Metallothionein messenger RNA regulation in the macular mutant mouse: An animal model of Menkes's kinky-hair disease

MT-mRNA levels in tissue were measured in normal and macular mutant mice. The MT-mRNA level in tissues (kidney, intestine, liver, brain, spleen, thymus, lung and heart) of 7-day-old mutants was not changed compared to normal mice. Kidney MT-mRNA levels in the mutant foetus at 18 days of gestation and in the 3- and 7-day-old mutant were not changed compared compared to normal mice, with the exception of the 1-day-old mutant. Intestine and liver MT-mRNA levels in the mutant foetus at 18 days gestation and in the 1-, 3- and 7-day-old mutant were not changed compared to normal mice.