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ID 52857
フルテキストURL
著者
Wakamori, Takaaki Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Neurol Surg
Agari, Takashi Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Neurol Surg
Yasuhara, Takao Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Neurol Surg Kaken ID researchmap
Kameda, Masahiro Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Neurol Surg Kaken ID researchmap
Kondo, Akihiko Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Neurol Surg
Shinko, Aiko Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Neurol Surg
Sasada, Susumu Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Neurol Surg
Sasaki, Tatsuya Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Neurol Surg
Furuta, Tomohisa Kibi Int Univ, Dept Psychol
Date, Isao Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Neurol Surg ORCID Kaken ID publons researchmap
抄録
Objective: We wished to relate severity of Parkinson's disease (PD) with cognitive function in relation to cerebral blood flow (CBF). Methods: Eighty-one consecutive PD patients were enrolled in this study. We used Mini-Mental State Examination (MMSE) and Wechsler Adult Intelligence Scale-Third edition (WAIS-III) to evaluate cognitive functions, and three-dimensional stereotactic ROI template (3DSRT) and Statistical Parametric Mapping (SPM) 8 to evaluate single photon emission CT (SPECT) recordings of regional CBF. Results: The mean MMSE score of PD patients was 27.4 +/- 2.4. The scores of most patients were higher than 23/30. On the other hand, the mean Full-scale IQ of PD patients was 88.4 +/- 17.3 in WAIS-III, which was lower than that of normal controls. In particular, visuospatial function score of most patients was lower. There was significant correlation between cognitive scores and Hoehn & Yahr stage and hallucinatory episodes. PD Patients with stage III and IV showed significant deterioration in cognitive functions compared to stage II patients. Analysis of CBF revealed relative reductions in perfusion in the cerebral cortex relative to that in normal control. SPM 8 showed that cognitive functions in PD patients were positively correlated with rCBF in the thalamus and cingulate gyrus. Conclusions: This is the study to demonstrate the cognitive impairments in PD patients using WAIS-III. Visuospatial dysfunction might be caused by decrease in rCBF in the parietal and occipital lobes and dorsolateral prefrontal cortex. The severity of cognitive impairments in PD patients was correlated with disease severity and hallucinatory episodes.
キーワード
Parkinson's disease
Cognitive functions
Disease severity
Hallucinations
SPECT
発行日
2014-04
出版物タイトル
Parkinsonism and Related Disorders
20巻
4号
開始ページ
415
終了ページ
420
ISSN
1353-8020
資料タイプ
学術雑誌論文
関連URL
http://ousar.lib.okayama-u.ac.jp/metadata/52827
言語
English
著作権者
(C) 2014 Elsevier Ltd. All rights reserved.
論文のバージョン
author
査読
有り
DOI
Web of Science KeyUT