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ID 56686
フルテキストURL
著者
Abdel‐Sattar, El‐Shaymaa Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
Miyoshi, Shin‐ichi Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
Elgaml, Abdelaziz Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
抄録
Vibrio mimicus is an estuarine bacterium, while it can cause severe diarrhea, wound infection, and otitis media in humans. This pathogen secretes a relatively important toxin named V. mimicus metalloprotease (VMP). In this study, we clarified regulation of the VMP production according to the quorum-sensing master regulatory protein named LuxR. First, the full length of luxR gene, encoding LuxR, was detected in V. mimicus strain E-37, an environmental isolate. Next, the putative consensus binding sequence of LuxR protein could be detected in the upstream (promoter) region of VMP encoding gene, vmp. Finally, the effect of disruption of luxR gene on the expression of vmp and production of VMP was evaluated. Namely, the expression of vmp was significantly diminished by luxR disruption and the production of VMP was severely altered. Taken together, here we report that VMP production is under the positive regulation of the quorum-sensing master regulatory protein, LuxR.
キーワード
LuxR protein
Metalloprotease
Quorum-sensing
Vibrio mimicus
備考
This is an Accepted Manuscript of an article published by WILEY-BLACKWELL
発行日
2016-05-10
出版物タイトル
Journal of Basic Microbiology
56巻
10号
出版者
WILEY-BLACKWELL
開始ページ
1051
終了ページ
1058
ISSN
0233111X
NCID
AA10522008
資料タイプ
学術雑誌論文
言語
English
OAI-PMH Set
岡山大学
論文のバージョン
author
PubMed ID
DOI
Web of Science KeyUT
関連URL
isVersionOf https://doi.org/10.1002/jobm.201600002
プロジェクト
インド感染症共同研究