Experimental Studies on Hypersplenism Part 1 Experimental Splenic Anemia by Abdominal Sympathectomy of Splenic Branches

After the abdominal sympathectomy of splenic branches in nomal rabbits, the auther studied the blood and bone marrow pictures and iron metaborism, and obtained the following results. 1) In the peripheral blood picture a transient decrease in the erythrocyte count, hemoglobin content and platelet count could be observed. 2) In the bone marrow picture an increase and inhibition of maturation in the erythroid system could be observed. 3) Serum iron decreased conspicuously. However, the depot iron was as usual or increased a little. 4) In the bone marrow picture a little decrease in Sideroblast could be observed. 5) In the serum and spleen extracts, the existence of anemia producing toxic factor could not be observed. 6) From these observation, the author concluded that the principal cause of this anemia produced by ligating splenic and coronary Veins of the stomach lay in the inhibition on the mobilization of depot iron.