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ID 55208
JaLCDOI
フルテキストURL
Thumnail 71_3_249.pdf 3.32 MB
著者
Washio, Kana Department of Pediatrics, Okayama University Hospital
Muraoka, Michiko Department of Pediatrics, National Hospital Organization Fukuyama Medical Center
Kanamitsu, Kiichiro Department of Pediatrics, Okayama University Hospital
Oda, Megumi Department of Pediatrics, Okayama University Hospital
Shimada, Akira Department of Pediatrics, Okayama University Hospital ORCID Kaken ID researchmap
抄録
 We diagnosed a female infant with Langerhans cell histiocytosis (LCH) who was refractory to conventional chemotherapy. She showed refractory inflammation that was complicated with hemophagocytic lymphohistiocytosis (HLH) during LCH chemotherapy; therefore, we changed the protocol to HLH2004 (dexamethasone, cyclosporine A and VP16). However, there were no signs of hematological recovery. We therefore performed cord blood transplantation with reduced-intensity conditioning, and she achieved complete remission for over 2 years. As salvage therapy for refractory LCH, hematopoietic stem cell transplantation may be a good therapeutic choice, especially when LCH is complicated with HLH.
キーワード
langerhans cell histiocytosis (LCH)
hemophagocytic lymphohistiocytosis (HLH)
hematopoietic stem cell transplantation (HSCT)
reduced-intensity conditioning (RIC)
refractory
Amo Type
Case Report
発行日
2017-06
出版物タイトル
Acta Medica Okayama
71巻
3号
出版者
Okayama University Medical School
開始ページ
249
終了ページ
254
ISSN
0386-300X
NCID
AA00508441
資料タイプ
学術雑誌論文
言語
English
著作権者
CopyrightⒸ 2017 by Okayama University Medical School
論文のバージョン
publisher
査読
有り
PubMed ID