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ID 32680
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Author
Tsai, Ching-Lin
Lin, Tang-Kue
Hung, Mei-Huei
Abstract

<P>Glycocalyx is suggested to play an important role in the pathogenesis of biomaterial-centered infection. Using an accurate and sensitive method to quantify glycocalyx and bacterial adherence, we have demonstrated that the producer of the most glycocalyx also exhibited the highest adherence index, whereas low producers exhibited the least (p less than 0.01). Additionally, at various concentrations the high producer had the greater tendency to adhere and grow on stainless steel wires and tubes (p less than 0.001). The adherence index, referred as the ratio of tritiated thymidine uptake on wires to colony forming units (CFU), was also the highest in high producers. The adherence index increased as the glycocalyx index increased. It was suggested that glycocalyx production enhanced the adherence of Staphylococcus epidermidis to biomaterials and caused persistent and intractable infections. In short, the glycocalyx index and the adherence index can be reliable indices of biomaterial-centered infection.

Keywords
glycocalyx
bacterial adherence
Staphylococcus epidermidis biomaterial infection
colony forming units
Amo Type
Article
Publication Title
Acta Medica Okayama
Published Date
1992-02
Volume
volume46
Issue
issue1
Publisher
Okayama University Medical School
Start Page
11
End Page
16
ISSN
0386-300X
NCID
AA00508441
Content Type
Journal Article
language
English
File Version
publisher
Refereed
True
PubMed ID
Web of Science KeyUT