Studies on the Metabolism of Iron and Copper in Hypoplastic Anemia Part 2. The Effect of the Toxic Factor (Anemia-Inducing Substance) in the Serum of the Patient with Hypoplastic Anemia on the Iron and Copper Metabolisms of Rabbits

The following results were obtained by the serum injections of the patient suffering from hypoplastic anemia to rabbits 1. The serum iron evidently increased, and the repeated injections were more effective than a single injection; and furthermore, the effectiveness of such injections increased with each additional injection. The serum copper increased slightly, but the difference between the repeated injections and the single one was hardly observable in this instance. 2. By the repeated injections the urine iron tended to increase, but the urine copper showed no marked change. 3. In the fractional estimation of the visceral non-hemin iron by the same method, the fraction Ⅲ increased in all viscera and the visceral copper showed a pronounced increase in the liver.