このエントリーをはてなブックマークに追加
ID 53518
フルテキストURL
31_2103.pdf 157 KB
著者
座間味 義人 岡山大学大学院医歯薬学総合研究科臨床薬学分野 ORCID Kaken ID publons researchmap
高取 真吾 日本新薬創薬研究所
合田 光寛 岡山大学大学院医歯薬学総合研究科臨床薬学分野
小山 敏広 岡山大学大学院医歯薬学総合研究科臨床薬学分野 ORCID Kaken ID publons researchmap
岩谷 有希子 岡山大学大学院医歯薬学総合研究科臨床薬学分野
Jin, Xin 岡山大学大学院医歯薬学総合研究科臨床薬学分野
Takada-Doi, Shima 山田養蜂場本社研究開発部
川﨑 博己 岡山大学大学院医歯薬学総合研究科臨床薬学分野 Kaken ID publons
抄録
Royal jelly (RJ) is known to contain excellent nutrition and a variety of biological activities. The present study was designed to investigate the effects of RJ on insulin resistance (hyperinsulinemia) in fructose-drinking rats (FDR; insulin resistance animal model). Male Wistar rats (6 weeks old) received 15% fructose solution in drinking water for 8 weeks. FDR showed significant increases in plasma levels of insulin and triglyceride, Homeostasis Model Assessment ratio (HOMA-R, an index of insulin resistance), and systolic blood pressure, but not blood glucose levels, when compared with control rats. RJ (100, 300mg/kg, p.o.) treatment for 8 weeks significantly decreased the plasma levels of insulin and triglyceride, HOMA-R, without affecting blood glucose or total cholesterol levels and tended to lower systolic blood pressure. In isolated and perfused mesenteric vascular beds of FDR, RJ treatment resulted in a significant reduction in sympathetic nerve-mediated vasoconstrictor response to periarterial nerve stimulation (PNS) and tended to increase the calcitonin gene-related peptide (CGRP) nervemediated vasodilator response to PNS, compared with those in untreated FDR. However, RJ treatment did not significantly affect norepinephrine-induced vasoconstriction or CGRP-induced vasodilation. These results suggest that RJ could be an effective functional food to prevent insulin resistance associated with the development of hypertension.
キーワード
royal jelly
fructose-drinking rat
insulin resistance
periarterial nerve function
備考
コンテンツの著作権は日本薬学会が有します。
発行日
2008-11-01
出版物タイトル
Biological & Pharmaceutical Bulletin
31巻
11号
出版者
日本薬学会
出版者(別表記)
The Pharmaceutical Society of Japan
開始ページ
2103
終了ページ
2107
ISSN
09186158
NCID
AA10885497
資料タイプ
学術雑誌論文
言語
English
著作権者
© The Pharmaceutical Society of Japan
論文のバージョン
publisher
査読
有り
DOI
PubMed ID
Web of Science KeyUT