The mutual effects of N0(2) + Cd(2+) and N0(2) + Zn(2+) on the mitochondrial membrane.

The mutual effects of NaNO(2) + CdCl(2) and NaNO(2) + ZnCl(2) on the oxidative phosphorylation of rat liver mitochondria were examined and following results were obtained. (1) Mixed solution of NaNO(2) and CdCl(2) more decreases respiratory control index at any concentration of NaNO(2) (0-8.6mM) than the index without addition of 4.3μM CdCl(2) respectively. (2) Mixed sollution of CdCl(2) and NaNO(2) more decreases respiratory control index at any concentration of CdCl(2) (0-10μM) than the index without addition of 5mM NaNO(2) respectively. (3) Mixed sollution of NaNO(2) and ZnCl(2) more decreases relative activity of State-3 and dinitrophenol stimulated respiration at any concentration of NaNO(2) (0-8.6mM) than the activity without addition of 4.3μM ZnCl(2) respectively. (4) Mixed sollution of ZnCl(2) and NaNO(2) more decreases relative activity of State-3 and dinitrophenol stimulated respiration at any concentration of ZnCl(2) (0-10μM) than the activity without addition of 5mM NaNO(2) respectively.