Relation of the Heinz body in Erythrocyte with Isonicotinic acid Hydrazid and Nitromin

Experimental studies in both vitro and in vivo on the relation of the Heinz body in erythrocytes with the drug having NH(2)-radical, isonicotinic acid (INAH) and the nitromin (NMO) have been attempted and the results obtained were reported as follows: 1. There seems to be practically no influence on the formation of Heinz body in erythrocytes in vitro of the concentration less than INAH 100mg/dl or NMO 10mg/dl of these drugs used. However, it was found that the formation of Heinz body in erythrocytes could be accelerated in vitro of the drug concentration above INAH 500mg/dl or NMO 50mg/dl. 2. Heinz body in erythrocytes of the circulating blood did not appear when rabbits were administered orally of INAH (4mg/kg pro die) for 17 days; while the Heinz body would show up in the erythrocytes when NMO was intravenously given to rabbits for 30 days, (0.5mg/kg pro die for a period of 18 days and 2mg/kg pro die for remaining 12 days).