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ID 51443
フルテキストURL
著者
Tayra, Judith Thomas Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Neurol Surg
Kameda, Masahiro Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Neurol Surg
Yasuhara, Takao Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Neurol Surg
Agari, Takashi Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Neurol Surg
Kadota, Tomohito Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Neurol Surg
Wang, Feifei Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Neurol Surg
Kikuchi, Yoichiro Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Neurol Surg
Liang, Hanbai Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Neurol Surg
Shinko, Aiko Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Neurol Surg
Wakamori, Takaaki Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Neurol Surg
Vcelar, Brigitta Polymun Sci GmbH
Weik, Robert Polymun Sci GmbH
Date, Isao Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Neurol Surg
抄録
Parkinson's disease is characterized by progressive degeneration of dopaminergic neurons. Thus the development of therapeutic neuroprotection and neurorescue strategies to mitigate disease progression is important. In this study we evaluated the neuroprotective/rescue effects of erythropoietin Fc fusion protein (EPO-Fc) and carbamylated erythropoietin Fe fusion protein (CEPO-Fc) in a rat model of Parkinson's disease. Adult female Sprague-Dawley rats received intraperitoneal injection of EPO-Fc, CEPO-Fc or PBS. Behavioral evaluations consisted of rota-rod, cylinder and amphetamine-induced rotation tests. In the neuroprotection experiment, the CEPO-Fc group demonstrated significant improvement compared with the EPO-Fc group on the amphetamine-induced rotation test throughout the four-week follow-up period. Histologically, significantly more tyrosine hydroxylase (TH)-positive neurons were recognized in the substantia nigra (SN) pars compacta in the CEPO-Fc group than in the PBS and EPO-Fc groups. In the neurorescue experiment, rats receiving CEPO-Fc showed significantly better behavioural scores than those receiving PBS. The histological data concerning striatum also showed that the CEPO-Fc group had significantly better preservation of TH-positive fibers compared to the PBS and EPO-Fc groups. Importantly, there were no increases in hematocrit or hemoglobin levels in the CEPO-Fc group in either the neuroprotection or the neurorescue experiments. In conclusion, the newly developed CEPO-Fc might confer neuroprotective and neurorescue benefits in a rat model of Parkinson's disease without the side effects associated with polycythemia. CEPO-Fc might be a therapeutic tool for patients with Parkinson's disease.
キーワード
Carbamylated erythropoietin
Dopamine
Neuroprotection
Neurorescue
Parkinson's disease
発行日
2013-03-28
出版物タイトル
Brain Research
1502巻
出版者
Elsevier Science Bv
開始ページ
55
終了ページ
70
ISSN
0006-8993
資料タイプ
学術雑誌論文
オフィシャル URL
http://dx.doi.org/10.1016/j.brainres.2013.01.042
関連URL
http://ousar.lib.okayama-u.ac.jp/metadata/51453
言語
English
OAI-PMH Set
岡山大学
著作権者
(C) 2013 Elsevier B.V. All rights reserved.
論文のバージョン
author
査読
有り
DOI
Web of Sience KeyUT