フルテキストURL J_Pharm_Sci_130_1_24.pdf
著者 Tangsucharit, Panot| Takatori, Shingo| Zamami, Yoshito| Goda, Mitsuhiro| Pakdeechote, Poungrat| Kawasaki, Hiromu| Takayama, Fusako|
キーワード Acetylcholine-induced vasodilatation CGRPergic nerves Muscarinic receptor subtypes Rat mesenteric arteries
発行日 2016-01
出版物タイトル Journal of Pharmacological Sciences
130巻
1号
出版者 Japanese Pharmacological Society
開始ページ 24
終了ページ 32
ISSN 1347-8613
NCID AA11806667
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
著作権者 https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
論文のバージョン publisher
PubMed ID 26825997
DOI 10.1016/j.jphs.2015.12.005
Web of Science KeyUT 000369700500004
関連URL https://doi.org/10.1016/j.jphs.2015.12.005
著者 座間味 義人| 高取 真吾| 岩谷 有希子| 山脇 康佑| 宮下 智子| 藪前 奈々| 高山 房子| 見尾 光庸| 川﨑 博己|
発行日 2008-03-01
出版物タイトル 藥學雜誌
128巻
3号
資料タイプ 学術雑誌論文
JaLCDOI 10.18926/AMO/31835
フルテキストURL fulltext.pdf
著者 Takayama, Fusako| Nakamoto, Kazuo| Kawasaki, Hiromu| Mankura, Mitsumasa| Egashira, Toru| Ueki, Keiji| Hasegawa, Azusa| Okada, Shigeru| Mori, Akitane|
抄録 <p>Vitis coignetiae Pulliat (Yamabudo) is used as a health juice and wine based on the abundant polyphenols and anthocyanins in its fruit. However, it is not known whether the leaves of this plant confer similar benefits. This study investigated the hepatoprotective effects of aqueous extracts from Vitis coignetiae Pulliat leaves (VCPL) in an animal model of nonalcoholic steatohepatitis (NASH). Rats were fed a choline-deficient high-fat diet for four weeks to generate fatty livers. NASH was induced by oxidative stress loading. Ten weeks later, blood and liver samples were collected from anesthetized animals and assessed biochemically, histologically, and histochemically to determine the extent of oxidative stress injury and the overall effects of VCPL. Six-week VCPL extract supplementation reduced serum levels of liver enzymes, decreased CYP2E1 induction, increased plasma antioxidant activities and delayed the progression of liver fibrosis. The findings suggested that VCPL has strong radical-scavenging activity and may be beneficial in preventing NASH progression.</p>
キーワード Yamabudo nonalcoholic steatohepatitis antioxidant hepatoprotection
Amo Type Original Article
発行日 2009-04
出版物タイトル Acta Medica Okayama
63巻
2号
出版者 Okayama University Medical School
開始ページ 105
終了ページ 111
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 19404342
Web of Science KeyUT 000265457600005