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Author
Okada, Masahiro Department of Biomaterials, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University ORCID Kaken ID
Hara, Emilio Satoshi Department of Biomaterials, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
Yabe, tsushi Department of Biomaterials, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
Okada, Kei Department of Applied Chemistry and Biotechnology, Faculty of Engineering, Okayama University
Shibata, Yo Department of Conservative Dentistry, Division of Biomaterials and Engineering, Showa University School of Dentistry
Torii , Yasuhiro Department of Comprehensive Dentistry, Okayama University Hospital
Nakano, Takayoshi Division of Materials and Manufacturing Science, Graduate School of Engineering, Osaka University
Matsumoto, Takuya Department of Biomaterials, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University Kaken ID researchmap
Abstract
A variety of polymer‐ and ceramic‐based soft‐tissue adhesives have been developed as alternatives to surgical sutures, yet several disadvantages regarding the mechanical properties, biocompatibility, and handling hinder their further application particularly when applied for immobilization of implantable devices. Here, it is reported that a biocompatible and tough metal, titanium (Ti), shows instant and remarkable adhesion properties after acid treatment, demonstrated by ex vivo shear adhesion tests with mouse dermal tissues. Importantly, in vivo experiments demonstrate that the acid‐treated Ti can easily and stably immobilize a device implanted in the mouse subcutaneous tissue. Collectively, the acid‐treated Ti is shown as a solid‐state instant adhesive material for biological soft tissues, which can have diverse applications including immobilization of body‐implantable devices.
Keywords
acid treatment
adhesive
hydrophobic interaction
soft tissue
titanium
Published Date
2020-05-07
Publication Title
Advanced Materials Interfaces
Volume
volume7
Issue
issue9
Publisher
Wiley
Start Page
1902089
ISSN
2196-7350
Content Type
Journal Article
language
英語
OAI-PMH Set
岡山大学
Copyright Holders
© 2020 The Authors.
File Version
publisher
DOI
Web of Science KeyUT
Related Url
isVersionOf https://doi.org/10.1002/admi.201902089
License
https://creativecommons.org/licenses/by-nc-nd/4.0/
Funder Name
Japan Society for the Promotion of Science
助成番号
18K09637
JP25220912
JP25293402