就いて en-subtitle= kn-subtitle= en-abstract= kn-abstract=For the purpose of observing the influences of the spleen on the production of the platelet in bone marrow the author performed the bone-marrow tissue culture (cover-slip method) of guinea pigs and observed the function of megakaryocytes, and obtained the follo wing results. 1. In the bone marrow tissue culture of the guinea pigs transplanted with homoioplastic spleen conducted from time to time to the megakaryocyte function, when compared with that of the control group transplanted with normal spleen, shows a marked decline transiently about 3 to 5 days after the operation, but by 20th to 30th day it shows hardly any significant difference from that of the control. 2. In the bone-marrow tissue culture of normal guinea pigs added with Ringer's solution of spleen extract of normal guinea pigs, the extract at a higher concentration brings about a fall in the megakaryocyte function whereas on the contrary at a higher concentration it accelerates the function. 3. From these results it seems that the spleen of normal guinea pigs with the aid of some fluid agent acts on the thrombopoiesis of the bone marrow interchangeably either suppressingly or acceleratingly, but from the physiological aspect the suppressing action seems to be slightly stronger. en-copyright= kn-copyright= en-aut-name=KitajimaKoichi en-aut-sei=Kitajima en-aut-mei=Koichi kn-aut-name=喜多島康一 kn-aut-sei=喜多島 kn-aut-mei=康一 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医学研究科 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=2 article-no= start-page=729 end-page=743 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600130 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Experimental Studies on the Influences of Spleen on the Hematopoietic Function of Bone Marrow Part 2. Influences of Spelenectomy, Homoioplastic Transplantation of Spleen, and of Spleen Extract on the Leucopoietic Function of the Rabbit Bone Marrow kn-title=脾臓の骨髄造血機能に及ぼす影響に関する実験的研究 第2編 剔脾脾他家移植及び脾エキスが家兎骨髄白血球系造血に及ぼす影響に就いて en-subtitle= kn-subtitle= en-abstract= kn-abstract=In order to observe the influences of spleen on the leucopoietic function of bone marrow the author performed the bone-marrow tissue culture (by cover-slip method) of rabbits, and obtained the following results. 1. In the observations on the bone-marrow tissue culture of the splenectomized rabbits conducted from time to time, the relative growth rate, the cell density index and the wandering velocity of pseudoeosinophils all show a transient acceleration with their peak around 4 to 7 days after the operation, while on the contrary the carbon particle phagocytic ability of pseudoeosinophils shows a transient fall. However, all these values return to respective levels of the control, normal rabbits without splenectomy, about 3 weeks after the operstion. 2. In the bone-marrow tissue culture of the rabbits transplanted with homoioplastic spleen conducted from time to time, the relative growth rate, the cell density index and the wandering velocity of pseudoeosinophils all show a transient fall around 5 to 10 days after the operation, but no marked change can be observed in the carbon particle phagocytic ability of pseudoeosinophils. However, all these values resurn approximately to those of the control, rabbits transplanted with normal kidney, about 30 days after the operation. 3. In the bone-marrow tissue culture of normal rabbits with addition of Ringer's solution of normal rabbit spleen extract, the extract at a higer concentration has a suppressing effect on the relative growth rate, the wandering velocity and the carbon particle phagocytic ability of pseudoeosinophils, while the extract at a lower concentration mostly gives a slightly accelerating effect. 4. From these results it seems that the spleen of normal rabbits with aid of some fluid agent adjusts the production of the leucocyte series of the bone marrow either suppressingly or acceleratingly. However, from the physiological aspect the suppressing action seems to be slightly superior and hence the over-production of the granulocyte series of the bone marrow as well as the incomplete maturation of granulocytes seem to be controled. en-copyright= kn-copyright= en-aut-name=KitajimaKoichi en-aut-sei=Kitajima en-aut-mei=Koichi kn-aut-name=喜多島康一 kn-aut-sei=喜多島 kn-aut-mei=康一 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医学研究科 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=2 article-no= start-page=713 end-page=727 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600130 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Experimental Studies on the Influences of Spleen on the Hematopoietic Function of Bone Marrow Part 1. Influences of Splenectomy, Homoioplastic Transplantation of Spleen, and of Spleen Extract on the Erythropoietic Function of the Rabbit Bone Marrow kn-title=脾臓の骨髄造血機能に及ぼす影響に関する実験的研究 第1編 剔脾,脾他家移植及び脾エキスが家兎骨髄造赤血球機能に及ぼす影響に就て en-subtitle= kn-subtitle= en-abstract= kn-abstract=With the purpose to study the influences of the spleen on the erythropoietic function of bone marrow the cell suspension culture of the rabbit bone marrow was conducted, and the following results were obtained. 1. In the bone-marrow tissue culture of splenectomized rabbits conducted from time to time the rate of the increase in the number of erythrocytes is temporarily accelerated having its peak around 4 to 7 days after the operation as compared with the control, while on the contrary, the increase in hemoglobin declines slightly. About three weeks after the operation both values of erythrocytes and hemoglobin return approximately to those in the control group, normal ones without splenectomy. 2. In the bone-marrow tissue culture of the rabbits transplanted with hemoioplastic spleenand conducted from time to time, the rate of the increase in the number of erythrocytes temporarily declines having the minimum around the fifth day after the operation and the rate of the increase in hemo-globin falls slightly around the fifth day but by around the thenth day it shows a slight acceleration, as compared with those of the control, rabbits transplanted with normal kidney. However, after about 30 days both of these values return approximately to those of the control. 3. In the observations of the bone-marrow tissue culture of normal rabbits with addition of Ringer's solutions of normal rabbit spleen extract at various concentrations, the extract at a higher concentration brings about the fall in the increasing rate of erythrocytes and hemoglobin, while on the contrary it brings about a slight acceleration in the increasing rate of both at a lower concentration. 4. From these results it is assumed that the spleen of the normal rabbit with the aid of some body-fluid agent adjusts the erythropoietic function of the bone marrow either suppressingly or acceleratingly, but from the physiological aspect the suppressing action seems to be superior: namely, an abnormal formation of the erythrocyte series is suppressed, while on the other hand the hemoglobin synthesis seems to be accelerated, thus suppressing the incomplete maturation of erythrocytes. en-copyright= kn-copyright= en-aut-name=KitajimaKoichi en-aut-sei=Kitajima en-aut-mei=Koichi kn-aut-name=喜多島康一 kn-aut-sei=喜多島 kn-aut-mei=康一 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医学研究科 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=2 article-no= start-page=695 end-page=711 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600130 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on Nucleic Acid Metabolism in Pulmonary Tuberculosis Part 2. Alteration of Urine Ketoenolsubstances and the Effects of Vitamin B(12) and Folic Acid kn-title=肺結核症の核酸代謝に関する研究 第2編 肺結核症の尿ケトエノール物質の消長並びにこれに及ぼすビタミンB(12)及び葉酸の影響について en-subtitle= kn-subtitle= en-abstract= kn-abstract=Studying urine ketoenolsubstances (KES) and the effects of vitamin B(12) and folic acid in the healthy and pulmonary tuberculosis cases, and the following results were obtained. 1. An increase in the urine KES was noted in the cases of moderately and far advanced pulmonary tuberculosis. 2. In the healthy and postoperative cases, the urine KES were increased from two hours after the administration of vitamin B(12), and from one hour after the administration of folic acid respectively. 3. These effects of vitamin B12 and folic acid were decreased in such order as minimal, moderately advanced and far advanced pulmonary tuberculosis. 4. Following the administration of folic acid, an increased precipitation was noted on the determination of the urine KES. This precipitation would be a source of error and might be a excretion of folic acid itself. 5. The effects of these vitamines were quite the same in the cases who had the breakfast with rice and soybean soup at the same time with the administration of vitamin B(12) or folic acid. 6. The effects of these vitamines were quite the same in the cases who had breakfast and vitamin B(12) or folic acid at the same time and also in the cases who had PAS-calcium later on. However, attention should be paid for the determination of the urine KES because of the precipitation due to PAS-calcium. 7. It was supposed that vitamin B(12) and folic acid did not have an effect upon dietary purine body metabolism, but promote general metabolisms and thus effect upon nucleic acid metabolism. Vitamin B12 and folic acid did not regulate the metabolism of KES which were excreted in the far advanced pulmonary tuberculosis cases. en-copyright= kn-copyright= en-aut-name=OhsumiMichiko en-aut-sei=Ohsumi en-aut-mei=Michiko kn-aut-name=大隅美智子 kn-aut-sei=大隅 kn-aut-mei=美智子 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一内科教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=2 article-no= start-page=677 end-page=694 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600130 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on Nucleic Acid Metabolism in Pulmonary Tuberculosis Part 1. Uric acid Metabolism and the Effects of Vitamin B(12) and Folic Acid kn-title=肺結核症の核酸代謝に関する研究 第1編 肺結核症の尿酸代謝並びにこれに及ぼすビタミンB(12)及び葉酸の影響について en-subtitle= kn-subtitle= en-abstract= kn-abstract=Observing the amount of uric acid excretion into the urine in the healthy and various stages of pulmonary tuberculosis cases and studying the effects of vitamin B(12) and folic acid, and the following results were obtained. 1. An increase in the amount of uric acid excretion into the urine was noted in the cases of moderately and far advanced pulmonary tuberculosis. 2. In the healthy and postoperative cases of pulmonary tuberculosis cases, an increase, both in the concentration and the amount, of uric acid excretion into the urine was noted one hour after the administration of vitamin B(12). A slight decrease or unchanged in the amount of uric acid excretion into the urine was observed, one hour after the administration of folic acid, and an increase of it was seen in the urine after 4 hours. 3. The effects of vitamin B(12) and folic acid were less evident in the far advanced cases of pulmonary tuberculosis and rather marked in the minimal cases. 4. The same effects were observed in the cases who had the breakfast only of rice and soybean soup at the same time with the administration of vitamin B(12) or folic acid. Increased uric acid excretion into the urine was observed in the cases who had breakfast alone. 5. The effects of these vitamines were quite the same in the cases who had breakfast and vitamin B(12) or folic acid at the same time and also in the cases who had PAS-calcium later on. 6. It was supposed that vitamin B(12) and folic acid did not have an effect upon dietary purine bodies metabolism, but promote general metabolism and thus effect upon nucleic acid metabolism. Vitamin B(12) and folic acid have presumably regulated the uric acid metabolism in the cases of far advanced pulmonary tuberculosis. en-copyright= kn-copyright= en-aut-name=OhsumiMichiko en-aut-sei=Ohsumi en-aut-mei=Michiko kn-aut-name=大隅美智子 kn-aut-sei=大隅 kn-aut-mei=美智子 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一内科教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=2 article-no= start-page=671 end-page=676 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600130 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on Particular Environmental Influences to a Few Components of Blood in Mountainous Farm Village Part 2. Alteration of Serum Electrolytes, Especially of Calcium, in Various Conditions kn-title=農山村の特種環境が血液中二，三の成分に及ぼす影響に関する研究 第2編 各種条件下における血液無機物質特にカルシウム量の変動について en-subtitle= kn-subtitle= en-abstract= kn-abstract=Studying the influences of particular environment in the mountainous farm village of Okunoto-district to serum electrolytes, especially to calcium, and the following results were obtained. 1. Serum calcium in the healthy farmers including both sexes demonstrated gradual alteration throughout the year with the minimum peak at May and June. 2. Serum electrolytes of the healthy male and female farmers were determined in both farming and leisure seasons for farmers. In the farming seasons, serum calcium was evidently decreased in both sexes compared with the leisure seasons for farmers, and, contrariwise, potassium was increased, and sodium was almost unchanged or slightly increased during the farming seasons. 3. It was supposed that such decrease in serum calcium during the farming seasons was not due to the influence of ultraviolet ray but to poor calcium intake by their eating habits and to fatigue as a result of the particular condition, the farming seasons. 4. In the control group of the healthy individuals other than farmers, serum calcium demonstrated almost no change throughout the year except for a very slight decrease during the periods of April, May and June. 5. In the school children, a decrease in serum calcium was noted during the winter time when ultraviolet rays were diminished. This indicated the fact that many babies suffering from rickets in this district. Such tendencies were also seen in the pregnant females. 6. A decrease in serum calcium due to diminution of ultraviolet rays were observed not only in the babies but in the school children and pregnant females except for the adults in good health. 7. A marked restoration of serum calcium level was noted 2 months after the administration of vitamin D and ultraviolet rays as a treatment of rickets. en-copyright= kn-copyright= en-aut-name=ShinoharaToshio en-aut-sei=Shinohara en-aut-mei=Toshio kn-aut-name=篠原敏夫 kn-aut-sei=篠原 kn-aut-mei=敏夫 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一内科教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=2 article-no= start-page=663 end-page=670 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600130 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on Particular Environmental Influences to a Feu Components of Blood in Mountainous Farm Village Part 1. Serum Protein Fractions in Various Conditions kn-title=農山村の特種環境が血液中二,三の成分に及ぼす影響に関する研究 第1編 各種条件下における血清蛋白像について en-subtitle= kn-subtitle= en-abstract= kn-abstract=Studying the influences of particular envireronment in the mountainous farm village of Hokuriku-district to serum protein fractions, and the following results were obtained. 1. In the farming seasons, in contrast to the leisure seasons for farmers, a slight decrease in total serum protein and a relative increase in α1, α2 and β-globulin were noted. 2. In the cases of malnutrition, seen during the farming seasons, a decrease in total serum protein, especially in albumin fraction, and a relative increase in α1, α2 and β-globulin were noted. 3. The changes of the serum proteins during the farming seasons were rather due to poor nutrition and fatigue than seasonable climates. 4. In the cases of pulmonary tuberculosis, increased total protein, decreased albumin and increased α1, α2 and γ-globulin were noted in the severe cases, on the other hand, in the mild or convalescent cases, a slight increase of γ-globulin was observed. 5. In the group of essential hypertension, a decrease in albumin and an increase in α1 and β-globulin were noted only in the severe cases with complications. 6. In the cases of angina pectoris with coronary insufficiency, a slight decrease in albumin and a slight increase in γ-globulin were seen, however, these changes were disappeared in the convalescent stages. In the cases of myocardial infarction, a slight decrease in total serum protein, a marked decrease in albumin and a slight increase in β and especially γ-globulin were observed. 7. In the cases of valvular heart diseases, a decrease in albumin and an increase in γ-globulin in the compensated phase, and in the decompensated phase these tendencies have become evident. 8. In the cases of stomach cancer especially of its terminal stage, a marked decrease in total serum protein, especially in albumin, and a moderate increase in γ, and a relative increase in α1, α2 and β globulin were noted. 9. In the cases of peptic ulcer, gastric and duodenal, a decrease in albumin and an increase in α1, and α2 globulin were observed. 10. In the pregnant females, no changes in serum protein fractions by 5 th month but thereafter a slight increase in α1, α2 and β-globuin and an increase in albumin were noted. These changes were evident especially in the cases of hyperemesis. en-copyright= kn-copyright= en-aut-name=ShinoharaToshio en-aut-sei=Shinohara en-aut-mei=Toshio kn-aut-name=篠原敏夫 kn-aut-sei=篠原 kn-aut-mei=敏夫 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一内科教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=2 article-no= start-page=653 end-page=662 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600130 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the Mechanism of Bile Pigment Formation in Vivo Part 2. Studies on the Bile Pigment in the Bile following the Administration of the Decompositions of Hemeglobin kn-title=生体内胆汁色素生成過程に関する研究 第2編 血色素分解産物負荷による胆汁中胆汁色素の検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Studying the formation process of the bile pigment in vivo with reference to the vicisitude of the bile pigment in the bile following the administration of the docompositions of hemoglobin into the portal vein of the rabbit with artificial biliary fistula. And the following results were obtained. 1. Following the administration of saline into the portal vein, production of the bile pigment in the liver was transiently depressed and then increased because of choleretic action of saline. 2. Following the administration of verdohemochrome solution, which was decomposed into biliverdin and, in part, was deoxidized to bilirubin. verdohemochrome was excreted in the healthy cases. The decomposition process was prolonged or less in the cases with blocked reticuloendothelial systems, and little decomposition was observed in the cases with liver impairments. 3. Following the administration of biliverdin solution to the healthy cases, the majority of biliverdin was excreted unchanged but part of it was deoxidized to bilirubin. There was no such evidence in the cases with blocked reticuloendothelial system and was very slight degree in the cases with liver impairment. In consequence, the deoxidation of biliverdin was presumably due to reticuloendothelial system. However, in the cases with blocked reticuloendothelial system or liver impairment, it was supposed that biliverdin was excreted from the liver and easily deoxidized into bilirubin. en-copyright= kn-copyright= en-aut-name=AkagiKaoru en-aut-sei=Akagi en-aut-mei=Kaoru kn-aut-name=赤木香 kn-aut-sei=赤木 kn-aut-mei=香 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一内科教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=2 article-no= start-page=645 end-page=651 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600130 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the Mechanism of Bile Pigment Formation in vivo Part 1. On the Mechanism of Bile Pigment Formation in the Liver of Rabbit kn-title=生体内胆汁色素生成過程に関する研究 第1編 家兎肝臓内胆汁色素生成機序について en-subtitle= kn-subtitle= en-abstract= kn-abstract=Irrigation experiments were performed on the liver of rabbit determining bilirubin and biliverdin in the bile and irrigating solution, and the following results were obtained. 1. Upon irrigation with hemoglobin added blood, bilirubin was not detected from the irrigating solution, however, the excretion of biliverdin and indirect bilirubin resulted from decomposition of hemoglobin, was observed. It is hard to determin whether these biliverdin and indirect bilirubin really stemmed from hemoglobin or from hemolysis during the irrigation. The reticuloendothelial system in the liver and liver cells played important roles in the formation of biliverdin and indirect bilirubin from hemoglobin. 2. Upon irrigation with verdohemochrome added blood, the verdohemochrome was easily decomposed into biliverdin and bilirubin. They were excreted into the bile, and reticuloendothelial system and liver cells would be involved in these depositions. 3. Upon irrigation with biliverdin added blood, over a half of the biliverdin was excreted into the bile. The excreting biliverdin was found to be two forms, the one was biliverdin without any change and the other was bilirubin deoxidized from biliverdin. In the cases with impairment of reticuloendothelial system and/or of liver cells, the excretions of these pigments were rather accelated. The process of the deoxidization of biliverdin into bilirubin took place not only in reticuloendothelial system but even after the excretion from the liver into the bile ducts. 4. In the mechanism of bile pigment formation, not only the reticuloendothelial system played an important role but the liver cells did. en-copyright= kn-copyright= en-aut-name=AkagiKaoru en-aut-sei=Akagi en-aut-mei=Kaoru kn-aut-name=赤木香 kn-aut-sei=赤木 kn-aut-mei=香 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一内科教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=2 article-no= start-page=601 end-page=607 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600130 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on Serological Reactions in Infectious Hepatitis Part 2. Studies on Hetero-Erythrocyte Agglutination Reaction in Infectious Hepatitis kn-title=肝炎の血清反応に関する研究 第2編 流行性肝炎における異種赤血球凝集反応に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Observing erythrocyte agglutination reaction mainly in infectious hepatitis and with considerations of the correlation between sheep and rabbit erythrocyte agglutination and of absorption test, the following results were obtained. 1. In infectious hepatitis, the agglutination titer for rabbit erythrocyte agglutination reaction exhibited fairly high value and appeared to be almost paralled with that for sheep erythrocyte agglutination reaction. In this experiment, however, it seemed to be difficult to argue on the presence of Forssman-antibody. 2. The erythrocyte agglutination reaction with trypsin modified sheep erythrocytes showed fairly high titers in infectious hepatitis and even in other diseases compared with the agglutination titers for sheep erythrocyte agglutination reaction (Paul-Bunnell reaction). But, the alteration of these titers were approximately in proportion to those of Paul-Bunnell reaction. 3. In the absorption test of the sheep erythrocyte agglutination reaction in infectious hepatitis, the absorptions for boiled guinea pig kidney, guinea pig liver, bovine and sheep erythrocyte were quite variable and irregular. But, in a fairly number of cases of infectious hepatitis, moderately increased absorptions for guinea pig kidney and bovine erythrocytes were observed. In view of the alteration of the absorptions, during the periods of infections, the difference of the nature of the antibodies in infectious hepatitis and normal sera was predicted. en-copyright= kn-copyright= en-aut-name=HinoMasuo en-aut-sei=Hino en-aut-mei=Masuo kn-aut-name=日野益雄 kn-aut-sei=日野 kn-aut-mei=益雄 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一内科教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=2 article-no= start-page=593 end-page=600 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600130 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on Serological Reactions in Infectious Hepatitis Part 1. Studies on Auto-Liver-Antibody by Means of Colloidion Agglutination Reaction kn-title=肝炎の血清反応に関する研究 第1編 コロジウム凝集反応による肝自己抗体の検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Studying the significance of serological diagnosis of auto-liver-antibody by means of collodion agglutination reaction, and also observing the production of the antibody following a few experimental liver impairments, the following results were obtained. 1. Positive titers of agglutination was determined as 128 times since the majority of the collodion agglutination reactions in the healthy individuals as well as in the cases of extrahepatic diseases, demonstrated below 128 times. 2. The positive titers of agglutination were noted in 73.9% on investigating the auto-liver-antibody of infectious hepatitis by means of the collodion agglutination reaction. 3. Observing the alteration of the auto-liver-antibody of infectious hepatitis by means of the collodion agglutination reaction and complement fixation reaction, it was noted that the collodion agglutination was more sensitive and that there were relatively high positive titers of the antibody in the acute stages (the second and third week) as well as in the chronic stages. 4. In the mutual relations between the quantities of the auto-liver-antibody detected by the agglutination reaction, the various clinical pictures and the laboratory data of infectious hepatitis, the reactive positive titer of agglutination have increased in proportion to serum colloid liver function tests, serum bilirubin (over 1 to 2 mg. %), positive urine urobilinogen reaction, and to hepato-splenomegalia. No evident correlation was noted between the reactive positive titers of agglutinations and the hemograms of infectious hepatitis, but in the group of the positive reaction fairy numbers of the cases with lymphocytosis and monocytosis were seen, compared with the group of negative ones. 5. Detecting the auto-liver-antibody by means of the collodion agglutination reaction have reflected the clinical pictures fairly well and would be a effective means for clarify the pathophysiology of hepatic diseases. 6. For the purpose of the investigation regarding the production of the auto-liver-antibody in case of aseptic liver impairment, experiments were performed such as aseptic squeezing, cauterization and ligation of the common bile duct. In these experiments, a production of the auto-liver-antibody was confirmed, in relatively early stages, by means of the collodion agglutination reaction. en-copyright= kn-copyright= en-aut-name=HinoMasuo en-aut-sei=Hino en-aut-mei=Masuo kn-aut-name=日野益雄 kn-aut-sei=日野 kn-aut-mei=益雄 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一内科教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=2 article-no= start-page=587 end-page=591 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600130 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Spectrochemical Studies on Bile Pigment Part 2. Spectrochemical Features of Biliverdin, Bilirubin and of their Decomposition Pigments kn-title=胆汁色素の分光化学的研究 第2編 Biliverdin, Bilirubin及びその分解によつて生ずる各種色素の分光化学的諸性状について en-subtitle= kn-subtitle= en-abstract= kn-abstract=After clarifying the spectrochemical features of biliverdin and bilirubin, absorption spectral analyses of their oxidative decompositions, absorption spectral analyses of their oxidative decompositions, following chromatographic fractions, were performed, and the following results were obtained. 1. As biliverdin was unstable chemically, accessory products were easily formed by washing bilirubin with water. 2. Choletelin, propentdyopent urochron etc, were proved, following the oxidation of biliverdin, 3. A blue colored chemically unstable substance was present after the oxidation of bilirubin, at wihch time the formations of biliverdin, propentdyopent and urochrom were proved in the absorption spectra. en-copyright= kn-copyright= en-aut-name=HizutaTuguo en-aut-sei=Hizuta en-aut-mei=Tuguo kn-aut-name=日伝二雄 kn-aut-sei=日伝 kn-aut-mei=二雄 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一内科教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=2 article-no= start-page=581 end-page=586 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600130 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Spectrochemical Studies on Bile Pigment. Part 1. Spectrochemical Studies on the Pigments in Urine, Especially on the Bile Pigment kn-title=胆汁色素の分光化学的研究 第1編 尿色素特にその胆汁色素の分光化学的検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=1. The absorption spectra of urobilin, bilirubin, uroerythrin, urochrom A and urochrom B were determined after separating them from urine. 2. In the absorption spectra using some solvents, there were other absorption spectra which were specific to the solvents and unspecific to the solutes. The mechanism of these absorption spectra was clarified. 3. Besides urochrom, uroerythrin had the most contributing factor to the color of urine, on the other hand urobilin and bilirubin were displaying very little rolls. en-copyright= kn-copyright= en-aut-name=HizutaTuguo en-aut-sei=Hizuta en-aut-mei=Tuguo kn-aut-name=日伝二雄 kn-aut-sei=日伝 kn-aut-mei=二雄 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一内科教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=2 article-no= start-page=569 end-page=579 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600130 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on Leukocyte Functions in Case of Liver Impairment Part 2. Leukocyte Motility and Leukocyte Phagocytosis of Indiaink in Experimental Liver Impairment kn-title=肝障碍時に於ける白血球機能に関する研究 第2編 実験的肝障碍時の白血球遊走速度並びに墨粒貪喰能に就いて en-subtitle= kn-subtitle= en-abstract= kn-abstract=Observing leukocyte motility and leukocyte phagocytosis of India-ink in the two groups of cases, the one of the which had formic acid allyl for only once and the other had daily small dosis, and studying the effect to the motility and phagocytosis of leukocyte of various drugs for infectious hepatitis, and the following results were obtained. 1. Following the administration of formic acid allyl (30 mg/kg), the leukocyte motility was accelated within one hour and thereafter depressed abruptly. On the other hand, the phagocytosis of Indiaink have dicreased after giving formic acid allyl. Both functions of leukocyte depressed markedly in the cases given increased formic acid allyl up to 50 mg/kg. 2. Following the administration of formic acid allyl, no effect to the both functions by giving Cortisone, unclear by DOCA, and an accelation and regaining of the both fnnctions were noted by giving ACTH. Regaining of the motility, not of the phagocytosis, from depressed state and further accelation were observed following the administration of 5% dextrose in water. Ferric chlorophyll preparations had the leukocyte motility regained from depressed state following the administration of formic acid allyl of 30 mg/kg, but no effect was seen after 50 mg/kg of formic acid allyl. There was no effect by ferric chlorophyll. Glucuronic acid showed a transient effect do leukocyte motility, but not to the phagocytosis of India-ink. 3. The both functions of leukocyte have markedly depressed, the maximum at 9th day in the cases who had been having formic acid allyl 10 mg/kg for 4 days. 4. In the above cases a slight improvement to the both functions of leukocyte was seen by giving Cortisone or DOCA, a distinctive improvement, on the other hand, by ACTH. 5% dextrose in water was effective only for leukocyte motility, and ferric chlorophyll demonstrated a slight effect for the both functions and so did glucuronic acid although transient for the phaocytsois. en-copyright= kn-copyright= en-aut-name=NishidaTakeshi en-aut-sei=Nishida en-aut-mei=Takeshi kn-aut-name=西田彪 kn-aut-sei=西田 kn-aut-mei=彪 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一内科教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=2 article-no= start-page=561 end-page=567 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600130 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on Leukocyte Functions in Case of Liver Impairment Part 1. Motility and Phagocytosis of Leukocyte in Experimental Liver Impairment kn-title=肝障碍時に於ける白血球機能に関する研究 第1編 肝炎患者の白血球遊走速度並びに墨粒貪喰能に就いて en-subtitle= kn-subtitle= en-abstract= kn-abstract=Observing leukocyte motility and leukocyte phagocytosis of Indiaink on the infectious hepatitis cases, and the following results were obtained. 1. In the healthy individuals, the leukocyte motility was ranging over 22.05 to 35.71 μ/min. and 1.88 to 2.22 in the leukocyte phagocytosis of India-ink. 2. In the acute hepatitis cases, the leukocyte motility was depressed initially and was then accelated in the convalescent stadium. Leukocyte phagocytosis of India-ink showed similar tendencies although they were fairly variable in the clinical courses. 3. The both functions of leukocyte showed approximate correlations to the impairments of liver functions. 4. In the acute hepatitis cases, the both functions of leukocyte were depressed in almost parallel with fever and leukocytosis. 5. In the chronic hepatitis cases, the leukocyte motility was within normal range, however, the phagocytosis of India-ink was depressed in some cases. The leukocyte motility showed approximate correlation to the impairments of liver function, on the other hand, the phagocytosis of India-ink did not always showed such correlation. en-copyright= kn-copyright= en-aut-name=NishidaTakeshi en-aut-sei=Nishida en-aut-mei=Takeshi kn-aut-name=西田彪 kn-aut-sei=西田 kn-aut-mei=彪 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一内科教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=2 article-no= start-page=553 end-page=560 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600130 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Histological Studies on Experimental Hepatitis Part 2. On the Histological Changes of the Internal Organs of Mouse Given Daily Small Dosis of Arsenious Acid Orally, with Ectromelia virus Infection kn-title=実験的肝炎の組織学的研究 第2編 亜砒酸少量連日投与廿日鼠にEetromelia virusを感染させた場合の体内諸臓器の組織学的変化について en-subtitle= kn-subtitle= en-abstract= kn-abstract=Observing the histological changes of the internal organs of the mice, having daily oral administrations of arsenious acid and simultaneous oral infection of Ectromelia virus and of the mice infected Ectromelia virus 4 days after the beginning of the arsenious acid administration, in compared with those that had daily arsenious acid without the infection, and the following results were obtained. 1. In the cases had the continuous administration of arsenious acid administration, in compared with those that had daily arsenious acid without the infection, and the following results were obtained. In the liver of the same cases, degeneration and necrosis of the liver cells and nuclei were marked, on the other hand, regenerations of the liver cells in association with round cell infiltrations were noted. There were extensive parenchimal impairments in the kideny and heart as well. 2. In the cases with Ectromelia virus infection on the 4 th day after the beginning of the arsenious acid administration, much severe vascular damages, and degenerations and necrosis of the liver parenchyma especially marked in the peripheral areas of the lobules were observed There were more extensive parenchymal imparments in the kidney and heart. 3. The cases with both Ectromelia virus infection and the administration of the arsenic acid presented the pathological findings summed up both of damages but especially marked in the vascular regions. In the cases with viral infection following the arsenious acid intoxication, the vascular damages due to the intoxication gave some influences upon the further pathological changes. 4. The vascular damages caused by the arsenious acid intoxication appeared to be essentially similar to those of Ectromelia virus infections. en-copyright= kn-copyright= en-aut-name=EndoKenichi en-aut-sei=Endo en-aut-mei=Kenichi kn-aut-name=遠藤憲一 kn-aut-sei=遠藤 kn-aut-mei=憲一 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一内科教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=2 article-no= start-page=545 end-page=552 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600130 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Histological Studies on Experimental Hepatitis Part 1. On the Histological Changes of the Internal Organs of Mouse Following the Oral Administrations of the Various Concentrations of Arsenious Acid kn-title=実験的肝炎の組織学的研究 第1編 種々な濃度の亜砒酸を経口投与した場合の体内諸臓器の組織学的変化に就いて en-subtitle= kn-subtitle= en-abstract= kn-abstract=Observing the histological changes of the internal organs of mouse following the oral administrations of 0.5 cc of arsenious acid in various concentrations, and the following results were obtained. 1. In the cases given 0.5 and 1.0% of arsenious acid orally, marked degenerations of the parenchymal cells ware observed mainly in the kidney and heart. But, vascular damages were present in every organ, especially evident in the liver and spleen; hypertrophy of stelliform cells, destruction, dilatation, hyperemia, swelling and roughness of the vascular walls. 2. In the cases given daily 0.05% arsenious acid orally, increased degenerations of the parenchymal cells in the kidney and heart, comparing with initial stadium, was noted. But, the similar vascular damages were observed in the organs especially in the liver and spleen. Moreover, the lymphatic spaces have been dilated progressively, and some serous exudates was seen in the lymphatic spaces of the liver on the 6 th day. 3. In the cases given daily 0.05% arsenious acid orally. nodules accompanied with diffuse infiltration of round cells were observed on the 6 th day. On the 7 th to 8 th day, there appeared coagulation necrosis in which central areas were almost full of polymorphnucleous leucocytes, stelliform cells and degenerative products from the liver cells. Small necrosis composed of lymphocytes and stelliform cells was seen on the 9 th to 10 th days. 4. As the histological changes of the mouse organs described above, were quite similar to those of the infectious hepatitis cases, this study would offer some suggestions to clarify the contributing factors in the pathology of infectious hepatitis. en-copyright= kn-copyright= en-aut-name=EndoKenichi en-aut-sei=Endo en-aut-mei=Kenichi kn-aut-name=遠藤憲一 kn-aut-sei=遠藤 kn-aut-mei=憲一 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一内科教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=2 article-no= start-page=537 end-page=544 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600130 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on Liver Biopsy Chapter 2. Studies on Bilifustin like Substance in the Liver and its Entity kn-title=肝生検に関する研究 第2編 肝臓内Bilifuscin様物質の検出とその本態に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=A cases thought to be a I. N. Dubin & F, B. Johson's constitutional hemolytic icterus, a case with carcinoma of the stomach and a case with posthepatitic syndrome were described in this study. In the latter two cases, brown colored granules in the liver cells were noted. Studying these granules histochemically, in comparison with histochemical features of granules which were considered to bilifuscin or its analogous substance obtained following the administration of blood, verdohemoglobin and biliverdin into the subcutaneous tissues of mouse, these granules were not I. N. Dubin's lipofuscin like pigment but precipitation of bilifuscin in the liver cells stemmed from decomposition of bilirubin as results of abnormal bilirubin metabolism. en-copyright= kn-copyright= en-aut-name=UedaYutaka en-aut-sei=Ueda en-aut-mei=Yutaka kn-aut-name=植田胖 kn-aut-sei=植田 kn-aut-mei=胖 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学綿一内科教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=2 article-no= start-page=521 end-page=535 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600130 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on Liver Biopsy Chapter 1. Correlations between Liver Biopsy Findings and Liver Function Tests in Infectious Hepatitis kn-title=肝生検に関する研究 第1編 流行性肝炎に於ける肝生検所見と肝機能検査成績との関係に就いて en-subtitle= kn-subtitle= en-abstract= kn-abstract=35 cases of acute viral hapatitis and 60 cases of chronic hepatitis underwent needle liver biopsies, and the studies were made on the correlations between histological findings and liver function tests of these cases, and the following results were obtained. 1. In the preicteric and icteric stages of the acute viral hepatitis cases, cephalin cholesterol flocculation test, serum bilirubin and Azorubin-S excretion test presented closest correlations with histological findings of the liver. 2. In the convelescent stages of acute viral hepatitis, delayed recoveries were observed in Glisson's capsules and peripheral areas of the lobules rather than liver cells. in these cases, 63.3% of cephalin cholesterol flocculation test and Azorbin-S excretion test had mutual relations with histological pictures. 3. In the chronic hepatitis cases there was no evidence of close correlation between liver function tests and histological findings. 4. In the chronic hepatitis cases, in whom pseudolobules were formed histologically, hyperbilirubinemia, various serum colloid liver function tests and pigment excretion tests were all positive. 5. In the hepatitis type II (H. Eppinger) cases, a dissociation was observed between liver function tests and histological findings despite severe icterus and advanced impairment of the liver cells. en-copyright= kn-copyright= en-aut-name=UedaYutaka en-aut-sei=Ueda en-aut-mei=Yutaka kn-aut-name=植田胖 kn-aut-sei=植田 kn-aut-mei=胖 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一内科教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=2 article-no= start-page=515 end-page=520 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600130 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Transaminase of Brain (U) Effects of Psychotropic and Neurotropic Drugs on the Transaminase Activities kn-title=脳のトランスアミナーゼ 第2編 各種向精神・神経薬のダイコクネズミ脳組織トランスアミナーゼ活性に及ぼす影響 en-subtitle= kn-subtitle= en-abstract=Effects of 18 psychotropic and 3 neurotropic drugs were measured by the author on the glutamic-aspartic transaminase (GAT) activities in the rat brain homogenates. 1. Chlorpromazine, chlopromazine sulfoxide, acetylpromazine, levomepromazine, mepazine and perphenazine inhibited GAT, while prochlorperazine showed no effect. Both of diethazine and promethazine did not effect on GAT. 2. Pipradrol and dimethylaminoethanol activated GAT, while methylphenidate showed no effect. 3. Azacyclonol, amobarbital, phenobarbital, methyprylon, glutethimide and primidone were inhibitory in acion on GAT. 4. LSD-25 inhibited to GAT and bemegride did not effect on. 5. In the effect on GAT, similarities of imipramine to the phenothiazine derived depressants, or differences of diethazine and promethazine from other phenothiazine derivatives seemed to be causad due to the resemble or different distance between two nitrogen atoms. kn-abstract=ダイコクネズミ脳homogenateを用い，グルタミン酸-アスパラギン酸トランスアミナーゼ（GAT）活性に及ぼす18種の向精神薬，および3種の向神経薬の影響を測定した. 1. フエノチアジン系向精神薬は， Prochlorperazineを除く他の6種はいずれもGAT阻害を示し，阻害作用はChlorpromazineに最も強かつた. Chlorpromazine S-oxideはChlorpromazineに比してGAT阻害作用は著しく弱い. 2種のフエノチアジン系向神経薬はGAT活性に影響をみなかつた. 2. AzacyclonolはGAT阻害を示し， LSD-25は高濃度で阻害を示したが低濃度では影響を与えなかつた. 3. 中枢刺戟剤4種のうち， PipradrolとDMAEは促進， Methylphenidateは影響なく， Tofranilは阻害を示した. 4. バルビツール酸系睡眠剤AmobarbitalとPhenobarbital，非バルビツール酸系睡眠剤MethyprylonとGlutethimideは，すべて阻害を示した.しかるにバルビツール酸拮抗剤BemegrideはGATに無影響であつた.抗てんかん剤Primidoneは阻害を示した. 5. 実験に用いた中枢抑制剤13種のうち12種が阻害を示した. 6. GATに及ぼす作用において， ImipramineとChlorpromazineの類似， DiethazineやPromethazineとChlorpromazineとの差異を，化学構造における2個のN原子間の距離の一致と相異に対応すると考えた. en-copyright= kn-copyright= en-aut-name=OnoMasaya en-aut-sei=Ono en-aut-mei=Masaya kn-aut-name=小野昌也 kn-aut-sei=小野 kn-aut-mei=昌也 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部神経精神医学教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=2 article-no= start-page=507 end-page=513 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600130 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Transaminase of Brain (I) Transaminase Activities of the Monkey and Human Brain kn-title=脳のトランスアミナーゼ 第1編 タイワンザル脳およびヒト脳におけるトランスアミナーゼ活性について en-subtitle= kn-subtitle= en-abstract=The author measured the transaminase activities of eighteen amino acids with α-keto-glutarate in a Pithecus monkey brain and in two human brains, one obtained from a man died from accident and another from a woman died of senile psychosis due to brain atrophy. 1. In the monkey brain, alanine and valine showed low activities in the cerebral cortex in comparison with other parts but γ-amino-β-hydroxybutyric acid showed a low activity. 2. In normal human brain, lower activities of valine, leucine and three ω-amino acids were showed in the cerebral cortex, which were different from the monkey and lower vertebrates. 3. The markedly atrophic cerebral cortex was more similar to the lower vertebrates than to the normal human brain in high activities of alanine, leucine, valine and γ-amino-β-hydroxybutyric acid. But an increase of activities of histidine, proline and ornithine was not similar to both of normal human and animal brain. These high activities of histidine and praline correspond unlikely to the transamination only. kn-abstract=タイワンザル脳，事故死ヒト脳の大脳皮質，大脳白質および小脳皮質，さらに高度の脳萎縮を伴い老人性痴呆にて死亡したヒト脳の大脳皮質を用い， 11種のα-アミノ酸， 3種のω-アミノ酸， 3種のヂアミノ酸，システイン酸，タウリンについて，組織のトランスアミナーゼ活性を測定した. 1. タイワンザル脳では，大脳皮質においてアラニンとバリンの活性が他部より低く，γ-アミノ酪酸とγ-アミノ-β-オキシ酪酸が高い. 2. 健常人脳では，アスパラギン酸，セリンが大脳皮質に，ヒスチジン，ロイシン，バリンが小脳皮質にて他部より高く，アラニン，フエニールアラニン，システイン酸は大脳白質において低い活性を示した. 3. タイワンザルおよび健常ヒト脳の大脳皮質では，いずれもアスパラギン酸，グリシン，フエニールアラニン，オルニチン，システイン酸の高い活性，およびアラニンの低い活性の点で他の下等動物脳と異なる. 4. 健常ヒト大脳皮質は，バリン，ロイシンおよび3種のω-アミノ酸の低い活性を以つてサルおよび下等動物と異なる. 5. 萎縮したヒト大脳皮質は，アラニン，ロイシン，バリン，γ-アミノ-β-オキシ酪酸の活性が健常ヒト大脳皮質より高く，むしろ下等動物のそれに近い.ヒスチジン，プロリン，オルニチンのグルタミン酸生成の著しい増加は健常ヒト脳および下等動物脳のいずれとも異なるが，ヒスチジンとプロリンはトランスアミナーゼ活性増加のみによるものかどうか疑わしい. en-copyright= kn-copyright= en-aut-name=OnoMasaya en-aut-sei=Ono en-aut-mei=Masaya kn-aut-name=小野昌也 kn-aut-sei=小野 kn-aut-mei=昌也 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部神経精神医学教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=2 article-no= start-page=489 end-page=506 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600130 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A Clinicohistological Study of Bleeding Mechanism in Myomata of the Uterus kn-title=子宮筋腫の出血機序に関する臨床的研究並びに内膜血管の組織学的及び形態学的研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Genital bleeding as a main symptome of myoma of the uterus is not uncommonly encountered by gynecologist. Clinical and histological studies were carried on both entdometria and ovaries of 24 patients with myoma of the uterus. Specific attention was paid to clarify the bleeding mechanism from this diease, using histological and transparently modeled specimens of the blood vessels. The transparent specimens were made as follows. After hysterectomy was done, a pigment solution was injected into the vessels and then, after an adequate dehydration, the specimens were trausferred to methylsalcilate for immersion. The binocular stereomicroscope was used for the present study. Results of the study are summarized in the following. 1) Menstrual abnormality was found in 70,9% of all the cases. 2) The endometrial and ovarian histology has the same cyclic changes as the normal does, and the endometrial secretory phase is compatible with the corpus luteam in the ovary. 3) The majority of cases showed endometrial hyperplasia. 4) In case of submucous myomata, a striking difference of the endometrial thickness and the histologic pictures between the surface endometria above the myomata and the other areas. 5) The blood vessels of myomatous endometria have the same cycle as those of the normal do. Although the intramuscular blood vessels in influenced by the myomata mass, there is no specific morphological changes found in the endometrial blood vessels. 6) In this study, no venous sinus was observed in the endometrium. 7) It would appear that the menstrual abnormality under myoma of the uterus may be caused by the mechanical effect from the myomatous mass upon the endometrial and myometrial vessels. en-copyright= kn-copyright= en-aut-name=SeoTakashi en-aut-sei=Seo en-aut-mei=Takashi kn-aut-name=瀬尾貴 kn-aut-sei=瀬尾 kn-aut-mei=貴 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部産科婦人科学教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=2 article-no= start-page=461 end-page=471 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600130 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A Study on the Human Fetal Membranes under the Electron Microscope kn-title=人卵膜（特に羊膜）の電子顕微鏡的研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=This paper is concerned with morphologic and functional clarification of the human fetal membranes under the electron microscope. The materials were taken from those of early and middle in pregnancy upon eurretage or subtotal hysterectomy, and those of late in pregnancy on cesarean section. and full term normal delivery. These materials, after taken, are immediately fixed in mixed solution of osmic acid and veronal buffer solution and kept in refrigerator for 30 minutes, After rinsing them by water for 30 minutes, dehydration was carried on in ethanol series (50%, 70%, 80%, 90%, 100%) for 30 minutes in each. Sectioning was performed by ultramicrotome and then submitted to electron microscope examination. The results are as follows: 1) Chorionic membrane early in pregnancy shows a significant distinction between the syncitial cell layer and Langhans' cell layer. 2) Syncitial cells have no cellular demarcation each other. 3) Cilia of the syncitial cells project into the intervillous spaces. 4) Intercellular combination of amniotic epithelial cell is not depandant on so-called intercellular bridges, but on stratification of the cytoplasmic project. 5) There is a wavy appearance on the amniotic epithelial cells, beneath which the sawteeth like cytoplamic projects are united with the underlying connective tissues. 6) As pregnancy progresses, the epithelial cell becomes taller followed by its cylindrical modification late in pregnancy. 7) Mitochondria are found rarely in the amniotic epithelial cells, and no secretory vacuoles and granules were seen. Golgi apparatus appears to be not well-preserved. From these findings, it is assumed that there is no secretory activity present in the amniotic epithelial cells. Perhaps, it may thus be denied that amniotic fluid is produced by the amnion. en-copyright= kn-copyright= en-aut-name=TanakaHajime en-aut-sei=Tanaka en-aut-mei=Hajime kn-aut-name=田中一 kn-aut-sei=田中 kn-aut-mei=一 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部産科婦人科学教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=2 article-no= start-page=437 end-page=460 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600130 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the Adrenal Cortical Function in So-Called Banti's Disease Part 2. Influences of the Sera of the So-Called Banti's Disease on the Adrenal Cortical Function of Albino Rats kn-title=所謂バンチ氏病における副腎皮質機能に関する研究 第2編 患者血清の白鼠副腎皮質機能に及ぼす影響 en-subtitle= kn-subtitle= en-abstract= kn-abstract=After a single or successive intramuscular injections of the patients with so-called Banti's disease into albino rats the author observed the adrenal cortical function hourly or daily and obtained the following results. 1. The number of peripheral erythrocytes was markedly decreased in both those given a single and those given the successive injections. This fact proves the existence of anemia inducing factor in the sera of so-called Banti's disease. 2. A fall in the adrenal cortical reserve funetion can be recognized after the successive injection. 3. There can be recognized no fixed tendency in the change of Na, K, Cl, Na/K in the serum. 4. The weight of the adrenal gland shows a slight decrease after the successive injections. 5. The total ascorbic acid of adrenals decreases after the single injection, while on the contrary, it increaaes markedly by degrees in the successive injections. 6. Histochemically in the case of the single injection, lipid granules of the adrenal cortex decrease in number and grow finer in the fascicular zone, while in the successive injections they become grosser and reticular in the fascicular and glcmerular zones. 7. The histological picture of the adrenal cortex in the successive injections reveals the swelling of the capsule and of the glomerular zone, hyperemia and the regressive changes in the nuclei and protoplalma in the reticular zone, but hardly any change can be observed in the fascicular zone. 8. From these findings it seems that the adrenal cortical function is acclerated in the case of the single injection, while the function is decreased in the successive injections. And these changes are definitely caused by anemia producing factor in the sera of patients with so-called Banit's disease. en-copyright= kn-copyright= en-aut-name=ObayashiMiyuki en-aut-sei=Obayashi en-aut-mei=Miyuki kn-aut-name=大林幸 kn-aut-sei=大林 kn-aut-mei=幸 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=2 article-no= start-page=425 end-page=436 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600130 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the Adrenal Cortical Function in So-Called Banti's Disease Part 1. The Function of Adrenal Cortex of Patients with this Disease kn-title=所謂バンチ氏病における副腎皮質機能に関する研究 第1編 患者における副腎皮質機能 en-subtitle= kn-subtitle= en-abstract= kn-abstract=With a view to clarify the cause of so-called Banti's disease the author studied the adrenal cortical function in patients with this disease, and obtained the following results. 1. Elevation in the basal metabolic rates can be observed in many cases. 2. As for electrolytes in serum, sodium, potassium, chlorine and calcium are decreased, but phosphorus is increased to a high degree, while Na/K ratio is increased. 3. Robinsou Power-Kepler water test is positive in the majority of cases. 4. Blood sugar level in early morning is slightly high, and in the insulin sensitivity test, the insulin index has been found to have declined and restoration of lowered blood sugar is prolonged. 5. On measuring 17-KS and free chemocorticoids (Ch. C.) excreted in the urine, the amount of 17-KS is decreased conspicuously, but Ch. C. is increased slightly. 6. In the gel-ACTH loading test the adrenal cortical reserve function is declined. 7. After splenectomy the rate of the basal metabolism increases still further and the insulin sensitivity test yields about the normal values, but the adrenal cortical reserve function as observed by the gel-ACTH loading test does not show any change. 8. From these facts it is possible to assume that there is a decliue in the adrenal cortical function in this disease. en-copyright= kn-copyright= en-aut-name=ObayashiMiyuki en-aut-sei=Obayashi en-aut-mei=Miyuki kn-aut-name=大林幸 kn-aut-sei=大林 kn-aut-mei=幸 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END