Activation Energh for Rat's Brain Tissue Respiration III. Influence of Chlorpromazin Addition on Activation Energy for Respiration Enzym System of Untreated Rat's Whole Brain Homogenate

The author studied the effects of chlorpromazin 1.5 × 10(-4) M on the activation energy of respiration of whole brain homogenate of rats and obtained the results as follows: namely, by loading chlorpromazin 1.5 × 10(-4) M the rate of oxygen absorption decreases about 17-31 per cent, but the activation energy has been found to be about 10, 800 cal. This meàns that the value is the same as in the case without addition of chlorpromazin; and consequently the rate determining reaction is also identical.