start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=13
article-no=
start-page=2495
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20190708
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Alpinia zerumbet (Pers.): Food and Medicinal Plant with Potential In Vitro and In Vivo Anti-Cancer Activities
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=BACKGROUND/AIM:Plants play an important role in anti-cancer drug discovery, therefore, the current study aimed to evaluate the biological activity of Alpinia zerumbet (A. zerumbet) flowers.
METHODS:The phytochemical and biological criteria of A. zerumbet were in vitro investigated as well as in mouse xenograft model.
RESULTS:A. zerumbet extracts, specially CH2Cl2 and MeOH extracts, exhibited the highest potent anti-tumor activity against Ehrlich ascites carcinoma (EAC) cells. The most active CH2Cl2 extract was subjected to bioassay-guided fractionation leading to isolatation of the naturally occurring 5,6-dehydrokawain (DK) which was characterized by IR, MS, 1H-NMR and 13C-NMR. A. zerumbet extracts, specially MeOH and CH2Cl2 extracts, exhibited significant inhibitory activity towards tumor volume (TV). Furthermore, A. zerumbet extracts declined the high level of malonaldehyde (MDA) as well as elevated the levels of superoxide dismutase (SOD) and catalase (CAT) in liver tissue homogenate. Moreover, DK showed anti-proliferative action on different human cancer cell lines. The recorded IC50 values against breast carcinoma (MCF-7), liver carcinoma (Hep-G2) and larynx carcinoma cells (HEP-2) were 3.08, 6.8, and 8.7 ?g/mL, respectively.
CONCLUSION:Taken together, these findings open the door for further investigations in order to explore the potential medicinal properties of A. zerumbet.
en-copyright=
kn-copyright=
en-aut-name=ZahraMaram Hussein
en-aut-sei=Zahra
en-aut-mei=Maram Hussein
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=
en-aut-name=SalemTarek A. R.
en-aut-sei=Salem
en-aut-mei=Tarek A. R.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=
en-aut-name=El-AaragBishoy
en-aut-sei=El-Aarag
en-aut-mei=Bishoy
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=
en-aut-name=YosriNermeen
en-aut-sei=Yosri
en-aut-mei=Nermeen
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=
en-aut-name=EL-GhlbanSamah
en-aut-sei=EL-Ghlban
en-aut-mei=Samah
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=
en-aut-name=ZakiKholoud
en-aut-sei=Zaki
en-aut-mei=Kholoud
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=
en-aut-name=MareiAmel H.
en-aut-sei=Marei
en-aut-mei=Amel H.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=
en-aut-name=Abd El-WahedAida
en-aut-sei=Abd El-Wahed
en-aut-mei=Aida
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=
en-aut-name=SaeedAamer
en-aut-sei=Saeed
en-aut-mei=Aamer
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=
en-aut-name=KhatibAlfi
en-aut-sei=Khatib
en-aut-mei=Alfi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=
en-aut-name=AlAjmiMohamed F.
en-aut-sei=AlAjmi
en-aut-mei=Mohamed F.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=
en-aut-name=ShathiliAbdulrahman M.
en-aut-sei=Shathili
en-aut-mei=Abdulrahman M.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=
en-aut-name=XiaoJianbo
en-aut-sei=Xiao
en-aut-mei=Jianbo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=13
ORCID=
en-aut-name=KhalifaShaden A. M.
en-aut-sei=Khalifa
en-aut-mei=Shaden A. M.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=14
ORCID=
en-aut-name=El-SeediHesham R.
en-aut-sei=El-Seedi
en-aut-mei=Hesham R.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=15
ORCID=
affil-num=1
en-affil=Division of Chemistry and Biotechnology, Graduate School of Natural Science and Technology, Okayama University
kn-affil=
affil-num=2
en-affil=Department of Biochemistry, College of Medicine, Qassim University
kn-affil=
affil-num=3
en-affil=Division of Chemistry and Biotechnology, Graduate School of Natural Science and Technology, Okayama University
kn-affil=
affil-num=4
en-affil=Department of Chemistry, Faculty of Science, Menoufia University
kn-affil=
affil-num=5
en-affil=Biochemistry Division, Chemistry Department, Faculty of Science, Menoufia University
kn-affil=
affil-num=6
en-affil=Department of Chemistry, Faculty of Science, Menoufia University
kn-affil=
affil-num=7
en-affil=Department of Chemistry, Faculty of Science, Menoufia University
kn-affil=
affil-num=8
en-affil=Department of Chemistry, Faculty of Science, Menoufia University
kn-affil=
affil-num=9
en-affil=Department of Chemistry, Quaid-i-Azam University
kn-affil=
affil-num=10
en-affil=Department of Pharmaceutical Chemistry, Faculty of Pharmacy, International Islamic University Malaysia
kn-affil=
affil-num=11
en-affil=Pharmacognosy Group, College of Pharmacy, King Saud University
kn-affil=
affil-num=12
en-affil=Al-Rayan Research and Innovation Center, Al-Rayan Colleges
kn-affil=
affil-num=13
en-affil=Institute of Chinese Medical Sciences, University of Macau
kn-affil=
affil-num=14
en-affil=Clinical Research Centre, Karolinska University Hospital
kn-affil=
affil-num=15
en-affil=Department of Chemistry, Faculty of Science, Menoufia University
kn-affil=
en-keyword=Alpinia zerumbet
kn-keyword=Alpinia zerumbet
en-keyword=5,6-dehydrokawain
kn-keyword=5,6-dehydrokawain
en-keyword=Ehrlich ascites carcinoma
kn-keyword=Ehrlich ascites carcinoma
en-keyword=anti-tumor
kn-keyword=anti-tumor
en-keyword=anti-oxidant
kn-keyword=anti-oxidant
END