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ID 30749
JaLCDOI
フルテキストURL
著者
Komiyama, Takamitsu Okayama University
Nishida, Keiichiro Okayama University Kaken ID publons researchmap
Yorimitsu, Masanori Okayama University
Doi, Hideyuki Okayama University
Miyazawa, Shinichi Okayama University
Kitamura, Ai Okayama University
Yoshida, Aki Okayama University
Nasu, Yoshihisa Okayama University
Ozaki, Toshifumi Okayama University Kaken ID publons researchmap
抄録
Ossification disturbance in femoral head reportedly is seen in the Spontaneously Hypertensive rats (SHR) between ages of 10 and 20 weeks. We investigated serum and tissue levels of insulin-like growth factor-1 (IGF-1) and vascular endothelial growth factor (VEGF) in SHR relevant to the ossification disturbance and osteonecrosis of the femoral head. Serum levels of IGF-1 and VEGF were significantly lower in SHR than in Wistar Kyoto rats (WKY) at weeks 5, 10, 15 and 20 (p<0.005). The incidence of histological ossification disturbance of the femoral head was higher in SHR (59%) than in WKY (40%) at week 20. Lower serum and local levels of VEGF in SHR appeared to be related to the incomplete ossification of the femoral heads. Immunohistochemical study showed significantly lower numbers of IGF-1 and VEGF positive chondrocytes in the femoral epiphyseal cartilage of SHR than in those of WKY at weeks 10, 15 and 20. Our results suggest that local and/or systemic levels of IGF-1 and VEGF between ages of 5 and 20 weeks might play roles in the pathogenesis of ossifi cation disturbance of the femoral head in SHR.
キーワード
spontaneous hypertensive rats
insulin like growth factor-1
vascular endothelial growth factor
ossification disturbance
osteonecrosis
Amo Type
Article
発行日
2006-06
出版物タイトル
Acta Medica Okayama
60巻
3号
出版者
Okayama University Medical School
開始ページ
141
終了ページ
148
ISSN
0386-300X
NCID
AA00508441
資料タイプ
学術雑誌論文
言語
English
論文のバージョン
publisher
査読
有り
PubMed ID
Web of Science KeyUT