Experimental Study on the Intravenous HCl-procaine Treatment for Anuria and Oliguria Part I. Study by the Renal Clearance Method

The author has studied on the effect of intravenous HCl-procaine treatment for oliguria caused by hemolyzed blood administration, anestesia, operation, burn and corrosive sublimate intoxication, by means of renal clearance method. 1. The clearance level fell down in every case manipulated as above, and it was remarkable especially in the cases of burn and corrosive sublimate intoxication. 2. For these kidney insufficiencies intravenous HCl-procaine administration had result of restoring the urinary quantity, approximately up to 100% in every case. 3. By that treatment the urea clearance showed marked improvement, renal blood flow and glomerular filtration rate were increased from 10 to 100% in every case. 4. Those effects were remakable in the case of hemolyzed blood administration, anesthesia and especially in burn case, but were not expectable in the case of operation and corrosive sublimate intoxication. because of the extreme burden and of the marked organic changes in rabbits respectively.