ID 32047
JaLCDOI
FullText URL
Author
Watanabe, Akiharu
Higashi, Toshihiro
Nagashima, Hideo
Abstract

A reproducible animal model of fulminant hepatic failure was developed by intraperitoneal administration of D-galactosamine hydrochloride to Sprague-Dawley rats. Biochemical and morphological hepatic injury and brain edema resembled human fulminant hepatic failure. This model would facilitate further studies of the pathogenesis of brain dysfunction and evaluation of treatment in fulminant hepatic failure.

Keywords
fulminant hepatic failure
brain edema
massive liver injury
hepatic encephalopathy
Amo Type
Article
Publication Title
Acta Medica Okayama
Published Date
1979-12
Volume
volume33
Issue
issue6
Publisher
Okayama University Medical School
Start Page
443
End Page
450
ISSN
0386-300X
NCID
AA00508441
Content Type
Journal Article
language
English
File Version
publisher
Refereed
True
PubMed ID
NAID