| URI | http://ousar.lib.okayama-u.ac.jp/metadata/48261 |
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| フルテキストURL | 66_2_111.pdf.pdf ( 1.5MB ) 公開日 2012-05-02
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| タイトル | Neurite Outgrowth of PC12 Mutant Cells Induced by Orange Oil and d-Limonene via the p38 MAPK Pathway |
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| 著者 | | 著者 | |
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| Author | Motoda Hirotoshi |
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| 著者 | |
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| Author | Kasanami Yoshiko |
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| 抄録 | We studied the effects of natural essential oil on neurite outgrowth in PC12m3 neuronal cells to elucidate
the mechanism underlying the action of the oils used in aromatherapy. Neurite outgrowth can be induced by nerve growth factor (NGF), where ERK and p38 MAPK among MAPK pathways play important roles in activating intracellular signal transduction. In this study, we investigated whether d-limonene, the major component of essential oils from oranges, can promote neurite outgrowth in PC12m3 cells, in which neurite outgrowth can be induced by various physical stimulations. We also examined by which pathways, the ERK, p38 MAPK or JNK pathway, d-limonene acts on PC12m3 cells. Our results showed that neurite outgrowth can be induced when the cells are treated with d-limonene. After treatment with d-limonene, we observed that p38 MAPK is strongly activated in PC12m3 cells, while ERK is weakly activated. In contrast, JNK shows little activity. A study using an inhibitor of p38 MAPK revealed that neurite outgrowth in PC12m3 cells is induced via the activation of p38 MAPK by d-limonene. The results thus indicate that d-limonene may promote neural cell differentiation
mainly via activation of the p38 MAPK pathway. |
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| キーワード | essential oil
d-limonene
p38 MAP kinase
PC12 mutant cells
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| 発行日 | 2012-04 |
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| 出版物タイトル | Acta Medica Okayama |
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| 巻 | 66 |
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| 号 | 2 |
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| 出版者 | Okayama University Medical School |
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| 開始ページ | 111 |
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| 終了ページ | 118 |
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| ISSN | 0386-300X |
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| NCID | AA00508441 |
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| 資料タイプ | 学術雑誌論文 |
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| 本文言語 | 英語
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| OAI-PMH Set | 岡山大学
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| 著作権者 | CopyrightⒸ 2012 by Okayama University Medical School |
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| 論文のバージョン | publisher |
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| PubMed ID | 22525469
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| Amo Type | Original Article |
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