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ID 52800
フルテキストURL
著者
Tani, Makiko Okayama Univ Hosp, Dept Anesthesiol & Resuscitol
Morimatsu, Hiroshi Okayama Univ Hosp, Perioperat Management Ctr Kaken ID researchmap
Takatsu, Fumiaki Okayama Univ, Sch Med
Morita, Kiyoshi Okayama Univ Hosp, Dept Anesthesiol & Resuscitol
抄録
Little is known on the clinical effects of chloride on critically ill patients. We conducted this retrospective, observational study in 488 critically ill patients to investigate the incidence of chloride abnormalities, effects of hypochloremia in acid-base disorders, and association between chloride and clinical outcome. The study involved retrieval of arterial blood gas analyses, biochemical and demographical data from electrical records as well as quantitative acid-base analyses. For statistical analysis, the patients were stratified into three groups according to their chloride level (normal range: 98-106 mEq/L). The distribution of chloride levels was hyperchloremia 16.6%, normochloremia 74.6%, and hypochloremia 8.8%. The hypochloremic group was significantly alkalemic (P < 0.0001) and has significantly higher apparent strong ion difference (SIDa) (P < 0.0001) compared to the two other groups. The hypochloremic group had significantly longer stays in the ICU and hospital (P < 0.0001) with higher mortality (P < 0.0001). However, multiple regression analysis showed that chloride was not an independent factor of poorer outcome. In conclusion, the acid-base characteristics of the hypochloremic patients were alkalemia coexisting with higher SIDa. And although it was not an independent prognostic factor, hypochloremia was related to poorer outcome in critically ill settings.
発行日
2012
出版物タイトル
The Scientific World Journal
2012巻
ISSN
1537-744X
資料タイプ
学術雑誌論文
関連URL
http://ousar.lib.okayama-u.ac.jp/metadata/52524
言語
English
著作権者
© 2012 Makiko Tani et al.
論文のバージョン
publisher
査読
有り
DOI
Web of Science KeyUT