The study of measles virus in dog kidney cultured cells Part II. Comparative observation of sensitivity and pathogenic morphological changs to measles virus infection of dog kidney cells and other kinds of cultured cells

A comparative study on the susceptibility of measles virus and pathological changes of cells in culture was carried out with dog kidney cells and many other cultured cells by inoculating measles virus into the media of cultures. As the result it was found that FL cells and HeLa cells demonstrated the highest infectivity, followed by that of dog kidney cells. Monkey cells (MS cells) and human amnion cells (JJC-3 cells) also showed a fair degree of infectivity to measles virus (the report on such cells has not yet been made public). On the other hand, L cells and hamster kidney cells, what had been generally reported to be readily infected by measles virus were found to show a low infectivity only, indicating them to be not suitable cells for such a study. In the case of dog kidney cells infected with measles virus, viral proliferation could be observed clearly during the period 4 to 7 days after the inoculation.