start-ver=1.4
cd-journal=joma
no-vol=70
cd-vols=
no-issue=8
article-no=
start-page=3041
end-page=3051
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1958
dt-pub=19580831
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=The P.H. and Proteins in the Saliva of Patients with Cervical Carcinoma
kn-title=子宮頸癌患者の唾液P.H.及び蛋白質に就いて
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=As the auxiliary diagnosis for carcinoma of the cervix the author evaluated the pH, whole proteins. and protein fractions in the saliva; and obtained the following results: 1) The pH of the saliva in patients with cervical carcinoma is lower than that in the case of normal non-pregnant women, and it becomes more marked with the lapse of time. In 25.6 per cent of the patients in Stage Ⅰ an abnormally low pH of under 6.2 can be observed, showing a significant difference as compared with the normal non-pregnant women; but as the percentage is low, it can not be so useful for an early diagnosis. 2) In 9.6 per cent of those whose improvement is good at follow-up examinations after treatment such an abnormally low pH can be found, and in them pH returns to the normal level only after one year. In 33.3 per cent of those whose prognosis is poor, an abnormally low pH value can be recognized. In the follow-up examinations successively abnormally low pH can be found in 8.0 per cent of those with a good improvement, and in 66.6 per cent of those with a poor improvement. Sixty per cent of those showing abnormally low pH successively are those with a poor prognosis. 3) The amount of whole protein in the saliva of patient with cervical carcinoma shows a slight increase over 46.2 mg/dl in the case of normal non-pregnant women. Statistically a significant difference at 79.0 mg/dl can only be recognized in those at Stage Ⅳ. As for the percentage of those showing as abnormally high as 72.26 mg/dl, 28.9 per cent of those in Stage Ⅱ show abnormally high value as compared with normal non-pregnant women, but it has little value for diagnosis. 4) An increase in whole protein can be recognized in the anemic patient showing sahli value of under 59 per cent. 5) No significant difference can be recognized in the protein fractions of the saliva in the patients with cervical carcinoma as compared with normal non-pregnant women. From these data it is assumed that the evaluations of the whole protein content and protein fractions in the saliva are not so useful as an auxiliary diagnosis of cervical carcinoma, but the continuous follow-up estimations of pH of the saliva for the purpose of discovering the recurrence of cervical carcinoma at an early stage enable us to foresee it, and such follow-up examinations will offer us an important criterion for the judging of the conditions after treatment.
en-copyright=
kn-copyright=

en-aut-name=KawadaKenji
en-aut-sei=Kawada
en-aut-mei=Kenji
kn-aut-name=河田謙二
kn-aut-sei=河田
kn-aut-mei=謙二
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部産科婦人科学教室
END

start-ver=1.4
cd-journal=joma
no-vol=70
cd-vols=
no-issue=8
article-no=
start-page=3029
end-page=3040
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1958
dt-pub=19580831
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=The Irradiation Susceptibility of Cervical Carcinoma, with a Special Reference to the Metastasis to Lymph Nodes
kn-title=子宮頸癌の放射線感受性に関する研究 特に転移淋巴節に就いて
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Preoperative roentgen-irradiation (unilaterally 1-12 times) treatment was given to 216 cases with cervical carcinoma, and 24 hours after the completion of irradiation Okabayashi's radical extensive hysterectomy was performed. The author studied the irradiation susceptibility of metastased cancer cells by comparing the original site of cancer with metastased lesions and the metastatic irradiated side with non-irradiated side, with a special emphasis on the mitosis of cancer cells. As for the significance between C.P.L. type (Imai) of the primary cancer and the metastatic foci, the change in the mitotic picture due to roentgen irradiation in C-type metastatic foci is significantly greater than that in L-type metastatic foci; and therefore, the irradiation susceptibility in C-type can be said higher. Namely, in this instance the irradaation susceptibility and the prognosis have the same tendency. As for the relationship between Nagase's classification (Types Ⅰ, Ⅱ, Ⅲ) of the primary cancer and its metastatic foci, the change in mitotic picture due to roentgen irradiation in the case of Type Ⅱ metastatic focus is greater than in Type Ⅰ metastatic focus, and the irradiation susceptibility in Type Ⅱ tends to be higher. In other words, in this instance the irradiation susceptibility is in no way associated with the prognosis. Therefore, it is dangerous to deduce the prognosis from the irradiation susceptibility of cancer cells. Numbers of giant cells appearing due to irradiation increase in proportion to the degree of the destruction of the cancer focus irradiated upon. Therefore, in the observation of dividing cells in the irradiated cancer focus, it is essential to pay attention not only to the change in the number of cells but also to the variety of the degeneration picture. The degree of degeneration in dividing cells increases in propoetion to the irradiation amount, and by a irradiation more than 1,300 r (deep dosis) the mitotic picture changes markedly, thus bringing about the cell disintegration. On applying an irradiation tube on the anterior surface, its lower margin is placed just above the pubic symphysis, and its inner margin is about 2 cm. outside the medial line; and on applying it on the posterior or lateral side, its lower margin is placed on both greater trochanters; and from the posterior side it is irradiated at the angle 20℃ to the side of the head. In other words, it is believed that main lymph nodes in the pelvis are almost all equally irradiated by irradiation at the sites mentioned above.
en-copyright=
kn-copyright=

en-aut-name=OmuraMakio
en-aut-sei=Omura
en-aut-mei=Makio
kn-aut-name=大村真喜雄
kn-aut-sei=大村
kn-aut-mei=真喜雄
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部産科婦人科学教室
END

start-ver=1.4
cd-journal=joma
no-vol=70
cd-vols=
no-issue=8
article-no=
start-page=3013
end-page=3027
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1958
dt-pub=19580831
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=The Infiltration of the Cervical Carcinoma into the Vaginal Wall and the Relationship between the Cancer Infiltration into the Vaginal Wall and the Recurrence at the Vaginal Stump Section Ⅰ. The Infiltration of the Cervical Carcinoma into the Vaginal Wall Section Ⅱ. The Relationship between the Cancer Infiltration into the Vaginal Wall and the Recurrence at the Stump of the Vagina
kn-title=子宮頸癌の腟壁癌浸潤並びに腟壁癌浸潤と腟断端再発との関係に関する研究 第Ⅰ編 子宮頸癌の腟壁癌浸潤について 第Ⅱ編 腟壁癌浸潤と腟断端再発との関係について
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=For the carcinoma of the cervix the vaginal wall can be an object of cancer invasion, and it is closely associated with the postoperative recurrence at the stump of the vagina and also with the prognosis. In the present study the author carried out histological investigations of the vaginal wall of the patients who had Okabayashi's radical extensive hysterectomy in our clinic; and in Section Ⅰ are presented the results of investigations on the manner of cancer invasion into the vaginal wall in 160 recent unselected cases, and in Section Ⅱ the relationship between the recurrence at the vaginal stump and the vaginal-wall invasion as well as prophylactic effect of concomitant use of radium on the recurrence at the vaginal stump are described concerning 102 older specimens. Section 1. As for the invasion of the cervical carcinoma 62 cases (38.8%) out of 160 cases have been verified to have the cancer invasion, and there are some differences between the macroscopic and histological findings; and even in the 39 cases whose findings coincide with one another, in about one third of them the cancer invasion has been found 5 mm deeper in the histological examination than in the macroscopic examination. Next, the incidence of the cancer invasion into the vaginal wall is greater in more advanced age; more in the cervical canal cancer than cancer in the vaginal portion; more frequeut in Stage Ⅱ than in Stage Ⅰ; in a retrocessive type of growth; in the case where the outward appearance of the lesion is ulcerous; in the C.P.L. classification more in L-type; and more in the case where the cancer propagated to the endometrium than in the case without such apropagation; likewise in the case where the cancer propagated to the corpus uterus; and more frequent in the case with lymph node metastasis. As for the incidence of the cancer infiltration to various layers of the vaginal wall, the epidermal infiltration, the epidermal + submucous tissue, and the epidermal + submucous + muscular layers occupy two thirds of the total, and as for the invasion of each layer it is slightly more frequent in the epidermal layer. No difference can be observed in the frequency of the cancer invasion as regrads the sites of the vaginal wall (anterior, posterior, right, and left), and the cancer infiltration into the vaginal wall is always contiguous. Section Ⅱ. As regards the relationship between the cancer invasion into the vaginal wall and the recurrence at the stump of the vagina, out of 47 cases with recurrence 35 cases (74.4%) proved to have infiltration into the vaginal wall, and 8 cases had the cancer invasion penetrated as far as the vaginal stump. In those that had the recurrence at the vaginal stump the majority of them consisted of the vaginal cancer, cancer of Stage Ⅱ and Ⅲ, ulcerous exterior appearance, retrocessive type of growth, L Type, and moderately matured type. In comparing the 35 recurrent cases having the cancer invasion into the vaginal wall with those cases without recurrence at the vaginal stump, it has been clarified that the recurrence at the vaginal stump is more liable to occur in Type L with the vaginal-wall invasion and in the case whose distance between the tip of the infiltration and the stump end is less than 5 mm. Moreover, for the prevention of the recurrence at the vaginal stump taking the data in Section I into consideration, for the cases without vaginal-wall infiltration the conventional 3 cm-resection of the vaginal wall is indicated, while for the cases with vaginal-wall infiltration it is necessary to resect the vaginal wall over 1.8 cm. below the tip of macroscopic infiltration in view of the shrinkage of the specimens examined and the fact that histologically the infiltration goes deeper than macroscopic finding. In addition, when the cancer infiltration is marked and there is a danger of recurrence it is possible to prevent such a recurrence by radium therapy. In our laboratory the proximal dosage of radium used is 1,000 mg elh.
en-copyright=
kn-copyright=

en-aut-name=SimizuSyoji
en-aut-sei=Simizu
en-aut-mei=Syoji
kn-aut-name=清水昭爾
kn-aut-sei=清水
kn-aut-mei=昭爾
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部産科婦人科学教室
END

start-ver=1.4
cd-journal=joma
no-vol=70
cd-vols=
no-issue=8
article-no=
start-page=3001
end-page=3011
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1958
dt-pub=19580831
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=A Study on the Irradiation Susceptibility of Cervical Carcinoma
kn-title=子宮頸癌の放射線感受性に就いて
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Since Broders and Martzlff's report on the relation of irradiation susceptibility of the cervical carcinoma with the prognosis, there appeared many studies on the same subject by various investigators. And with the recent reports on the C.P.L. classification and Nagase's classification it has become clearly established that there is a close relationship between the irradiation susceptibility and prognosis. In the present paper are presented the results of observations on histological changes, especially changes in the mitotic picture and the appearance of giant cells, in the tissue specimens prepared before and after irradiation from 205 operable cases with cervical carcinoma, who had been treated with irradiation (mainly bard roentgen and some by radium irradiation) and then operated on by Okabayashi's method during the periodfrom August 1956 to December 1957, and also presented are comparative studies of these results with the CPL classification and Nagase's classification. 1) The histological changes turn generally markedly with incresed amount of radiation, but the change observable in each individual case reveals a marked individualistic difference, yet showing not necessarily any parallelism in the histologicai change with the amount of radiation within the surface dosis of 3,600 r. 2) No specific relationship exists between the histological change and the C.P.L. classification or Nagase's classification. 3) As for the change in the mitotic picture, the normal mitosis is rapidly diminished by irradiation, finally disappearing completely with the increase in the amount of radiation, while on the contrary abnormal mitosis is markedly enhanced by irradiation. 4) As for the relationship between the change in the mitotic picture and the C.P.L. classification, in the case given six roentgen irradiations (surface dosis of 1,800 r.) there is no significant relationship, but in the cases given 12 rounds of irradiation (surface dosis of 3,600 r.) the change in Type C is greater than that in Type L. 5) As regrads the relationship between the chang in the mitotic picture and Nagase's classification, no specific relationship can be recgonized in the cases administered with 6 rounds of irradiation an increase in the appearance of abnormal mitosies in Type Ⅰ is more pronounced than that in Type Ⅱ or Type Ⅲ. 6) Giant cells appear increasingly after six rounds or more of irradiation; and in the cases given 12 rounds of irradiation they appear significantly more numerously in Type C according to the CPL classification while more significantly in Type Ⅰ according to Nagase's classification. The actions of irradiation on cancer tissue may be roughly divided into a direct action on cancer cells and an indirect action derived from the influences on the local interstitial tissues and on the systemic metabolism. However, it seems that the irradiadiation susceptivility first of all and subsequently the problem related the prognosis can be solved only when these direct and indirect actions are summarily studied.
en-copyright=
kn-copyright=

en-aut-name=MiyakeMasaaki
en-aut-sei=Miyake
en-aut-mei=Masaaki
kn-aut-name=三宅昌秋
kn-aut-sei=三宅
kn-aut-mei=昌秋
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部産科婦人科学教室
END

start-ver=1.4
cd-journal=joma
no-vol=70
cd-vols=
no-issue=8
article-no=
start-page=2987
end-page=3000
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1958
dt-pub=19580831
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=A Study on the Irradiation Susceptibility of Cervical Carcinoma by Means of Vaginal Contents
kn-title=膣内容による子宮頸癌の放射線感受性に関する研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=By giving preoperative roentgen-Irradiation treatment to 225 operable cases of cervical carcinoma, admitted to the Department of Obstetrics and Gynecology, Okayama University Medical School, from August 1, 1956 to December 31, 1957, and later operated upon by Okabayashi's radical extensive hysterectomy, the author carried out the following observations: Namely, by observing changes in the T.P.T. cell count due to roentgen irradiation; the degree of changes in cancer tissue; and R.M. Graham's sensitization response and radiation reaction, and after studying mutual relationship of these, the author obtained the following results. 1. It seems possible to know the roentgen susceptibility of the cancer by observing the manner of the increase brought about by roentgen irradiation in T.P.T. cell count in the vaginal contents. 2. The sensitization response is in no way involved in the cancer-tissue change due to roentgen irradiation, and it seems that the sensitization response is not representing the roentgen susceptibility of the cancer. 3. Radiation reaction fluctuates well correspondingly with the cancer-tissue change brought about by roentgen irradiation, and it seems that the radiation reaction represents the roentgen susceptibility of the cancer. 4. It has been possible to clarify the inter-relationship in the results of Ukida, A. Glucksmann, and R. M. Grahdm, and also it has been possible to explain them without discrepancy.
en-copyright=
kn-copyright=

en-aut-name=IkenoueYoshio
en-aut-sei=Ikenoue
en-aut-mei=Yoshio
kn-aut-name=池上誼郎
kn-aut-sei=池上
kn-aut-mei=誼郎
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部産科婦人科学教室
END

start-ver=1.4
cd-journal=joma
no-vol=70
cd-vols=
no-issue=8
article-no=
start-page=2977
end-page=2986
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1958
dt-pub=19580831
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=The Influences of Various Vitamins on the Megakaryocytes in Bone Marrow Tissue Culture Part 3. A Study on the Function of the Bone Marrow Megakaryocyte in Experimental Vitamin C-Deficient Guinea Pigs
kn-title=骨髄組織培養法による各種ビタミンの骨髄亘核球機能に及ぼす影響 第3編 実験的ビタミンC欠乏海猽に於ける骨髄巨核球機能について
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=In order to study the megakaryocyte function in vitamin C-deficiency (avitaminosis) the author observed the fluctuation of the thrombocyte count in experimental vitamin C-deficient guinea pigs, and next, by performing the bone marrow tissue culture of the femur of these animals, the following results were obtained: 1. The thrombocyte count decreased markedly in the vitamin C-deficient guinea pigs. 2. The megakaryocyte function in these vitamin C-deficient animals was markedly lowered as compared with that of the normal. 3. The lowered megakaryocyte function in the vitamin C-deficient guinea pigs could be brought back to the normal level by adding vitamin C 0.01 mg/c.c. directly to the medium. From these findings it has been clarified that vitamin C and the function of megakaryocytes are closely related because the lowering of the magakaryocyte function is induced by the decrease in the number of thrombocytes in vitamin C-deficiency.
en-copyright=
kn-copyright=

en-aut-name=HayashiKazuo
en-aut-sei=Hayashi
en-aut-mei=Kazuo
kn-aut-name=林和雄
kn-aut-sei=林
kn-aut-mei=和雄
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部平木内科
END

start-ver=1.4
cd-journal=joma
no-vol=70
cd-vols=
no-issue=8
article-no=
start-page=2967
end-page=2976
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1958
dt-pub=19580831
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=The Influences of Various Vitamins on the Megakaryocytes in Bone-Marrow Tissue Culture Part 2. The Effect of Vitamin C on the Function of the Bone Marrow Megakaryocyte in Normal Persons and in Hypoplastic Anemia
kn-title=骨髄組織培養法による各種ビタミンの骨髄巨核球機能に及ぼす影響 第2編 健康人並に再生不良性貧血患者骨髄巨核球機能に及ぼすビタミンCの影響
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=With a view to clarify the hemostatic mechanism of vitamin C the author conducted the bone marrow tissue culture of normal persons and observed the effect of direct addition of vitamin C on the megakaryocyte function; and also studied the co-operative action of vitamin C and folic acid or B(12) when added in such combinations on the same function of megakaryocytes. Next, by adding a large quantity of vitamin C to the bone marrow tissue culture of hypoplastic anemia the author pursued the fluctuation in the thrombocyte count and the change in the megakaryocyte function. The results are as follows: 1. The megakaryocyte function was markedly increased by the addition of vitamin C 0.01 mg/c.c. 2. In the case of addition of vitamin C and folic acid or B(12) combined, the effect on the megakaryocyte function was rather less than when each of these substances was added singly, thus showing no co-operative action between these substances. 3. When vitamin C 1,000 mg was daily injected continuously to the patients with hypoplastic anemia, in two out of the five patients the thrombocyte count markedly increased and the megakaryocyte function was also strikingly enhanced.
en-copyright=
kn-copyright=

en-aut-name=HayashiKazuo
en-aut-sei=Hayashi
en-aut-mei=Kazuo
kn-aut-name=林和雄
kn-aut-sei=林
kn-aut-mei=和雄
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部平木内科
END

start-ver=1.4
cd-journal=joma
no-vol=70
cd-vols=
no-issue=8
article-no=
start-page=2957
end-page=2966
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1958
dt-pub=19580831
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=The Influences of Various Vitamins on the Megakaryocytes in Bone Marrow Tissue Culture Part 1. The Influences of Various Vitamins (excluded V.C) directly added to the Bone Marrow Tissue Culture on the Function of the Bone Marrow Megakaryocyte
kn-title=骨髄組織培養法による各種ビタミンの骨髄巨核球機能に及ぼす影響 第1編 骨髄巨核球機能に及ぼす各種ビタミン（ビタミンCを除く）直接添加の影響
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=With the purpose to elucidate the influences of various vitamins on the function of megakaryocytes as well as to investigate the effect of B(12) and folic acid on the same function in idiopathic thrombocytopenic purpura, the author conducted a series of tissue culture (cover-slip method) of human bone marrow with direct addition of various vitamins (excluded V.C) on one hand and vitamin B(12) and folic acid to the bone marrow of the patients with the idiopathic purpura on the other; and obtained the following results: 1. With the addition of B(12) 50 γ/c.c. or 15 γ/c.c. the function of megakaryocytes was somewhat promoted. 2. In the case of addition of folic acid 0.015 mg/c.c. the function of megakaryocytes was markedly increased. 3. In the case of the addition of vitamin B(12) and folic acid in combination, these two substances acted in concert with one another. 4. The addition of such vitamins as B(1), co-carboxylase, vitamin B(2), B(6), P, K, and nicotinic acid showed no effect at all on the megakaryocyte function. 5. B(12) as well as folic acid acted directly to stimulate the megakaryocyte function of idiopathic thrombocytopenic purpura.
en-copyright=
kn-copyright=

en-aut-name=HayashiKazuo
en-aut-sei=Hayashi
en-aut-mei=Kazuo
kn-aut-name=林和雄
kn-aut-sei=林
kn-aut-mei=和雄
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部平木内科
END

start-ver=1.4
cd-journal=joma
no-vol=70
cd-vols=
no-issue=8
article-no=
start-page=2951
end-page=2956
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1958
dt-pub=19580831
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Polarographic Studies on the Proteins of the Cerebrospinal Fluid Part 3. The Comparison between the Filtrate Proteins of the Superior Spinal Fluid and those of the Lumbar Spinal Fluid
kn-title=髄液蛋白のポーラログラフ的研究 Ⅲ 上部及び腰椎髄液中の濾液蛋白の比較
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The author performed the polarographic secondary reaction on the superior and the lumbar spinal fluid in the general paresis and schizophrenia. The first 10.cc. obtained by pneumoencephalography was taken as the lumbar spinal fluid (L) and the 10 cc. obtained after the first 100 cc was taken as the superior spinal fluid (V). 1. As for the wave form there is essentially no difference between the general paresis and schizophrenia, but the general paresis shows somewhat clearer two-step wave form in both L and V. The wave height in the general paresis is L > V, while that in the schizophrenia is L < V, showing an inverse relation ship. L/V in the general paresis is greater than 1.0 and in the schizophrenia less than 1.0. 2. Tropp's crossing point of L is 2.8 mg% and V 1.8 mg% in the schizophrenia while L is 1.3 mg% and V 0.8 mg% in the general paresis, showing a fairly lower value in the latter. 3. As for the reaction toward the urea denaturation generally in the general paresis N/D shows relation of L > V, while in the schizophrenia it is L < V, indicating a distinct difference in the filtrates of the spinalfluids between the two groups. 4. It is assumed that the pituitary hormones are involved in the origin of spinalfluid mucoprotein.
en-copyright=
kn-copyright=

en-aut-name=FujitaHidehiko
en-aut-sei=Fujita
en-aut-mei=Hidehiko
kn-aut-name=藤田英彦
kn-aut-sei=藤田
kn-aut-mei=英彦
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部神経精神医学教室
END

start-ver=1.4
cd-journal=joma
no-vol=70
cd-vols=
no-issue=8
article-no=
start-page=2939
end-page=2949
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1958
dt-pub=19580831
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Polarographic Studies on Proteins of the Cerebrospinal FluidPart 2. The Polarographic Protein-Wave of the Diseased Cerebrospinal Fluid
kn-title=髄液蛋白のポーラログラフ的研究 Ⅱ 病的髄液のポーラログラフ蛋白波
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=In the polarographical study on the cerebrospinal fluid in 115 cases of various neuropsychiatric patients the author used the ratios N/D and H(2)/H(1) as the mutual general criteria for experimental results and obtained the following data: 1. In the primary reaction no polarographic peculiarity in the wave form, wave height, the ratio N/D (N = native wave height, D = denatured wave height) and the ration H(2)/H(1) (H(1) = the primary wave height, H(2) = the secondary wave height) due to various diseases could be recognized; but Tropp's crossing point was 16.0 mg% , in the general paresis revealing a fairly greater value in the general paresis than that in the case of schizophrenia. 2. In the secondary reaction it has been possible to divide various disease into two groups by the ration N/D. Namely, a general paresis group with the value under 0.6 and another schizophrenic group with value over 0.6. Furthermore, the relationship between Wasserman*s test and clinical symptoms on one hand and N/D on the other has been studied. 3. Filtrate of the cerebrospinal fluid seems to belong to the substance called mucoprotein by Winzler et al., but it is different from the filtrate of serum.
en-copyright=
kn-copyright=

en-aut-name=FujitaHidehiko
en-aut-sei=Fujita
en-aut-mei=Hidehiko
kn-aut-name=藤田英彦
kn-aut-sei=藤田
kn-aut-mei=英彦
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部神経精神医学教室
END

start-ver=1.4
cd-journal=joma
no-vol=70
cd-vols=
no-issue=8
article-no=
start-page=2931
end-page=2937
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1958
dt-pub=19580831
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Polarographic Studies on Proteins of the Cerebrospinal Fluid Part 1. Studies on General Characteristics of the Cerebrospinal Fluid Wave and the Same in Schizophrenics
kn-title=髄液蛋白のポーラログラフ的研究 Ⅰ 髄液蛋白波の一般的特性及び分裂病者髄液蛋白波について
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The author carried out polarographical studies on proteins of the cerebrospinal fluid, and also investigated general characteristics of the wave of the cerebrospinal fluid proteins by the routine polarography, using the cerebrospinal fluid of schizophrenic patients as the material. The results are as follows: 1. Tropp's crossing point proved to be 10.0 mg% in the primary reaction while it was 3.7 mg% in the secondary reaction. 2. As for the polarogram of the cerebrospinal fluid of schizophrenia, the primary reaction clearly shows a two-step wave, being always H(2) > H(1). In the secondary reaction the wave form approaches close to the single wave, but still it is H(2) > H(1). By the urea denaturation both H(1) and H(2) somewhat decrease in the primary reaction, whereas both increase slightly in the secondary reaction. 3. It has been clarified that the substances involved in the primary and secondary reactions in the cerebrospinal fluid are different from the similar substances in the serum.
en-copyright=
kn-copyright=

en-aut-name=FujitaHidehiko
en-aut-sei=Fujita
en-aut-mei=Hidehiko
kn-aut-name=藤田英彦
kn-aut-sei=藤田
kn-aut-mei=英彦
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部神経精神医学教室
END

start-ver=1.4
cd-journal=joma
no-vol=70
cd-vols=
no-issue=8
article-no=
start-page=2913
end-page=2930
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1958
dt-pub=19580831
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on the Oxygen Consumption and Glycolysis in BoneMarrow Tissue Part 3. The Effect of Vitamins on the Oxgen Consumption of Rabbit Bone Marrow
kn-title=骨髄の組織呼吸並びに解糖作用に関する研究 第3編 家兎骨髄の組織呼吸作用に及ぼす各種ビタミンの影響
en-subtitle=
kn-subtitle=
en-abstract=With Warburg's apparatus the author studied the effects of the addition of various vitamins such as vitamin B(1), FMN, FAD, vitamin B(6), nicotinamide, folic acid, vitamin B(12) and vitamin C directly to the bone marrow of the femur of normal rabbits, and obtained the following results: 1. Vitamin B(1) has no effect on the respiration of the bone marrow. 2. It has been confirmed that FMN at the concentration of 10⁻³ g/di acts as to promote the respiration of the bone marrow. 3. FAD at the concentration of 10⁻² g/dl likewise acts as to accelerate the respiration of the bone marrow, 4. Vitamin B(6) at the high concentration tends to inhibit the respiration of the bone marrow, while it has been found that it accelerates the respiration at the cocentration 10⁻⁴ g/dl. 5. Nicotinamide at the high concentration tends to inhibit the respiration of the hone marrow, while it has accelerated the respiration at the concentration 10⁻⁴ g/dl. 6. It appears that folic acid at the concentrations of 10⁻¹ g/dl and 10 ⁻³ g/dl promotes the respiration of the bone marrow.
7. Vitamin B(12)at the concentrations of 10⁻⁴ g/dl and 10⁻⁵ g/dl seems to accelerate the respiration of the bone marrow, and especially at 10⁻⁴ g/dl the oxygen consumption every 10 minutes increases along with the lapse of time. 8. Vitamin C at the concentration 10⁻¹ g/dl inhibits the respiration of the bone marrow, but at the concentrations 10⁻³ g/dl and 10⁻⁴ g/dl promotes the respiration. From these it appears that FMN, FAD, vitamin B(6), nicotinamide, folic acid, vitamin B(12), and vitamin C at the appropriate concentrations act directly on the bone marrow as to promote its metabolism, and lead to the acceleration of the hematopoietic function. Particularly vitamin B(12) which demonstrated the periodical and gradual increase in the oxygen consumption every 10 minutes seems to posses a direct hematopoietic action on the bone marrow.
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=ShimizuNorimitsu
en-aut-sei=Shimizu
en-aut-mei=Norimitsu
kn-aut-name=清水紀光
kn-aut-sei=清水
kn-aut-mei=紀光
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部平木内科教室
END

start-ver=1.4
cd-journal=joma
no-vol=70
cd-vols=
no-issue=8
article-no=
start-page=2901
end-page=2912
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1958
dt-pub=19580831
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on the Oxygen Consumption and Glycolysis in Bone Marrow Tissue Part 2. The Effect of Suspension Solutions on the Oxygen Consumption of Rabbit Bone Marrow
kn-title=骨髄の組織呼吸並びに解糖作用に関する研究 第2編 家兎骨髄の組織呼吸作用に及ぼす浮游液の影響
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=By suspending slices of bone marrow tissue of normal rabbit obtained from the femur in such solutions as Ringer's solution, Tyrode's solution or physiological saline solution, at pH 6.3, 6.8, 7.1, 7.4, 7.7 and 8.0, and by measuring oxygen consumption, the author studied the effect of suspension solutions on the respiration of the bone marrow. The results are as follows: 1. In Ringer's solution Q(o2) was highest, and stochastically there was significant difference in Q(o2) values in the case of the Tyrode's or the physiological saline solution. 2. The decreasing tendency in the oxygen consumption with lapse of time in the course of measuring was least in Ringer's solution, and likewise the variations in the average values of the maximum and the minimum Q(o2) were least in Ringer's solution. 3. As for the physiological saline solution at various ranges of pH, Q(o2) showed the greatest value at pH 7.4. Although there was no significant difference between the value at pH 7.4 and that at pH 7.1 stochastically, but there was significant difference between the value at pH 7.4 and those of other pH. Namely, pH 7.4 as the starting point, if the concentration leans either to acidic side or to alkaline side, Q(o2) tends to decrease, and moreover, the inhibition of Q(o2) is somewhat stronger on the acidic side than on the alkaline side. 4. In the physiological saline solution at various ranges of pH, the decreasing tendency of Q(o2) with the lapse of time is least at pH 7.1 ; and the rate of variations in the averages of the maximum and the minimum oxygen consumption is least at pH 7.7 ; and as the pH turns to more to alkaline side from this pH the decreasing tendency of Q(o2) is marked and also the increase in the rate of variation can be observed. In other words, for the determination of the respiration in bone marrow Ringer's solution is the most suitable one as the suspension solution; and it seems that the phosphate contained in the solution acts as to inhibit the respiration of bone marrow. And the optimal pH seems to lie in between pH 7.1 and pH 7.7 with pH 7.4 as an anchor concentration. Outside this range of pH the respiration of bone marrow is inhibited from the beginning and also the oxygen consumption decreases gradually along with the lapse of time.
en-copyright=
kn-copyright=

en-aut-name=ShimizuNorimitsu
en-aut-sei=Shimizu
en-aut-mei=Norimitsu
kn-aut-name=清水紀光
kn-aut-sei=清水
kn-aut-mei=紀光
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部平木内科教室
END

start-ver=1.4
cd-journal=joma
no-vol=70
cd-vols=
no-issue=8
article-no=
start-page=2885
end-page=2900
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1958
dt-pub=19580831
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on the Oxygen Consumption and Glycolysis in Bone Marrow Tissue Part 1. Comparative Studies on the Various Estimating Methods of Oxygen Consumption and Glycolysis in the Rabbit Bone Marrow
kn-title=骨髄の組織呼吸並びに解糖作用に関する研究 第1編 測定方法に関する基礎的研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=By placing a piece of rabbit bone marrow between two Graefe's messes and slowly drawing the messes outward, the author successfully obtained slices of the proximal limit thickness; and by the aid of Warburg's apparatus the oxygen consumption and glycolysis in the bone marrow tissue were estimated. At the same time by mincing the bone marrow tissue of the same rabbit, the method generally used by most other investigators, the estimations were made as the comparison. In addition, observations were carried out on the effect of time elements dividing them into the five following groups according the length of elapsed time from the onset; Group A : Those measured immediately after killing. Group B : Slices made immediately after killing but kept at 37℃ for 2 hours. Group C : Slices made immediately after killing but kept at 37℃ for 4 hours. Group D : Bone marrow in the cylindrical form preserved for 2 hours at 37℃. Group E : Bone marrow in the cylindrical form preserved for 4 hours at 37℃. 1. The slice method of my own device yielded Q(o2) 4.90 ± 0.35 (the average of 28 samples), Q(O2M) 3.62 ± 0.27 (average of 18 samples), Q(N2M) 7.63 ± 0.37 (average of 18 samples). 2. On the basis of the maximum Q(o2) by the slice method the proximal limit thickness of slices of normal rabbit bone marrow is 0.67 mm. 3. By mincing method the injury to the cells of the bone marrow is greater. 4. The amount of oxygen consumption decreases in proportion to the lapse of time after killing, especially the oxygen deficiency induces an irreversible disturbance of the cell function, and thus it appears that a rapid decrease in Q(o2) due to this disturbance. 5. It is presumed that glycolysis, especially anaerobic glycolysis, tends to be affected relatively less by the lapse of time after killing, but that the discharge of glycolytic enzymes into the suspension and the decrease in the enzyme activity are unavoidable. Summing up the above data for measuring of the respiration and glycolysis of the rabbit bone marrow, this slice method is the most suitable one; and the determination should be carried out as soon as practicable at the fixed intervals after killing.
en-copyright=
kn-copyright=

en-aut-name=ShimizuNorimitsu
en-aut-sei=Shimizu
en-aut-mei=Norimitsu
kn-aut-name=清水紀光
kn-aut-sei=清水
kn-aut-mei=紀光
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部平木内科教室
END

start-ver=1.4
cd-journal=joma
no-vol=70
cd-vols=
no-issue=8
article-no=
start-page=2829
end-page=2884
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1958
dt-pub=19580831
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Absorption Activity of the Oral Mucosa
kn-title=口腔粘膜の吸収能に就いて
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=By the use of trypan blue, i.e. lipoid insoluble acid stain, in order to make observation of absorption activity of the oral mucosa, animals' mucosa with rapid absorption activity, its location, absorbing process, and absorbing conditions were investigated. Then clinical and biological observation on absorption of hormone of the salivary gland was tried. Ⅰ. Mixture containing equal parts of 1 per cent solution of trypan blue and saturated sodium bicarbonate solution was dropped and painted over the normal oral mucosa of various kinds of animals, such as dog, cat, hamster, albino rat, chicken, elaphis virgatus, lizard, rana esculenta, eft, and crusian and absorption of the solution was observed. The results obtained were as follows: 1) Absorption varied according to the kinds of animals. 2) In general absorption of the lower verbetrata was more remarkable than that of mammals and birds. 3) In mammals that of dogs was more marked than that of cat, hamster and albino rat. 4) In dogs marked absorption was seen in buccal and sublingual mucosa, particularly at the sublingual and parotid salivary papillae and their surrounding areas. 5) In albino rats absorption was made at the hard palate corresponding to the tip of the tongue. Ⅱ. In premature dogs it was equal to that of mature dogs. Ⅲ. No absorption was seen in the oral mucosa of the dog's and rabbit's fetus, while slight one was seen around the erupted teeth of the guinea-pig's fetus. Ⅳ. T.B. was not introduced into the ep. cells of rabbit's oral mueosa in case of vital staining. Ⅴ. The effects of various factors on T.B. absorption of the oral mucosa in dogs' experiments were as follows: Absorption-stimulating factors are, local thermal stimulation, Grace helio lamp irradiation. roentgen irradiation of amount of 60 r to 100 r, radium irradiation of amount of 33 mg. h, to 66 mg. h., intracranial amputation of maxillary and mandibular divisions of trigeminal nerve just after the procedure. and local injection of Teabrom (T.E.A.B.), in the early stage of injection, while absorption-inhibiting factor was local cold stimulation and no absorption was stimulated in case of anemia of the head following ligation of the common carotid artery. Ⅵ. Parotin and Saliva-parotin, i.e. hormone of the salivary gland was painted over the oral mueosa of man, clog and rabbit. The results obtained were as follows: 1) Leucocytosis was noticed in cases of dog (1.2~5.0 mg./kg. of Parotin administered) and man (0.2~0.4 mg./kg. of Parotin or 0.1-0.2 mg./kg. of Saliva-parotin administered), 2) decrease of serum Ca. and leucocytosis in case of rabbit (1.0-5.0 mg./kg. of Parotin and Saliva-parotin administered), and 3) stimulated calcification of dentine in case of rabbit (5 mg./kg. of Parotin administered). These results Will suggest us the following factors as those effecting on absorbing mechanism of the oral mueosa, especially of the epithelium: 1) resistance, 2) intensity of surface tension, 3) intercellular density, 4) characteristics of chemical substances and solvent, and 5) special vital function of the cells.
en-copyright=
kn-copyright=

en-aut-name=IdeiKiyoo
en-aut-sei=Idei
en-aut-mei=Kiyoo
kn-aut-name=出井清雄
kn-aut-sei=出井
kn-aut-mei=清雄
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部歯科学教室
END

start-ver=1.4
cd-journal=joma
no-vol=70
cd-vols=
no-issue=8
article-no=
start-page=2817
end-page=2827
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1958
dt-pub=19580831
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Anaphylaxis and Oxidation-Reduction Potential Ⅱ: Effect of Antihistamine Drugs on Oxidation-Reduction Potential of Sensitized Animal Organ Tissues in in vitro Anaphylactic Shock
kn-title=感作動物臓器組織の試験管内における過敏症の発現とその電位に就いて 第2編 臓器組織の過敏症ショックに於ける電位変化に及ぼす抗ヒスタミン剤の影響
en-subtitle=
kn-subtitle=
en-abstract=The author studied the effect of the antihistamine drugs on the rise of the potential in in vitro anaphylactic shock. The liver slice of the guinea-pig sensitized with the horse serum (0.25 cc) was suspended in Tyrode solution, and then the horse serum was poured into this suspension, thus producing anaphylactic shock. The following antihistamine drugs were used; benadrine (aminoether derivative), pyribenzamine (ethylene-diamine derivative) and anergen (pheno-thiazine derivative). The results are summarized as follows: 1) The rise of potential of the sensitized guinea-pig liver by pouring the horse serum was inhibited by addition of antihistamine drugs. 2) In the inhibition of the rise of potential, benadrine of 3.3×10(-3) -3.3×10(-5) mg / cc was more effective than 3.3 (×) 10 (-6) -3.3×10(-7) mg / cc. 3) For the inhibition of the rise of potential in anaphylactic shock, addition of benabrine 30 to 45 minutes before pouring the serum was more effective than 10 to 20 mintes before pouring. 4) For the inhibition of the rise of potentiol in anaphylactic shock, benadrine and pyribenzamine showed nearly the same effect, but anergen seemed to be somewhat less effective than the other two ones.
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=ChikamotoKoki
en-aut-sei=Chikamoto
en-aut-mei=Koki
kn-aut-name=近祖康喜
kn-aut-sei=近祖
kn-aut-mei=康喜
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部微生物学教室
END

start-ver=1.4
cd-journal=joma
no-vol=70
cd-vols=
no-issue=8
article-no=
start-page=2811
end-page=2816
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1958
dt-pub=19580831
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Anaphylaxis and Oxidation-Reduction Potential Ⅰ: Potential-Time Curve of Sensitized Animal Organ Tissuea in in vitro Anaphylaxis
kn-title=感作動物臓器組織の試験管内における過敏症の発現とその電位に就いて 第1編 臓器組織の過敏症現象と電位時間曲線
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=In order to study the metabolic aspects at the time of anaphylaxis, the author investigated the potential-time curve of animal organ tissues in in vitro anaphylactic Shock. Thin slices of the liver and the kidney of the guinea-pig (about 300 g) sensitized with the horse serum (0.25 cc) were suspended in Tyrode solution and then the horse serum was poured into it, thus causing anaphylactic shock. The results are summarized as follows: 1) Pouring of the horse serum caused the rise of potential of the sensitized liver slice, which might be considered to be caused by anaphylactic shock. 2) In the potential-time curve of the kidney, no noticeable rise was caused by pouring the serum. 3) The rise of potential by pouring the serum did not vary for 30 to 150 minutes after startin the measurement of potential. 4) The variation of the amount of the serum from 0.3 to 0.003 cc caused no noticeable difference in the rise of potential. 5) In the desensitized organ slice of the guinea-pig, pouring of the serum showed no change but a gradual fall in the potential-time curve.
en-copyright=
kn-copyright=

en-aut-name=ChikamotoKoki
en-aut-sei=Chikamoto
en-aut-mei=Koki
kn-aut-name=近祖康喜
kn-aut-sei=近祖
kn-aut-mei=康喜
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部微生物学教室
END

start-ver=1.4
cd-journal=joma
no-vol=70
cd-vols=
no-issue=8
article-no=
start-page=2783
end-page=2809
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1958
dt-pub=19580831
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on Monocytic Leukemia by Means of Bone-Marrow Tissue Culture Part 3. Clinical Statistics of 30 Cases of Monocytic Leukemia diagnosed by Bone-Marrow Tissue Culture
kn-title=骨髓体外組織培養による単球性白血病の研究 第3編 骨髄体外組織培養により診断せし30例の単球性白血病の臨床統計
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=In the present report the results of the clinical statistcs are presented concerning 30 cases of monocytic leukemia, that were correctly diagnosed by tissue culture of the bone marrow during the past four years from January 1954 to December 1957. Characteristic findings on monocytic leukemia in comparison with other leukemias are as follows: 1. In clinical findings monocytic leukemia presented intermediate characters between those of the acute and the chronic types observable in other leukemias. 2. Monocytic leukemia often demonstrated a tendency to bleed, especially in the mouth, in the early developmental stage of this disease.
en-copyright=
kn-copyright=

en-aut-name=KawanoYoshihiko
en-aut-sei=Kawano
en-aut-mei=Yoshihiko
kn-aut-name=川野嘉彦
kn-aut-sei=川野
kn-aut-mei=嘉彦
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部平木内科教室
END

start-ver=1.4
cd-journal=joma
no-vol=70
cd-vols=
no-issue=8
article-no=
start-page=2773
end-page=2781
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1958
dt-pub=19580831
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on Monocytic Leukemia by means of Bone-MarrowTissue Culture Part 2. Studies on Cell Function of Bone Marrow by Wandering Velocity, Carbon- Particle Phagocytosis, and Neutral- Red Vital Staining
kn-title=骨髄体外組織培養による単球性白血病の研究 第2編 遊走速度,墨粒貪喰能, 中性紅生体染色性による骨髄の細胞機能に就て
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=By means of borne-marrow tissue culture, the author has investigated the wandering velocity, phagocytosis of carbon particles and neutral-red vital staining of neutrophils and monocytes in both patients and normal persons, and obtained the following results. 1. The wandering velocity of the neutrophils and monocytes in patients was lower than that in normal persons, and the span of cell-wandering in th former was shortened. 2. Phagocytosis of carbon particles of the neutrophils and monocytes in patients was decreased in comparison with that of the control. The time required for the phagocytosis of neutrophils in tissue culture to reach its peak is longer than that in the case of the control. The phagocytosis of the monocytes in patients gradually increased, making a similar curve as that of the control but a lower one, and both reached their peak in 24 hours. The peak of the former, however, was markedly lower. In addition, promonocytes occasionally showed very slight phagocytosis of carbon particles in the cases whose cell functions were not so markedly decreased. 3. As for the neutral-red vital staining the nutrophils and monocytes in patients were stained much more rapidly and more deeply but they fade very quickly as compared with those of the control. 4. From the above mentioned results, the author has confirmed the decrease in the cell functions of the bone marrow in monocytic leukemia.
en-copyright=
kn-copyright=

en-aut-name=KawanoYoshihiko
en-aut-sei=Kawano
en-aut-mei=Yoshihiko
kn-aut-name=川野嘉彦
kn-aut-sei=川野
kn-aut-mei=嘉彦
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部平木内科教室
END

start-ver=1.4
cd-journal=joma
no-vol=70
cd-vols=
no-issue=8
article-no=
start-page=2761
end-page=2771
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1958
dt-pub=19580831
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on Monocytic Leukemia by Means of Bone-Marrow Tisseu Culture Part 1. Findings on the Growth Area of Cells and Morphology of Living Cells
kn-title=骨髄体外組織培養による単球性白血病の研究 第1編 細胞増生帯所見及びその構成細胞の生態
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=In the study of monocytic leukemia by means of bone marrow tissue culture, the author has obtained the following results: 1. The rate of relative increase of the growth area fell down approximately to one third that of the control, but the cellular density in the growth area increased remarkably; and the boundary of the growth area was sharply defined from the surrounding area, indicating a marked acceleration of the cellular proliferative activity in this disease. 2. From the very characteristics of morphological findings, process of maturation, and superiority in numbers over other cellular series, in monocytic series appearing in the growth area, it is easy to make differential diagnosis of monocytic leukemia from other leukemias. 3. The juvenile type of the cells in monocytic series makes it possible to differentiate from other juvenile calls by the characteristic findings in morphology, thus enabling us to distinguish monocytic leukemia from other leukemias. 4. Monocytic leukemia and reticuloendotheliosis that have been commonly believed for a long time to be the same are really two entirely different diseases.
en-copyright=
kn-copyright=

en-aut-name=KawanoYoshihiko
en-aut-sei=Kawano
en-aut-mei=Yoshihiko
kn-aut-name=川野嘉彦
kn-aut-sei=川野
kn-aut-mei=嘉彦
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部平木内科教室
END

start-ver=1.4
cd-journal=joma
no-vol=70
cd-vols=
no-issue=8
article-no=
start-page=2749
end-page=2759
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1958
dt-pub=19580831
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Fundamental Studies on the Effect of Several Anti-Tuberculous Agents Part 3. Fundamental Study with Viomycin
kn-title=数種抗結核剤の薬剤効果に関する基礎的研究 第三編 Viomycinの基礎実験 附. 全編の総括
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The detailed report on viomycin (VM), the second anti-tuberculous antibiotics next to SM, is rare, and none at all on its use in combination with INAH or with INHG. Therefore, the author performed the in vitro experiments, acute toxicity tests, and VM treatment against mouse tuberculosis, and obtained the following results. 1. VM solution at the concentration of 15.0 inhibits the growth of tuberculous bacilli, and it acts against SM-resistant strain identically as against the SM-susceptible strain. 2. However, VM used in combination with SM, INAH, or INHG, acts as to assist one another, while VM combined with PAS has no effect at all. 3. LD(50) of VM in the case of subcutaneous injection to mouse is 1,626 mg/kg (±157.64 mg/kg). 4. For the mouse berculosis the effect of VM alone is weak, while VM and SM nsed in equal amount separately the effect of VM is about one half that of SM alone. 5. The use of VM comb ned with INAH or INHG is super ro to the effect of VM used alone, showing no significant difference from that of INAH or INHG used alone thus proving the addition of VM is ineffective. From these it is assumed that VM is effective to tuberculosis in the case only when the causative strain has the resistance against SM or INAH.
en-copyright=
kn-copyright=

en-aut-name=YoshikawaKiyoshi
en-aut-sei=Yoshikawa
en-aut-mei=Kiyoshi
kn-aut-name=吉川潔
kn-aut-sei=吉川
kn-aut-mei=潔
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部平木内科教室
END

start-ver=1.4
cd-journal=joma
no-vol=70
cd-vols=
no-issue=8
article-no=
start-page=2737
end-page=2748
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1958
dt-pub=19580831
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Fundamental Studies on the Effect of Several Anti-Tuberculous Agents Part 2. Fundamental Study with Pyrazinamide
kn-title=数種抗結核剤の薬剤効果に関する基礎的研究 第二編 Pyrazinamideの基礎実験
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=By performing in vitro and in vivo experiments with pyrazinamide (Pza) separately and in combination with other drugs, the author obtained the following results: 1. The concentration at which Pza, acting alone, inhibits the growth of H(37)Rv strain proves to be 200 γ/1cc. 2. Pza and SM in combination act quite collaboratingly, but either one of these in combination with PAS has no effect inhibiting the growth of tuberculous bacilli at all. However, Pza in combination with INAH or INHG presents a multiple action assisting one another. 3. The therapeutic effect to experimental mouse tuberculosis of Pza (250 mg/kg) alone is inferior to that of INAH (50 mg/kg) or INHG (500 mg/kg) given separately. 4. The effect of the treatment with Pza (250 mg/kg) + INAH (50 mg/kg), or Pza (250 mg/kg) + INHG (500 mg/kg) is superior to that of INAH or INHG alone, but this effect is not so efficacious enough to be valued as a bacteriocidal treatment in vivo. Moreover, the combination of Pza with INHG is slightly inferior to the combination of Pza with INAH. 5. The use pf Pza (250 mg/kg) alone on the mouse tuberculosis induced by the infection of INAH-10-resistant strain gives hardly any therapeutic effect. 6. The combinations of Pza-INAH and Pza-INHG are effective for the treatment of mouse tuverculosis induced by the infection of INAH-10γ-resistant strain. The effect of the combination therapy is slightly better than that of INAH or INHG alone, but the combination therapy of Pza with INAH does not differ from that of Pza with INHG in effectiveness.
en-copyright=
kn-copyright=

en-aut-name=YoshikawaKiyoshi
en-aut-sei=Yoshikawa
en-aut-mei=Kiyoshi
kn-aut-name=吉川潔
kn-aut-sei=吉川
kn-aut-mei=潔
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部平木内科教室
END

start-ver=1.4
cd-journal=joma
no-vol=70
cd-vols=
no-issue=8
article-no=
start-page=2723
end-page=2736
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1958
dt-pub=19580831
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Fundamental Studies on the Effect of Several Anti-Tuberculous Agents Part 1. In Vitro Studies on INAH, IHSM, and INHG
kn-title=数種抗結核剤の薬剤効果に関する基礎的研究 第一編 INAH, IHMS, INHGの試験管内実験
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=As there is no detailed report on the fundamental study concerning isonicotinic acid hydrazide (INAH) and two derivatives, isonicotinyl hydrazide metasulfonate (IHMS) and glucuronolacton isonicotinyl hydrazone (INHG), the author conducted in vitro studies with these three drugs and obtained the following results: 1. The action the three drugs, INAH, IHMS, and INHG at the concentration of 0.2 inhibits the growth of the standard strain of human tuberculous bacilli. Moreover, the antiseptic power of these drugs against tuberculous bacilli is stronger than that of SM, PAS or Tbl. 2. The resistance of tuberculous bacilli against there three drugs is acquired step by step quite easily and the rapidity of the acquiring of such resistance in the case of INHG seems to be slightly more rapid than the other two. 3. For preservation of the titer of the medium practically four weeks are about the limit, and when storing at the room temperature, one should exercise an extreme care. The disintegration of the medium due to warming even for a long duration of time occurs to a lesser extent as long as the temperature is not kept high. 4. As for the effect inhibiting the growth of tuberculous bacilli, combined use of INAH and SM is clearly discernible, and the effect of INAH combined with PAS can be observable only when PAS is used in the concentration of over 0.5 γ. The effect of combination of IHMS with SM or PAS and of INHG with SM or PAS is slightly inferior to that of INAH with SM-PAS.
en-copyright=
kn-copyright=

en-aut-name=YoshikawaKiyoshi
en-aut-sei=Yoshikawa
en-aut-mei=Kiyoshi
kn-aut-name=吉川潔
kn-aut-sei=吉川
kn-aut-mei=潔
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部平木内科教室
END

start-ver=1.4
cd-journal=joma
no-vol=70
cd-vols=
no-issue=8
article-no=
start-page=2707
end-page=2722
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1958
dt-pub=19580831
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Immuno-serological and Electrophoretic Studies on the Protein of Pregnant Urin Part Ⅰ Immuno-serological Study on the Protein of Pregnant Urin
kn-title=妊婦尿蛋白の血清免疫学的ならびに電気泳動学的研究 第1編 妊婦尿蛋白の血清免疫学的研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=1. Rabbits were immunized repeatedly with the protein urin of pregnant toxikosis (pregnant edema, pregnant nephrosis, preeclampsia, eclampsia), inflammation of kidney and nephrosis. As the result of this experiment above, rabbits had antiserum with high precipitin titels. 2. Rabbits which were immunized repeatedly (ten times) with the protein urin of pregnant edema, pregnant nephrosis and inflammation of kidney could easily get antiserum with high precipitin titels but only few precipitin quantities, and showed no heterogitis. On the other side rabbits which were immunized repeatedly (ten times) with the protein urin of preeclampsia, eclampsia and nephrosis could easily get antiserum with high precipitin titels with the increase of the precipitin quantity, this time and show slightly higher heterogitis. Consequently, it was found that race-speciality is more intensive in the former than in the latter. 3. It was assumed from the data of the author and of other members in our department that if pregnant toxikosis turn to preeclampsia or eclampsia by getting worse, evacuation of a part of specific protein which had not been found before was found in adult serum.
en-copyright=
kn-copyright=

en-aut-name=ItasakaTakuzi
en-aut-sei=Itasaka
en-aut-mei=Takuzi
kn-aut-name=板阪卓児
kn-aut-sei=板阪
kn-aut-mei=卓児
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部法医学教室
END

start-ver=1.4
cd-journal=joma
no-vol=70
cd-vols=
no-issue=8
article-no=
start-page=2701
end-page=2706
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1958
dt-pub=19580831
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on endemic polyradiculoneuritis (Guillain-Barre Syndrome) in the middle western part (Chugoku and Shikoku) of Japan. Part 3. On special cases
kn-title=中国, 四国地方に流行した一多発性神経根炎（ギランバレー症候群）に関する研究 第3編 特異症例に就て
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Among 126 cases of Guillain-Barre disease seen at the pediatric clinic of the Okayama University Hospital, there were one recurrent case, simultaneous occurrence of the disease in one pair of monoovular twin brothers and three pairs of affected brothers with occurrence of differend periods. 1. Regarding one recurrent case, it is considered that the individual got an imcomplete immunity and following reinfection, or he had sustained some accompanying neuro-allergic phanomen. 2. Some constitutional factors may be concerned to the pathogenesis of the twins and the three pairs of fraternal contraction.
en-copyright=
kn-copyright=

en-aut-name=KatoYojiro
en-aut-sei=Kato
en-aut-mei=Yojiro
kn-aut-name=加藤陽治郎
kn-aut-sei=加藤
kn-aut-mei=陽治郎
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部小児科教室
END

start-ver=1.4
cd-journal=joma
no-vol=70
cd-vols=
no-issue=8
article-no=
start-page=2689
end-page=2700
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1958
dt-pub=19580831
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on endemic polyradiculoneuritis (Guillain-Barre Syndrome) in the middle western part (Chugoku and Shikoku) of Japan. Part 2. Clinical Picture
kn-title=中国, 四国地方に流行した一多発性神経根炎（ギランバレー症候群）に関する研究 第2編 臨床像に就て
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The author statistically reviewed 125 cases of Guillain-Barre disease seen at the pediatric clinic of the Okayama University Hospital from 1949 to 1955, and the following results were obtained. 1. Most of the cases had a sudden onset without fever. 2. Flaccid symmetrical motor paralysis was observed in all cases. The paralysis began at the lower extremities in 79% of all cases and was more marked at the distal part than the proximal. 3. The paralysis became most severe from 3 to 10 days after the onset of the disease and then showed a rapid recovery. Tendon reflexes, however, remained weak or disappeared for longer period even after the recovery of motor function. 4. Syndrome of posterior spinal nerve root irritation was characteristic and lasted for longer period. 5. The facial nerve was most frequently affected among the cranial nerves. 6. The pleocytosis in the spinal fluid was found in no case, but dissociatio albumino-cytologique was observed in 81.3% of all cases. 7. Nineteen cases (15.2%) died from acute bulbar paralysis. 8. Reinvestigation of 83 cases after 8 months to 6 years revealed complete cure of all cases except for one case with slight weakness of motor power.
en-copyright=
kn-copyright=

en-aut-name=KatoYojiro
en-aut-sei=Kato
en-aut-mei=Yojiro
kn-aut-name=加藤陽治郎
kn-aut-sei=加藤
kn-aut-mei=陽治郎
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部小児科教室
END

start-ver=1.4
cd-journal=joma
no-vol=70
cd-vols=
no-issue=8
article-no=
start-page=2679
end-page=2688
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1958
dt-pub=19580831
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on endemic polyradiculoneuritis (Guillain-Barre Syndrome) in the middle western part (Chugoku and Shikoku) of Japan. Part 1. Epidemiology
kn-title=中国, 四国地方に流行した一多発性神経根炎（ギランバレー症候群）に関する研究 第1編 疫学に就て
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Three hundred and seventeen cases of polyradiculoneuritis with Guillain-Barre syndrome (G.B. disease) (including 125 cases admitted to the pediatric clinic of the Okayama University Hospital) during the period from 1949 to 1955 were epidemiologically investigated. 1. The place of the most frequent occurrence was Minomicho, Numakuma-gun of Hiroshima Prefecture. Six cases were found there among 6406 residents (0.093%) 2. Regarding the age distribution, most of them were between 2 and 6 years of age. (The highest frequency of occurrence being at 4 years of age.) More patients were found in the farmer's or fisherman's families. Male patients were more than the female. 3. There was observed a tendency that the epidemy started at Okayama and moved gradually to the south-west. Epidemiological observation of the patients at Minomicho showed that this disease was obviously infectious. 4. More frequent occurrence was seen in July and August, i.e. the most moist and rainy season. 5. Constitutional factors may probably conceren the occurrence of this disease, 6. Incubation period is considered to be between 5 and 20 days.
en-copyright=
kn-copyright=

en-aut-name=KatoYojiro
en-aut-sei=Kato
en-aut-mei=Yojiro
kn-aut-name=加藤陽治郎
kn-aut-sei=加藤
kn-aut-mei=陽治郎
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部小児科教室
END

start-ver=1.4
cd-journal=joma
no-vol=70
cd-vols=
no-issue=8
article-no=
start-page=2673
end-page=2677
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1958
dt-pub=19580831
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Free Amino- Nitrogen of the Brain Tissue Part 1 On the Amino- and Non-Protein-Nitrogen Contents in the Rat Brain
kn-title=脳のアミノ窒素 第1編 ダイコクネズミ脳アミノ窒素および非蛋白窒素量について
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Amino- and non-protein- nitrogen in fresh rats brains under variously treated conditions were determined. Amino- nitrogen was measured by the copper method of Pope and Stevens, non-protein-nitrogen by the micro-Kjeldahl procedure. The results were as follows: 1) In the normal control group, the mean of amino-N contents was 36.8 mg%, ranged from 34.3~38.5 mg/%, and the mean of non- protein-N was 161.1 mg%, ranging from 140.3~184.1 mg%. 2) In the case of repeated electroshocked rats (twice daily, amounted to 20~30 times), both amino-N and non-protein-N showed no appreciable change. These were also almost normal in the group injected with methylpropamine repeatedly (60 mg/kg daily, for 3 weeks). 3) In the hypophysectomized rats, amino-N contents were slightly lower than in the normal group, while in the group injected with chlorpromazine (10 mg/kg daily for 3 weeks), appreciable decrease of the non-protein-N contents was found. In general, it can be concluded that the contents of amino-nitrogen as well as non-protein-nitrogen keep relatively constant levels by those above-menthioned treatments.
en-copyright=
kn-copyright=

en-aut-name=YunoueShigeru
en-aut-sei=Yunoue
en-aut-mei=Shigeru
kn-aut-name=湯之上茂
kn-aut-sei=湯之上
kn-aut-mei=茂
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部神経精神医学教室
END