EXPERIMENTAL STUDIES ON JAPANESE B ENCEPHALITIS. 1. HAEMOGRAMS OF THE MICE INFECTED WITH JAPANESE B ENCEPHALITIS AND THE EFECTS OF RADIOACTVE P(32) ADMINISTRATION

Comparative studies on the haemograms of the mice infected with Japanese B encephalitis with or without the administration of radioactive P(32) were made. 1. In the haemogram of the infected mouse a decrease in the number of white blood cells was observed along with the duration, although there occurred no appreciable amount of changes in the numbers of red blood cells and reticulocytes and in the quantity of haemoglobin. This drop in the number of while blood cells was especially remarkable during the infection period. The classification of the white blood cells showed an increase in the percentage of neutrophilic leucocytes and a decrease in the absolute number of lymphocytes. 2. The administration of radio active P(32) to the normal mouse caused some haemogramaberrations, proportional to the amounts of doses: When 30 μc. p(32) was given, the numbers of red blood cells and reticulocytes and ihe quantity of haemogIobin remaining the same as usual, the number of white blood cells showed a considerable decrease, its minimum value appearing 4 or 5 days after the admininistration. 40 μc. dose gave rise to a slight decrease in the numbers of red blood.cells and reticuloocytes and in the quantity of haemoglobin, the decrease in white blood cell number being far more remarkable than that caused by 30 μc. administration. In both of these two cases, the increases in the percentage of neutrophilic leucocytes and the decreases in the absolute number of lymphocytes were also observed. 3. 30 μc. P(32) administration to the infected mouse induced no significant changes in the numbers of red blood cells and reticulocytes and in the quantity of haemo gIobin, but the number of leucocytcs showed a more marked decrease than that of the infected mouse with no P(32) administration, the increase in the percentage of neutrophilic leucocytes having been depressed. In addition, the elongation of the latent period for Encephalitis of the mice were recognized.

日本腦炎特輯號 II （岡山大学脳炎委員會）