Elsevier B.V. Acta Medica Okayama 1742-7061 57 2017 Biocompatible nanostructured solid adhesives for biological soft tissues 404 413 EN Masahiro Okada Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University Akira Nakai Department of Biomaterials, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University Satoshi Hara Emilio Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University Tetsushi Taguchi Polymeric Biomaterials Group, RCFM, National Institute for Materials Science Takayoshi Nakano Division of Materials and Manufacturing Science, Graduate School of Engineering, Osaka University Takuya Matsumoto Department of Biomaterials, Okayama University Over the past few years, the development of novel adhesives for biological soft tissue adhesion has gained significant interest. Such adhesives should be non-toxic and biocompatible. In this study, we synthesized a novel solid adhesive using nanostructured hydroxyapatite (HAp) and evaluated its physical adhesion properties through in vitro testing with synthetic hydrogels and mouse soft tissues. The results revealed that HAp-nanoparticle dispersions and HAp-nanoparticle-assembled nanoporous plates showed efficient adhesion to hydrogels. Interestingly, the HAp plates showed different adhesive properties depending upon the shape of their nanoparticles. The HAp plate made up of 17 nm-sized nanoparticles showed an adhesive strength 2.2 times higher than that of the conventional fibrin glue for mouse skin tissues. No potential conflict of interest relevant to this article was reported.