滝川正春

CCN3 (NOV) Drives Degradative Changes in Aging Articular Cartilage

フルテキストURL	fulltext.pdf
著者	Kuwahara, Miho\| Kadoya, Koichi\| Kondo, Sei\| Fu, Shanqi\| Miyake, Yoshiko\| Ogo, Ayako\| Ono, Mitsuaki\| Furumatsu, Takayuki\| Nakata, Eiji\| Sasaki, Takako\| Minagi, Shogo\| Takigawa, Masaharu\| Kubota, Satoshi\| Hattori, Takako\|
キーワード	cellular communication network factor 3 CCN3 NOV primary chondrocytes aging oxidative stress senescence p21 p53 SASP
発行日	2020-10-13
出版物タイトル	International Journal of Molecular Sciences
巻	21巻
号	20号
出版者	MDPI
開始ページ	7556
ISSN	1422-0067
NCID	AA12038549
資料タイプ	学術雑誌論文
言語	English
OAI-PMH Set	岡山大学
著作権者	© 2020 by the authors.
論文のバージョン	publisher
PubMed ID	33066270
DOI	10.3390/ijms21207556
Web of Science KeyUT	000585557400001
関連URL	isVersionOf https://doi.org/10.3390/ijms21207556

Roles of Interaction between CCN2 and Rab14 in Aggrecan Production by Chondrocytes

フルテキストURL	fulltext.pdf
著者	Hoshijima, Mitsuhiro\| Hattori, Takako\| Aoyama, Eriko\| Nishida, Takashi\| Kubota, Satoshi\| Kamioka, Hiroshi\| Takigawa, Masaharu\|
キーワード	cellular communication network factor 2 CCN2 CTGF Rab14 yeast two-hybrid chondrocyte ER stress aggrecan
発行日	2020-04-16
出版物タイトル	International Journal of Molecular Sciences
巻	21巻
号	8号
出版者	MDPI
ISSN	1422-0067
資料タイプ	学術雑誌論文
言語	English
OAI-PMH Set	岡山大学
著作権者	© 2020 by the authors.
論文のバージョン	publisher
PubMed ID	32316324
DOI	10.3390/ijms21082769
Web of Science KeyUT	000535565300111
関連URL	isVersionOf https://doi.org/10.3390/ijms21082769

Extracellular Vesicles Enriched with Moonlighting Metalloproteinase Are Highly Transmissive, Pro-Tumorigenic, and Trans-Activates Cellular Communication Network Factor (CCN2/CTGF): CRISPR against Cancer

フルテキストURL	fulltext.pdf
著者	Okusha, Yuka\| Eguchi, Takanori\| Tran, Manh T.\| Sogawa, Chiharu\| Yoshida, Kaya\| Itagaki, Mami\| Taha, Eman A.\| Ono, Kisho\| Aoyama, Eriko\| Okamura, Hirohiko\| Kozaki, Ken-Ichi\| Calderwood, Stuart K.\| Takigawa, Masaharu\| Okamoto, Kuniaki\|
キーワード	matrix metalloproteinase moonlighting metalloproteinase (MMP) protein moonlighting transcription factor extracellular vesicles oncosome genome editing CRISPR cellular communication network factor CCN2/CTGF
発行日	2020-04-04
出版物タイトル	Cancers
巻	12巻
号	4号
出版者	MDPI
開始ページ	881
ISSN	2072-6694
資料タイプ	学術雑誌論文
言語	English
OAI-PMH Set	岡山大学
著作権者	© 2020 by the authors.
論文のバージョン	publisher
PubMed ID	32260433
DOI	10.3390/cancers12040881
Web of Science KeyUT	000535587400110
関連URL	isVersionOf https://doi.org/10.3390/cancers12040881

Antiparkinson Drug Benztropine Suppresses Tumor Growth, Circulating Tumor Cells, and Metastasis by Acting on SLC6A3/DAT and Reducing STAT3

フルテキストURL	fulltext.pdf
著者	Sogawa, Chiharu\| Eguchi, Takanori\| Tran, Manh Tien\| Ishige, Masayuki\| Trin, Kilian\| Okusha, Yuka\| Taha, Eman Ahmed\| Lu, Yanyin\| Kawai, Hotaka\| Sogawa, Norio\| Takigawa, Masaharu\| Calderwood, Stuart K.\| Okamoto, Kuniaki\| Kozaki, Ken-Ichi\|
キーワード	drug repositioning/repurposing three-dimensional (3D) culture tumoroids dopamine transporter (DAT) benztropine signal transducer and activator of transcription (STAT) circulating tumor cell (CTC)
発行日	2020-02-24
出版物タイトル	Cancers
巻	12巻
号	2号
出版者	MDPI
開始ページ	523
ISSN	2072-6694
資料タイプ	学術雑誌論文
言語	English
OAI-PMH Set	岡山大学
著作権者	© 2020 by the authors.
論文のバージョン	publisher
PubMed ID	32102440
DOI	10.3390/cancers12020523
Web of Science KeyUT	000522477300269
関連URL	isVersionOf https://doi.org/10.3390/cancers12020523

Jiadifenolide induces the expression of cellular communication network factor (CCN) genes, and CCN2 exhibits neurotrophic activity in neuronal precursor cells derived from human induced pluripotent stem cells

フルテキストURL	fulltext.pdf
著者	Shoji, Masaki\| Ueda, Masako\| Nishioka, Megumi\| Minato, Hiroki\| Seki, Masahide\| Harada, Kenichi\| Kubo, Miwa\| Fukuyama, Yoshiyasu\| Suzuki, Yutaka\| Aoyama, Eriko\| Takigawa, Masaharu\| Kuzuhara, Takashi\|
キーワード	CCN signaling pathway CCN2 Jiadifenolide Neurotrophin iPS
発行日	2019-11-05
出版物タイトル	Biochemical and Biophysical Research Communications
巻	519巻
号	2号
出版者	Elsevier
開始ページ	309
終了ページ	315
ISSN	0006291X
資料タイプ	学術雑誌論文
言語	English
OAI-PMH Set	岡山大学
著作権者	© 2019 The Authors. Published by Elsevier Inc.
論文のバージョン	publisher
PubMed ID	31506177
DOI	10.1016/j.bbrc.2019.09.003
Web of Science KeyUT	00506404800015
関連URL	isVersionOf https://doi.org/10.1016/j.bbrc.2019.09.003

Cartilage-Specific Over-Expression of CCN Family Member 2/Connective Tissue Growth Factor (CCN2/CTGF) Stimulates Insulin-Like Growth Factor Expression and Bone Growth

著者	Tomita, Nao\| Hattori, Takako\| Itoh, Shinsuke\| Aoyama, Eriko\| Yao, Mayumi\| Yamashiro, Takashi\| Takigawa, Masaharu\|
発行日	2013-03-28
出版物タイトル	PLoS ONE
巻	8巻
号	3号
資料タイプ	学術雑誌論文

CCN Family Member 2/Connective Tissue Growth Factor (CCN2/CTGF) Has Anti-Aging Effects That Protect Articular Cartilage from Age-Related Degenerative Changes

著者	Itoh, Shinsuke\| Hattori, Takako\| Tomita, Nao\| Aoyama, Eriko\| Yutani, Yasutaka\| Yamashiro, Takashi\| Takigawa, Masaharu\|
発行日	2013-08-12
出版物タイトル	PLoS ONE
巻	8巻
号	8号
資料タイプ	学術雑誌論文

Promotion of Bone Regeneration by CCN2 Incorporated into Gelatin Hydrogel

著者	Kikuchi, Takeshi\| Kubota, Satoshi\| Asaumi, Koji\| Kawaki, Harumi\| Nishida, Takashi\| Kawata, Kazumi\| Mitani, Shigeru\| Tabata, Yasuhiko\| Ozaki, Toshifumi\| Takigawa, Masaharu\|
発行日	2008-06
出版物タイトル	Tissue Engineering Part A
巻	14巻
号	6号
資料タイプ	学術雑誌論文

Roles of heterotypic CCN2/CTGF-CCN3/NOV and homotypic CCN2-CCN2 interactions in expression of the differentiated phenotype of chondrocytes

著者	Hoshijima, Mitsuhiro\| Hattori, Takako\| Aoyama, Eriko\| Nishida, Takashi\| Yamashiro, Takashi\| Takigawa, Masaharu\|
発行日	2012-10
出版物タイトル	FEBS Journal
巻	279巻
号	19号
資料タイプ	学術雑誌論文

Mechanical stretch increases CCN2/CTGF expression in anterior cruciate ligament-derived cells

著者	Miyake, Yoshiaki\| Furumatsu, Takayuki\| Kubota, Satoshi\| Kawata, Kazumi\| Ozaki, Toshifumi\| Takigawa, Masaharu\|
発行日	2011-06-03
出版物タイトル	Biochemical and Biophysical Research Communications
巻	409巻
号	2号
資料タイプ	学術雑誌論文

Inhibition of tumor-stromal interaction through HGF/Met signaling by valproic acid

フルテキストURL	Fulltext.pdf fig.pdf table.pdf
著者	Matsumoto, Yohsuke\| Motoki, Takahiro\| Kubota, Satoshi\| Takigawa, Masaharu\| Tsubouchi, Hirohito\| Gohda, Eiichi\|
キーワード	hepatocyte growth factor valproic acid histone deacetylase inhibitor butyric acid trichostatin A induction tumor invasion dermal fibroblast
備考	Published with permission from the copyright holder.<br /> This is a author's copy,as published in Biochemical and Biophysical Research Communications, 2008 Vol.366 Issue.1 pp.110-116<br />\|
発行日	2008-02-01
出版物タイトル	Biochemical and Biophysical Research Communications
巻	366巻
号	1号
出版者	Academic Press
開始ページ	110
終了ページ	116
ISSN	0006-291X
NCID	AA00564395
資料タイプ	学術雑誌論文
言語	English
OAI-PMH Set	岡山大学
論文のバージョン	author
PubMed ID	18053801
DOI	10.1016/j.bbrc.2007.11.089
Web of Science KeyUT	000252392400018

Comparable response of ccn1 with ccn2 genes upon arthritis: An in vitro evaluation with a human chondrocytic cell line stimulated by a set of cytokines

著者	Moritani, Norifumi H\| Kubota, Satoshi\| Sugahara, Toshio\| Takigawa, Masaharu\|
発行日	2005-04-15
出版物タイトル	Cell Communication and Signaling
巻	3巻
号	1号
資料タイプ	学術雑誌論文

Connective Tissue Growth Factor Causes Persistent Proα2(I) Collagen Gene Expression Induced by Transforming Growth Factor-β in a Mouse Fibrosis Model

著者	Chujo, Sonoko\| Shirasaki, Fumiaki\| Kawara, Shigeru\| Inagaki, Yutaka\| Kinbara, Takuro\| Inaoki, Makoto\| Takigawa, Masaharu\| Takehara, Kazuhiko\|
発行日	2004-12
出版物タイトル	Journal of Cellular Physiology
巻	203巻
号	2号
資料タイプ	学術雑誌論文

Effect of connective tissue growth factor (CCN2/CTGF) on proliferation and differentiation of mouse periodontal ligament-derived cells

著者	Asano, Masahiro\| Kubota, Satoshi\| Nakanishi, Tohru\| Nishida, Takashi\| Yamaai, Tomoichiro\| Yosimichi, Gen\| Ohyama, Kazumi\| Sugimoto, Tomosada\| Murayama, Yoji\| Takigawa, Masaharu\|
発行日	2005-10-05
出版物タイトル	Cell Communication and Signaling
巻	3巻
号	1号
資料タイプ	学術雑誌論文

Interleukin-4 downregulates the cyclic tensile stress-induced matrix metalloproteinases-13 and cathepsin b expression by rat normal chondrocytes

JaLCDOI	10.18926/AMO/30956
フルテキストURL	fulltext.pdf
著者	Doi, Hideyuki\| Nishida, Keiichiro\| Yorimitsu, Masanori\| Komiyama, Takamitsu\| Kadota, Yasutaka\| Tetsunaga, Tomonori\| Yoshida, Aki\| Kubota, Satoshi\| Takigawa, Masaharu\| Ozaki, Toshifumi\|
抄録	<p>Mechanical stress plays a key role in the pathogenesis of cartilage destruction seen in osteoarthritis (OA). We investigated the effect of cyclic tensile stress (CTS) on the anabolic and catabolic gene expression of rat cultured normal chondrocytes using the Flexercell strain unit. The effects of interleukin (IL)-4, a chondroprotective cytokine, on the changes in gene expression induced by CTS were also investigated. CTS (7% elongation at 0.5 Hz) for 24 h did not affect the expression of aggrecan and type II collagen, whereas CTS significantly upregulated matrix metalloproteinase (MMP)-13 and cathepsin B mRNA expression by chondrocytes. IL-1beta expression was also signifi cantly upregulated by CTS up to 12 h. The upregulation of MMP-13 was observed at 3 h, which was earlier than that of IL-1beta. Furthermore, pre-treatment with IL-4 (10 ng/ml) suppressed both MMP-13 and cathepsin B induction by mechanical stress, as well as CTS-induced IL-1beta expression. Our results suggest that IL-4 might have a therapeutic value in the treatment of OA by downregulation of mechanical stress-induced MMP-13 and cathepsin B expression by chondrocytes.</p>
キーワード	IL-4 MMP cathepsin B mechanical stress aggrecanase
Amo Type	Original Article
発行日	2008-04
出版物タイトル	Acta Medica Okayama
巻	62巻
号	2号
出版者	Okayama University Medical School
開始ページ	119
終了ページ	126
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	English
論文のバージョン	publisher
査読	有り
PubMed ID	18464888
Web of Science KeyUT	000255297600008

Expression of Neurotrophins and Their Receptors Tropomyosin-related kinases (Trk) under Tension-stress during Distraction Osteogenesis

JaLCDOI	10.18926/AMO/30739
フルテキストURL	fulltext.pdf
著者	Aiga, Ayako\| Asaumi, Koji\| Lee, You Jin\| Kadota, Hiroaki\| Mitani, Shigeru\| Ozaki, Toshifumi\| Takigawa, Masaharu\|
抄録	The localization and expression of neurotrophins and their receptors during distraction osteogenesis was investigated in 72 male rat femurs (11 weeks old) to further clarify the concurrence of cellular and molecular events of new bone formation. After osteotomy, a 7-day lag phase was followed by distraction at the rate of 0.25 mm/12 h for 21 days (distraction phase), and a 7-day consolidation phase. The localization of neurotrophins (NGF, BDNF and NT-3) and their receptors tropomyosinrelated kinases (TRKA, TRKB and TRKC) by immunostaining showed positive staining in bone forming cells in each stage, although the presence and staining intensity varied by cell type and phase. The expressions of NGF, BDNF and NT-3 by real-time polymerase chain reaction (real-time PCR) showed that the peak of the mRNA expression of NGF occurred 10 days after distraction. NT-3 increased during bone extension, but decreased when distraction stopped. In contrast, BDNF continued to increase gradually throughout the distraction and consolidation phases. These findings suggest that neurotrophins and their receptors may play different roles in endochondral and intramembranous ossification in distraction osteogenesis. The tension stress caused by distraction may stimulate the expression of neurotrophins and their receptors, and promote osteogenesis.
キーワード	neurotrophin Trk distraction osteogenesis mechanical stress
Amo Type	Article
発行日	2006-10
出版物タイトル	Acta Medica Okayama
巻	60巻
号	5号
出版者	Okayama University Medical School
開始ページ	267
終了ページ	277
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	English
論文のバージョン	publisher
査読	有り
PubMed ID	17072373
Web of Science KeyUT	000241509000003

滝川 正春