Studies on the Anticonvulsive Effects of Diamox Part Ⅱ. The Effects of Diamox on the Free Amino Nitrogen in the Brain

The effects of Diamox on the free amino nitrogen in cats brain were measured The experiments were performed by Van-Slyke method taking the samples at 9 and 24 house respectively after the injection of Diamox. Concerning about the mean values of each 8 cases, the free aminonitrogen showed 25.9% increase at 9 hours, while 37.3% decrease at 24 house than the normal values. The anticonvulsive effects of Diamox were considered to be based on the ammonium management accompanying with the increases of glutamic acid. On the contrary, the decreases of the free amino nitrogen were considered to be based on the lack of the sources of glutamic acid synthesis.