start-ver=1.4 cd-journal=joma no-vol=104 cd-vols= no-issue=3-4 article-no= start-page=413 end-page=423 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=1992 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studis on the pathogenesis of idiopathic interstitial pneumonia Part 1. Analysis of local cellular response in lungs by bronchoalveolar lavage of patients with idiopathic interstitial pneumonia kn-title=特発性間質性肺炎の病態に関する研究　第2編　特発性間質性肺炎の気管支肺胞洗浄法による検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The cellular components in lungs of idiopathic interstitial pneumonia (IIP) and interstitial pneumonia with collagen disease (IP with CD) were examined by bronchoalveolar lavage (BAL) to analyze the pathogenesis of IIP. The findings of BAL fluid of IIP and IP with CD were increase of total cell count and increased percent of lymphocytes, neutrophils, eosinophils and basophil/mast cells in comparison with the normal control. The BAL fluid of the patients with IIP and IP with CD in active stage contained a higher proportion of lymphocyte, neutrophil, eosinophil and basophil/mast cell than those in a nonactive stage. Furthermore, an increase of T-cells and Ia positive T-cells was detected in the examination of lymphocyte subpopulation in BAL fluid of patients with IIP, while the lymphocyte subpopulation of peripheral blood showed no significant difference. Cellular components in BAL fluid of IIP patients treated with or without steroids were compared. Under steroid therapy a decrease of total cell count and eosinophil was shown in BAL fluids of patients with IIP. These findings indicate that various cells such as macrophage, lymphocyte, neutrophil eosinophil and basophil/mast cell in lungs play important roles in the pathogenesis of IIP and IP with CD. en-copyright= kn-copyright= en-aut-name=FujitaMichio en-aut-sei=Fujita en-aut-mei=Michio kn-aut-name=藤田道雄 kn-aut-sei=藤田 kn-aut-mei=道雄 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=Idiopathic interstitial pneumonia kn-keyword=Idiopathic interstitial pneumonia en-keyword=Bronchoalveolar lavage kn-keyword=Bronchoalveolar lavage en-keyword=Lymphocyte subpopulation kn-keyword=Lymphocyte subpopulation END start-ver=1.4 cd-journal=joma no-vol=104 cd-vols= no-issue=3-4 article-no= start-page=399 end-page=412 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=1992 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studis on the pathogenesis of idiopathic interstitial pneumonia Part 1. Clinical features including various laboratory and roentogenologic findings in regard to the response to the treatment kn-title=特発性間質性肺炎の病態に関する研究　第1編　臨床集計による特発性間質性肺炎の検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Clinical features, laboratory findings including hematological and biochemical exmination, pulmanary function test and chest x-ray findings of patients with idiopathic interstital pneumonia (IIP) were analyzed to determine the response to steroid therapy. Sixty three patients with IIP were analyzed in comparison with 43 patietns of interstitial pneumonia due to various diseases such as collagen disease, tuberculosis and chronic obstructive lung disease. Almost half of the patients with IIP were treated with steroids and improvement of interstitial pneumonia was shown only in the patients given steroid therapy. The improvement with steroid therapy was shown to the 50% in acute form of IIP, 32.1% in chronic form of IIP and 36.8% in total. Furthermore, the response of steroid therapy was better in patients with a relatively high oxygen level and high vital capacity and with no honeycombing on the chest X-ray film. These findings indicate the therapeutic effectivesess of steroid therapy in some patients and it should be started in the early stage of the clinical of IIP to obtain a good response rate. en-copyright= kn-copyright= en-aut-name=FujitaMichio en-aut-sei=Fujita en-aut-mei=Michio kn-aut-name=藤田道雄 kn-aut-sei=藤田 kn-aut-mei=道雄 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=idiopathic interstitial pneumonia kn-keyword=idiopathic interstitial pneumonia en-keyword=Steroid therapy kn-keyword=Steroid therapy en-keyword=Prognosis of IIP kn-keyword=Prognosis of IIP en-keyword=Chest x-ray finding kn-keyword=Chest x-ray finding END start-ver=1.4 cd-journal=joma no-vol=104 cd-vols= no-issue=3-4 article-no= start-page=387 end-page=398 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=1992 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on transferrin receptor of macrophages in iron metabolism Part 2. Regulation of tranferrin receptors on alveolar macorophages in iron-overloaded and iron-deficient conditions kn-title=鉄代謝におけるマクロファージのトランスフェリンレセプターに関する研究　第2編　鉄過剰及び鉄欠乏状態における肺胞マクロファージのトランスフェリンレセプターに関する検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Transferrin receptors (TfR) are involved in the first step of iron uptake into cells. To clarify the changes in TfR under various conditions, radiobinding assay of (125)I-labeled iron-saturated transferrin was performed in alveolar macrophages from 2 patients with idiopathic hemo-chromatosis and iron-overloaded or iron-deficient guinea pigs. Patients with idiopathic hemochromatosis showed a reduction in the Fe-TfR count on alveolar macrophages (5.0×10(4)/cell) as compared to that in healthy individuals (19.88±8.19×10(4)/cell). Concerning the Fe-TfR binding constant, no differnce was observed between patients with idiopathic hemochromatosis and healthy controls. The Fe-TfR count on alveolar macrophages was significantly lower in iron-overloaded guined pigs than in normal cntrols. The count was significantly elevated in iron-deficient guinea pigs. Concerning the Fe-TfR binding constant, none of the iron-overloaded and iron-deficient groups showed any significant difference from the normal controls. These findings suggest that experimentally-induced iron overload and iron deficiency may be autoregulated by intracellular iron levels. en-copyright= kn-copyright= en-aut-name=InadaToshio en-aut-sei=Inada en-aut-mei=Toshio kn-aut-name=稲田俊雄 kn-aut-sei=稲田 kn-aut-mei=俊雄 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=Transferrin receptor kn-keyword=Transferrin receptor en-keyword=Hemochromatotis kn-keyword=Hemochromatotis en-keyword=Iron overloaded kn-keyword=Iron overloaded en-keyword=Iron depleted Alveolar macrophage kn-keyword=Iron depleted Alveolar macrophage END start-ver=1.4 cd-journal=joma no-vol=104 cd-vols= no-issue=3-4 article-no= start-page=375 end-page=386 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=1992 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on transferrin receptor of macrophages in iron metabolism Part 1. Localization of tranferrin receptors on several kinds of macorophages kn-title=鉄代謝におけるマクロファージのトランスフェリンレセプターに関する研究　第1編　各種マクロファージにおけるトランスフェリンレセプターの局在に関する検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The delivery of iron into cells is mediated by transferrin via its receptors that reside on the cell surface. To clarify the role of reticuloendothelial cells in iron metabolism, the distribution of transferrin receptors on macrophages in various organs and on peripheral blood monocytes was examined by scanning electron microscopy and radiobinding assay. Radiobinding assay of human alveolar macrophages revealed the presence of 19.88±8.19×10(4) diferric trabsferrin receptors per cell (mean±SD) and a binding constant of 4.42±3.41×10(8)M(-1). Human peritoneal macrophages and macrophages in the thoracic cavity had fewer diferric transferrin receptors (2.68×10(4), 8.10×10(4), 4.3×10(3) and 2.1×10(4) receptors/cell). Peripheral blood monocytes had no diferric transferrin receptors. Diferric transferrin receptors were also found on guinea pig alveolar macrophages (2.25±0.78×10(4)) and peritoneal macrophages (1.6±0.2×10(3)), while they were absent on rat alveolar and peritoneal macro-phages. Scanning electron microscopic findings in guinea pig alveolar macrophages revealed a patch-formed distribution of apotransferrin receptors and diferric transferrin receptors on the characteristic ruffle-covered surface of macrophages. The number of transferrin rece-ptors varied among individual cells even within the same species or same organs. These findings suggest that the macrophages with transferrin receptors in various organs of human and guinea pigs are heterogeneous among different species and cells, and have different functions in iron metabolism. en-copyright= kn-copyright= en-aut-name=InadaToshio en-aut-sei=Inada en-aut-mei=Toshio kn-aut-name=稲田俊雄 kn-aut-sei=稲田 kn-aut-mei=俊雄 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=Transferrin receptor kn-keyword=Transferrin receptor en-keyword=RIA kn-keyword=RIA en-keyword=SEM kn-keyword=SEM en-keyword=Macrophage kn-keyword=Macrophage en-keyword=Monocyte kn-keyword=Monocyte END start-ver=1.4 cd-journal=joma no-vol=104 cd-vols= no-issue=3-4 article-no= start-page=365 end-page=374 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=1992 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A comparative study of the lumbrical muscles in the hand kn-title=手の虫様筋の比較解剖学的研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Human amd monkey hands were dissected, together with the forepaws of the dog, rabbit and kangaroo. These dissections showed that the human lumbrical muscle inserting into the proximal phalanx or dividing into two tails belongs to an atavistic anomaly. In the kangaroo, the first lumbrical muscle commonly arose from the long flexor tendon of the first finger and the deep flexor tendon of the second finger. This strongly suggests that these tendons (or M. Flexor pollicis longus and M. flexor digitorum profundus) are homologous. en-copyright= kn-copyright= en-aut-name=IkebuchiYoshifumi en-aut-sei=Ikebuchi en-aut-mei=Yoshifumi kn-aut-name=池渕佳史 kn-aut-sei=池渕 kn-aut-mei=佳史 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二解剖学教室 en-keyword=手 kn-keyword=手 en-keyword=前足 kn-keyword=前足 en-keyword=虫様筋 kn-keyword=虫様筋 en-keyword=指背腱膜 kn-keyword=指背腱膜 END start-ver=1.4 cd-journal=joma no-vol=104 cd-vols= no-issue=3-4 article-no= start-page=355 end-page=364 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=1992 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Superoxide dismutase activity in rheumatoid arthritis : its measurement and clinical implication kn-title=慢性関節リウマチにおける Superoxide Dismutase (SOD) 活性の測定と臨床的意義に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=In chronic inflammations of rheumatoid arthritis (RA), polynuclear leukocytes, macro-phages, synovial cells and other inflammatory cells release reactive oxygen species (ROS) and cause tissue impairment, and are regarded as the responsible agents in this pathological condition. In the present study, the electron spin resonance (ESR) method was used to measure superoxide dismutase (SOD) in 76 knee synovial fluid samples from rheumatoid knee joints and to compare the results with those of osteoarthritic knee joints and postraumatic arthritis. There was no significant difference in the SOD activity between PA and OA patients knee joint fluid, which was higher than that in patients with posttraumatic arthritis. The SOD activity in RA knee joint fluid showed no correlation with serum CRP (C-reactive protein) or erythrocyte sedimentation rate, indices of inflammation. According to Larsen's Grading of rtheumatoid knee radiography, patients with moderate RA changes (grade V or W) show higher SOD activity than patients with early (grade T or U) and terminal RA (grade　X). Our findings suggest that the SOD actvity in RA knee joint fluid is a valid index of articular destruction. en-copyright= kn-copyright= en-aut-name=OnoueJinichi en-aut-sei=Onoue en-aut-mei=Jinichi kn-aut-name=尾上仁一 kn-aut-sei=尾上 kn-aut-mei=仁一 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部整形外科学教室 en-keyword=superoxide dismutase kn-keyword=superoxide dismutase en-keyword=rheumatoid arthritis kn-keyword=rheumatoid arthritis en-keyword=electron spin resonance kn-keyword=electron spin resonance END start-ver=1.4 cd-journal=joma no-vol=104 cd-vols= no-issue=3-4 article-no= start-page=341 end-page=354 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=1992 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Adequate antiplatelet therapy on the basis of individual variation in platelet aggregation in the late period after cardiovascular surgery kn-title=血小板凝集能の個体差を考慮した至適抗血小板療法―心臓血管外科手術後遠隔期における検討― en-subtitle= kn-subtitle= en-abstract= kn-abstract=Platelet aggregation was studied on 670 samples of 20 healthy controls and 279 patients in the late period after cardiovascular surgery. Aggregating agents used were 0.5 and 2.0μM ADP as well as 2mM arachidonic acid (AA). Among the healthy controls, a maximum aggregation rate over 18% (ADP 0.5μM) was considered hyperaggregability, those under 47% (ADP 2μM) or under 78% (AA 2mM) consid-ered hypoaggregability. Maximun aggregation rate in patients not given antiplatelt agents widely varied from hyperaggregability to hypoaggregability. There was a positive correlation botween the first sample and the second one gained from each patient. This suggested that individual variation existed on platelet aggregation. Maximum aggregation rate significatly decreased by ticlopidine for ADP and by aspirin for AA. Both ADP and AA should be used for platelet aggregation. Comparison among three groups of different ticlopidine doses revealed that the doses should be decided on the basis of platelet aggregation for each patient. Thrombotic or hemorrhagic complications were observed in only 9 cases. Four of 7 cases of thrombotic complicatiion showed hyperaggregability and only 1 case showed hypoaggregability. Both cases of hemorrhagic complication showed hypoaggregability. These findings suggest that indication for antiplatelet therapy and doses of antiplatelet agent should be decided in consideration of individual variation on platelet aggregation. en-copyright= kn-copyright= en-aut-name=TsushimaYoshimasa en-aut-sei=Tsushima en-aut-mei=Yoshimasa kn-aut-name=津島義正 kn-aut-sei=津島 kn-aut-mei=義正 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一外科学教室 en-keyword=血小板凝集能 kn-keyword=血小板凝集能 en-keyword=抗血小板薬 kn-keyword=抗血小板薬 en-keyword=ADP kn-keyword=ADP en-keyword=アラキドン酸 kn-keyword=アラキドン酸 en-keyword=術後遠隔期 kn-keyword=術後遠隔期 END start-ver=1.4 cd-journal=joma no-vol=104 cd-vols= no-issue=3-4 article-no= start-page=331 end-page=340 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=1992 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Dectection of human papillomavirus genome in papillomas of head and neck region kn-title=頭頸部乳頭種病変におけるヒトパピロ−マウィルスの関与 en-subtitle= kn-subtitle= en-abstract= kn-abstract=To investigate the etiological role of human papillomavirus (HPV), 14 cases of papillomas in head and neck region were examined virologically and clinicopathogically. Both dot blot and Southern blot hybridization methods were applied for HPV DNA detection. In all cases of multiple laryngeal papillomas, either HPV 6 (2 cases) or HPV 11 (2 cases) genomes were detected. The presence of the HPV genomes provides strong evidence for the HPV etiology of these laryngeal papilloma. In one case of sinonasal papilloma (exophytic type). HPV 6 DNA was detected. No HPV genome was found in the DNA from the remaining 4 sinonasal papillomas. However, their clincopathological findings suggested the viral etiology. No HPV genome was proved in 4 oral papillomas. Furthermore, neither clinical course nor histopathological findings suggested viral etiology. The sensitivity of blot hybridization (Vira probe HPV) in detecting HPV DNA was the same as that of Southern blot hybridization. en-copyright= kn-copyright= en-aut-name=KawakamiTakashi en-aut-sei=Kawakami en-aut-mei=Takashi kn-aut-name=川上登史 kn-aut-sei=川上 kn-aut-mei=登史 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部耳鼻咽喉科学教室 en-keyword=乳頭種 kn-keyword=乳頭種 en-keyword=Human Papillomavirus kn-keyword=Human Papillomavirus en-keyword=Dot Blot Hybridization kn-keyword=Dot Blot Hybridization en-keyword=Southern Blot Hybridization kn-keyword=Southern Blot Hybridization END start-ver=1.4 cd-journal=joma no-vol=104 cd-vols= no-issue=3-4 article-no= start-page=323 end-page=330 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=1992 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=1,25-Dihydroxyvitamin D(3) stimulates the secretion of insulin-like growth factor binding protein 3 (IGFBF-3) by cultured human osteosarcoma cells kn-title=1,25-DihydroxyvitaminD(3)によるヒト骨肉腫細胞 MG63 からのinsulin-like growth factor binding protein 3 の産生増加 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Several types specific insulin-like growth factor binding proteins (IGFBPs) are produced by peripheral tissue-derived cells and they modulate the functions of insulin-like growth factors. In this study, both the secretion of IGFBP-3 from a human osteosarcoma cell line MG63 and effects of 1, 25-dihydroxyvitamin D(3) (1,25-(OH)(2)D(3)) on the production of IGFBP-3 were investigated. The β subunit of IGFBP-3 was detected immunocytochemically in the perinuclear cytoplasm of MG63 cells. Immunoblotting and SDS-PAGE analysis revealed that both 140-150KD MW entire molecules and 40-60KD MW β subinit molecules of IGFBP-3 were present in cell-conditionel media. 1,25-(OH)(2)D(3) stimulated the production of the IGFBP-3 molecule by MG63 cells. The concentration of IGFBP-3 conditioned media began to rise at 24 hours after the addtiton of 10(-9)M of 1,25-(OH)(2)D(3) and reached the peak level at 48 hours. Dose-dependent effects of 1,25-(OH)(2)D(3) were demonstrated. These findings show that MG63 produces IGFBP-3 and that 1,25-(OH)(2)D(3) stimulates the production of this protein. These findings suggest that the synergistic effects of 1,25-(OH)(2)D(3) on the action of IGF-I on osteoblastic cells may be modulated by locally produced IGFBP-3. en-copyright= kn-copyright= en-aut-name=MoriwakeTadashi en-aut-sei=Moriwake en-aut-mei=Tadashi kn-aut-name=守分正 kn-aut-sei=守分 kn-aut-mei=正 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部小児科学教室 en-keyword=1,25 (OH)(2)D(3) kn-keyword=1,25 (OH)(2)D(3) en-keyword=insulin-like growth factor binding protein 3 kn-keyword=insulin-like growth factor binding protein 3 en-keyword=human osteosarcoma cell line MG63 kn-keyword=human osteosarcoma cell line MG63 END start-ver=1.4 cd-journal=joma no-vol=104 cd-vols= no-issue=3-4 article-no= start-page=311 end-page=321 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=1992 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Analysis of varieties on receptor recognition by type 1 fimbriated Escherichia coli kn-title=タイプ1線毛保有大腸菌のレセプター認識能の多様性の解析 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The role of type 1 fimbriae has well been discussed for analyzing the mechanisms of infectious diseases of the urinary tract. In this study, the ability and variety of mannose-receptor recognition in 92 strains of clinically isolated Escherichia coli were examined using various mannose-carriers such as guinea pig red blood cells, Saccharomyces cerevisiae cells and two carriers, latex and liposome. Type 1 fimbriated E. coli showed a variety of reactivity to the receptors on different mannose-carriers. Effects of mannose-carriers and inhibitors in agglutination assays were examined using 48 strongly haemagglutinable strains. In the recognition of Man (1-2) Man-carriers, a high affinity to pNPα-D-mannose was observed in the highly reactive strains to the receptor on liposomes. The MIC ratios of D-mannose to pNPα-D-mannose significantly correlated to the reactivities of these strains to the receptor on the liposome. By the values of MIC ratio, these strains could be classified into two groups ; reactive and non-reactive strains. In the recognition of Man (1-3) Man-carriers, MIC ratios of D-mannose to pNPα-D-mannose differed among more highly reactive strains to Man (1-3) Man-latex, and AUT strains showed stronger reactivity and lower MIC ratio than AUC and ABP strains. The adhesins of type 1 fimbriae were divided into at least 4 type (α, β, γ and δ). en-copyright= kn-copyright= en-aut-name=KobayashiNaoki en-aut-sei=Kobayashi en-aut-mei=Naoki kn-aut-name=小林直樹 kn-aut-sei=小林 kn-aut-mei=直樹 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部細菌学教室 en-keyword=Type 1 fimbriae kn-keyword=Type 1 fimbriae en-keyword=Adhesin kn-keyword=Adhesin en-keyword=Receptor recognition kn-keyword=Receptor recognition en-keyword=Urinary tract infection kn-keyword=Urinary tract infection END start-ver=1.4 cd-journal=joma no-vol=104 cd-vols= no-issue=3-4 article-no= start-page=297 end-page=310 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=1992 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Clinical and histological studies on steroid-induced avascular necrosis of the femoral head, especially in ststemic lupus erythematosus kn-title=ステロイド性大腿骨頭壊死症の病態に関する研究―全身性エリテマトーデス(SLE)を中心に― en-subtitle= kn-subtitle= en-abstract= kn-abstract=Clinical and radiological studies were performed on avascular necrosis of the femoral head (ANF) in 220 hips 140 patients including 51 hips of 28 patients with systemic lupus erythe-matosus (SLE group). Sixty-nine hips of 41 patients wee treated with corticosteroid adminis-tration (S group) and 100 hips of 71 patients without corticosteroid administration (Non-S group). All patients with SLE were treated with corticosteroid adminstration. Thirty-one femoral heads (11 heads of SLE group, 9 heads of S group and 11 heads of Non-S group) were resected at operations nad studied histologically. Seventy-seven hips at an early stage showed that collapse of the femoral heads occurred in 80% without 3 years and no differences were found among these group. In the SLE group, bilateral involvement, multiple bone necrosis and predilection for young females were apparent. Collapse of the femoral head and subcapital fractures were more frequently seen in the SLE group. Histologically, almost all heads even in the SLE group showed repair process such as enchondral ossification and appositional bone formation, while the heads with subcapital fracture showed no such no such changes. en-copyright= kn-copyright= en-aut-name=UsuiMasaaki en-aut-sei=Usui en-aut-mei=Masaaki kn-aut-name=臼井正明 kn-aut-sei=臼井 kn-aut-mei=正明 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部整形外科学教室 en-keyword=大腿骨頭壊死症 kn-keyword=大腿骨頭壊死症 en-keyword=全身性エリテマトーデス(SLE) kn-keyword=全身性エリテマトーデス(SLE) en-keyword=病態 kn-keyword=病態 END start-ver=1.4 cd-journal=joma no-vol=104 cd-vols= no-issue=3-4 article-no= start-page=287 end-page=295 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=1992 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Evaluation of laparoscopic ovarian multiple punch resections kn-title=排卵障害における腹腔鏡下卵巣 multiple punch resection の適応について en-subtitle= kn-subtitle= en-abstract= kn-abstract=Laparoscopic multiple punch resections were applied on the surface of the ovaries in 38 infertile patients who did not have spontaneous ovulation, and the effects on the clinical aspects of ovulation and gestation, and endocrinological state were examined. The patients were categorized into three groups to determine the indication of this treatment as follows. Group A (n=9) : ovulated under administration of 100mg/day clomiphene. Group B (n=22) : ovulated under administration of 200mg/day clomiphene, failed to ovulate under administra-tion of 100mg/day. Group C (n=7) : failed to ovulate even under administration of 200mg/day. The dose of clomiphene to induce ovulation was reduced in 8 (89%) in group A, 19 (86%) in Group B and 6 (86%) patients in group C. Although no patients became pregnant in group A, 17 (77%) in Group B and 5 (71%) in Group C became pregnant after this treatment. Irre-spective of the good clinical outcome, no endocrinological improvements was found in the results of LH-RH test and serum testosterone leves. These findings suggest that this treat-ment is effective on the patients with severe anovulation, and that this effect is not based on the endocrinological improvement but ont the local mechanical factors. en-copyright= kn-copyright= en-aut-name=HiranoYukio en-aut-sei=Hirano en-aut-mei=Yukio kn-aut-name=平野由紀夫 kn-aut-sei=平野 kn-aut-mei=由紀夫 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部産科婦人科学教室 en-keyword=laparoscopic ovarian multiple punch resection kn-keyword=laparoscopic ovarian multiple punch resection en-keyword=laparoscopic ovarian electrocautery kn-keyword=laparoscopic ovarian electrocautery en-keyword=infertillity kn-keyword=infertillity en-keyword=polycystic ovarian ayndrome kn-keyword=polycystic ovarian ayndrome en-keyword=clomiphene citrate kn-keyword=clomiphene citrate END start-ver=1.4 cd-journal=joma no-vol=104 cd-vols= no-issue=3-4 article-no= start-page=267 end-page=286 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=1992 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Changes of the afterdischarge threshold during the limbic or neocortical kindling in cats kn-title=辺縁系および新皮質キンドリング形成に伴う後発射誘発閾値の変化 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The afterdischarge threshold (ADT) in the limbic foci is reduced during limbic kindling. However, the changes of the ADT in the remote brain regions which receives no kindling stimuli remain unknown. To investigate the progressive neuronal changes during kindling, changes of the DAT were observed in the primary kindled sites and seconday unstimulated sites (pyriform cortex : PC and entorhinal cortex : EC) in amygdala (AM), hippocampal (HIPP) or neocortical (anterior portion of the suprasylvian gyrus : SS) kindled cats. The seizur threshold rapidly decreased, not only in the primary focus (AM or HIPP) but also in the remote brain regions (PC and EC), in the early process of acquisition of the limbic epileptogenesis and that the reduction of the ADT was closely related to the development of seconday epileptogenesis. In perticular, the PC could acquire the neuronal hypere xcitability during limbic kindling. However, in contrast to limbic foci, no signgificant changes of the ADT in either primary focus (SS) or secondary focus (PC and EC) was observed. This suggest-ed that the necortical seizure develops due to another neuronal mechanism which differs from the mechanism of the limbic seizure. en-copyright= kn-copyright= en-aut-name=SaneiToshifumi en-aut-sei=Sanei en-aut-mei=Toshifumi kn-aut-name=實井俊典 kn-aut-sei=實井 kn-aut-mei=俊典 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部神経精神医学教室 en-keyword=kindling kn-keyword=kindling en-keyword=afterdischarge threshold kn-keyword=afterdischarge threshold en-keyword=transfer phenomenon kn-keyword=transfer phenomenon en-keyword=epilepsy kn-keyword=epilepsy en-keyword=cat kn-keyword=cat END start-ver=1.4 cd-journal=joma no-vol=104 cd-vols= no-issue=3-4 article-no= start-page=259 end-page=266 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=1992 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Experimental and clinical studies on interferon and its inducers Part 2. β-carboxyethylgermanium sesquioxide (Ge-132) in the management of acute nonlymphocytic leukemia patients at remission phase kn-title=インターフェロン並びにインターフェロン誘発剤に関する基礎的・臨床的研究　第2編　急性非リンパ性白血病寛解期における β-Carboxyethylgermanium sesquioxide (Ge-132) の臨床効果 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The clinieal of Ge-132 in the management of acute nonlymphocytic leukemia (ANLL) patients at remission phase were studied. Twenty-two ANLL patients with complete remission were randomized into Groups A and B. Patients in Group A were treated with the combianation with Ge-132 (2,250mg/day ; p. o daily) and intermittent-alternating chemotherapy 〔daunorubicin, vincristine, cytosine arabinoside and prednisolone (DVCP)/aclarubicin vincristine cytosine arabinoside and prednisolone (AVCP)〕and patients in Groyp B were treated with intermittent-alter nating chemotherapy (DVCP/AVCP) alone. Evaluable patients were 7 in Group A and 10 in Group B. Remission duration and survival time were not significantly different between Groups A and B. (median remission duration ; 5.7 month in Group A vs 8.1 month in Group B/median surival time ; 23.9month in Group A vs 18.3month in Group B) The rates of second remission in relapsed cases were not significantly different between Groups A and B.〔2 of 7,(28.6%) in Group A vs 3 of 10,(30.0%) in B〕Ge-132 did not accelerate the recovery from myelosuppression after intensification with the DVCP regimen. The incidence of liver damage and levels of serum GOT and GPT tended to be lower in Group A than in Group B. In this clinical study the incidence of liver damage tended to be lowere in patients treated with Ge-132. The liver damage which often develops during intensificantion chemotherapy, not only limits the chemotherapy but also causes adverse effects on the quality of life of the patient. In part 1 of this series, Ge-132 was reported to activate the neutrophil chemiluminescence. Ge-132 seems to be useful in the management of ANLL patients not only by the enhancement of the host defense system but also by the prevenation of liver damage. en-copyright= kn-copyright= en-aut-name=FukumotoMitsuhiro en-aut-sei=Fukumoto en-aut-mei=Mitsuhiro kn-aut-name=福本光宏 kn-aut-sei=福本 kn-aut-mei=光宏 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=Ge-132 kn-keyword=Ge-132 en-keyword=Biological response modifier kn-keyword=Biological response modifier en-keyword=Acute nonlymphocytic leukemia kn-keyword=Acute nonlymphocytic leukemia en-keyword=Immunotherapy kn-keyword=Immunotherapy END start-ver=1.4 cd-journal=joma no-vol=104 cd-vols= no-issue=3-4 article-no= start-page=247 end-page=258 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=1992 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Experimental and clinical studies on interferon and its inducers Part 1. Effects of interferon and its inducers on neutrophil chemiluminescence kn-title=インターフェロン並びにインターフェロン誘発剤に関する基礎的・臨床的研究　第1編　インターフェロン並びにインターフェロン誘発剤の好中球 Chemiluminescence に及ぼす影響 en-subtitle= kn-subtitle= en-abstract= kn-abstract=To evaluate one the effects of interferon (IFN) and its inducers on neutrophil functions neutrophil chemiluminescence (ChL) was assayed on 31 healthy individuals, nine patients treated with IFN-α (human lymphoblastoid interferon, 3×10(6)units/day i. m. daily) and 11 patients treated with Ge-132 (2,250mg/day p. o. daily). The base lines (BLs), peak levels (PLs) and times to PLs (PLs) of neutrophil ChL were examined before, one week and one month after the treatment. The direct effects of IFN-α, Ge-132 and OK-432 on neutrophil ChL were also evaluated by using an in vitro experimental system. PLs were significantly increased one week after the treatment with IFN-α or Ge-132. However, they were decreased to the pretreatment level one month after the treatment. In vitro experimental system IFN-α enhanced PLs of neutrophil ChL showing dose and time dependencies. On the other hand Ge-132 and OK-432 showed no direct effect on neutrophil ChL in vitro. These findings suggest that IFN-α and Ge-132 enhance the host defense mechanism by the activation of neutrophil functions, and also suggest that they have some benefits not only in the clinical management of cancer but also of chronic infection. en-copyright= kn-copyright= en-aut-name=FukumotoMitsuhiro en-aut-sei=Fukumoto en-aut-mei=Mitsuhiro kn-aut-name=福本光宏 kn-aut-sei=福本 kn-aut-mei=光宏 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=Interferon kn-keyword=Interferon en-keyword=Ge-132 kn-keyword=Ge-132 en-keyword=Ok-143 kn-keyword=Ok-143 en-keyword=Neutrophil Chemiluminescence kn-keyword=Neutrophil Chemiluminescence END start-ver=1.4 cd-journal=joma no-vol=104 cd-vols= no-issue=3-4 article-no= start-page=241 end-page=246 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=1992 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The effect of cyclosporin A on liver regeneration kn-title=肝再生に及ぼす Cyclosporin A の影響 en-subtitle= kn-subtitle= en-abstract= kn-abstract=When lymphokine activiated killer cells (LAK cell) induced by IL-2 are infused into the same strain C(3)H mice following 70% partial hepatectomy, they display an action to suppress liver regeneration. Therefore, when Cyclosporin A (CsA) which inhibits IL-2 production was administerd to mice following partial hepatectomy, we studied as our indicator the labeling index of hepatic parenchyma cells using Brdu. Our findings showed that proliferation of live cells at 36 hours following partial hepatectomy was promoted by CsA, and the streongest promotion occuring at a dose of 5mg/kg. Before anf after hepatectomy when CsA was administered at 10mg/kg for 3 dadys, a further strong proliferation increasing effect was observed, and under these conditions at 48 and 60 hours after hepatectomy a significant increase in liver weight was observed. Give the above results, CsA it thought to have a promoting effect in liver regeneration following hepatectomy. en-copyright= kn-copyright= en-aut-name=YamamotoHiroshi en-aut-sei=Yamamoto en-aut-mei=Hiroshi kn-aut-name=山本浩史 kn-aut-sei=山本 kn-aut-mei=浩史 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一外科学教室 en-keyword=Cyclosporin A kn-keyword=Cyclosporin A en-keyword=肝再生 kn-keyword=肝再生 END start-ver=1.4 cd-journal=joma no-vol=104 cd-vols= no-issue=3-4 article-no= start-page=235 end-page=239 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=1992 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Cationic iron colloid as a mounting mediator of biological microsamples for scanning electron microscopy kn-title=陽性荷電鉄コロイドを用いた走査電顕用微小生物試料の載台 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Ferric chloride, when boiled with hydrazine hydrate and cacodylic acid, is converted into a fine cationic iron colloid. This colloid allowed good adhesion of biological micro-samples, inculuding the fixed ones, to the glass slips and facilitated the scanning electron micropscopy of these samples. The colloid was much more powerful in this mounting than the usually used and expensive poly-L-lysine. Living cells, such as human red blood cells, are esaily and sufficiently mounted with L-lysine or L-arginine on the glass slips. en-copyright= kn-copyright= en-aut-name=OukouchiHideki en-aut-sei=Oukouchi en-aut-mei=Hideki kn-aut-name=大河内秀記 kn-aut-sei=大河内 kn-aut-mei=秀記 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二解剖学教室 en-keyword=走査電子顕微鏡 kn-keyword=走査電子顕微鏡 en-keyword=微小試料の載台 kn-keyword=微小試料の載台 en-keyword=陽性荷電鉄コロイド kn-keyword=陽性荷電鉄コロイド END start-ver=1.4 cd-journal=joma no-vol=104 cd-vols= no-issue=3-4 article-no= start-page=221 end-page=234 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=1992 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Effects of kainic acid, quisqualic acid and their antagonist on rat electrocorticoprams and on monoamine metabolite levels in rat striatum estimated by brain dialysis method kn-title=カイニン酸, キスカル酸およびその拮抗薬投与にともなう脳波および線条体モノアミン代謝産物の変動 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The CNS action of kanie acid (KA), quisqualic acid (QA) and 1-(4-chlorobenzoyl)-piperazine-2, 3-dicarboxylic acid (pCB-PzDA) was investigated in male Sprague Dawley rats, and their effects on monoamina metabolite levels in rat striatum were studied using brain dialysis. Intracerebroventricularly injected KA and QA (100nmol) induced spike discharges, and pCB-PzDA (100nmol) suppressed electrocorticograms (ECoG) for 1 hour. pCB-PzDA aggravated KA induced spike discharges and inhibited QA-induced spike discharges. Dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) levels increased transitorily by injection of 100nmol and continuously by injection of 100nmol of KA. KA increased the 5-hydroxyindoleachtic acid (5-HIAA) level 2 hours after the administration dose-dependently. Though 10nmol of QA increased the HVA level slightly, 100nmol of QA increased the DOPAC, HVA and 5-HIAA levels. Though 100nmol of pCB-PzDA increased the DOPAC and HVA levels, it inhibited the increases in DOPAC, HVA and 5-HIAA levels induced by KA. On the other hand,pCB-PzDA inhibited the increases in DOPAC, HVA and 5-HIAA levels induced by QA for 1 hour, after which the DOPAC and HVA levels increased additively. These finding suggest that pCB-PzDA acts not only as a non-NMDA antagonist but also on dopaminergic neurons directly. en-copyright= kn-copyright= en-aut-name=YamamotoMasatsune en-aut-sei=Yamamoto en-aut-mei=Masatsune kn-aut-name=山本正恒 kn-aut-sei=山本 kn-aut-mei=正恒 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部脳代謝研究施設機能生化学部門 en-keyword=kainic acid kn-keyword=kainic acid en-keyword=quisqualic acid kn-keyword=quisqualic acid en-keyword=pCB-PzDA kn-keyword=pCB-PzDA en-keyword=brain dialysis kn-keyword=brain dialysis en-keyword=monoamine metabolism kn-keyword=monoamine metabolism END start-ver=1.4 cd-journal=joma no-vol=104 cd-vols= no-issue=3-4 article-no= start-page=205 end-page=219 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=1992 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Typological interrelationships of the human scalenus muscles, brachial plexus and subclavian artery kn-title=類型学的にみた斜角筋, 腕神経叢, 鎖骨下動脈の相互関係 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Dissection of 227 Japanese adult cadavers showed that the scaleus anterior and medius muscles are interconnected with each other by some muscle bundles which run between the roots of the plexus brachialis. The subclavian artery originates in the intersegmental arteries. Taking this fact into consideration, we illustrated a typological diagram which can explain some positional anomalies of the subclavian artery and the roots of plexus brachiails. The inconsistent scalenus minimus muscle may be an aberrant slip separated from the scalenus medius muscle by the subclavian artery which may originate in the fifth or sixth intersegmental artery. en-copyright= kn-copyright= en-aut-name=YamamotoChugo en-aut-sei=Yamamoto en-aut-mei=Chugo kn-aut-name=山本仲吾 kn-aut-sei=山本 kn-aut-mei=仲吾 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二解剖学教室 en-keyword=斜角筋 kn-keyword=斜角筋 en-keyword=鎖骨下動脈 kn-keyword=鎖骨下動脈 en-keyword=腕神経叢 kn-keyword=腕神経叢 en-keyword=斜角筋隙 kn-keyword=斜角筋隙 END