Studies on the Phosphoric Acid Metabolism of the Brain with Radioactive Isotope (32)P Part 3. The Influences of various Drugs on the Phophoric Acid Metabolism of the Brain

With the purpose to study the influences of chlorpromazine and cardiazol on the phosphoric acid metabolism of the brain the author studied the changes in the mode of the migration of (32)P that had been previously injected into the cisterna magna of test animals (rabbits). As the results it has been found that the phosphoric acid metabolism in the brain is generally inhibited by the chlorpromazine administration, especially (32)P migration to phospholipid fractions is markedly suppressed. And by the cramp due to cardiazol administration the amount of (32)P migrating to acid-soluble fractions both organic and inorganic is increased, while the same to phospholipid fraction, nucleic acid fraction and phosphoprotein fraction is decreased.