Clinical significance of anti-asialoglycoprotein receptor autoantibodies, detected by a capture-immunoassay, in autoimmune liver diseases

In the development of autoimmune chronic acive hepatitis (AIH), the pathogenic relevance of antimmune responses against asialoglycoprotein recepter (ASGPR) has been implicated. We have previously developed a capture enzyme-linked immunsorbent assay (ELISA) for detection of anti-ASGPR antibodies and found a high prevalence of anti-ASGPR antibodies in AIH and primary biliary cirrhosis (PBC). IN this study, to clarify the clinical singnifi-cance of the measurement of anti-ASGPR antibodies in autimmune live diseases we studied correlations between thee isotype of the anti-ASGPR antibody.In AIH, the anti-ASGPR antibody titer was positively correlated with serum γ-globulin and IgM values, but not with serum transaminase. The anti-ASGPR antibody titer in histogically-active disease with piecmeal necrosis was signififcantly higher then that in quiescent disease. The most common Isotype of anti-ASGPR antibodies detected in active AIH was IgM. We encountered a case of AIH where the tirer of IgM anti-ASGPR antibody decreased by induction of remission with steroid therapy. These results suggest that the measurement of IgM isotope anti-ASGPR antiody might be useful for the evaluation of disease activity and effects of therapy in AIH patients.

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