The α-type streptococci and cow sera with phosphatid obtained from the cerebral grey matter of cows were given as antigen in the auricular vein of adult rabbits. The effective injections were repeatedly performed for 10 months after the last sensitisation and then the animals were let alone for 4-6 months without any management.
Thus the chronic local cerebral anaphylactic rabbits were made. And the glycolysis and tissue respiration in the specimens of the cortex were investivestigated with Warburg's apparatus. Both of glycolysis and tissue respiration in the group of anaphylactic rabbits generally showed lower values than those in the group of normal rabbits, especially that in the group of cow sara with phosphatid was more marked. The Meyerhof's index showed no difference from the normal.