| JaLCDOI |
10.18926/AMO/31835
|
| フルテキストURL |
fulltext.pdf
|
| 著者 |
Takayama, Fusako|
Nakamoto, Kazuo|
Kawasaki, Hiromu|
Mankura, Mitsumasa|
Egashira, Toru|
Ueki, Keiji|
Hasegawa, Azusa|
Okada, Shigeru|
Mori, Akitane|
|
| 抄録 |
<p>Vitis coignetiae Pulliat (Yamabudo) is used as a health juice and wine based on the abundant polyphenols and anthocyanins in its fruit. However, it is not known whether the leaves of this plant confer similar benefits. This study investigated the hepatoprotective effects of aqueous extracts from Vitis coignetiae Pulliat leaves (VCPL) in an animal model of nonalcoholic steatohepatitis (NASH). Rats were fed a choline-deficient high-fat diet for four weeks to generate fatty livers. NASH was induced by oxidative stress loading. Ten weeks later, blood and liver samples were collected from anesthetized animals and assessed biochemically, histologically, and histochemically to determine the extent of oxidative stress injury and the overall effects of VCPL. Six-week VCPL extract supplementation reduced serum levels of liver enzymes, decreased CYP2E1 induction, increased plasma antioxidant activities and delayed the progression of liver fibrosis. The findings suggested that VCPL has strong radical-scavenging activity and may be beneficial in preventing NASH progression.</p>
|
| キーワード |
Yamabudo
nonalcoholic steatohepatitis
antioxidant
hepatoprotection
|
| Amo Type |
Original Article
|
| 発行日 |
2009-04
|
| 出版物タイトル |
Acta Medica Okayama
|
| 巻 |
63巻
|
| 号 |
2号
|
| 出版者 |
Okayama University Medical School
|
| 開始ページ |
105
|
| 終了ページ |
111
|
| ISSN |
0386-300X
|
| NCID |
AA00508441
|
| 資料タイプ |
学術雑誌論文
|
| 言語 |
English
|
| 論文のバージョン |
publisher
|
| 査読 |
有り
|
| PubMed ID |
19404342
|
| Web of Science KeyUT |
000265457600005
|
