start-ver=1.4
cd-journal=joma
no-vol=104
cd-vols=
no-issue=1-2
article-no=
start-page=197
end-page=203
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1992
dt-pub=1992
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=第116回　岡山外科会
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=小川潔
kn-aut-sei=小川
kn-aut-mei=潔
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=104
cd-vols=
no-issue=1-2
article-no=
start-page=195
end-page=196
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1992
dt-pub=1992
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=第4回　岡山骨移植研究会
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=岡山骨移植研究会
kn-aut-sei=岡山骨移植研究会
kn-aut-mei=
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=104
cd-vols=
no-issue=1-2
article-no=
start-page=187
end-page=194
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1992
dt-pub=1992
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=An expert system for valvular heart disease using MRI and its clinical applications
kn-title=心臓弁膜症のMR画像診断支援システムの開発とその臨床応用に関する研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=MRI is a valuable tool for diagnosing heart disease today. The cardiac blood flow is determined by an MRI image analysis and expert system. Image data are taken by a TV camera and digitalized. After gray level thresholding and region segmentation, the boundary of the regurgitant flow region is precisely extracted. Using this expert system, a doctor can easily make an accurate diagnosis of the valvular heart disease. This method should prove useful for the diagnosis of various heart diseases.
en-copyright=
kn-copyright=

en-aut-name=NakagawaTomio
en-aut-sei=Nakagawa
en-aut-mei=Tomio
kn-aut-name=中川富夫
kn-aut-sei=中川
kn-aut-mei=富夫
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部放射線医学教室
en-keyword=expert system
kn-keyword=expert system
en-keyword=MRI
kn-keyword=MRI
en-keyword=valvular heart disease
kn-keyword=valvular heart disease
END

start-ver=1.4
cd-journal=joma
no-vol=104
cd-vols=
no-issue=1-2
article-no=
start-page=177
end-page=185
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1992
dt-pub=1992
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Treatment of small cell lung cancer in the elderly
kn-title=老年者肺小細胞癌の化学療法に関する研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=To assess the progress and limitation of chemotherapy in the treatment of small cell lung cancer in the elderly, we analyzed 218 patients in a protocol study between 1982 and 1990. There were 101 elderly patients (age of ≧ 66 years) and 117 non-elderly patients (age of ≦ 65 years). Response to chemotherapy with or without chest irradiation was similar for the elderly and the non-elderly; the complete response rate was 52% for limited disease (LD) and 33% for extensive disease (ED) in the elderly, and it was 68% for LD and 23% for ED in the non-elderly. Survival figures of the two groups were similar; the median survival time was 12.6 monthes for the elderly and 14.5 months for the non-elderly, and the 3-year surival rate was 14% for both groups. Hematologic toxicity was more frequent and severe in the elderly than in the non-elderly but the difference was not significant. Non-hematologic toxicity was comparable for the two groups, with an exception that the elderly showed a tendency of being predisposed to renal toxicity. In conclusion, elderly patients eligible for entry into a protocol study can benefit from intensive treatment just as younger patients can.
en-copyright=
kn-copyright=

en-aut-name=HinoNorihiko
en-aut-sei=Hino
en-aut-mei=Norihiko
kn-aut-name=日野理彦
kn-aut-sei=日野
kn-aut-mei=理彦
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第二内科学教室
en-keyword=肺小細胞癌 Small cell lung cancer
kn-keyword=肺小細胞癌 Small cell lung cancer
en-keyword=老年者 Erderly patients
kn-keyword=老年者 Erderly patients
en-keyword=化学療法 Chemotherapy
kn-keyword=化学療法 Chemotherapy
en-keyword=副作用 Side effect
kn-keyword=副作用 Side effect
END

start-ver=1.4
cd-journal=joma
no-vol=104
cd-vols=
no-issue=1-2
article-no=
start-page=165
end-page=176
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1992
dt-pub=1992
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Two useful indicators for the preoperative prediction of pulmonary and cardiac complications after lung resection
kn-title=肺切除術における術後心肺合併症発生予測のための指数設定及びその臨床的有用性の検討
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Two indicators (Risk score and Resection Index) for pulmonary and cardiac complications after lung resection were evaluated on 182 patients with bronchogenic carcinoma by quantita-tive technetium 99m macroaggregation albumin (MAA) perfusion scanning preoperatively and who then underwent lung resection. After surgerg, the correlations between preoperative lung function and the development of postoperative pulmonary and cardiac complications (PPCC) were examined in each case. The Risk score consisted of eight parameters (% FVC, FEV 1.0%, % MVV, % MMF, V50/HT, V25/HT, % peak flow, and % DLco), and a value of from 0 to 8 was assigned. In the patients with a Risk score of 0, PPCC occurred in 5 of the 71 cases, while complications were noted in 26 of the 94 patients with a Risk score from 1 to 5 and in 14 of the 17 patients with a score of over 6. The Resection Index was calculated from the predicted postoperative FEV 1.0 from the quantitative 99m Tc MAA perfusion scan and the predicted FEV 1.0, PPCC occurred in 20 of the 27 patients with a Resection Index of below 40%, 25 of the 131 patients with an index of 40% to 65%, and none of the 24 with an index over 65%. Both indicators had a good correlation with the occurrence of PPCC. These two indicators, the Risk score and the Resection Index, were clincally useful for predicting PPCC preoperatively and may help reduce the incidence of PPCC.
en-copyright=
kn-copyright=

en-aut-name=KobashiYuichi
en-aut-sei=Kobashi
en-aut-mei=Yuichi
kn-aut-name=小橋雄一
kn-aut-sei=小橋
kn-aut-mei=雄一
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第二外科学教室
en-keyword=肺癌
kn-keyword=肺癌
en-keyword=肺切除術
kn-keyword=肺切除術
en-keyword=術前肺機能
kn-keyword=術前肺機能
en-keyword=術後心肺合併症発生予測
kn-keyword=術後心肺合併症発生予測
en-keyword=肺血流シンチグラフィー
kn-keyword=肺血流シンチグラフィー
END

start-ver=1.4
cd-journal=joma
no-vol=104
cd-vols=
no-issue=1-2
article-no=
start-page=151
end-page=164
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1992
dt-pub=1992
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Effect of deep hypothermia under total spinal anesthesia on blood flow distribution of cardiac output in dogs
kn-title=全脊髄麻酔を用いた表面冷却低体温時の臓器血流分布に関する研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The systemic blood flow distribution of cardiac output of adult dogs, the brain temperature of which was kept at 24℃ by a simple hypothermia method under total spinal anesthesia was investigated. The systemic blood distribution was measured using a redioactive tracer microsphere (51Cr, 85Sr, 125I : 15±5μ in diameter) before total spinal anesthesia, after total spinal anesthesia and under deep hypothermia. Cardiac output was reduced to 83% of the control after total spinal anesthesia and to 38% of the control under hypothermia. The systemic blood re-distribution to each organ determined from the gamma-ray value of trapped redioactive microspheres tended, to be higher than the control value after the total spinal anesthesia in the brain, the heart and the kidney, but to be lower in the gastrointestinal tract. The systemic blood re-distribution to each organ except the liver decreased equally under hypothemia. That is, marked blood re-distribution accompanied by low cardiac output was not recognized. This method could be a safe and useful means for determining blood distribution during open heart surgery.
en-copyright=
kn-copyright=

en-aut-name=ShioteAkihiro
en-aut-sei=Shiote
en-aut-mei=Akihiro
kn-aut-name=塩手章弘
kn-aut-sei=塩手
kn-aut-mei=章弘
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第一外科学教室
en-keyword=hypothermia
kn-keyword=hypothermia
en-keyword=total spinal block
kn-keyword=total spinal block
en-keyword=radioactive microsphere
kn-keyword=radioactive microsphere
en-keyword=blood flow distribution of cardiac output
kn-keyword=blood flow distribution of cardiac output
END

start-ver=1.4
cd-journal=joma
no-vol=104
cd-vols=
no-issue=1-2
article-no=
start-page=145
end-page=150
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1992
dt-pub=1992
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Measurement of Danazol and its metabolites by automated direct assay system
kn-title=全自動分析装置による Danazol とその代謝産物の測定
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=An automated direct assay system using high performance liquid chromatography was developed for teh measurement of Danazol ; DA and its two metabolites, △(1)-2-hydroxymethylethisterone (△(1)-2-HME), and 2-hydroxymethylethisterone (2-HME), in biologi-cal fluid (human serum and ascites). Serum concentrations of these compounds were measured up to 24 h following a single oral administration of 200mg of DA to 6 females with en-dometriosis. The maximum serum concentration of DA, △(1)-2-HME and 2-HME was 208, 44 and 58ng/ml, respectively. The serum half-life of DA, △(1)-2-HME and 2-HME was 7.9, 4.3 and 4.4 h, respectively. The mean serum concentration of DA and its two metabolites at the the sampling time (2 h after oral administration of 200mg of DA every 4 weeks) hardly changed in the patients administered 400mg/day of DA over a period of 16 weeks. DA and △(1)-2-HME were detectable in ascites 2, 4 and 8 h after oral administration of 200mg of DA, and 2-HME was detectable in ascites at 4 and 8 h. This system could quantify DA and its matabolites easily and simultaneously, and was considered to be valuable in the studies on the relationship between the pharmaco-kinetics and the clinical effects of DA.
en-copyright=
kn-copyright=

en-aut-name=KiyamaSatoshi
en-aut-sei=Kiyama
en-aut-mei=Satoshi
kn-aut-name=木山智之
kn-aut-sei=木山
kn-aut-mei=智之
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部産科婦人科学教室
en-keyword=高速液体クロマトグラフィー
kn-keyword=高速液体クロマトグラフィー
en-keyword=ダナゾール
kn-keyword=ダナゾール
en-keyword=ダナゾール代謝産物
kn-keyword=ダナゾール代謝産物
END

start-ver=1.4
cd-journal=joma
no-vol=104
cd-vols=
no-issue=1-2
article-no=
start-page=137
end-page=144
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1992
dt-pub=1992
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Estrogen binding capacity in cytosol fraction of human uterine cervix : effect of estrogen and anti-estrogens
kn-title=ヒト子宮頸部組織における細胞質分画エストロゲン結合能とそれに影響する因子について
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The estrogen binding activity in the human uterine cervix was measured, and the effect of natural and synthesized steroids on the activities was determined. To assay the estrogen binding activity, the asmple was incubated with 10nM [(3)H] estradiol-17β at 30℃ for 2 hours. Then dextran-coated charcoal (DCC) was added to a final concentration of 0.5% to separate bound/free (B/F) estradiol. Estrogen binding activity was determined by subtracting the activity found in the heated sample from the corresponding activity in the untreated sample. For this purpose it was found appropriate to heat the sample at 40℃ for 60 minutes. The dissociation constant obtained from the Scatchard plot analysis was : kd=2.0×10(-9)M. A variety of steroids at the same molar concentration (1.0 μM) were added to the sample to determine their effects on the estrogen binding activity. For binding with [(3)H] estradiol-17β, the synthetic estrogens were strongly inhibitory, the anti-estrogen agents were strong-ly to moderately inhibitory. Dannazol, which has been used for the treatment of en-dometriosis, was found to be as effective as androgens. All of those inhibitory effects occur-red in a non-competitive manner.
en-copyright=
kn-copyright=

en-aut-name=KobayashiShunzo
en-aut-sei=Kobayashi
en-aut-mei=Shunzo
kn-aut-name=小林俊三
kn-aut-sei=小林
kn-aut-mei=俊三
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部産科婦人科学教室
en-keyword=uterine cervix
kn-keyword=uterine cervix
en-keyword=estrogen receptor inhibition
kn-keyword=estrogen receptor inhibition
END

start-ver=1.4
cd-journal=joma
no-vol=104
cd-vols=
no-issue=1-2
article-no=
start-page=129
end-page=136
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1992
dt-pub=1992
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on pulmonary granuloma formation by Propionibacterium acnes in sarcoidosis Part 2. Interleukin-2 production and responsiveness to Interleukin-2 of alveolar lymphocytes stimulated in experimental pulmonary granulomatosis produced by Propionibacterium acnes
kn-title=サルコイドーシスの肺肉芽腫形成に対する Propionibacterium acens の関与に関する研究　第2編　Propionibacterium acens による実験的肺肉芽腫症における肺胞リンパ球の Interleukin-2 産生及び Interleukin-2　受容体発現のついて
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The role of Propionibacterium acnes (P. acnes) isolated from a high percentage of patients with sarcoidosis by Dr. Honnma, as a cause of sarcoidosis was examined. Interleukin-2 (IL-2) production and the responsiveness to IL-2 of alveolar lymphocytes stimulated by P. acnes were examined in vitro in a guinea pig model. The animals were divided into 4 groups, normal guinea pigs (group 1), guinea pigs intracutaneously presensitized with P. acnes and intratracheally challenged by saline (group 2), guinea pigs presensitized as above and intratracheally challenged with P. acnes (group 3), and guinea pigs presensitized as above and intratracheally challenged by P. acnes-pyridine extract residue (P. acnes-PER)(group 4). The production of IL-2 by alveolar lymphocytes stimulated by P. acnes-PER for 48 hours was determined using the method described by Gillis et al. The responsiveness of alveoloar lymphocytes to IL-2 was evaluated by 3H-TdR uptake in the presence and absence of P. acnes-PER. The amount of IL-2 produced by alveolar lymphocytes was 0.6±1.1, 0.7±1.1, 21.2±27.9 and 329.4±294.1 u/ml (M±SD), respectively, in groups 1, 2, 3 and 4. The value of IL-2 production in groups 3 and 4, the intratracheally challenged groups, was significantly higher htna that in groups 1 and 2, the control groups (p<0.02, p<0.01). By contrast, the IL-2 production of peripheral lymphocytes in groups 1, 2, 3 and 4 was 0, 7.4±10.3, 8.6±15.7 and 9.3±8.9 u/ml, respectively. The amount of IL-2 produced was about one-tenth thar of alveolar lymphocytes. In the intratracheally challenged groups, the responsiveness to IL-2 of alveolar lymphocytes in the presence and absence of P. acnes-PER was 12,514±12,766 and 6,611±7,066 for group 3, and 12,362±9,414 and 5,818±5,494 dpm, respectively, for group 4. The responsiveness to IL-2 of alveolar lymphoctyes in group 4 was signifincantly increased by stimulation with P. acnes-PER (p<0.05), but that in groups 1 and 2, control groups, was not different. Our findings indicate that P. acnes-PER stimulated IL-2 production from alveolar lymphocytes and induced a functionally active state of alveolar lymphocytes to IL-2 in this guinea pig model. In conclusion, the role of alveolar lymphocytes in an animal model stimulated by P. acnes appears to be consistent with that obtained on the sarcoidosis patients we previously reported.
en-copyright=
kn-copyright=

en-aut-name=MoriYoshihiro
en-aut-sei=Mori
en-aut-mei=Yoshihiro
kn-aut-name=森由弘
kn-aut-sei=森
kn-aut-mei=由弘
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第二内科学教室
en-keyword=experimental pulmonary granulomatosis
kn-keyword=experimental pulmonary granulomatosis
en-keyword=guinea pig
kn-keyword=guinea pig
en-keyword=Propionibacterium acens
kn-keyword=Propionibacterium acens
en-keyword=Interleukin-2
kn-keyword=Interleukin-2
en-keyword=Interleukin-2 receptor
kn-keyword=Interleukin-2 receptor
END

start-ver=1.4
cd-journal=joma
no-vol=104
cd-vols=
no-issue=1-2
article-no=
start-page=117
end-page=127
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1992
dt-pub=1992
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on pulmonary granuloma formation by Propionibacterium acnes in sarcoidosis Part 1. Interleukin-2 production and receptor expression of alveolar lymphocytes stimulated by Propionibacterium acnes in sarcoidosis
kn-title=サルコイドーシスの肺肉芽腫形成に対する Propionibacterium acens の関与に関する研究　第1編　サルコイドーシス肺胞リンパ球のPropionibacterium acens に対する Interleukin-2 産生及び Interleukin-2　受容体発現のついて
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=We previously reported that alveolar lymophocytes in patients with active sarcoidosis are sensitized Propionibacterium acnes (P. acnes) which may play a significant role in the induction of alveolitis in these patients. We further investigated the production of Interleukin-2 (IL-2), and the responsiveness to IL-2 of alveolar lymphocytes obtained from sarcoidosis patients and stimulated by P. acnes in vitro. In 21 untreated  sarcoidosis patients, 7 treated patients and 13 control subjects, the mean IL-2 activity of fluid released from cultured alveoloar lymphocytes was 9.8±15.7 (M±SD), 1.9±4.7 and 0.2±0.8 u/ml respectively. The IL-2 activity of lymphocytes from untreated patients was significantly higher than that of control subjects (p<0.02). Neither perioheral lymphocytes in sarcoidosis patients nor in controls produced IL-2 stimulated by P. acnes. The responsiveness of alveloar lymphocytes to recombinant IL-2 was evaluated by 3H-thymidine uptake in the presence and absence of P. acnes. Lymphocytes stimulated by P. acnes showed a significantly increased uptake (3,766±3,929 dpm) compred to ustimulated lymphocytes (1,123±968 dpm) obtained from 11 untreated sarcoidosis patients (p<0.02). On the other hand, the responsiveness of lymphocytes obtained from 6 control subjects was low regardless of stimulation by P. acnes. There was a significant correlation (p<0.05) between the P. acnes-induced production of IL-2 by alveolar lymphocytes and the blastogenesis of alveloar lymphocytes in untreated sarcoidosis patietnes. Our findings indicate that P. acnes stimulated IL-2 production and IL-2 receptor induction in alveolar lymphocytes from patients with active sarcoidosis. This study supported our hypothesis that P. acnes could be an antigen causing sarcoidosis.
en-copyright=
kn-copyright=

en-aut-name=MoriYoshihiro
en-aut-sei=Mori
en-aut-mei=Yoshihiro
kn-aut-name=森由弘
kn-aut-sei=森
kn-aut-mei=由弘
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第二内科学教室
en-keyword=sarcoidosis
kn-keyword=sarcoidosis
en-keyword=Propionibacterium acens
kn-keyword=Propionibacterium acens
en-keyword=Interleukin-2
kn-keyword=Interleukin-2
en-keyword=Interleukin-2 receptor
kn-keyword=Interleukin-2 receptor
en-keyword=alveolar lymphocyte
kn-keyword=alveolar lymphocyte
END

start-ver=1.4
cd-journal=joma
no-vol=104
cd-vols=
no-issue=1-2
article-no=
start-page=107
end-page=115
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1992
dt-pub=1992
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Anticoagulant effect of nafamostat mesilate (FUT) and cepharanthin on the small-caliber prosthesis implantation in the small venous system
kn-title=メシル酸ナファモスタットとセファランチンの併用による小口径静脈再建後早期における抗血栓作用に関する実験的研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The anticoagulant effect of nafamostat mesilate(FUT, a protease inhibitor) plus cepharanthin (CE) after small-caliber graft implantation into the canine jugular veins was compared with that of heparin (HE) or urokinase (UK). Twenty-four dogs were used in this study. Sauvage EXS Dacron grafts 5mm in diameter were implanted into external jugular veins. Immediately after impantation, continuous administration of drugs was started through posterior auricular veines. Coagulation test were carried out serially during perfusion. Three hours after implantation, the grafts were removed and examined macro-and microscopically. The dogs were divided into 4 groups : 1)Control group ; 2)UK group (2000u/kg/hr) ; 3)HE group (0.25mg/kg/hr) ; and 4)FUT plus CE group, FUT (0.3mg/kg/hr) plus CE (0.7mg/kg/hr). All grafts were thrombosed in the control group and UK group. However, no thrombus was found in the HE group anf FUT plus CE group. Coagulation tests revealed that fibrinogen and AT-�V decreased significantly in the UK group (p<0.05), ACT and APTT was gradually prolonged in the HE group (p<0.05), and there was no significant change in the FUT plus CE group. These findings suggest that FUT plus CE may not only decrease early thrombus formation, but may also maintain the balance of the coagulation system. The combination of FUT plus CE may be useful anticoagulant therapy during the postoperative period when the risk of bleeding remains.
en-copyright=
kn-copyright=

en-aut-name=OkanoKazuo
en-aut-sei=Okano
en-aut-mei=Kazuo
kn-aut-name=岡野和雄
kn-aut-sei=岡野
kn-aut-mei=和雄
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第二外科学教室
en-keyword=抗血栓作用
kn-keyword=抗血栓作用
en-keyword=メシル酸ナファモスタット
kn-keyword=メシル酸ナファモスタット
en-keyword=セファランチン
kn-keyword=セファランチン
en-keyword=小口径人工血管
kn-keyword=小口径人工血管
en-keyword=静脈再建
kn-keyword=静脈再建
END

start-ver=1.4
cd-journal=joma
no-vol=104
cd-vols=
no-issue=1-2
article-no=
start-page=97
end-page=106
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1992
dt-pub=1992
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Attitude toward mental disorders : A comparative study of a attitude of nurses and attendants between Japan and Brazil
kn-title=精神障害の対する態度―日本, ブラジルの看護婦, 看護士の態度の比較研究―
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Attitude of nureses and attendants toward mental disorders was studied by using question-naire in Japan and Brazil. By factor analysis, three factors, negative attitude toward mental disorders and misunder-standing, positive attitude toward mental disorders and mental health ideology were extracted. The score of negative attitude toward mental disorders and misunderstanding was high in Brazil. This was suspected to be caused by poor knowledge about mental disorders. The score of positive attitude toward mental disorders was similar in Japan and Brazil. The score of mental health ideology was high in Japan. Mental health ideology is important to improve the attitude toward mental disorders both Japan and Brazil. It is important to spread knowledge about mental disorders in Brazil. In Japan, it is important to increase the interest in mental disorders.
en-copyright=
kn-copyright=

en-aut-name=TakenamiKatsuko
en-aut-sei=Takenami
en-aut-mei=Katsuko
kn-aut-name=武南克子
kn-aut-sei=武南
kn-aut-mei=克子
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部神経精神医学教室
en-keyword=精神障害に対する態度
kn-keyword=精神障害に対する態度
en-keyword=因子分析
kn-keyword=因子分析
en-keyword=精神保健的観念
kn-keyword=精神保健的観念
en-keyword=関心度
kn-keyword=関心度
END

start-ver=1.4
cd-journal=joma
no-vol=104
cd-vols=
no-issue=1-2
article-no=
start-page=83
end-page=95
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1992
dt-pub=1992
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on laser photocoagulation for retinopathy of prematurity
kn-title=レーザー光凝固による未熟児網膜症の治療に関する研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Forty eyes in twenty-two cases in the active phase of retinopathy of prematurity were treated with laser photocagulation. Thiry (93.7%) of the 32 eyes in type I and intermediate type were found in the cicartrical phase grade 1. In type �U in which cryocautery was used as combination therapy, only 2 eyes (25.0%) were found in grade 1, 2 eyes (25.0%) in grade 2, 1 eye (12.5%) in grade 4 and 3 eyes (37.5%) in grade 5. All 21 eyes in which photocoagulation was performed up to the middle of stage 3 were found in grade 1 (100%). However, among 11 eyes in which photocoagulation were performed in late stage 3, 9 eys (81.8%) were found in grade 1, and 2 eyes (18.2%) in grade 2. In conclusion, if adequate laser photocoagulation is performed in avascular ares at the middle of stage 3 of type �T and intermediate type, treatment  in cicartrical phase grade 1 is possible. Laser photocoagulation is clearly more effective than the xenon are photocoagula-tion or cryocautery. However, in type �U it is difficult to control the condition by photocagulation alone, and early diagnosis followed by combination therapy using cryocautery is reqired.
en-copyright=
kn-copyright=

en-aut-name=OhtakiChiaki
en-aut-sei=Ohtaki
en-aut-mei=Chiaki
kn-aut-name=大滝千秋
kn-aut-sei=大滝
kn-aut-mei=千秋
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部眼科学教室
en-keyword=未熟児網膜症
kn-keyword=未熟児網膜症
en-keyword=レーザー光凝固
kn-keyword=レーザー光凝固
END

start-ver=1.4
cd-journal=joma
no-vol=104
cd-vols=
no-issue=1-2
article-no=
start-page=63
end-page=74
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1992
dt-pub=1992
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Clinical and radiological study of femoral neck fractures in patients with rheumatoid arthritis
kn-title=慢性関節リウマチ患者における大腿骨頸部骨折の臨床的ならびにX線学的研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Clinical and radiological studies were performed on 58 patients with rheumatoid arthritis (RA) who had sustained 64 femoral neck fractures. All but one patietns werre female, the mean age was 66.5 years, and mean duration of RA was 17 years. Only 3 hips showed rheumatoid changes. Sixteen fractures of 14 patietns were spontaneous fractures without trauma. Ipsilateral total knee replacements were performed on 5 patients with spontaneous fractures. Results of treatment were analyzed on 47 fractures in 43 patients that could be followed up for more than 1 year (mean 42 months). Clinical results were evaluated by ability of ambula-tion and complications such as nonunion and avascular necrosis of the femoral head. All 4 fractures treated conservatively and 5 of 9 displaced fractures treated by internal fixation developed complications. Femoral head replacements had a high rate of proximal migration (23.8%) and distal migration (76.2%), and ambulation ability was lowered significantly in 10 patients with distal migration for more than 5 mm. On the other hand, satisfactory results were obtained on all 6 fractures treated by total hip replacements (THR). THR is advisable for tratmetn of displaced femoral neck fracture in patients with RA.
en-copyright=
kn-copyright=

en-aut-name=KawamuraMasahide
en-aut-sei=Kawamura
en-aut-mei=Masahide
kn-aut-name=川村正英
kn-aut-sei=川村
kn-aut-mei=正英
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部整形外科学教室
en-keyword=慢性関節リウマチ
kn-keyword=慢性関節リウマチ
en-keyword=大腿骨頸部骨折
kn-keyword=大腿骨頸部骨折
en-keyword=spontaneous fracture
kn-keyword=spontaneous fracture
en-keyword=治療成績
kn-keyword=治療成績
END

start-ver=1.4
cd-journal=joma
no-vol=104
cd-vols=
no-issue=1-2
article-no=
start-page=75
end-page=82
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1992
dt-pub=1992
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Effect of immunosuppressive substance against the potency of natural human tumor necrosis factor as biological response modifier
kn-title=Biological response modifier としての Tumor necrosis fator の効果に対する Immunosuppressive substance の作用の検討
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=TNF is a cytokine with the activity of a BRM (biological response modifier). TNF-α and TNF-β enhanced NK activity of peripheral blood mononucleocytes of a normal donor, but not in a cancer patient. ISS, a glocoprotein extracted from the ascitic fluid of a colon cancer patient with immunosuppressive properties, ia also detected in large quantities in the serum of cancer patients. NK activity of a normal donor which was in an immunosuppressive state by the administration of ISS was not affected by treatment of TNF-α or TNF-β, but the suppressed NK activity was improved by the combination of TNF with IFN-α or IFN-γ. On the other hand, NK activity of a cancer patient treated with anti-IS antiserum which was obtained from serum of rabbit immunized by ISS was enhanced by both TNFs. These findings suggest that ISS suppresses the effect of TNFs on NK activity. Furthermore, the effect of TNF as a BRM is inhibited in cancer patients due to the high dose of ISS in the serum, and that the combination of TNF with other cytokines, such as IFN, is more effective than the single use of TNF, clinically.
en-copyright=
kn-copyright=

en-aut-name=YasuiYoshimasa
en-aut-sei=Yasui
en-aut-mei=Yoshimasa
kn-aut-name=安井義政
kn-aut-sei=安井
kn-aut-mei=義政
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第一外科学教室
en-keyword=biological response modifier (BRM)
kn-keyword=biological response modifier (BRM)
en-keyword=tumor necrosis fator (TNF)
kn-keyword=tumor necrosis fator (TNF)
en-keyword=immunosuppressive substance (IS 物質)
kn-keyword=immunosuppressive substance (IS 物質)
en-keyword=natural killer (NK) 活性
kn-keyword=natural killer (NK) 活性
END

start-ver=1.4
cd-journal=joma
no-vol=104
cd-vols=
no-issue=1-2
article-no=
start-page=57
end-page=62
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1992
dt-pub=1992
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Accessory upper lateral cutaneous nerve of the arm (cutaneous branch of the suprascapular nerve), and unusual suprascapular nerves
kn-title=副上外側上腕皮神経（肩甲上神経の皮枝）と異常な鎖骨上神経
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=A well-duveloped nervous branch supplying the upper lateral cutanea of the arm, which arose from the suprascapular nerve, ran beneath the acromio-clavicular joint and pentrated the deltoid muscle, is described. In usual cases, this branch is thin and sometimes referred to as the accessory upper lateral cutaneous branch of the arm (Murakami)(or subacromial cutaneous nerve, Yamada). Some unusual supraclavicular nerves, which penetrated the clavicular bone or ran under this bone, are also described.
en-copyright=
kn-copyright=

en-aut-name=HorieMasashi
en-aut-sei=Horie
en-aut-mei=Masashi
kn-aut-name=堀江正司
kn-aut-sei=堀江
kn-aut-mei=正司
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第二解剖学教室
en-keyword=副上外側上腕皮神経
kn-keyword=副上外側上腕皮神経
en-keyword=肩甲上神経の皮枝
kn-keyword=肩甲上神経の皮枝
en-keyword=鎖骨上神経の破格
kn-keyword=鎖骨上神経の破格
END

start-ver=1.4
cd-journal=joma
no-vol=104
cd-vols=
no-issue=1-2
article-no=
start-page=51
end-page=56
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1992
dt-pub=1992
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Clinicopathological studies in patients with colorectal cancers without lymphnode metastasis
kn-title=リンパ節転移を認めない大腸癌の臨床病理学的検討
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The clinicopathologic findines and the prognosis of 154 patients without regional lymph nodes metastasis or distant metastasis (n(-)group) were compared with those in 134 patients with regional lymph nodes metastasis and without distant netastasis (n(+)group). The mean age of the n(-) group was significantly younger than that of the n(+) group (p<0.05) and there was no significant sexual preponderance. The proportion of the cases without lymphatic vessel invasion in the n(-) group was significantly higher than in the n(+) group (p<0.01). The proportion of the cases without venous invasion was significantly higher in the n(-) group than in the n(-) group (p<0.05). There was no difference in cumulative surval rate of patients in then(-) group than in the n(+) group (p<0.05). There was no difference in cumulative survial rate of patients in the n(-) group in respect to the background factors such as sex, tumor site, and venous invasion. However, the survial rate of patients whose cancer invasion was limited within the mucosa (m), submucosa (sm) and musclar propria (pm) was significantly better than that of patients who had subserosal or subadventitial penetration (ss(al)), serosal or adeventitial penetration (s(a2)) and cancer invasion adjacent organs (si(ai))(p<0.05). The survial rate of patients with lymphatic vessel invasion was significantly higher than that of patients without lymphatic vessel invasion (p<0.05). That the poor prognostic factors in n(-) colorectal cancer patients are cancer penetration to/beyond ss(al), or positive lymphatic vessal invasion.
en-copyright=
kn-copyright=

en-aut-name=ShiikiShigeo
en-aut-sei=Shiiki
en-aut-mei=Shigeo
kn-aut-name=椎木滋雄
kn-aut-sei=椎木
kn-aut-mei=滋雄
aut-affil-num=1
ORCID=

en-aut-name=FuchimotoSadanori
en-aut-sei=Fuchimoto
en-aut-mei=Sadanori
kn-aut-name=淵本定儀
kn-aut-sei=淵本
kn-aut-mei=定儀
aut-affil-num=2
ORCID=

en-aut-name=IwagakiHiromi
en-aut-sei=Iwagaki
en-aut-mei=Hiromi
kn-aut-name=岩垣博巳
kn-aut-sei=岩垣
kn-aut-mei=博巳
aut-affil-num=3
ORCID=

en-aut-name=HamadaHiroshi
en-aut-sei=Hamada
en-aut-mei=Hiroshi
kn-aut-name=浜田史洋
kn-aut-sei=浜田
kn-aut-mei=史洋
aut-affil-num=4
ORCID=

en-aut-name=HizutaAkio
en-aut-sei=Hizuta
en-aut-mei=Akio
kn-aut-name=日伝晶夫
kn-aut-sei=日伝
kn-aut-mei=晶夫
aut-affil-num=5
ORCID=

en-aut-name=OiritaKunzo
en-aut-sei=Oirita
en-aut-mei=Kunzo
kn-aut-name=折田薫三
kn-aut-sei=折田
kn-aut-mei=薫三
aut-affil-num=6
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第一外科学教室

affil-num=2
en-affil=
kn-affil=岡山大学医学部第一外科学教室

affil-num=3
en-affil=
kn-affil=岡山大学医学部第一外科学教室

affil-num=4
en-affil=
kn-affil=岡山大学医学部第一外科学教室

affil-num=5
en-affil=
kn-affil=岡山大学医学部第一外科学教室

affil-num=6
en-affil=
kn-affil=岡山大学医学部第一外科学教室
en-keyword=大腸癌
kn-keyword=大腸癌
en-keyword=リンパ節転移
kn-keyword=リンパ節転移
en-keyword=n(0)
kn-keyword=n(0)
END

start-ver=1.4
cd-journal=joma
no-vol=104
cd-vols=
no-issue=1-2
article-no=
start-page=39
end-page=49
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1992
dt-pub=1992
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Fine blood vascular casting by monomeric methacrylate injection and microwave treatment
kn-title=メタクリレート単量体注入とマイクロウェーブプロセッサー急速加温による微細血管鋳型法
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=A modified injection replica SEM method was introduced. Thorough injection of a resin mixture (monomeric metacrylate containing 1% benzoyl peroxide and 1% N, N-dimethylaniline) prior to the microwave treatment prepares good and fine blood vascular casts or replicas of brain, hypophysis, pineal body, thyroid gland and other organs. These casts sufficiently withstood ionbombardment and were useful for scanning electron microscopy. In this casting, preliminary perfusion fixation prior to the resin injection was always necessary because the mixture was toxic to the vascular walls and destroyed them.
en-copyright=
kn-copyright=

en-aut-name=HinenoyaHitoshi
en-aut-sei=Hinenoya
en-aut-mei=Hitoshi
kn-aut-name=日根野谷仁
kn-aut-sei=日根野谷
kn-aut-mei=仁
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第二解剖学教室
en-keyword=マイクロウェーブ　プロセッサー
kn-keyword=マイクロウェーブ　プロセッサー
en-keyword=微細血管鋳型法
kn-keyword=微細血管鋳型法
en-keyword=走査電子顕微鏡
kn-keyword=走査電子顕微鏡
END

start-ver=1.4
cd-journal=joma
no-vol=104
cd-vols=
no-issue=1-2
article-no=
start-page=29
end-page=38
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1992
dt-pub=1992
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=The reconstructive surgery of head and neck cancers
kn-title=頭頸部癌の再建外科―当科における再建術式の臨床的観察―
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Thiry nine reconstructive surgeries were performed in 37 cases of head and neck cancers from January, 1989 to August, 1991 in our department. The best functional results were obtained on deglutition, swallowing and phonatin after intraoral and/or mesopharyngeal reconstruction using free radial forearm flaps. The free jejunal transposition procedure had the lowest complication rate. The rectus abdominus musculocutaneous free flap was used for nasal, paranasal reconstruction. Esthetics could be presereved by this reconstruction method due to mider postoperative atrophy and contraction. Eye sockets for the artificial eyes were made with eye conjunctiva in 3 canses of extended total maxillectomy with the orbital exenteration. The use of microvas-cular free flaps in this new plastic surgery resulted in the decrease of refusal of operations in maxillectomy canses.
en-copyright=
kn-copyright=

en-aut-name=WatanabeShuichi
en-aut-sei=Watanabe
en-aut-mei=Shuichi
kn-aut-name=渡辺周一
kn-aut-sei=渡辺
kn-aut-mei=周一
aut-affil-num=1
ORCID=

en-aut-name=KawakamiTakashi
en-aut-sei=Kawakami
en-aut-mei=Takashi
kn-aut-name=川上登史
kn-aut-sei=川上
kn-aut-mei=登史
aut-affil-num=2
ORCID=

en-aut-name=InokuchiIkuo
en-aut-sei=Inokuchi
en-aut-mei=Ikuo
kn-aut-name=井口郁雄
kn-aut-sei=井口
kn-aut-mei=郁雄
aut-affil-num=3
ORCID=

en-aut-name=UnoKin-ya
en-aut-sei=Uno
en-aut-mei=Kin-ya
kn-aut-name=宇野鉄哉
kn-aut-sei=宇野
kn-aut-mei=鉄哉
aut-affil-num=4
ORCID=

en-aut-name=OhomichiTakuya
en-aut-sei=Ohomichi
en-aut-mei=Takuya
kn-aut-name=大道卓也
kn-aut-sei=大道
kn-aut-mei=卓也
aut-affil-num=5
ORCID=

en-aut-name=FukazawaMotoharu
en-aut-sei=Fukazawa
en-aut-mei=Motoharu
kn-aut-name=深沢元晴
kn-aut-sei=深沢
kn-aut-mei=元晴
aut-affil-num=6
ORCID=

en-aut-name=YonedaTakaaki
en-aut-sei=Yoneda
en-aut-mei=Takaaki
kn-aut-name=米田孝明
kn-aut-sei=米田
kn-aut-mei=孝明
aut-affil-num=7
ORCID=

en-aut-name=FukushimaKunihiro
en-aut-sei=Fukushima
en-aut-mei=Kunihiro
kn-aut-name=福島邦博
kn-aut-sei=福島
kn-aut-mei=邦博
aut-affil-num=8
ORCID=

en-aut-name=MasudaYu
en-aut-sei=Masuda
en-aut-mei=Yu
kn-aut-name=増田游
kn-aut-sei=増田
kn-aut-mei=游
aut-affil-num=9
ORCID=

en-aut-name=KamikawaYasuaki
en-aut-sei=Kamikawa
en-aut-mei=Yasuaki
kn-aut-name=上川康明
kn-aut-sei=上川
kn-aut-mei=康明
aut-affil-num=10
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部耳鼻咽喉科学教室

affil-num=2
en-affil=
kn-affil=岡山大学医学部耳鼻咽喉科学教室

affil-num=3
en-affil=
kn-affil=岡山大学医学部耳鼻咽喉科学教室

affil-num=4
en-affil=
kn-affil=岡山大学医学部耳鼻咽喉科学教室

affil-num=5
en-affil=
kn-affil=岡山大学医学部耳鼻咽喉科学教室

affil-num=6
en-affil=
kn-affil=岡山大学医学部耳鼻咽喉科学教室

affil-num=7
en-affil=
kn-affil=岡山大学医学部耳鼻咽喉科学教室

affil-num=8
en-affil=
kn-affil=岡山大学医学部耳鼻咽喉科学教室

affil-num=9
en-affil=
kn-affil=岡山大学医学部耳鼻咽喉科学教室

affil-num=10
en-affil=
kn-affil=岡山大学医学部第一外科学教室
en-keyword=再建外科
kn-keyword=再建外科
en-keyword=頭頸部癌
kn-keyword=頭頸部癌
en-keyword=有茎 (筋) 皮弁
kn-keyword=有茎 (筋) 皮弁
en-keyword=遊離 (筋) 皮弁
kn-keyword=遊離 (筋) 皮弁
END

start-ver=1.4
cd-journal=joma
no-vol=104
cd-vols=
no-issue=1-2
article-no=
start-page=21
end-page=27
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1992
dt-pub=1992
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Antitumor effect of interferon-α, γ and/or tumor necrosis factor-α against human colon cancer line (LoVo) transplanted into nude mice
kn-title=ヌードマウス可移植性ヒト大腸癌細胞株 LoVoに対する interferon-α,-γ, tumor necrosis factor-α の抗腫瘍効果の検討
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=We investigated the in vivo antitumor effect of recombinant human interferon-α,γ (IFN-α,γ) and/or recombinant human tumor necrosis factor-α (TNF-α) against human colon cancer cells (LoVo) transplanted into nude mice. LoVo cells were very sensitive to IFN-γ and slightly sensitive to IFN-α and resistant to TNF-α in vitro by dye uptake method. Intravenous administration of IFN-γ significantly inhibited tumor growth transplanted subcutaneously into nude mice, but IFN-α and/or TNF-α did not show any antitumor effect. Labeling index on stanining with bromodeoxyuridune and mitotic index of LoVo cells treated with IFN-α,γ or TNF-α differed slightly from those of the control group. We previously reported that the synergistic antitumor effects on the three cell lines could be examined by the combined use of IFN-α and TNF-α and the mechanism of the synergism was arrested in the S phase of cell cycle of target cells. However in the cese of LoVo cells, the combined use of IFN-α and TNF-α was not effective and did not arrest the cells in tha S phase of cell cycle. Therefore, arrest in the S phase was suspected to be responsible from the synergistic antitumor activity of IFN-α and TNF-α on the sensitive targets.
en-copyright=
kn-copyright=

en-aut-name=KataokaKazuhiko
en-aut-sei=Kataoka
en-aut-mei=Kazuhiko
kn-aut-name=片岡和彦
kn-aut-sei=片岡
kn-aut-mei=和彦
aut-affil-num=1
ORCID=

en-aut-name=NaomotoYoshio
en-aut-sei=Naomoto
en-aut-mei=Yoshio
kn-aut-name=猶本良夫
kn-aut-sei=猶本
kn-aut-mei=良夫
aut-affil-num=2
ORCID=

en-aut-name=MuroMasahiko
en-aut-sei=Muro
en-aut-mei=Masahiko
kn-aut-name=室雅彦
kn-aut-sei=室
kn-aut-mei=雅彦
aut-affil-num=3
ORCID=

en-aut-name=KojimaKazushi
en-aut-sei=Kojima
en-aut-mei=Kazushi
kn-aut-name=小島一志
kn-aut-sei=小島
kn-aut-mei=一志
aut-affil-num=4
ORCID=

en-aut-name=HorikiSadayuki
en-aut-sei=Horiki
en-aut-mei=Sadayuki
kn-aut-name=堀木貞幸
kn-aut-sei=堀木
kn-aut-mei=貞幸
aut-affil-num=5
ORCID=

en-aut-name=HizutaAkio
en-aut-sei=Hizuta
en-aut-mei=Akio
kn-aut-name=日伝晶夫
kn-aut-sei=日伝
kn-aut-mei=晶夫
aut-affil-num=6
ORCID=

en-aut-name=TanakaNoriaki
en-aut-sei=Tanaka
en-aut-mei=Noriaki
kn-aut-name=田中紀章
kn-aut-sei=田中
kn-aut-mei=紀章
aut-affil-num=7
ORCID=

en-aut-name=OritaKunzo
en-aut-sei=Orita
en-aut-mei=Kunzo
kn-aut-name=折田薫三
kn-aut-sei=折田
kn-aut-mei=薫三
aut-affil-num=8
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第一外科学教室

affil-num=2
en-affil=
kn-affil=岡山大学医学部第一外科学教室

affil-num=3
en-affil=
kn-affil=岡山大学医学部第一外科学教室

affil-num=4
en-affil=
kn-affil=岡山大学医学部第一外科学教室

affil-num=5
en-affil=
kn-affil=岡山大学医学部第一外科学教室

affil-num=6
en-affil=
kn-affil=岡山大学医学部第一外科学教室

affil-num=7
en-affil=
kn-affil=岡山大学医学部第一外科学教室

affil-num=8
en-affil=
kn-affil=岡山大学医学部第一外科学教室
en-keyword=nude mouse
kn-keyword=nude mouse
en-keyword=human colon cancer
kn-keyword=human colon cancer
en-keyword=interferon
kn-keyword=interferon
en-keyword=tumor necrosis factor
kn-keyword=tumor necrosis factor
en-keyword=cell cycle
kn-keyword=cell cycle
END

start-ver=1.4
cd-journal=joma
no-vol=104
cd-vols=
no-issue=1-2
article-no=
start-page=11
end-page=19
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1992
dt-pub=1992
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on the mechanism of Creola body formation in experimental asthma using guinea pigs
kn-title=気管支喘息における喀痰中の Creola body に関する研究　第2編　モルモットの慢性喘息モデルによる Creola body の形成機序についての検討
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=To carify the mechanism of Creola body formation in the sputum of bronchial asthmatics, guinea pigs were actively sensitized by intraperitoneal injection and provoked bronchial reactions by inhalation of aerosolized ascaris antigen. Then broncholalveolar lavage fluid (BALF) and lung tissue were examined by cytological and histological analyses. Agglomerated bronchial epithelial cells (CrB) appeared in the BALF obtained from guinea pigs in the asthma model. The frequency of CrB in the BALF of guinea pigs in the asthma model tended to increase with increase in the number of daily antigen pigs antigen inhalation and eosino-phils in the BALF. The histological findings of bronchi showed that infitration of eosinophils and submucosal edema in the bronchi, hypertrophy and protrusion of the papillary formation of bronchial epithelial layer to the bronchial lumen, and also desquamation of the layer. These findings were mainly seen at the central bronchi in guinea pigs after 8 days of antigen inhalation. These findings suggest that CrB is formed by the epithelial tissue damage caused by the chemial mediators of eosinophils and also by chronic bronchospasm. Their appearance may be an index for organic tissue damage in the pre-serious stage of asthma.
en-copyright=
kn-copyright=

en-aut-name=IsoshimaKoji
en-aut-sei=Isoshima
en-aut-mei=Koji
kn-aut-name=磯嶋浩二
kn-aut-sei=磯嶋
kn-aut-mei=浩二
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第二内科学教室
en-keyword=Creola body
kn-keyword=Creola body
en-keyword=BALF
kn-keyword=BALF
en-keyword=guinea pig
kn-keyword=guinea pig
en-keyword=asthma model
kn-keyword=asthma model
en-keyword=eosinophil
kn-keyword=eosinophil
END

start-ver=1.4
cd-journal=joma
no-vol=104
cd-vols=
no-issue=1-2
article-no=
start-page=1
end-page=9
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1992
dt-pub=1992
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Clinical significance of Creola body in the sputum of bronchial asthmatics
kn-title=気管支喘息における喀痰中の Creola body に関する研究　第1編　気管支喘息患者喀痰中における Creola body の臨床的意義についての検討
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=To examine the clinicopathology of agglomerated bronchial epithelial cells, i. e. Creola body (CrB), in the sputum, the incidence of CrB stained by Papanicoloaou's method was evaluated in 46 bronchial asthmatics and 10 patients with obstructive pulmonary diseases, and then was compared with the pathogenetic factors of bronchial asthma. CrB was observed specifically in the sputum of bronchial asthmatics. CrB-positive cases had asthma attacks for more than 4 days and a high incidence of eosinophils in the sputum, but not CrB-negative cases. The presence of CrB in the sputum tended to be high in non-atopic asthmatics with a low serum IgE level, but had no significant correlation with either the incidence of neutrophils in the sputum, the present age of patients, the severity of the disease or bronchial hyperresponsiveness to acetylcholine.
 These findines suggest that the involvement of histolesional factors such as persistent bronchial contraction and release of major basic protein from eosinophils in the airway may lead to the formation of CrB. Also the appearance of CrB may be a useful index for pre-serious stage of asthma.
en-copyright=
kn-copyright=

en-aut-name=IsoshimaKoji
en-aut-sei=Isoshima
en-aut-mei=Koji
kn-aut-name=磯嶋浩二
kn-aut-sei=磯嶋
kn-aut-mei=浩二
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第二内科学教室
en-keyword=bronchial asthma
kn-keyword=bronchial asthma
en-keyword=sputum
kn-keyword=sputum
en-keyword=Creola body
kn-keyword=Creola body
en-keyword=eosinophil
kn-keyword=eosinophil
en-keyword=neutrophil
kn-keyword=neutrophil
END