骨髄組織培養法による各種ビタミンの骨髄亘核球機能に及ぼす影響 第3編 実験的ビタミンC欠乏海猽に於ける骨髄巨核球機能について

In order to study the megakaryocyte function in vitamin C-deficiency (avitaminosis) the author observed the fluctuation of the thrombocyte count in experimental vitamin C-deficient guinea pigs, and next, by performing the bone marrow tissue culture of the femur of these animals, the following results were obtained: 1. The thrombocyte count decreased markedly in the vitamin C-deficient guinea pigs. 2. The megakaryocyte function in these vitamin C-deficient animals was markedly lowered as compared with that of the normal. 3. The lowered megakaryocyte function in the vitamin C-deficient guinea pigs could be brought back to the normal level by adding vitamin C 0.01 mg/c.c. directly to the medium. From these findings it has been clarified that vitamin C and the function of megakaryocytes are closely related because the lowering of the magakaryocyte function is induced by the decrease in the number of thrombocytes in vitamin C-deficiency.