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ID 57816
フルテキストURL
著者
Terazaki, Miyuki Graduate School of Natural Science and Technology, Okayama University
Shiomoto, Kei-ichi Graduate School of Natural Science and Technology, Okayama University
Mizoguchi, Haruki Graduate School of Natural Science and Technology, Okayama University ORCID Kaken ID researchmap
Sakakura, Akira Graduate School of Natural Science and Technology, Okayama University ORCID Kaken ID publons researchmap
抄録
Thioureas bearing electron-deficient aryl groups show high catalytic activity in the biomimetic bromocyclization of geranyl derivatives. The reaction of geranyl derivatives with N-bromosuccinimide (NBS) proceeds rapidly in CH2Cl2 to give the corresponding bromocyclization products in high yields as a ca. 1:1 mixture of endo- and exo-isomers. The reactivity of geranyl derivatives highly depends on the terminal substituent: electron-donating substituents increase the reactivity, while electron-withdrawing substituents decrease the reactivity.
備考
This document is the Accepted Manuscript version of a Published Work that appeared in final form in Organic Letters, copyright © American Chemical Society after peer review and technical editing by the publisher.
発行日
2019-03-12
出版物タイトル
Organic Letters
21巻
7号
出版者
American Chemical Society
開始ページ
2073
終了ページ
2076
ISSN
1523-7060
NCID
AA11347843
資料タイプ
学術雑誌論文
言語
English
OAI-PMH Set
岡山大学
著作権者
© American Chemical Society
論文のバージョン
author
PubMed ID
DOI
Web of Science KeyUT
関連URL
isVersionOf https://doi.org/10.1021/acs.orglett.9b00352
Citation
Org. Lett. 2019, 21, 7, 2073-2076 Publication Date:March 12, 2019 https://doi.org/10.1021/acs.orglett.9b00352