Oxidation of G-6-P, 6-P-G and R-5-P in the Epileptic Cerebral Cortex

The oxidations of G-6-P, 6-P-G and R-5-P in the human epileptic cerebral cortex were measured by Warburg's manometer and compared with those of non-epileptic cerebral cortex. The results were as follows: 1) The oxidation of G-6-P, 6-P-G and R-5-P in epileptic cerebral cortex, showed stronger tendency to be controlled than that of the non-epileptic. 2) The oxidation of G-6-P and 6-P-G were more accerelated by the addition of TPN in both cases, and then the difference of oxidation in the each cases of epileptic and non-epileptic cerebral cortex became less. 3) From the facts mentioned above, it is considered that the shunt pathway of glucose metabolism, i. e. Warburg-Dickens scheme, exists in the brain also as in the liver.