Basic Studies on Metastatic Activity of Malignant Tumors Part I. A Study on Fibrinolytic Activity in the Malignant Tumors and the Host Tissues

In standard plate, supernatants of the crushed tissues of both stomach carcinomas and gastric mucous membrane without any carcinoma yielded a strong fibrinolysis. In general carcinoma tissues were remarkably activated by adding streptokinase in the supernatants. It is presumed that those phenomena indicate a increasing tendency of proactivator and activator in both tissues. Fibrinolytic activity is in high degree in epithelial tissue comparing with none epithelial tissue and brain tissue. In heated plate, fibrinolysis caused by any kind of crashed gastric carcinoma tissue is strong and not affected by streptokinase. Therefore, increased quantity of plasmin or protease like substance might be assumed in the carcinoma tissue. Fibrinolysis of epithelial element is stronger in heated plate than that of none-epithelial tissue and brain tissue. Those result indicated that there is a certain relationship among the lytic activity of protein substrate, metastatic ability and primaly tissue of the tumors.