ID 55854
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Author
Takahashi, Yuko Department of Breast and Endocrine Surgery, Okayama University Hospital
Shien, Tadahiko Department of Breast and Endocrine Surgery, Okayama University Hospital
Sakamoto, Ai Department of Obstetrics and Gynecology, Okayama University Hospital
Tsuyumu, Yuko Department of Nursing, Okayama University Hospital
Yoshioka, Ryo Department of Breast and Endocrine Surgery, Okayama University Hospital
Uno, Maya Department of Breast and Endocrine Surgery, Okayama University Hospital
Hatono, Minami Department of Breast and Endocrine Surgery, Okayama University Hospital
Kochi, Mariko Department of Breast and Endocrine Surgery, Okayama University Hospital
Kawada, Kengo Department of Breast and Endocrine Surgery, Okayama University Hospital
Tsukioki, Takahiro Department of Breast and Endocrine Surgery, Okayama University Hospital
Iwamoto, Takayuki Department of Breast and Endocrine Surgery, Okayama University Hospital
Ikeda, Hirokuni Department of Breast and Endocrine Surgery, Okayama University Hospital
Taira, Naruto Department of Breast and Endocrine Surgery, Okayama University Hospital
Matsuoka, Junji Department of Palliative and Supportive Medicine, Okayama University Hospital
Nakatsuka, Mikiya Department of Obstetrics and Gynecology, Okayama University Hospital
Doihara, Hiroyoshi Department of Breast and Endocrine Surgery, Okayama University Hospital
Abstract
Adverse effects on fertility are a significant problem for premenopausal breast cancer patients. Since April 2009, we have been referring young patients for fertility counseling provided by a multidisciplinary team. Here we evaluated the efficacy and safety of our current fertility preservation approach. We retrospectively analyzed the cases of 277 patients < 45 years old at diagnosis, which was made between 2009 and 2016. Seventy-two (26%) patients received fertility counseling. Seventeen (6%) of the 277 patients decided to preserve their fertility before starting adjuvant systemic therapy. Six (35%) patients underwent oocyte cryopreservation, and 11 (65%) married patients opted for embryo cryopreservation. There were no pregnancies among the patients undergoing oocyte cryopreservation, whereas 3 (27%) of the patients who opted for embryo cryopreservation became pregnant. Two (12%) patients stopped endocrine therapy after 2 years in an effort to become pregnant, but their breast cancers recurred. Though the problem of fertility loss for breast cancer patients is important and we should assess the infertility risk for all patients, we should also consider the prognosis. In June 2016, we launched a prospective multicenter cohort study to evaluate the efficacy and safety of fertility preservation in greater detail.
Keywords
fertility preservation
multidisciplinary
breast cancer
young patients
Amo Type
Original Article
Published Date
2018-04
Publication Title
Acta Medica Okayama
Volume
volume72
Issue
issue2
Publisher
Okayama University Medical School
Start Page
137
End Page
142
ISSN
0386-300X
NCID
AA00508441
Content Type
Journal Article
language
英語
Copyright Holders
CopyrightⒸ 2018 by Okayama University Medical School
File Version
publisher
Refereed
True
PubMed ID