Osimertinib inhibits the MYLK4-mediated phosphorylation of CDKAL1 to suppress stemness and chemoresistance in rhabdomyosarcoma

ITANO, Takuto

doi:10.1038/s41392-025-02548-6

ID	70693
Title Alternative	オシメルチニブはMYLK4依存的なCDKAL1リン酸化を阻害し横紋筋肉腫におけるがん幹細胞性と化学療法耐性を抑制する
FullText URL	K0007565_abstract_review.pdf 358 KB K0007565_fulltext.pdf 1.09 MB K0007565_other.pdf 1.59 MB K0007565_summary.pdf 19.5 KB
Author	ITANO, Takuto Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
Note	岡山大学審査学位論文 Itano, T., Huang, R., Ozaki, T. et al. Osimertinib inhibits the MYLK4-mediated phosphorylation of CDKAL1 to suppress stemness and chemoresistance in rhabdomyosarcoma. Sig Transduct Target Ther 11, 26 (2026). https://doi.org/10.1038/s41392-025-02548-6
Published Date	2026-03-25
Content Type	Thesis or Dissertation
Grant Number	甲第7565号
Granted Date	2026-03-25
Thesis Type	Doctor of Philosophy in Medical Science
Grantor	岡山大学
Thesis FullText	Thesis or Dissertation (See FullText URL)
Related Url	isVersionOf https://doi.org/10.1038/s41392-025-02548-6
language	English
File Version	ETD
Grant ID	15301甲第7565号
PubMed ID	41565624
Copyright Holders	© The Author(s) 2026
DOI	10.1038/s41392-025-02548-6
License	http://creativecommons.org/licenses/by/4.0/