start-ver=1.4
cd-journal=joma
no-vol=104
cd-vols=
no-issue=5-6
article-no=
start-page=713
end-page=720
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1992
dt-pub=1992
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=第117回　岡山外科会
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=OritaKunzo
en-aut-sei=Orita
en-aut-mei=Kunzo
kn-aut-name=折田薫三
kn-aut-sei=折田
kn-aut-mei=薫三
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=104
cd-vols=
no-issue=5-6
article-no=
start-page=701
end-page=711
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1992
dt-pub=1992
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on the pathogenesis of interstitial pneumonia of collagen vascular diseases Part 2. Examination of interleukin 2 receptor in interstitial pneumonia of collagen vascular diseases
kn-title=膠原病肺の病態に関する研究　第2編　膠原病肺における血清中および気管支肺胞洗浄液中 soluble IL-2 receptor の検討
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Abnormality of cellular immunity has been reported in the pathogenesis of collagen vascular diseases (CVD). IL-2 and IL-2 receptors play important roles as immunological regulation in CVD. In this study, the soluble forms of IL-2 receptor (sIL-2R) and IL-2 receptor positive lymphocytes (CD25) were analyzed to evaluate the role of IL-2R in the pathogenesis of interstitial pneumonia (IP) of CVD such as RA, SLE, polymyositis/dermatomyositis (PM/DM), and PSS and idiopathic interstitial pneumonia (IIP) as a disease control. High levels of sIL-2R were found in sera of patients with IP of CVD. The level of soluble IL-2R in sera of RA without IP correlated with the disease activity of the joints, while the level of sIL-2R in sera of RA with IP was higher than in that of RA without IP. Soluble IL-2R in bronchoalveolar lavage fluind (BALF) was also measured and the level was higher in IP with CVD. There were fewer IL-2R positive lymphocytes in the peripheral blood of CVD with IP than in the normal controls or IIP cases, although the serum level of sIL-2R was higher in CVD with IP and IIP than in the normal controls. These findings indicate that actibve immunological activities involving IL-2/IL-2R/sIL-2R systems play an important role in the pathogenesis of IP of CVD.
en-copyright=
kn-copyright=

en-aut-name=YokotaSatoshi
en-aut-sei=Yokota
en-aut-mei=Satoshi
kn-aut-name=横田聡
kn-aut-sei=横田
kn-aut-mei=聡
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第二内科学教室
en-keyword=collagen vascular disease
kn-keyword=collagen vascular disease
en-keyword=interstitial pneumonia
kn-keyword=interstitial pneumonia
en-keyword=bronchoalveolar lavage
kn-keyword=bronchoalveolar lavage
en-keyword=soluble IL-2 receptor
kn-keyword=soluble IL-2 receptor
en-keyword=IL-2 receptor positive lymphocyte
kn-keyword=IL-2 receptor positive lymphocyte
END

start-ver=1.4
cd-journal=joma
no-vol=104
cd-vols=
no-issue=5-6
article-no=
start-page=687
end-page=700
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1992
dt-pub=1992
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on the pathogenesis of interstitial pneumonia of collagen vascular diseases Part 1. Cellulae responses of interstitial pneumonia of collagen vascular diseases by bronchoalveolar lavage
kn-title=膠原病肺の病態に関する研究　第1編　膠原病肺の気管支肺胞洗浄法による細胞反応について
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Various pulmonary involvements have been reported in collagen vascular diseases (CVD). Interstitial pneumonia (IP) is one of the common complications. The pathogenesis of IP is still obscure. In this study bronchoalveolar lavage (BAL) was applied to analyze the cellular response in the pathological changes in the bronchioloalveolar regions in IP of CVD such as RA, SLE, polymyositis/dermatomyositis and PSS. Increased total cell counts and  cellular density in the BAL fluid were shown in most of the CVD with IP. Furthermore, a relative decrease in the percetn of macrophages and increase in the percent of lymphocytes, neutrophils, eosinophils and basophil/mast cells in BALL fluid were revealed, the increase being more marked in active IP than in non-active IP. T-cell subsetes of lymphocytes in the BALL fluid were analyzed with flow cytometry. A decrease in the CD4/CD8 ratio was shown in most of the IP with CVD except for RA in which the CD4/CD8 ratio was increased. Total cell count and percentage of macrophage was higher in the smoking group than in the non-smoking group of IP with RA. These findings indicate that cellular responses obtained by BAL could be useful not only for analyzing the pathogenesis of IP of CVD but also for evaluating the disease activity of IP.
en-copyright=
kn-copyright=

en-aut-name=YokotaSatoshi
en-aut-sei=Yokota
en-aut-mei=Satoshi
kn-aut-name=横田聡
kn-aut-sei=横田
kn-aut-mei=聡
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第二内科学教室
en-keyword=collagen vascular disease
kn-keyword=collagen vascular disease
en-keyword=interstitial pneumonia
kn-keyword=interstitial pneumonia
en-keyword=bronchoalveolar lavage
kn-keyword=bronchoalveolar lavage
en-keyword=lymphocyte subsets
kn-keyword=lymphocyte subsets
END

start-ver=1.4
cd-journal=joma
no-vol=104
cd-vols=
no-issue=5-6
article-no=
start-page=677
end-page=686
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1992
dt-pub=1992
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=The relationship between thermotolerance and changes of cell cycle after hyperthemia in culture cells
kn-title=培養細胞における細胞周期の変動と熱耐性の発現に関する研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=To examine the apperance of thermotolerance in a random growing population, changes in cell cycle fractions after hyperthermia, thermosensitivity and thermotolerance during the cell cycle were studied in mouse NIH3T3 cell. Progression of S phase cells was disturbed slightly and a marked increase of G(2) + M cells fraction (G(2)-block) was observed after heating (43℃ 60min, 44℃ 20min, 40min, and 45℃ 10 min). Maximun thermotolerance after 10, 20, and 30min at 45℃ appeared at 6, 12 and 45 hrs after heating, respectively. G(0) cell stimulated with frsh medium containing 10% calf serum, entered into the G(1) and S phase. When these cells were exposed to 45℃ for 30min at each point after stimulation, the thermosensitivity to heating changed with progression of time after the stimulation. S phase cells showed the highest thermosensitivity. Thermotolerance of S phase was larger than that of G(1) phase. The mechanisms involved in the appearance of thermotolerance were discussed.
en-copyright=
kn-copyright=

en-aut-name=MatsubaraShinichiro
en-aut-sei=Matsubara
en-aut-mei=Shinichiro
kn-aut-name=松原伸一郎
kn-aut-sei=松原
kn-aut-mei=伸一郎
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部放射線医学教室
en-keyword=熱耐性
kn-keyword=熱耐性
en-keyword=細胞周期
kn-keyword=細胞周期
en-keyword=培養細胞
kn-keyword=培養細胞
en-keyword=ハイパーサーミア
kn-keyword=ハイパーサーミア
END

start-ver=1.4
cd-journal=joma
no-vol=104
cd-vols=
no-issue=5-6
article-no=
start-page=663
end-page=675
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1992
dt-pub=1992
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Organization of the reticular network of rabbit palatine tonsils
kn-title=ウサギの口蓋扁桃における細網線維構築
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The collagen fiber network of rabbit palatine tonsils was studied by scanning electron microscopy (SEM) of alkali-water macerated tissues. Tissue sections adjacent to the SEM specimens were also observed by light microscopy. The collagen fibers, which consisted of collagen fibrils, branched out or fused together, thus forming the collagen networks as a whole. The collagen networks within the follicles were coarse, while those within the interfollicular areas were dense. The interfolliculae area that surrounded or was adjacent to the follicle had dense networks arranged in a concentric pattern around the follicles. Such a dense collagen network may be the site in which lymphocytes actively migrate. In the interfollicular area, there were high endothelial venules (HEVs) and lymphatic vessels which were surrounded by collagen sheaths. These venules and lymphatic vessels had many pores through which the lymphocytes appeared to migrate. Transmission electron microscopy of lead-stained tissue samples showed that the reticular fibers were closely associated with the thin cytoplasmic processes of the reticular cells. These processes were in direct contanct with the lymphocytes and had many pores or fenestrae.
en-copyright=
kn-copyright=

en-aut-name=YamaneTatsuo
en-aut-sei=Yamane
en-aut-mei=Tatsuo
kn-aut-name=山根辰生
kn-aut-sei=山根
kn-aut-mei=辰生
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部耳鼻咽喉科学教室
en-keyword=扁桃
kn-keyword=扁桃
en-keyword=細網線維
kn-keyword=細網線維
en-keyword=コラーゲン線維
kn-keyword=コラーゲン線維
en-keyword=ウサギ
kn-keyword=ウサギ
en-keyword=低温アルカリ消化・走査電子顕微鏡法
kn-keyword=低温アルカリ消化・走査電子顕微鏡法
END

start-ver=1.4
cd-journal=joma
no-vol=104
cd-vols=
no-issue=5-6
article-no=
start-page=651
end-page=661
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1992
dt-pub=1992
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Analysis of referrals from a clinic in a remoted area
kn-title=地域診療所における患者紹介の分析
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=To clarify the health needs in a community, three hundred and ten referrals from a public clinic in a typical Japanese rural area were reviewed concerning age, sex, medical facility to which the patient was referred, reason for referral, and disease from January 1, 1986 to December 31, 1990. The referral patients were classified into 4 groups by age ; 0-19, 20-49, 50-69, 70 years old and older. The number of referrals, admissions, operations, and emergency referrals were divided by the number of consultations to obtain the referral, admission, operation, and emergency referral rates, respectively. Haysshi's third method of quantifica-tion was used to analyze the characteristics of the referrals. The referral rates did not differ among the age groups except for the referral rate of men under 20. However, the admission rate increased with age. The operation rate at the age of 50 and older was higher than that of referrals under 50. The emergency referral rate at the age of 70 and older was higher than that of referrals under 70. All rates of adult men were higher than those of adult woman. Analysis by Hayashi's third method of quantification revealed that 4 major characteristics of referrals were "admission factor", "referral facility factor", "disease factor", and "referral reason factor". In conclusion, it is informative and useful for the primary care physician to analyze referral patients to determine the health needs in the community and the kind of primary care services that should be provided.
en-copyright=
kn-copyright=

en-aut-name=HamadaHirohisa
en-aut-sei=Hamada
en-aut-mei=Hirohisa
kn-aut-name=濱田裕久
kn-aut-sei=濱田
kn-aut-mei=裕久
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部衛生学教室
en-keyword=患者紹介
kn-keyword=患者紹介
en-keyword=紹介率
kn-keyword=紹介率
en-keyword=入院率
kn-keyword=入院率
en-keyword=手術率
kn-keyword=手術率
en-keyword=救急紹介率
kn-keyword=救急紹介率
END

start-ver=1.4
cd-journal=joma
no-vol=104
cd-vols=
no-issue=5-6
article-no=
start-page=639
end-page=649
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1992
dt-pub=1992
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Long-term follow-up study od total hip replacement in rheumatoid arthritis
kn-title=慢性関節リウマチにおける全人工股関節置換術長期成績に関する研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=A long-term follow up study was performed on 125 total hip replacements (THR) in 95 rheumatoid patients. The average follow up time was 8 years and 5 months, ranging from 5 to 17 years. Except in 26 cases of death or 9 incomplete histories at the follow-up, 62 cases were investigated both clinically and radiologically. For the operations, two types of prostheses (Charnley and C-Muller ) were used. According to the Japan Orthopaedic Association (JOA) hip score, the preoperative score improved from 32.9 to 57.1 points at the final postoperative evaluation. In the radiological assessment using the method by Nagaya and Uno, a clear zone was seen around the acetabular cup in 82.2% of the hips and around the femoral stem in 53.2%. Rate of loosening corresponding to stage �V and �W was 20.2% in the acetabular side and 32.9% in the femoral side. Charnley-type group was better than C-Muller type both in clinical and radiological assessments. Twelve cases had lost walking ability. As postoperative complications, deep infections occurred in 4 hips, femoral shaft fracture in 4 hips, dislocation in 1 hip and revision due to aseptic loosening in 4 hips. THR may be useful for rheumatoid patients and improve the quality of life in the case of long-term disease if careful pre-and post-operative care is provided.
en-copyright=
kn-copyright=

en-aut-name=OosakiKazuhiko
en-aut-sei=Oosaki
en-aut-mei=Kazuhiko
kn-aut-name=大�ｱ和彦
kn-aut-sei=大�ｱ
kn-aut-mei=和彦
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部整形外科学教室
en-keyword=慢性関節リウマチ
kn-keyword=慢性関節リウマチ
en-keyword=全人工股関節置換術
kn-keyword=全人工股関節置換術
en-keyword=長期追跡調査
kn-keyword=長期追跡調査
en-keyword=合併症
kn-keyword=合併症
END

start-ver=1.4
cd-journal=joma
no-vol=104
cd-vols=
no-issue=5-6
article-no=
start-page=625
end-page=637
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1992
dt-pub=1992
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Metallothionein gene expression in rat liver following intraperitonal endotoxin administration
kn-title=エンドトキシン投与ラットにおける肝内メタロチオネイン遺伝子発現に関する研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=To clarify the functions of hepatic metallothioneins (MTs) after the administration of endotoxin (lipopolysaccharide : LPS), we investigated the expression on MT genes in the bacterial endoxin-treated rat liver by Norhern blot hybridization and in situ hybridization methol with riboprobes synthesized from mouse cDNA of MT-�U chronologically. Northern blot analysis revealed a rapid increase in the amount of MT gene transcripts in the liver 3 hours after the administration of LPS, with a maximum at 6 to 12 hours followed by a gradual decrease. In the in situ hybridization method, MT genes are expressed in the liver lobule for 3 hours after the adiminstration of LPS, and hepatocellular damage was observed at 6 hours after the LPS administration initially and expanded most extensively at 18 hours. During this peripd, MT genes are expressed in intact tissue intensely and specifically. At 24 hours after the administration, transcripts of the MT gene were detected in intact hepatocytes around the shrinking necrotic area. These findings suggest that MTs protect the liver cells by scavenging the free radicals, which probably cause liver cell damage due to LPS administration, and that MTs provide the zinc ions necessary for stabilizing the cell membrane and to heal the liver cell damge.
en-copyright=
kn-copyright=

en-aut-name=TagaNaoyuki
en-aut-sei=Taga
en-aut-mei=Naoyuki
kn-aut-name=多賀直行
kn-aut-sei=多賀
kn-aut-mei=直行
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部麻酔・蘇生学教室
en-keyword=エンドトキンショック
kn-keyword=エンドトキンショック
en-keyword=メタロチオネイン
kn-keyword=メタロチオネイン
en-keyword=in situ hybridization
kn-keyword=in situ hybridization
END

start-ver=1.4
cd-journal=joma
no-vol=104
cd-vols=
no-issue=5-6
article-no=
start-page=617
end-page=624
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1992
dt-pub=1992
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Ascorbic acid incerases 1,25-dihydroxyvitamin D(3) effect in human osteosaroma cell line MG63
kn-title=アスコルビル酸による 1,25dihydroxyvitaminD(3) 作用の増強―培養ヒト骨肉腫細胞 MG63 における検討―
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=We eximined the interaction between 1,25-dihydroxyvitamin D(3) and ascorbic acid in the human osteosarcoma cell MG63 by measuring alkaline phosphatase (ALP) activity. Both vitamins induced ALP activity in this cell line. Simultaneous addition of both ascorbic and 1,25-dihydroxyvitamin D(3) induced much higher ALP activity than each vitamin alone. Pretreatment of MG63 with ascorbic acid or type I collagen, increased the ALP activity induced by 1,25-dihydroxyvitamin D(3). Binding assay anf immunoblotting analysis showed that the number of vitamin D receptors was increased in MG63 pretreated with ascorbic acid. In conclusion,ascorbic acid stimulates collagen production of MG63, and collagen increases the vitamin D receptor content. The increase in vitamin D receptor content potentiates the activity of 1,25-dihydroxyvitamin D(3) in this cell line.
en-copyright=
kn-copyright=

en-aut-name=KuriharaMakoto
en-aut-sei=Kurihara
en-aut-mei=Makoto
kn-aut-name=栗原信
kn-aut-sei=栗原
kn-aut-mei=信
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部小児科学教室
en-keyword=MG63
kn-keyword=MG63
en-keyword=1,25dihydroxyvitaminD(3)
kn-keyword=1,25dihydroxyvitaminD(3)
en-keyword=ascorbic acid
kn-keyword=ascorbic acid
en-keyword=type I coollagen
kn-keyword=type I coollagen
en-keyword=vitaino D recepter
kn-keyword=vitaino D recepter
END

start-ver=1.4
cd-journal=joma
no-vol=104
cd-vols=
no-issue=5-6
article-no=
start-page=609
end-page=616
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1992
dt-pub=1992
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Expression of period (per) repeat sequence consisting in Drosophila clock gene in the rat brain
kn-title=ショウジョウバエ時計遺伝子に存在する Period (per) repeat を持つ遺伝子のラット脳内発現
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The clock gene of Drosophila containing a hexamer repeat sequence (ACAGGC)n(period, per, repeat) is reported to be involved in the circadian rhythm. Young et al. (1985) cloned a mouse genomic DNA with the per repeat (cp202). In this study, temporal and spatial expres-sion of CP2.2F. and RB15 was examined in the adult rat branin by in situ hybridization. The former is a family of genes detected by using cp2.2 as a probe, and the latter is a gene corresponding to pRB15, one of the 11 rat brain cDNA recombinants homologous to cp2.2. Both genes were expressed in almost all neurons. Fluctuation of the genes under the light-dark cycle was apparently observed in the suprachiasmatic nucleus ; an intensive hybridization signal in the middle of the day and a weak in the middle of the night (p<0.01). However, the signal stayed relatively constant in other brain regions. Expression of both genes was detected in some glial and ependymal cells in the day but few at night. The present findings suggest that CP2.2F. and RB15 are involved in the circadian rhythm in the rat nervous system.
en-copyright=
kn-copyright=

en-aut-name=ShibataNaoki
en-aut-sei=Shibata
en-aut-mei=Naoki
kn-aut-name=柴田直樹
kn-aut-sei=柴田
kn-aut-mei=直樹
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部脳神経外科学教室
en-keyword=circadian rhythm
kn-keyword=circadian rhythm
en-keyword=period repeat sequence
kn-keyword=period repeat sequence
en-keyword=rat brain
kn-keyword=rat brain
en-keyword=suprachiasmatic nucleus
kn-keyword=suprachiasmatic nucleus
en-keyword=in situ hybridization
kn-keyword=in situ hybridization
END

start-ver=1.4
cd-journal=joma
no-vol=104
cd-vols=
no-issue=5-6
article-no=
start-page=601
end-page=608
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1992
dt-pub=1992
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Renal hemodynamics in improvement of diabetic nephropathy in stage �V and �W
kn-title=�V, �W期糖尿病性腎症の改善における腎血行動態に関する研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Diabetic nephropathy is characterized by specific morphological changes and impairment of renal hemodynamics. To determine whether diabetic nephripathy could be improved by improvement of renal hemodynamics, 80μg/day of prostaglandin E(1) (PGE(1)) was administered daily for 4 weeks to 19 non-insulin-dependent diabetic inpatients with overt proteinuria. In 6 patients who initialy had daily urinary protein (UP) values above 3.5g/day, the UP value was sinificantly reduced by PGE(1) administration (p<0.05). However, in 6 patients who initially had UP values above 200mg/day and below 3.5g/day, the UP value was unchanged. In the former group, creatinine clearance was significantly reduced during PGE(1) administration (p<0.05), but was restored after termination of PGE1 adminstration (ns). Serum creatinine, serum total protein and serum albumin values were unchanged by PGE(1) administration in both groups. One petient who had a UP level above 200mg/day showed marked improvement on his renogram during PGE(1) administration and in 7 patiests who had UP values below 200mg/day, the ratio of plasma renin activity 120 minutes after furosemide injection in an upright posture to that of basal condition (PRA120/0) was significantly reduced. These findings inducate that PGE(1) increased renal blood flow, and suggest that improvement of renal hemodynamics is an important method of therapy for diabetic nephropathy with overt proteinuria.
en-copyright=
kn-copyright=

en-aut-name=IchikiKen
en-aut-sei=Ichiki
en-aut-mei=Ken
kn-aut-name=市木研
kn-aut-sei=市木
kn-aut-mei=研
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第三内科学教室
en-keyword=糖尿病性腎症
kn-keyword=糖尿病性腎症
en-keyword=蛋白尿
kn-keyword=蛋白尿
en-keyword=腎血行動態
kn-keyword=腎血行動態
en-keyword=プロスタグランディンE(1)
kn-keyword=プロスタグランディンE(1)
en-keyword=糸球体過剰濾過
kn-keyword=糸球体過剰濾過
END

start-ver=1.4
cd-journal=joma
no-vol=104
cd-vols=
no-issue=5-6
article-no=
start-page=591
end-page=599
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1992
dt-pub=1992
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Mitral valve replacement with preservation of the posterior mitral apparatus for mitral stenosis : An analysis of postoperative cardiac function and its correlations with ultrastructural changes in the myocardial cells
kn-title=僧帽弁狭搾症に対する後尖温存術式後の左心機能―心筋変性度との関連―
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Postoperative cardiac function was evaluated by dynamic exercise echocardiography in 36 cases with mitral stenosis, and electron microscopic examination of the LV myocardial cells was also carried out. Ultrastructual changes of the LV myocardial cells were graded into scores (EM-score). EM-scores correlated with % FS (r=-0.54), mVcf (r=-0.60) at rest and % FS (r=-0.54), mVcf (r=-0.50) after exercise. In 36 cases, 25 cases underwent conventional MVR (group �T) and 11 underwent MVR with preservation of the posterior mitral apparatus (group �U). When postoperative cardiac function was compared in 13 cases less than 4 of EM-score in group �T because EM-scores were less than 4 in all cases in group �U, no difference was observed in two groups except for mVcf at rest. The vaulues of % △FS and % △mVcf in group �T were better than those in group �U. This suggests that preservation of the hypertrophic and sclerotic subvalvular tissue in mitral stenosis disturebs the LV diastolic wall motion.
en-copyright=
kn-copyright=

en-aut-name=ShichijoTakeshi
en-aut-sei=Shichijo
en-aut-mei=Takeshi
kn-aut-name=七条健
kn-aut-sei=七条
kn-aut-mei=健
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第二外科学教室
en-keyword=僧帽弁狭搾症
kn-keyword=僧帽弁狭搾症
en-keyword=後尖温存術式
kn-keyword=後尖温存術式
en-keyword=運動負荷
kn-keyword=運動負荷
en-keyword=術後心機能
kn-keyword=術後心機能
en-keyword=心筋変性度
kn-keyword=心筋変性度
END

start-ver=1.4
cd-journal=joma
no-vol=104
cd-vols=
no-issue=5-6
article-no=
start-page=581
end-page=590
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1992
dt-pub=199212
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Response of luteinizing hormone and follicle stimulating hormone to luteinizing hormone-releasing hormone in prepubertal and pubertal chidren, as measured by a highly sensitive immunradiometric assay
kn-title=LHRH 負荷試験による小児期のゴナドトロピン分泌予備能に関する検討ー高精度 LH, FSH 測定法 (IRMA 法) による分泌動態の解析ー
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=To investigate the age-related changes in the pituitary responsiveness to luteinizing hormone-releasing hormone (LH-RH), the consentrations of serum luteinizing hormone (LH) and follicle stimulating hormone (FSH) were measured before and after LH-RH administra-tion using the highly sensitive immunoradiometric assay (IRMA) in 283 normal children (161 males and 77 females) between 4 and 14 years old and in 22 patients (18 males and 4 females) with pituitary dwarfism. Then, the area of response above the basal level [integrated response(Σ)] of LH and FSH during 60 minutes after LH-RH injection was calculated to evaluate the pituitary response to LH-RH. The integrated LH responses progressively increased in the boys from 8 years of age and in the girls from 6 years of age, and they continued to increase up to 14 years of age. The integrated FSH response showed a significant decrease in all grups in the girls, but did not show any change in the boys. In patients with pituitary dwarfism who were subsequently found to be gonadotropin deficient, the level of Σ LH60 was low (below-2SD) It is concluded that integrated responses of gonadotropins, especially LH, to LH-RH are useful to evaluate the maturation of the hypothalamic-pituitary-gonadal axis, and that incre-ment of LH responsiveness to LH-RH already begins before the onset of puberty. The peak appearance time of gonadotropins after LH-RH is also important in the assessment of the maturation of the hypothalamic-pituitary-gonadal axis because FSH reached its peak carlier in the pubertal group than in the prepubertal group.
en-copyright=
kn-copyright=

en-aut-name=HiguchiJoji
en-aut-sei=Higuchi
en-aut-mei=Joji
kn-aut-name=樋口譲二
kn-aut-sei=樋口
kn-aut-mei=譲二
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部小児科学教室
en-keyword=LHRH
kn-keyword=LHRH
en-keyword=LH
kn-keyword=LH
en-keyword=FSH
kn-keyword=FSH
en-keyword=下垂体性小人症
kn-keyword=下垂体性小人症
en-keyword=ゴナドトロピン分泌不全
kn-keyword=ゴナドトロピン分泌不全
END

start-ver=1.4
cd-journal=joma
no-vol=104
cd-vols=
no-issue=5-6
article-no=
start-page=571
end-page=579
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1992
dt-pub=1992
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=The cytoskeleton of the pancreatic acinar cells observed by detergent perfusion method
kn-title=Detergent 灌流法による膵臓線房細胞の細胞骨格の観察
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=To investigate the cytoskeleton of the pancreatic acinar cells by electron microscopy, the pancreas of several species (dog, rabbit guinea pig, rat and mouse) was perfused with a mixture of a low concentration of glutaraldehyde and Triton X-100 via the pancreatic duct. After perfusion, the pancreas was fixed with 2.5% glutaraldehyde and processed for scanning and transmission electron microscopy. Scanning electron microscopy demonstrated that the water-soluble cytoplasmic matrices were successively removed by the detergent treatment. Transmission electron microscopy demontrated that without detergent treatment, the acinar cells had many secretory granules at the apical region, the nuclei were located at the base of the cell, and rough-surfaced endoplasmic reticulum and mitochondria throughout the cytoplasm. Microvilli were present at the luminal side and apical subplasmalemmal region showed a homogeneous appearance. With detergent treatment, the core filament in microvilli projected into the apical terminal web which attached to the junctional complex at the lateral membrane. Intermediate filamemts and microtubules were observed in the cytoplasm around the nuclei, and thin filaments were also found around the secretory granules.
en-copyright=
kn-copyright=

en-aut-name=TanakaYukiko
en-aut-sei=Tanaka
en-aut-mei=Yukiko
kn-aut-name=田中由紀子
kn-aut-sei=田中
kn-aut-mei=由紀子
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第一解剖学教室
en-keyword=膵臓
kn-keyword=膵臓
en-keyword=細胞骨格
kn-keyword=細胞骨格
en-keyword=detergent 灌流法
kn-keyword=detergent 灌流法
en-keyword=電子顕微鏡
kn-keyword=電子顕微鏡
END

start-ver=1.4
cd-journal=joma
no-vol=104
cd-vols=
no-issue=5-6
article-no=
start-page=561
end-page=569
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1992
dt-pub=1992
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Three dimensional organization of collagen fibril network of the guinea pig tympanic membrane : Scanning electron microscopic study of the alkali/water treated samples
kn-title=モルモット鼓膜固有層コラーゲン線維網の三次元的組織構築 : アルカリ水浸軟法を用いた走査電気顕微鏡による観察
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Three dimensional organization of the collagen fibril network of the guinea pig tympanic membrane was studied by a modified alkali/water maceration method and scanning electron microscopy. The collagen fibril network of the tympanic membrane is formed of the outer radial fibril bundles and inner circular fibril bundles and additional oblique and parabolic fibril bundles. In the lower half of the tympanic membrane, long radial bundles arising from the umbo and the lower two-fifths of the malleus handle spread radially to blend into the fibrocartilageous tympanic ring. In the upper half portion of the tympanic membrane, short radial bundles run antero- or posterosuperiorly almost paralled with each other connecting the upper three-fifths of the handle of the malleus and the tymanic ring. Oblique bundles running oblique against circular bundles were found only in the inferior portion of the tympanic membrane and the parabolic bundles running parabolically aganinst the circular bundles were observed in the antero- and posterosuperior, anterior and posterior portion of the tympanic membrane. The oblique and parabolic bundles merge with the circular bundles in places but with only a few connections with the radial bundles in the outer layer. At the periphery of the tympanic membrane, circular bundles increase in number to form a thick band of collagen fibrils, annular ligament. Beneath the annular ligament, the radial bundles blend with these special circular bundles. The radial and circular bundles are considered to be the main bundles of the tympanic membrane responsible for the mechanical property to the tympanic membrane. The oblique and parabolic bundles seem to strenghen the connection of the radial and circular fibrils forming a collagen network in the connective layer of the tympanic membrane.
en-copyright=
kn-copyright=

en-aut-name=TasakaShuji
en-aut-sei=Tasaka
en-aut-mei=Shuji
kn-aut-name=田坂周治
kn-aut-sei=田坂
kn-aut-mei=周治
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部耳鼻咽喉科学教室
en-keyword=guinea pig
kn-keyword=guinea pig
en-keyword=tympanic membrane
kn-keyword=tympanic membrane
en-keyword=collagen fibril
kn-keyword=collagen fibril
en-keyword=alkari-hydro-maceration
kn-keyword=alkari-hydro-maceration
en-keyword=scanning electron microscope
kn-keyword=scanning electron microscope
END

start-ver=1.4
cd-journal=joma
no-vol=104
cd-vols=
no-issue=5-6
article-no=
start-page=549
end-page=559
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1992
dt-pub=1992
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Cardiac function and nutrition in patients with mitral valve disease
kn-title=僧帽弁膜症患者の心機能と栄養障害に関する検討
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=To examine the influence of cardiac function on the nutriture, operated cases of mitral valve disease were evaluated for preoperative cardiac function by morbid type and were examined for the influence of cardiac function on the pre- and post-operative nutriture. The findings revealed that the hypofunctional group showed no difference in visceral protein index from the normal group preoperatively, and showed significant decreases in % IBW, % TSF, and CHI, indexes of fat stores and skeletal muscle mass. The hypofunctional group also showed low value of PPD intracutaneous reaction, an index of the immunological status. The early postoperative nutriture of the hypofunctional group showed changes similar to those in the normal group and was less influenced by the preoperative cardiac function. These findings suggest that the cardiac function influences the body composition and immunological status and that somatometry and PPD intracutaneous reaction are useful for the nutritional assessment of heart diseases.
en-copyright=
kn-copyright=

en-aut-name=MiyazakiItsuhiro
en-aut-sei=Miyazaki
en-aut-mei=Itsuhiro
kn-aut-name=宮崎医津博
kn-aut-sei=宮崎
kn-aut-mei=医津博
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第二外科学教室
en-keyword=僧帽弁膜症
kn-keyword=僧帽弁膜症
en-keyword=心臓悪液質
kn-keyword=心臓悪液質
en-keyword=心機能
kn-keyword=心機能
en-keyword=栄養障害
kn-keyword=栄養障害
en-keyword=栄養評価
kn-keyword=栄養評価
END

start-ver=1.4
cd-journal=joma
no-vol=104
cd-vols=
no-issue=5-6
article-no=
start-page=539
end-page=548
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1992
dt-pub=1992
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Experimental study for safety of continuous wave ultrasound : Fetal death, anomalies, juvenile behavior, learning and fertility
kn-title=超音波連続波照射の安全性に関する研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Rat fetuses were extra-abdominaly exposed to 2 MHz continuous wave ultrasound, with 1.5 or 2.5W/c�u of spatial average (SATA) intensity, for 15 min at 7.5 to 11.5 days of pregnancy. Fetal anomalies were observed only in the groups exposed to 2.5 and 1.5W/c�u at 9.5 days of pregnancy but its occurrence was not statistically significant. Intrauterine fetal deaths were most prevalent in the group exposed to 2.5W/c�u at 9.5 days of pregnancy, followed by the group exposed to 2.5W/cm2 at 10.5 and 7.5 days of pregnancy. At three months after birth, the behavior (open field test), the learning ability (avoiding study and single straight pathway test) and the fertility of these exposed rats were compared with those in non-exposed rats. In the avoiding study, there was statistically less avoidability in the group exposed to 2.5W/c�u at 9.5 days of pregnancy than the non-exposed group. In the other tests, no significant differences could be found between the exposed group and non-exposed group. These findings indicated that rat fetuses at 9.5 days of pregnancy are most senstive to continuous wave ultrasound exposure followed by fetuses at 10.5 or 7.5 days of pregnancy.
en-copyright=
kn-copyright=

en-aut-name=KawaiJunichirou
en-aut-sei=Kawai
en-aut-mei=Junichirou
kn-aut-name=河相淳一郎
kn-aut-sei=河相
kn-aut-mei=淳一郎
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部産科婦人科学教室
en-keyword=超音波連続波照射
kn-keyword=超音波連続波照射
en-keyword=生物学的効果
kn-keyword=生物学的効果
en-keyword=胎仔奇形
kn-keyword=胎仔奇形
en-keyword=学習試験
kn-keyword=学習試験
END

start-ver=1.4
cd-journal=joma
no-vol=104
cd-vols=
no-issue=5-6
article-no=
start-page=517
end-page=537
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1992
dt-pub=1992
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Study of serum enzyme leucine aminopeptidase (LAP) isozyme in lung cancer
kn-title=肺癌患者における血清酵素 Leucine Aminopeptidase (LAP) Isozyme の研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Serum leucine sminopeptidase (LAP) activity and its isozyme fraction were assayed in 73 primary lung cancer patients with the passage of time before the operation to 3 years after the operation. The LAP activity showed a high value in 25% of the patients before the operation, but did not exhibit a significant change after the operation. By contrast, the isozyme Y fraction showed a high value in 71% of the patients before thee operation and normalization was observed in half of them 1 month after the operation. There was no significant difference in the Y fraction with the size of tumor before the operation, but a significant fall wes observed after curative resection. About half of the patients in whom the Y fraction showed a high value before the operation died within 1 year after the operation. Furthemore, the subsequent prognosis was unfavorable evan in patients in whom the value was normalized after the operation, and a high Y fraction value before the operation seemed to serve as a parameter of unfavorable prognosis.
en-copyright=
kn-copyright=

en-aut-name=OkazakiTetuo
en-aut-sei=Okazaki
en-aut-mei=Tetuo
kn-aut-name=岡崎哲郎
kn-aut-sei=岡崎
kn-aut-mei=哲郎
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第二外科学教室
en-keyword=leucine amino-peptidase
kn-keyword=leucine amino-peptidase
en-keyword=isozyme
kn-keyword=isozyme
en-keyword=Y分画比
kn-keyword=Y分画比
en-keyword=肺癌
kn-keyword=肺癌
en-keyword=予後
kn-keyword=予後
END

start-ver=1.4
cd-journal=joma
no-vol=104
cd-vols=
no-issue=5-6
article-no=
start-page=511
end-page=516
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1992
dt-pub=1992
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Haptoglobin and carcinoma of uterine cervix
kn-title=子宮頚癌症例におけるハプトグロビン
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Haptoglobin is commonly known as a hemoglobin binding protein, and is an acute phase protein. Haptoglogin increases in inflammation and cancer, and acts as an immunosupressive agent. The relationship between serum haptoglobin and clinical staga and prognosis was studied in 127 uterine carcinoma patients. The haptoglobin level increased in relation to the clincal stage. Abnormal haptoglobin levels (mean+2SD or more) were studied in 127 patients. They were found in 0/37 cases (0.0%) in stage �T, 2/48(4.2%) in stage �U, 9/31(29.0%) in stage �V and 7/11 (63.6%) in stage �W(p<0.0001). Sixteen cases with abnormal haptoglobin level found in stages �V and �W, and eight cases (50.0%) died within one year. Twenty-six cases with a normal haptoglobin level were found in stages �V and �W. Only one case (3.8%) died within one year. The clinical stage ia a most important prognostic factor. However, the cases with an abnormal haptoglobin level had poor prognosis within one year in this study. Determination of the haptoglogin level prior to treatment will be useful for the selection of the high risk group of carcinoma of uterine cervix.
en-copyright=
kn-copyright=

en-aut-name=EndoSetsuo
en-aut-sei=Endo
en-aut-mei=Setsuo
kn-aut-name=遠藤節夫
kn-aut-sei=遠藤
kn-aut-mei=節夫
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部産科婦人科学教室
en-keyword=ハプトグロビン
kn-keyword=ハプトグロビン
en-keyword=子宮頚癌
kn-keyword=子宮頚癌
END

start-ver=1.4
cd-journal=joma
no-vol=104
cd-vols=
no-issue=5-6
article-no=
start-page=501
end-page=510
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1992
dt-pub=1992
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=The usefulness of ultrasongraphy in endometrial carcinoma : Particularly comparing transabdominal and transvaginal ultrasonography
kn-title=子宮体癌に対する超音波断層法の有用性について―経腹走査と経腟走査の比較を中心に―
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Between April, 1986 and March, 1991, 60 patients who underwent surgical treatment for endometrial carcinoma at the Department of Obstetrics and Gynecology, Okayama University Hospital, were preperatively examined by transvaginal ultrasonography (TV) and trans-abdominal ultrasonography (TA). The findings obtained were compared with the pathological findings to determine their usefulness in evaluating myometrial invasion and cervical invasion of endometrial carcinoma. Sensitvity of the lesion was 98.3% by TV and 80.0% by TA (p<0.01). Accuracy of the presence of myometrial invasion was 88.3% by TV and 70.0% by TA. Moreover, in evaluating the depth of myometrial invasion in three degrees (MO : Tumor limited to endometrium, M1 : Invasion to<1/2 myometrium, and M2 : Invasion >1/2 myometrium), the accuracy was 85.0% by TV and 61.7% by TA (p<0.01). In regard to the minimum width of the intact myometrium and the thickness of the high echoic area measured by each method, significant differences were obserevd between the M2-group and the other two group by the two methods. These p-values in TV were more significant than those in TA. In evaluating the presence of cervical invasion, the accuray was 95.0% by TV, while 88.3% by TA. Thus TV was found to be more useful than TA in the evaluation of both myometrial invasion and cerical invasion.
en-copyright=
kn-copyright=

en-aut-name=TomokuniHirotaka
en-aut-sei=Tomokuni
en-aut-mei=Hirotaka
kn-aut-name=友國弘敬
kn-aut-sei=友國
kn-aut-mei=弘敬
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部産科婦人科学教室
en-keyword=子宮体癌
kn-keyword=子宮体癌
en-keyword=筋層浸潤
kn-keyword=筋層浸潤
en-keyword=頚部浸潤
kn-keyword=頚部浸潤
en-keyword=経腟走査
kn-keyword=経腟走査
en-keyword=超音波断層法
kn-keyword=超音波断層法
END

start-ver=1.4
cd-journal=joma
no-vol=104
cd-vols=
no-issue=5-6
article-no=
start-page=489
end-page=499
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1992
dt-pub=1992
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=The usefulness of transvaginal ultrasonography and MRI in endometrial carcinama : Evaluating myomertrial and cervical invasion
kn-title=子宮体癌に対する経腟走査超音波断層法とMRIの有用性について―筋層浸潤と頚部浸潤の評価―
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Between October, 1988 and March, 1991, twenty-mine patients with endometrial carcinoma bad both transvaginal ultrasonography (TVUS) and magnetic resonance imaging (MRI) performed following hysterectomy at the Departmetn of Gynecology and Obstetrics, Okayama University Medical School. The findings were compared with the pathological findings to determine the usefulness of each method. The sensitivity of dectecthing myometrial invasion was 100% by TVUS and 96% by MRI. The accuracy was 86% by each method. The depth of myometrial invasion was classified into 3 degrees [no myometrial invasion, superficial invasion (?1/2), deep invasion (>1/2)]. The correct diagnostic rate was 86% by TVUS and MRI. The minimum width and the minimum/maximum width ratio of the intact myometrium obtained by each method in the pathological deep invasion group were significantly lower than those obtained in the other two groups (p<0.01). The sensitivity, the accuracy and the specificity of detecting cervical invasion were 89%, 93% and 95% by both methods. There was no difference between TVUS and MRI for diagnosing myometrial and cerical invasion of endometrial carcinoma.
en-copyright=
kn-copyright=

en-aut-name=YoshiharaEisuke
en-aut-sei=Yoshihara
en-aut-mei=Eisuke
kn-aut-name=吉原英介
kn-aut-sei=吉原
kn-aut-mei=英介
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部産科婦人科学教室
en-keyword=子宮体癌
kn-keyword=子宮体癌
en-keyword=経腟走査超音波断層法
kn-keyword=経腟走査超音波断層法
en-keyword=MRI
kn-keyword=MRI
en-keyword=筋層浸潤
kn-keyword=筋層浸潤
en-keyword=頚部浸潤
kn-keyword=頚部浸潤
END

start-ver=1.4
cd-journal=joma
no-vol=104
cd-vols=
no-issue=5-6
article-no=
start-page=483
end-page=487
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1992
dt-pub=1992
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=A case of fibromuscular dysplasia with large cerebral aneurysm at the bifurcation of the vertebral artery to cerebellar artery associated with renal hypertensin
kn-title=腎動脈性高血圧に推骨動脈―後下小脳動脈分岐部巨大動脈瘤を合併した線維筋性異形成の一例
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=A 27-year-old man was admitted with symptoms of hypertension and headache. His soft palate and uvula were deviated to the right. The left side of his tongue was atrophic with fasciculation. Plasma renin activity, plasma angiotensin-I and aldosteron levels were elevated. Renal arteriography revealed membranous-stenosis with poststenotic dilation at the mid and peripheral portion of the renal artery, which was consistent with the findings of fibromus-cular dysplasia (FMD). Large aneurysm at the bifucation of the vertebral artery to postero-inferior cerebellar artery was observed by cerebral arteriography. The patient was treated with medication for renal hypertension. Percutaneous embolization of the aneurysm was performed. In conclusion, the present case had a giant cerebral aneurysm, located at a rare portion and was diagnosed before its rupture. Examination of the cerebral artery was essential in renal FMD.
en-copyright=
kn-copyright=

en-aut-name=NakagawaHiroshi
en-aut-sei=Nakagawa
en-aut-mei=Hiroshi
kn-aut-name=中川裕
kn-aut-sei=中川
kn-aut-mei=裕
aut-affil-num=1
ORCID=

en-aut-name=KusachiShozo
en-aut-sei=Kusachi
en-aut-mei=Shozo
kn-aut-name=草地省蔵
kn-aut-sei=草地
kn-aut-mei=省蔵
aut-affil-num=2
ORCID=

en-aut-name=OkaTakefumi
en-aut-sei=Oka
en-aut-mei=Takefumi
kn-aut-name=岡岳文
kn-aut-sei=岡
kn-aut-mei=岳文
aut-affil-num=3
ORCID=

en-aut-name=UrabeNorio
en-aut-sei=Urabe
en-aut-mei=Norio
kn-aut-name=占部則生
kn-aut-sei=占部
kn-aut-mei=則生
aut-affil-num=4
ORCID=

en-aut-name=NogamiKunio
en-aut-sei=Nogami
en-aut-mei=Kunio
kn-aut-name=野上邦夫
kn-aut-sei=野上
kn-aut-mei=邦夫
aut-affil-num=5
ORCID=

en-aut-name=TakemotoMasao
en-aut-sei=Takemoto
en-aut-mei=Masao
kn-aut-name=竹本雅雄
kn-aut-sei=竹本
kn-aut-mei=雅雄
aut-affil-num=6
ORCID=

en-aut-name=MorishitaNaoya
en-aut-sei=Morishita
en-aut-mei=Naoya
kn-aut-name=森下直也
kn-aut-sei=森下
kn-aut-mei=直也
aut-affil-num=7
ORCID=

en-aut-name=InoueKimihito
en-aut-sei=Inoue
en-aut-mei=Kimihito
kn-aut-name=井上公仁
kn-aut-sei=井上
kn-aut-mei=公仁
aut-affil-num=8
ORCID=

en-aut-name=TsujiTakao
en-aut-sei=Tsuji
en-aut-mei=Takao
kn-aut-name=辻孝夫
kn-aut-sei=辻
kn-aut-mei=孝夫
aut-affil-num=9
ORCID=

en-aut-name=TomitaSusumu
en-aut-sei=Tomita
en-aut-mei=Susumu
kn-aut-name=富田亨
kn-aut-sei=富田
kn-aut-mei=亨
aut-affil-num=10
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第一内科学教室

affil-num=2
en-affil=
kn-affil=岡山大学医学部第一内科学教室

affil-num=3
en-affil=
kn-affil=岡山大学医学部第一内科学教室

affil-num=4
en-affil=
kn-affil=岡山大学医学部第一内科学教室

affil-num=5
en-affil=
kn-affil=岡山大学医学部第一内科学教室

affil-num=6
en-affil=
kn-affil=岡山大学医学部第一内科学教室

affil-num=7
en-affil=
kn-affil=岡山大学医学部第一内科学教室

affil-num=8
en-affil=
kn-affil=岡山大学医学部第一内科学教室

affil-num=9
en-affil=
kn-affil=岡山大学医学部第一内科学教室

affil-num=10
en-affil=
kn-affil=岡山大学医学部脳神経外科学教室
en-keyword=線維筋性異形成
kn-keyword=線維筋性異形成
en-keyword=脳動脈瘤
kn-keyword=脳動脈瘤
en-keyword=腎動脈性高血圧
kn-keyword=腎動脈性高血圧
END

start-ver=1.4
cd-journal=joma
no-vol=104
cd-vols=
no-issue=5-6
article-no=
start-page=471
end-page=482
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1992
dt-pub=1992
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Effects of typtophan metabolites on brain function : Electrocorticographical study
kn-title=トリプトファン代謝産物のラット脳機能に対する影響の研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The effects of tryptophan (Trp) metabolites administered into right cerebroventricle (1μmol) on the electrocorticograms (ECoG) of rats were studied to investigate the roles of Trp metabolites in the brain function. Kynurenine, anthranilic acid, and xanthurenic acid has no effect on ECoG until the end of recording 4 hours after the administration. 3-Hydroxykynurenine had a suppressive effect on the ECoG transitory, and kynurenic acid suppressed ECoG slightly. 3-Hydroxyanthranilic acid which is a metabolite of 3-hydroxykynurenine, induced spike discharges with a long latency (60-230 min after the administration). 3-Hydroxyanthranilic acid is thought to be metabolized to o-aminophenol, quinolinic acid and picolinic acid. Among the 3-hydroxyanthranilic acid metabolites, o-aminophenol induced spike discharges a few min after the administration, and the spike discharges a few min after the administrations, and the spike discharges lasted 60 min. On the other hand, quinolinic acid suppressed ECoG, and picolinic acid had no effect. These electrocorticographic findings suggest that 3- hydroxyanthranilc acid might induce spike discharges after metabolization to o-aminophenol.
en-copyright=
kn-copyright=

en-aut-name=NishijimaYutaka
en-aut-sei=Nishijima
en-aut-mei=Yutaka
kn-aut-name=西嶋寛
kn-aut-sei=西嶋
kn-aut-mei=寛
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学歯学部口腔外科学第一講座
en-keyword=kynurenic acid
kn-keyword=kynurenic acid
en-keyword=3-hydroxyanthranilic acid
kn-keyword=3-hydroxyanthranilic acid
en-keyword=o-aminophenol
kn-keyword=o-aminophenol
en-keyword=quinolinic acid
kn-keyword=quinolinic acid
en-keyword=experimental seizures
kn-keyword=experimental seizures
END

start-ver=1.4
cd-journal=joma
no-vol=104
cd-vols=
no-issue=5-6
article-no=
start-page=457
end-page=469
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1992
dt-pub=1992
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Metallothionein induction in the rat kidneys by endotoxin and zinc administration
kn-title=エンドトキシンおよび亜鉛投与ラットにおける腎メタロチオネインの誘導に関する実験的研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Metallothionein (MT) induction in the rat kidneys by endotoxin and zinc was investigated at the MT-protein level and the MT-mRNA level. The MT-mRNA level increased 3-6 hr after endotoxin administration, which suggested that MT was not transported from an other organ, but was de novo synthesized. Two MT-protein isoforms, MT-�T and MT-�U, were induced by administration of both endotoxin and zinc. The maximum levels of the proteins were seen 9 hr after administration of endotoxin and zinc. The span life of the renal MT induced by zinc was shorter than that of the liver MT induced by zinc. The MT-�U isoform was predominantly induced by both inducers, endotoxin and zinc, and the ratios of MT-�U to MT-�T were relatively constant. The finding that MT-�T and MT-�U were almost equally induced by zinc in the liver indicate that MT induction is controlled by an organ-specific system.
en-copyright=
kn-copyright=

en-aut-name=KanaiYoshizumi
en-aut-sei=Kanai
en-aut-mei=Yoshizumi
kn-aut-name=金居義純
kn-aut-sei=金居
kn-aut-mei=義純
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部麻酔・蘇生学教室
en-keyword=エンドトキシン
kn-keyword=エンドトキシン
en-keyword=亜鉛
kn-keyword=亜鉛
en-keyword=腎メタロチオネイン
kn-keyword=腎メタロチオネイン
en-keyword=高速液体クロマトグラフィー
kn-keyword=高速液体クロマトグラフィー
END

start-ver=1.4
cd-journal=joma
no-vol=104
cd-vols=
no-issue=5-6
article-no=
start-page=445
end-page=455
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1992
dt-pub=1992
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on pathogenesis of intractable asthma Part 2. Clinical features of late onset intractable asthma
kn-title=難治性喘息の発症病態に関する研究　第2編　中高年発症型難治性喘息の臨床像について
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=To clarify the pathogenesis of late onset intractable asthma (LOIA), 102 asthmatics were classified into early (<40y.o.) and late onset asthma (>40y.o.), or intractable and non-in-tractable asthma. Clinical and allergic examinations were evaluated in each asthma group. Sixty nine percent of the late onset asthmatics had perennial type attacks. IgG-as well as IgE-mediated allergic reactions were suggested by the findings of immediate skin reaction, IgE RIST and RAST score to Candida allergen and reactivity of basophils to anti-immunoglobulin antisera in LOIA. Neutrophils in bronchoalveolar lavage fluid increased significantly in LOIA as compared with the early onset intractable asthma (EOIA) groups (p<0.05). In the pulmonary function test, a striking fall of % V25 was observed in both EOIA ans LOIA. The chest X-ray film frequently revealed microndular shadows in LOIA. Marked morphological changes in the transbronchial lung biopsied specimens were observed in the late onset asthmatics. These findings suggest that a non-IgE reaction, neutrophil infiltration in the local allergic site and histolpgical changes of lung tissue lead to LOIA.
en-copyright=
kn-copyright=

en-aut-name=NakayamaKengo
en-aut-sei=Nakayama
en-aut-mei=Kengo
kn-aut-name=中山堅吾
kn-aut-sei=中山
kn-aut-mei=堅吾
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第二内科学教室
en-keyword=late onset
kn-keyword=late onset
en-keyword=intractable asthma
kn-keyword=intractable asthma
en-keyword=IgG
kn-keyword=IgG
en-keyword=neutrophil
kn-keyword=neutrophil
en-keyword=transbronchoscopic lung biopsy
kn-keyword=transbronchoscopic lung biopsy
END

start-ver=1.4
cd-journal=joma
no-vol=104
cd-vols=
no-issue=5-6
article-no=
start-page=433
end-page=443
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1992
dt-pub=1992
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on pathogenesis of intractable asthma Part 1. Characteristices of clinical and immuno-pathological findings in intractable asthma
kn-title=難治性喘息の発症病態に関する研究　第1編　難治性喘息の臨床的検討
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=To clarify the pathogenesis of intractable asthma, clinical features, allergic examinations, pulmonary functions and histological finding were evaluated in 27 intractable asthmatics compared with 33 non-intractable asthmatics. Almost all of the intractable asthmatics had chronic and perennial asthma attacks and also had highly frequent episodes of respiratory infection. IgG-as well as IgE-mediated allergic reactions were proved by the findings of skin reaction, IgE RAST score, precipitating antibody and reactivity of basophils to anti-immunoglobulin antisera in the intractable asthmatics but not in the non-intactable asthmatics. Neutrophils of BALF and peripheral blood increased markedly in the intractable asthmatics as compared with the non-intractable asthmatics. The fall of % V(25) on flow volume curve in the intractable asthmatics, indicated small air way obstruction. Micronodular shadows on the chest X-ray film were frequently seen in the intractable asthmatics. Many histological findings were shown on lung specimens obtained by TBLB in the intrac-table asthmatics. These findings indicate that multiple factors of allergic reaction mediated by IgG, migrated neutrophils and organic changes of lung tissue lead to severe and intractable asthma attack.
en-copyright=
kn-copyright=

en-aut-name=NakayamaKengo
en-aut-sei=Nakayama
en-aut-mei=Kengo
kn-aut-name=中山堅吾
kn-aut-sei=中山
kn-aut-mei=堅吾
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第二内科学教室
en-keyword=intractable asthma
kn-keyword=intractable asthma
en-keyword=Candida
kn-keyword=Candida
en-keyword=IgG
kn-keyword=IgG
en-keyword=neutrophil
kn-keyword=neutrophil
en-keyword=transbronchoscopic lung biopsy
kn-keyword=transbronchoscopic lung biopsy
END

start-ver=1.4
cd-journal=joma
no-vol=104
cd-vols=
no-issue=5-6
article-no=
start-page=425
end-page=431
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1992
dt-pub=1992
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Effect of splenectomy and immuno-potentiator on tumor-bearing mice
kn-title=担癌マウスにおける摘脾と免疫賦活剤の効果
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=To determine the effect of splenectomy on tumor growth, the immunological role of the spleen was studied at various time intervals following subcutaneous implantation of MH-134 hepatoma cells into syngeneic C(3) H/He mice.
 Both tumor neutralizing activity and PHA-suppressor cell activity were generated. the former reached a maximum on the 28th day of implantation, and belonged to Lyt-1(+)2(-)T cells. The latter appeared on the 3rd day, decreased once, and increased again. Mainly, this suppres-sive activity was found in Lyt-1(+)2(-)T cells on the 3rd day and in nylon-wool-adherent cells after the 14th day. Splenectomy or sham splenectomy (sham ope) was performed on the 3rd day of implantation. There was no significant difference in tumor growth between the groups. Immunotherapy with lentinan effectively suppressed tumor grouth both in the tumor-bearing mice that had splenectomy and in those that had sham ope, with no significant difference in tumor growth between the two groups. Therefore, the effectiveness of splenectomy on tumor growth might be difficult to evaluate, since these opposite activities are simultaneously induced in the spleen of tumor-bearing mouse.
en-copyright=
kn-copyright=

en-aut-name=TakatsukaShojiro
en-aut-sei=Takatsuka
en-aut-mei=Shojiro
kn-aut-name=竹束正二郎
kn-aut-sei=竹束
kn-aut-mei=正二郎
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第一外科学教室
en-keyword=摘脾
kn-keyword=摘脾
en-keyword=中和活性
kn-keyword=中和活性
en-keyword=サプレッサー細胞活性
kn-keyword=サプレッサー細胞活性
en-keyword=Lyt-1(+)2(-)T 細胞
kn-keyword=Lyt-1(+)2(-)T 細胞
en-keyword=レンチナン
kn-keyword=レンチナン
END