start-ver=1.4 cd-journal=joma no-vol=67 cd-vols= no-issue=5 article-no= start-page=1035 end-page=1047 dt-received= dt-revised= dt-accepted= dt-pub-year=1955 dt-pub=19550531 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Experimental Studies on the Pathogenicity of Echinostoma cinetorchis Heterotopic parasitism, Echinostoma cinetorchis in the Liver kn-title=Echinostoma cinetorchisの病原性に関する実験的研究 Echinostoma cinetorchisの肝内異所寄生に就て en-subtitle= kn-subtitle= en-abstract= kn-abstract=In the previous paper the author reported the pathological studies on the animals affected by Echinostoma cinetorchis with some endemiological observations presenting the fundamental knowledge on the pathogenicity of this worm. The purpose of this paper is to reveal the mechanism of heterotopic parasitism of this worm and pathologic changes in the liver which have been found unexpectedly on the two cases of affected animals as introduced briefly in the previous paper. The experiments revealed the mechanism of this curious heterotopic parasitism of this intestinal parasitic trematoda, i.e. 1. Repeated feeding of metacercaria proved that this worm acutually can invide into the liver (passing through the common bile ducts) and grow in the intrahepatic ducts. 2. The feeding test proved that the worms invide more frequently into the liver of starved animals than of those of normally nurished, indicating the starvation gave a better condition for the invasion into the liver. 3. On the other hand, the massive parasitism in intestine also caused frequent intrahepatic invasion, though the massive feeding of metacercaria not always resulted in the massive intestinal parasitism. The pathologic changes seen on the attacked liver are summarized as follows. 1. The defect or desquamation of the epithelium of the bile ducts surrounding the worm body, which will be the results of mechanic injury given by the parasite. 2. Generallized cholangitis and pericholangitis which would be induced by the mechanic injury followed by bacterial infection. This was accompanied by the inflammatory changes of the parenchym and the vessels of pfortal system. 3. Focal necrosis of the liver cells caused by the secoundery induced disturbances of circulatory system which developed to the purulent foci elswhere. 4. Exsudative and proliferative inflammation on the tissues surrounding the eggs of the worm. en-copyright= kn-copyright= en-aut-name=SoKenji en-aut-sei=So en-aut-mei=Kenji kn-aut-name=宗謙治 kn-aut-sei=宗 kn-aut-mei=謙治 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部病理学教室 END start-ver=1.4 cd-journal=joma no-vol=67 cd-vols= no-issue=5 article-no= start-page=1017 end-page=1022 dt-received= dt-revised= dt-accepted= dt-pub-year=1955 dt-pub=19550531 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=SUGAR METABOLISM UNDER HIGH TEMPERATURE CHAPTER III. INFLUENCES OF RETICULOENDOTHELIAL SYSTEM ON SUGAR METABOLISM UNDER HIGH TEMPERATURE kn-title=高温環境下に於ける糖代謝 第3編 高温環境下に於ける糖代謝に及ぼす網内系機能の影響 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The glycogen content in both livers and muscles as well as the blood sugar values were measured after letting guinea pigs standing for 2 hours at room temperature or at 41°. After imposition of a definite dose of India ink, lithion-carmine and “Koha” of neo-cyamine and in some cases together with vitamin C, and the following results were obtained: 1. By imposing these drugs, liver glycogen decreased slightly in India ink and pretty in lithion-carmine cases. 2. Liver glycogen content much more decreased by exposing the animal to high temperature after imposing these drugs, and the degree between India ink and lithion-carmine cases was almost the same, but, from the viewpoint of the degree of the decrease caused by drug itself, the India ink case was strongly influenced by high temperature. In a similar condition. liver glycogen content of the “Koha”-imposed was markedly high than the nonimposed. 3. The decrease of liver glycogen content under high temperature after imposition of these drugs. was slightly inhibited in India ink case by simultaneous imposition of vitamin C, while accelerated contrarily in the other cases by it. 4. Muscle glycogen content showed almost no change in India ink case, and it increased contrarily in lithion-carmine case. 5. Muscle glycogen content always decreased by exposure to high temperature after imposing these drugs, and vitamin C showed scarcely any effective action on these conditions. 6. The blood sugar values stayed at normal range in India ink case, but decreased in lithion-carmine case. It, furthermore, always increased by further imposition of vitamin C under high temperature. These influences to increase or decrease the value were most apparent in lithion-carmine case. en-copyright= kn-copyright= en-aut-name=ObaraYoshio en-aut-sei=Obara en-aut-mei=Yoshio kn-aut-name=小原美夫 kn-aut-sei=小原 kn-aut-mei=美夫 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一内科教室 END start-ver=1.4 cd-journal=joma no-vol=67 cd-vols= no-issue=5 article-no= start-page=1007 end-page=1015 dt-received= dt-revised= dt-accepted= dt-pub-year=1955 dt-pub=19550531 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=SUGAR METABOLISM UNDER HIGH TEMPERATURE CHAPTER II. INFLUENCES OF SEVERAL HORMONES AND AUTONOMIC NERVOUS TOXINS ON SUGAR METABOLISM UNDER HIGH TEM PERATURE kn-title=高温環境下に於ける糖代謝 第2編 高温環境下に於ける糖代謝に及ぼす二，三のhormone及び自律神経毒の影響 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The glycogen content in both livers and muscles as well as the blood sugar values were measured after letting guinea pigs standing for 2 hours at room temperature or at 41°C. after imposition of a definite dose of insulin, Thyradin, adrenalin, pilocarpine and atropine and in some cases together with vitamin C, and the following results were obtained: 1. Though liver glycogen always decreased by imposing these drugs, the action of pilocarpine seemed to be weaker than Thyradin, and the ones of insulin, adrenalin and atropine were most apparent in a similar degree. 2. Liver glycogen content decreased further by exposing the animals to high temperature after imposing these drugs, but the degree, from the viewpoint of the decrease caused by drug itself, was not so different among these drugs except insulin, which introduced an apparent decrease, and agreed well with the degree of the cases exposed to high temperature without imposition of these drugs. 3. The decrease of liver glycogen content of the animals exposed to high temperature after imposition of these drugs was inhibited by simultaneous imposition of vitamin C, and the inhibition was predominant over the decrease owed to insulin or atropine. 4. Muscle glycogen content decreased slightly by adrenalin and apparently by atropine, and the other drugs seemed to have no obvious action. 5. Muscle glycogen content decreased more or less in all cases by being exposed to kigh temperature after imposition of the drugs, and the degree, from the viewpoint of the decrease caused by drug itself, was higher in adrenalin and pilocarpine cases than in insulin and Thyradin cases, and the one of an atropine case was far low agreeing with the case exposed to high temperature without imposition of the drug. 6. The decrease of muscle glycogen content under high temperature after imposition of these drugs was more or less inhibited by simultaneous imposition of vitamin C, but these effects appeared hardly on insulin and pilocarpine cases, while the action of vitamin C was predominant over the action of atropine. 7. Though blood collection made the blood sugar values increase, the values in all cases except atropine imposition, which made the value much more increase than the non-imposed, grew lower than the one before collection, and the degree was most obvious to insulin case. 8. The blood sugar values under high temperature after imposition of these drugs decreased further in insulin, Thyradin and pilocarpine cases, while increased in an adrenalin case and the increase in an atropine case was accelerated. 9. By further imposition of vitamin C on the above mentioned cases, the blood sugar values were influenced by vitamin C in a way to inhibit both the decrease in a Thyradin case and the increase in atropine and adrenalin caes, but no influence was proved in insulin and pilocarpine cases. en-copyright= kn-copyright= en-aut-name=ObaraYoshio en-aut-sei=Obara en-aut-mei=Yoshio kn-aut-name=小原美夫 kn-aut-sei=小原 kn-aut-mei=美夫 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一内科教室 END start-ver=1.4 cd-journal=joma no-vol=67 cd-vols= no-issue=5 article-no= start-page=1001 end-page=1006 dt-received= dt-revised= dt-accepted= dt-pub-year=1955 dt-pub=19550531 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=SUGAR METABOLISM UNDER HIGH TEMPERATURE CHAPTER I. INFLUENCES OF VITAMIN C ON SUGAR METABOLISM UNDER HIGH TEMPERATURE kn-title=高温環境下に於ける糖代謝 第1編 高温環境下に於ける糖代謝に及ぼすvitamin Cの影響 en-subtitle= kn-subtitle= en-abstract= kn-abstract=1. Imposition of vitamin C on mice made glycogen content of livers and muscles increase contrary to the decreases of blood sugar values. 2. Glycogen content of liver decreased remarkably by exposing mice or guinea pigs to high temperature, but the decrease grew far slight by preliminary imposition of vitamin C on them and the content became higher contrarily in some doses of vitamin C imposed. 3. No influence was proved on glycoden content of muscles of mice or guinea pigs by exposing them to high temperature or having imposed vitamin C beforehand. 4. An increase of blood sugar value was caused by blood collection by heart puncture of mice and guinea pigs, and by letting them expose to high temperature a remarkable increase of blood sugar values was obtained in the latter comparing with no influence in the former. The above mentioned increases were inhibited by preliminary imposition of vitamin C showing rather a decrease by increased imposition of it. en-copyright= kn-copyright= en-aut-name=ObaraYoshio en-aut-sei=Obara en-aut-mei=Yoshio kn-aut-name=小原美夫 kn-aut-sei=小原 kn-aut-mei=美夫 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一内科教室 END start-ver=1.4 cd-journal=joma no-vol=67 cd-vols= no-issue=5 article-no= start-page=991 end-page=999 dt-received= dt-revised= dt-accepted= dt-pub-year=1955 dt-pub=19550531 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Supplementary Notes on the Blood Gas in Cases of Manic-Depressive Psychosis kn-title=躁うつ病の血液瓦斯像 en-subtitle= kn-subtitle= en-abstract=Having measured 17 cases of manic-depressive psychosis, which in reality, have amounted to 21 cases in its frequency, about the blood gas, by making use of micro Van Slyke apparatus, we have arrived at the following results 1. Those changes that occur to blood gas, are no special feature in schizophrenia; it changes in manic-depressive psychosis too, as it state changes, 2. Blood gas in either at excited time, or in melancholic fit, both look very alike, giving rise to a decrease of CO(2) output, lowering in R. Q., shrinkage of the variances of tention, descent in CO(2) percentage of the cerebral blood. 3. Generally, in schizophrenia, such as decrease in CO(2) output, lowering of R. Q., decrease of the reserve alkali, take place, accompanied with an abatement in pH value both of the cerebral as well as arteries; but in manic-depressive psychosis, the pH value in the blood either of cerebral or arteries proves no marked change, yielding to a separation of certain pathological indications; which we may say, is wholly different from the schizophrenic case. 4. The blood gas in time of excitement or melancholic fit, obtains it normal value when they had improvement. kn-abstract=血液瓦斯像の変化は,分裂病に特異というわけでなくて,躁うつ病に於ても矢張り種々の変化を見せた.すなわち躁状態にあつては特に炭酸出現量が少いこと, R. Q. <0.9なること,脳内炭酸分圧の差が4mm以下であること,血液pHに変りがないこと,炭酸含有量,予備アルカリは寡いものと正常値が半々であること等である.又うつ病の瓦斯像は,脳血炭酸含有量,炭酸出現量が寡いこと, R. Q. <0.9なること,圧差が4mm以下であること,予備アルカリは低常半々であること, pHには変化は少いこと等々である.これで分る通り,躁状態とうつ状態の瓦斯像は極めてよく類似しており,両者の間で異るのは唯脳血炭酸含有量の少いのがうつ状態の時目立つている位のもので,取上げる程の相異がない.躁うつ両端の状態に対する瓦斯像が極めてよく似たものであるということは,この両者が状態像の上では異つているが,それは単に感情表出の外面的な相違で,それの根本的な生物化学的な面に於て相違なく,その近似性が瓦斯像の上に現われているものであれば極めて興味深いことであろう.尚躁うつ病を一つ疾患単位として,分裂病との相違を取上げてみよう.一般に躁うつ病では炭酸出現量の少いことが目立ち, R. Q. <0.9である点,及びpHに変化が見られぬことの3つであろう.炭酸出現量が少く, R. Q. <0.9の2項は,数々分裂病急性期に於て見るものであつたが,分裂病ではかゝる場合非常に数々予備アルカリの減少に加えて,普通pHの酸性側への移動が見られるのであつた.躁うつ病では,これらの協同的変化が見られず,いわば悪化指標*の分離が見られるのであつて,これが分裂病と躁うつ病とが発生病理の上で異なる部分を反影しているものと考えられないだろうか.さて,これらの悪化期瓦斯像は,寛解期に於て何れも回復を見せ,分裂病瓦斯像の際に設けた正常規準値を獲得するに至つて落着くのである.かくして瓦斯像は,躁うつ夫々の状態の変化と共に動き,その病像を反影するのである. en-copyright= kn-copyright= en-aut-name=KosakaMutsutosi en-aut-sei=Kosaka en-aut-mei=Mutsutosi kn-aut-name=高坂睦年 kn-aut-sei=高坂 kn-aut-mei=睦年 aut-affil-num=1 ORCID= en-aut-name=NozakiKimiaki en-aut-sei=Nozaki en-aut-mei=Kimiaki kn-aut-name=野崎公明 kn-aut-sei=野崎 kn-aut-mei=公明 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部精神病学教室 affil-num=2 en-affil= kn-affil=岡山大学医学部精神病学教室 END start-ver=1.4 cd-journal=joma no-vol=67 cd-vols= no-issue=5 article-no= start-page=985 end-page=989 dt-received= dt-revised= dt-accepted= dt-pub-year=1955 dt-pub=19550531 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=On the Blood Gas in the Glucose Load Test of Schizophrenic Patients kn-title=分裂病者葡萄糖負荷試験に於ける血液瓦斯像 en-subtitle= kn-subtitle= en-abstract=To begin with, the standard values of the arterial and cerebral blood gases were measured following our original methods. As the second step, 20ml of 40 per cent Glucose were injected in the brachial veine. Then, after 5, 15 and 20-40 minutes the arterial and cerebral blood gases were measured again respectively by the same methods. The results were obtained as follows: 1. The changes of clinical symptomes could not be seen by the load of glucose. 2. The blood gas after the load of glucose indicated a) R. Q. usually increased in the chronic progressive type, but shrinkaged in the chronic stationary type. b) In the excitatory state R. Q. usually shrinkaged, but in the stuporous or light stuporous state increased. c) In the convalesce favorable cases, R. Q. usually increaseed, but shrinkaged almost unchanged in the unfavorable cases. kn-abstract=1. 葡萄糖の負荷により症状,状態像の変を生じなかつた. 2. 糖負荷前後の瓦斯像は,慢性進行型に於てR. Q.が増大するもの多く,慢性停留型では反対に縮小した. 3. 葡萄糖の負荷により,興奮状態にあるものは一般にR. Q.の縮小を見,昏迷状態或は軽昏迷状態にあるものは,術後R. Q.が一般に増大した. 4. 予後良好なる症例にあつては,術後R. Q.は多く増大し,良好ならざるものにあつては術後R. Q.は縮小又は術前と殆ど変らぬことが多い. en-copyright= kn-copyright= en-aut-name=KosakaMutsutosi en-aut-sei=Kosaka en-aut-mei=Mutsutosi kn-aut-name=高坂睦年 kn-aut-sei=高坂 kn-aut-mei=睦年 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部精神病学教室 END start-ver=1.4 cd-journal=joma no-vol=67 cd-vols= no-issue=5 article-no= start-page=975 end-page=984 dt-received= dt-revised= dt-accepted= dt-pub-year=1955 dt-pub=19550531 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=EXPERIMENTAL STUDIES ON JAPANESE B ENCEPHALITIS WITH THE RADIOACTIVE P(32) 3. INFLUENCES OF RADIOACTIVE P(32) UPON JAPANESE B ENCEPHALITIS IN MICE kn-title=P(32)による実験的日本脳炎に関する研究 第三篇 日本脳炎罹患マウスに及ぼす放射性同位元素P(32)の影響に就いて en-subtitle= kn-subtitle= en-abstract= kn-abstract=The influences of P(32) upon the mice infected with Japanese B Encephalitis were investigated. On the course of this investigation, the effects of P(32) upon the formation of nuclear inclusion-body was also histologically determined on the brains of infected mice. With the mice which had been intracerebrally injected with the virus at the concentration of about LD(50) the delay of infection and prolonged survival time were usually observed when therapeutic doses of P(32) were intraperitoneally given. This was also the case when the virus had been inoculated intraperitoneally or intravenously. In all these cases, the formation of nuclear inclusion-body was always more distinct than that of the control references. en-copyright= kn-copyright= en-aut-name=OsadaTakahisa en-aut-sei=Osada en-aut-mei=Takahisa kn-aut-name=長田高寿 kn-aut-sei=長田 kn-aut-mei=高寿 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=67 cd-vols= no-issue=5 article-no= start-page=961 end-page=974 dt-received= dt-revised= dt-accepted= dt-pub-year=1955 dt-pub=19550531 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=EXPERIMENTAL STUDIES ON JAPANESE B ENCEPHALITIS WITH THE RADIOACTIVE P(32) 2. INVESTIGATION OF NUCLEIC ACID METABOLISM BY SCHMIDT & THANHAUSER'S MFTHOD IN THE ORGANS, BRAIN AND LIVER, OF MICE INFECTED WITH JAPANESE B ENCEPHALITIS VIRUS kn-title=P(32)による実験的日本脳炎に関する研究 第二篇 脳内病毒接種マウス脳及び肝に於ける核酸代謝のSchmidt & Thanhauser法による研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=In the previous paper by the same author the nucleic acid metabolism in some organs which was infected by Japanese B Encephalitis was studied by Schneider's method. Some detailed study by Schmidt & Thanhauser's method on this problem was further undertook and is going to be reported here. P(32) was used as the tracer throughout this investigation and was injected intraperitoneally into the mice at the acme stage of infection. After the time intervals of 6 and 24 hours were collected certain quantities of brain, which were then fractionated by Schmidt & Thanhauser's method into DNH- and RNA- fractions These nucleic acid fractions were investigated on their P(32) contents. By comparing the results with those obtained from the control references made by treating the healthy mice with P(32) in the same way, an increase in P(32)-activity was recognized at the DNA-fraction of the brain, this indicating the fact that, when mouse is infected with the virus, the DNA-fraction of the brain suffers a marked change. Similar investigation was also carried out at the incubation period. In this case, however, an increase in the P(32)-activity was observed at the DNA and PNA-fraction of the liver collected from the mice infected with the virus. It is fully interesting that this increase in P(32)-activity shows intimate accordance with the visceral phase of the disease. en-copyright= kn-copyright= en-aut-name=OsadaTakahisa en-aut-sei=Osada en-aut-mei=Takahisa kn-aut-name=長田高寿 kn-aut-sei=長田 kn-aut-mei=高寿 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=67 cd-vols= no-issue=5 article-no= start-page=957 end-page=960 dt-received= dt-revised= dt-accepted= dt-pub-year=1955 dt-pub=19550531 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=On the incidence of Japanese B encephalitis and seasonal distribution of mosquitoes in Okayama Prefecture in 1955 kn-title=1955年岡山県下に於ける蚊の消長と日本脳炎について en-subtitle= kn-subtitle= en-abstract= kn-abstract=The seasonal distribution of mosquitoes in Okayama Prefecture was investigated in 1955 by means of light-trap at Niizato, Niimi, Takahashi, Soja, Kurashiki, Tamashima and Okayama in connection with the incidence of Japanese B encephalitis. Culex pipiens, Culex tritaeniorhynchus and Anopheles sinensis were collected through the prefecture, more abundantly in the southern district than in the northern mountainous district. Culex tritaeniorhynchus appeared in enormous numbers during the hottest season from late July through August after comparatively cool days of early summer. A majority of infections (77 cases in all) with Japanese B encephalitis has been reported during the period of August, though early September, with the infection rate corresponding with the distribution of the mosquitoes. It is to be noted that the incidence of the encephalitis and the distribution of the mosquitoes, especially of C. tritaeniorhynchus in Okayama Prefecture are parallel to each other, and may be graded into three (north, middle and south) zones according to their respective intensity, in exact conformity with the isothermal geographical zones. en-copyright= kn-copyright= en-aut-name=InatomiSeiiti en-aut-sei=Inatomi en-aut-mei=Seiiti kn-aut-name=稲臣成一 kn-aut-sei=稲臣 kn-aut-mei=成一 aut-affil-num=1 ORCID= en-aut-name=KimuraMitiya en-aut-sei=Kimura en-aut-mei=Mitiya kn-aut-name=木村道也 kn-aut-sei=木村 kn-aut-mei=道也 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部寄生虫学教室 affil-num=2 en-affil= kn-affil=岡山大学医学部寄生虫学教室 END start-ver=1.4 cd-journal=joma no-vol=67 cd-vols= no-issue=5 article-no= start-page=951 end-page=955 dt-received= dt-revised= dt-accepted= dt-pub-year=1955 dt-pub=19550531 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Experimental studies on destruction of eggs of Ascaris lumbricoides Report 1 kn-title=蛔虫卵滅殺に関する研究 第1報 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The human nightsoil is believed to contain some substance inhibiting the development of Ascaris eggs and eventually destroying them. We had experimentally demonstrated Ascaris eggs are destroyed under a certain condition. in which albuminous puterraction takes place. A similar condition obtains during decomposition of the human nightsoil, provided that some change is brought about in the body of the fecal bacteria by the use of Methionine. en-copyright= kn-copyright= en-aut-name=InatomiSeiiti en-aut-sei=Inatomi en-aut-mei=Seiiti kn-aut-name=稲臣成一 kn-aut-sei=稲臣 kn-aut-mei=成一 aut-affil-num=1 ORCID= en-aut-name=KimuraMitiya en-aut-sei=Kimura en-aut-mei=Mitiya kn-aut-name=木村道也 kn-aut-sei=木村 kn-aut-mei=道也 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部寄生虫学教室 affil-num=2 en-affil= kn-affil=岡山大学医学部寄生虫学教室 END start-ver=1.4 cd-journal=joma no-vol=67 cd-vols= no-issue=5 article-no= start-page=933 end-page=950 dt-received= dt-revised= dt-accepted= dt-pub-year=1955 dt-pub=19550531 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Pharmacology of Circulation Through the Liver Part 2. Experiments with Dog's Liver Using Our Newly Devised Perfusion Apparatus kn-title=肝臓循環の薬理学的研究 第二編 諸種薬物の犬肝臓内循環に対する作用 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Perfusion of a dog liver was carried out with a circulating liver-perfusion apparatus, provided with two blood supplies from the artery and the portal vein, and the effect of various drugs on the changes of arterial and portal inflow, hepatic venous outflow, and the liver volume were recorded. From these recordings, sites and modes of action of drugs on blood vessels of the liver were examined. It was observed that there was a partially reciprocal relationship between the inflow of hepatic artery and of the portal vein. Adrenaline chiefly caused dilating action on the hepatic veins in a small dose, but when the dose was comparatively large, constriction of the arterial and portal branches being more predominant. However, the hepatic veins were opened in some liver preparations even when the dose of adrenaline was fairly large. The action of noradrenaline seemed to be fundamentally similar to that of adrenaline. The action of ephedrine and tyramine was similar to that of adrenaline though much weaker and more lasting. Histamine itself caused constriction of the hepatic veins but its action on blood vessels in other parts was much weaker. A small dose of adrenaline completely counteracted the histamine action on the hepatic vein. The actions of peptone and sinomenine were similar to that of histamine and it was assumed that the actions appeared through histamine release from the liver tissues. Under the experimental conditions employed, the action of sinomenine seemed to be stronger. The principal action of acetylcholine was constriction of the hepatic veins, which was far stronger than that reported by the previous workers on this animal, although this action was transitory and a secondary dilatation of the hepatic veins often followed. The action of pilocarpine was of the same type as that of acetylcholine but far weaker. A small dose of atropine suppressed these actions and itself dilated the hepatic veins. These observations strongly suggest the presence of the parasympathetic control of the liver circulation which had been overlooked to date. Barium salts effected strong constriction of the tributaries of the hepatic artery and this action was removed by papaverine. Strophanthine showed a histamine-type action and the action of pituitrin was also similar, though the action of pituitrin was sometimes similar to that caused by a small amount of adrenaline. Of the drugs acting chiefly on the hepatic veins, the comparatively stable histamine showed about the same effect by the arterial and portal injections, but the effect of adrenaline and acetylcholine which are unstable was far weaker when given into the portal vein. These facts suggest the presence of direct communications from the hepatic artery to the vein, i.e. the transhepatic arterial branches. en-copyright= kn-copyright= en-aut-name=YokoyamaGor? en-aut-sei=Yokoyama en-aut-mei=Gor? kn-aut-name=横山五郎 kn-aut-sei=横山 kn-aut-mei=五郎 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部薬理学教室 END start-ver=1.4 cd-journal=joma no-vol=67 cd-vols= no-issue=5 article-no= start-page=913 end-page=917 dt-received= dt-revised= dt-accepted= dt-pub-year=1955 dt-pub=19550531 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The Effect of Sugar Metabolites upon Ketosis of Alloxan Diabetic Rabbit kn-title=Alloxan糖尿病家兎のAceton体及び糖排泄に及ぼすTCA-Cycle構成物質及び糖の影響 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The administration of oxaloacetate, citrate, succinate, and fructose caused a decrease in ketonuria in alloxan diabetic rabbits, while glucose and fat increased ketone body urinary excretion in rabbits fed alloxan. However, all these substances administered caused a increase in urinary sugar excretion in rabbits fed alloxan. en-copyright= kn-copyright= en-aut-name=OishiTetsuya en-aut-sei=Oishi en-aut-mei=Tetsuya kn-aut-name=大石哲也 kn-aut-sei=大石 kn-aut-mei=哲也 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部生化学教室 END start-ver=1.4 cd-journal=joma no-vol=67 cd-vols= no-issue=5 article-no= start-page=909 end-page=912 dt-received= dt-revised= dt-accepted= dt-pub-year=1955 dt-pub=19550531 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Compartive Studies of Catalase, Cytochrome Oxidase, and Succinic Dehyrogenase of some Animal Tissues kn-title=無Catalase血液症の研究（第4編）各種動物の各種臓器に於けるCatalase, Cytochrome酸化酵素及び琥珀酸酸化酵素について en-subtitle= kn-subtitle= en-abstract= kn-abstract=The blood catalase level of ducks is known to be quite low, but no increased activity of cytochrome systems was observed in several tissues of ducks compared with the other animals. en-copyright= kn-copyright= en-aut-name=OishiTetsuya en-aut-sei=Oishi en-aut-mei=Tetsuya kn-aut-name=大石哲也 kn-aut-sei=大石 kn-aut-mei=哲也 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部生化学教室 END start-ver=1.4 cd-journal=joma no-vol=67 cd-vols= no-issue=5 article-no= start-page=905 end-page=908 dt-received= dt-revised= dt-accepted= dt-pub-year=1955 dt-pub=19550531 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the Acatalasemia Part III. An attempt to search a toxic substance in the blood of acatalasemia patients kn-title=無「カタラーゼ」血液症の研究 III. 患者血液抽出物に於ける「カタラーゼ」減少作用に就いての検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=A toxohormone-like fraction prepared from the blood of acatalasemia patients by the method of Nakahara was tested whether it could decrease the catalase content of liver and blood of the mice or not. Although no decrease of catalase cotent of these tissues was observed, the fraction prepared from the patients could kill the mice. However, the fraction prepared from normal blood had no toxic action on the mice. en-copyright= kn-copyright= en-aut-name=OkitaMinoru en-aut-sei=Okita en-aut-mei=Minoru kn-aut-name=沖田稔 kn-aut-sei=沖田 kn-aut-mei=稔 aut-affil-num=1 ORCID= en-aut-name=OishiTetsuya en-aut-sei=Oishi en-aut-mei=Tetsuya kn-aut-name=大石哲也 kn-aut-sei=大石 kn-aut-mei=哲也 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部生化学教室 affil-num=2 en-affil= kn-affil=岡山大学医学部生化学教室 END