Metabolism of γ-Aminobutyric Acid Part 1. Incorporation of γ-Aminobutyric Acid into Mouse Organs

An attempt was made to make a study on an incorporation of GABA with brain when it was administered to a mouse abdominal cavity. 1) When 0.5 mg per body gram weight of GABA was administered, the content in the mouse brain was not changed, although the one in the liver was rapidly and yet temporarily increased. 2) A one week successive administration, 0.3 mg per body gram weight of daily dosage could not make any change of the content in the brain. 3) A study with (14)C-GABA revealed a rapid temporary incorporation with the liver and the kidney and, in contrast, considerbly little with the brain.