西﨑正彦

Immune Modulation by Telomerase-Specific Oncolytic Adenovirus Synergistically Enhances Antitumor Efficacy with Anti-PD1 Antibody

著者	Kanaya, Nobuhiko\| Kuroda, Shinji\| Kakiuchi, Yoshihiko\| Kumon, Kento\| Tsumura, Tomoko\| Hashimoto, Masashi\| Morihiro, Toshiaki\| Kubota, Tetsushi\| Aoyama, Katsuyuki\| Kikuchi, Satoru\| Nishizaki, Masahiko\| Kagawa, Shunsuke\| Tazawa, Hiroshi\| Mizuguchi, Hiroyuki\| Urata, Yasuo\| Fujiwara, Toshiyoshi\|
キーワード	immune checkpoint programmed death-1 oncolytic adenovirus combined immunotherapy immunogenic cell death tumor infiltrating lymphocytes CD8 abscopal effect
備考	This fulltext is available in Jan. 2021.\|
発行日	2020-01-10
出版物タイトル	Molecular Therapy
巻	28巻
号	3号
出版者	Cell Press
開始ページ	794
終了ページ	804
ISSN	15250016
NCID	AA11475060
資料タイプ	学術雑誌論文
言語	English
OAI-PMH Set	岡山大学
論文のバージョン	author
PubMed ID	31991110
DOI	10.1016/j.ymthe.2020.01.003
Web of Science KeyUT	000518887200012
関連URL	isVersionOf https://doi.org/10.1016/j.ymthe.2020.01.003

Visualization of epithelial-mesenchymal transition in an inflammatory microenvironment-colorectal cancer network

著者	Ieda, Takeshi\| Tazawa, Hiroshi\| Okabayashi, Hiroki\| Yano, Shuya\| Shigeyasu, Kunitoshi\| Kuroda, Shinji\| Ohara, Toshiaki\| Noma, Kazuhiro\| Kishimoto, Hiroyuki\| Nishizaki, Masahiko\| Kagawa, Shunsuke\| Shirakawa, Yasuhiro\| Saitou, Takashi\| Imamura, Takeshi\| Fujiwara, Toshiyoshi\|
発行日	2019-11-8
出版物タイトル	Scientific Reports
巻	9巻
出版者	Nature Publishing Group
開始ページ	16378
ISSN	2045-2322
資料タイプ	学術雑誌論文
言語	English
OAI-PMH Set	岡山大学
著作権者	© The Author(s) 2019
論文のバージョン	publisher
PubMed ID	31705021
DOI	10.1038/s41598-019-52816-z
Web of Science KeyUT	000495372900001
関連URL	isVersionOf https://doi.org/10.1038/s41598-019-52816-z

PD-L1 expression combined with microsatellite instability/CD8+tumor infiltrating lymphocytes as a useful prognostic biomarker in gastric cancer

フルテキストURL	SR9_1_4633.pdf
著者	Morihiro, Toshiaki\| Kuroda, Shinji\| Kanaya, Nobuhiko\| Kakiuchi, Yoshihiko\| Kubota, Tetsushi\| Aoyama, Katsuyuki\| Tanaka, Takehiro\| Kikuch, Satoru\| Nagasaka, Takeshi\| Nishizaki, Masahiko\| Kagawa, Shunsuke\| Tazawa, Hiroshi\| Fujiwara, Toshiyoshi\|
発行日	2019-3-15
出版物タイトル	Scientific Reports
巻	9巻
出版者	Nature Publishing Group
開始ページ	4633
ISSN	2045-2322
資料タイプ	学術雑誌論文
言語	English
OAI-PMH Set	岡山大学
著作権者	© The Author(s) 2019
論文のバージョン	publisher
PubMed ID	30874607
DOI	10.1038/s41598-019-41177-2
Web of Science KeyUT	000461303000015
関連URL	isVersionOf https://doi.org/10.1038/s41598-019-41177-2

A Phase II Clinical Trial of the Efficacy and Safety of Short-term (3 days) Enoxaparin for the Prevention of Venous Thromboembolism after Gastric Cancer Surgery

JaLCDOI	10.18926/AMO/54601
フルテキストURL	70_5_401.pdf
著者	Kuroda, Shinji\| Kikuchi, Satoru\| Nishizaki, Masahiko\| Kagawa, Shunsuke\| Hinotsu, Shiro\| Fujiwara, Toshiyoshi\|
抄録	Although intermittent pneumatic compression (IPC) has become common as perioperative prophylaxis for venous thromboembolism (VTE) consisting of pulmonary thromboembolism (PE) and deep vein thrombosis (DVT), the prophylactic effect against VTE, especially lethal PE, is not yet satisfactory. Therefore, pharmacologic prophylaxis, such as with enoxaparin, is desirable. While the efficacy and safety of enoxaparin have been proven in several clinical trials, concern about bleeding with longterm (at least 7 days) use have potentially decreased its widespread adoption. We have launched a phase II study to evaluate the efficacy and safety of short-term (3 days) enoxaparin, in which a total of 70 gastric cancer patients undergoing gastrectomy will be recruited, and the primary endpoint is the incidence of DVT. This study could contribute to making pharmacologic prophylaxis for VTE more common.
キーワード	venous thromboembolism enoxaparin short-term use gastric cancer surgery
Amo Type	Clinical Study Protocols
発行日	2016-10
出版物タイトル	Acta Medica Okayama
巻	70巻
号	5号
出版者	Okayama University Medical School
開始ページ	401
終了ページ	404
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	English
著作権者	CopyrightⒸ 2016 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	27777435
Web of Science KeyUT	000388098700012

Recurrence after Endoscopic Curative Resection of Mucosal Gastric Cancer Associated with an Adjacent Neoplastic Precursor Lesion

JaLCDOI	10.18926/AMO/54421
フルテキストURL	70_3_213.pdf
著者	Kikuchi, Satoru\| Kagawa, Shunsuke\| Ohara, Toshiaki\| Kubota, Tetsushi\| Kuwada, Kazuya\| Kagawa, Tetsuya\| Kuroda, Shinji\| Shirakawa, Yasuhiro\| Nishizaki, Masahiko\| Fujiwara, Toshiyoshi\|
抄録	A 69-year-old man underwent endoscopic submucosal dissection (ESD) for early gastric cancer (EGC) at the lesser curvature in the angle of stomach. Histological examination revealed tub1, pM, ly0, v0, pLM(-), pVM(-), and the resection was considered curative. The scar after ESD was followed by esophagogastroduodenoscopy (EGD) and biopsy. Twenty months later, EGD showed an ulcerative lesion in the vicinity of the ESD scar, and histological examination of the biopsy specimen showed adenocarcinoma. A distal gastrectomy with lymph node dissection was then performed. Postoperative pathology showed tub1, pM, pN0, ly0, v0, and Stage 1A. Skip lesions were seen in the specimen resected by ESD, and the histological review confirmed so-called “dysplasia-like atypia” (DLA) between the lesions. It has been reported recently that in DLA, the dysplasia-like change involves only the bases of the pits, without upper pit or surface epithelium involvement, and it is said that the rate of DLA is higher in gastric cancer patients. We speculated that a precancerous lesion close to the resected cancer developed into a local recurrence.
キーワード	dysplasia-like atypia early gastric cancer endoscopic submucosal dissection local recurrence
Amo Type	Case Report
発行日	2016-06
出版物タイトル	Acta Medica Okayama
巻	70巻
号	3号
出版者	Okayama University Medical School
開始ページ	213
終了ページ	216
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	English
著作権者	CopyrightⒸ 2016 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	27339211
Web of Science KeyUT	000379406100009

Biological Ablation of Sentinel Lymph Node Metastasis in Submucosally Invaded Early Gastrointestinal Cancer

著者	Kikuchi, Satoru\| Kishimoto, Hiroyuki\| Tazawa, Hiroshi\| Hashimoto, Yuuri\| Kuroda, Shinji\| Nishizaki, Masahiko\| Nagasaka, Takeshi\| Shirakawa, Yasuhiro\| Kagawa, Shunsuke\| Urata, Yasuo\| Robert M Hoffman\| Fujiwara, Toshiyoshi\|
発行日	2014-12-19
出版物タイトル	Molecular Therapy
資料タイプ	学術雑誌論文

Fluorescence virus-guided capturing system of human colorectal circulating tumour cells for non-invasive companion diagnostics

著者	Shigeyasu, Kunitoshi\| Tazawa, Hiroshi\| Hashimoto, Yuuri\| Mori, Yoshiko\| Nishizaki, Masahiko\| Kishimoto, Hiroyuki\| Nagasaka, Takeshi\| Kuroda, Shinji\| Urata, Yasuo\| Goel, Ajay\| Kagawa, Shunsuke\| Fujiwara, Toshiyoshi\|
発行日	2014-05-28
出版物タイトル	Gut
資料タイプ	学術雑誌論文

A Genetically Engineered Oncolytic Adenovirus Decoys and Lethally Traps Quiescent Cancer Stem-like Cells in S/G(2)/M Phases

著者	Yano, Shuya\| Tazawa, Hiroshi\| Hashimoto, Yuuri\| Shirakawa, Yasuhiro\| Kuroda, Shinji\| Nishizaki, Masahiko\| Kishimoto, Hiroyuki\| Uno, Futoshi\| Nagasaka, Takeshi\| Urata, Yasuo\| Kagawa, Shunsuke\| Hoffman, Robert M.\| Fujiwara, Toshiyoshi\|
発行日	2013-12-01
出版物タイトル	Clinical Cancer Research
巻	19巻
号	23号
資料タイプ	学術雑誌論文

Mechanism of resistance to trastuzumab and molecular sensitization via ADCC activation by exogenous expression of HER2-extracellular domain in human cancer cells

著者	Yoshida, Ryosuke\| Tazawa, Hiroshi\| Hashimoto, Yuuri\| Yano, Shuya\| Onishi, Teppei\| Sasaki, Tsuyoshi\| Shirakawa, Yasuhiro\| Kishimoto, Hiroyuki\| Uno, Futoshi\| Nishizaki, Masahiko\| Kagawa, Shunsuke\| Fujiwara, Toshiyoshi\|
発行日	2012-11
出版物タイトル	Cancer Immunology, Immunotherapy
巻	61巻
号	11号
資料タイプ	学術雑誌論文

西﨑 正彦