Studies of Thoracic Duct Lymph Ⅱ. Changes of Characteristic of Thoracic Duct Lymph by the Administration of Allyl Formate and Influcences of Several Drugs on It

Vicissitudes of flowing lymph volume, total protein contents, albumin, globulin, A/G ratio, fibrinogen, and of non-protein nitrogen were followed by the administration of allyl formate on the thoracic duct-fistled dogs, and influences of desoxycorticosterone acetate, Acther, cortison, and glucuronic acid on the vicissitude were studied to get the following resulls: 1. Averaged flowing lymph volume on 25 sound dogs at 10 minutes from the thoracic duct-fistle formation was 3.5 cc, total protein nitrogen 511 mg, albumin nitrogen 266 mg/100 cc, globulin nitrogen 171 mg/100 cc, A/G ratio 1.35, fibrinogen nitrogen 33 mg/100 cc, and non-protein nitrogen was 31 mg/100 cc. 2. Administration of allyl formate brought an increase on flowing lymph volume and total protein contents, and the increase was apparent on albumin fraction in the early stage and on globulin fraction in the end stadium. A/G ratio, therefore, increased temporally in the early stage, and afterward the value reduced gradually to reach below that before the administration of allyl formate. Both fibrinogen and non-protein nitrogen increased. These results may suggest that allyl formate brings serous inflammatory process. 3. Administration of Syncorta, a preparate of desoxycorticosterone acetate, brought inhibition of increases of thoracic duct lymph volume and total protein volume, decrease of A/G ratio, and increase of fibrinogen on the allyl fomate-administered dog. It may be concluded that desoxycorticosterone acetate recovers the serous inflammatory process which has been brought by the administration of allyl formate. 4. No definite influence of Acther could be seen on both the sound and the allyl formate-administered with an exception of an increase of thoracic duct lymph volume by a small dosage of Acther. 5. A large dosage of Cortone, a preparate of cortisone, inhibited the serous inflammatory process temporally, but a small one on the contrary brought a remarkable increase of thoracic duct lymph volume. 6. Though temporary, Guronsan, a preparate of glucuronic acid, inhibited the serous inflammatory process induced by the administration of allyl formate.