Studies on Treatment of Wakana Disease Ⅱ. A new method of treatment of Wakana disease

In view of the anchylostomocidal effect against hookworm larvae as reported in the Part I of the present studies, chloroquine diphosphate, Stibnal and Mapharsen were used to treat the lung symptoms of Wakana disease, and the results obtained are as follows. 1. Chloroquine diphosphate administered intravenously proved to be effective in all the cases treated. There were no side effects and its prolonged administration was possible. Chloroquine diphosphate was far superior to the other two agents. 2. Chloroquine diphosphate was less effective when administered orally than administered intravenously, although the former method of administration was more convenient and feasible. 3. Although the effect of Stibnal was somewhat inferior to that of chloroquine diphosphate and its intravenous injection was sometimes followed by a transient increase of cough, the drug was nevertheless worthy of use. 4. The effect of Mapharsen was inferior to the above two drugs and its side effects were more often encountered. 5. From these data, a conclusion may be drawn that chloroquine diphosphate, particularly when administered intravenously, is indeed dramatic in relieving the lung symptoms of Wakana disease.