JaLCDOI 10.18926/AMO/58275
フルテキストURL 74_2_159.pdf
著者 Thar Htet San| Ota, Yoko| Fushimi, Soichiro| Fujisawa, Masayoshi| Yanai, Hiroyuki| Toda, Hiroko| Kunitomo, Tadayoshi| Kodama, Keisuke| Matsukawa, Akihiro|
抄録 Juvenile granulosa cell tumors (JGCTs) are rare ovarian tumors with overall good prognoses. They differ from adult granulosa cell tumors (AGCTs), which are well known for late recurrence. Most JGCTs (~97%) occur in individuals <30 years old. We report a recurrent JGCT in a 40-year-old woman 5 years after initial presentation. The histological appearance and lack of 402C>G missense point mutation of FOXL2 gene (characteristic of AGCT but absent in JGCT) allowed differentiation from AGCT. This is the first comprehensive report of JGCT with late recurrence. Although rare, late recurrence of JGCT can occur; long-term surveillance is suggested.
キーワード juvenile granulosa cell tumor late recurrence adult granulosa cell tumor
Amo Type Case Report
発行日 2020-04
出版物タイトル Acta Medica Okayama
74巻
2号
出版者 Okayama University Medical School
開始ページ 159
終了ページ 163
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
著作権者 CopyrightⒸ 2020 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 32341591
Web of Science KeyUT 000528278500010
著者 Hirano, Yutaka| Sugimoto, Seiichiro| Yamamoto, Sumiharu| Okada, Masanori| Otani, Shinji| Ohara, Toshiaki| Yamane, Masaomi| Matsukawa, Akihiro| Oto, Takahiro| Toyooka, Shinichi|
キーワード Brain dead donor Donation after cardiac death Lung transplantation Organ preservation Rejection
備考 This fulltext is available in Aug 2020|
発行日 2019-07-31
出版物タイトル General Thoracic and Cardiovascular Surgery
68巻
1号
出版者 Springer
開始ページ 57
終了ページ 62
ISSN 1863-6705
NCID AA12201344
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
論文のバージョン author
PubMed ID 31367969
DOI 10.1007/s11748-019-01181-9
Web of Science KeyUT 000511499200009
関連URL isVersionOf https://doi.org/10.1007/s11748-019-01181-9
フルテキストURL fulltext.pdf
著者 Yoshimura, Teizo| Nakamura, Kaoru| Li, Chunning| Fujisawa, Masayoshi| Shiina, Tsuyoshi| Imamura, Mayu| Li, Tiantian| Mukaida, Naofumi| Matsukawa, Akihiro|
キーワード macrophages chemokines cytokines inflammation tumor microenvironment breast cancer
発行日 2019-12-16
出版物タイトル International Journal of Molecular Sciences
20巻
24号
出版者 MDPI
ISSN 1422-0067
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
著作権者 © 2019 by the authors.
論文のバージョン publisher
PubMed ID 31888216
DOI 10.3390/ijms20246342
Web of Science KeyUT 000506840100235
関連URL isVersionOf https://doi.org/10.3390/ijms20246342
フルテキストURL fulltext.pdf
著者 Yamane, Kentaro| Misawa, Haruo| Takigawa, Tomoyuki| Ito, Yoshihiro| Ozaki, Toshifumi| Matsukawa, Akihiro|
キーワード hepatocyte growth factor spinal cord injury neural regeneration
発行日 2019-12-02
出版物タイトル International Journal of Molecular Sciences
20巻
23号
出版者 MDPI
開始ページ 6078
ISSN 1422-0067
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
著作権者 © 2019 by the authors.
論文のバージョン publisher
PubMed ID 31810304
DOI 10.3390/ijms20236078
Web of Science KeyUT 000504428300260
関連URL isVersionOf https://doi.org/10.3390/ijms20236078
JaLCDOI 10.18926/AMO/57956
フルテキストURL 74_1_73.pdf
著者 Yamane, Masaomi| Mandai, Yasuhiro| Ino, Hideo| Matsukawa, Akihiro| Toyooka, Shinichi|
抄録 In 2016, Gunma University Hospital’s Medical Accident Investigation Committee released a report reiterating the necessity of medical education and the need for surgeons to master non-technical skills. We designed a 17-h training course for surgical instructors, designed to teach participants how to sufficiently educate surgeon trainees and encourage their professional identity formation. A post-training survey showed that participants improved their awareness, and their behavioral changes led to favorable team performances. We then began offering a 3-h workshop focusing on the participants’ experiences. We propose that the training course using participant narratives is required and effective to establish surgeons’ self-reflection and professional identity as surgeons.
キーワード professional identity instructor training narrative
Amo Type Short Communication
発行日 2020-02
出版物タイトル Acta Medica Okayama
74巻
1号
出版者 Okayama University Medical School
開始ページ 73
終了ページ 76
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
著作権者 CopyrightⒸ 2020 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 32099252
JaLCDOI 10.18926/AMO/57946
フルテキストURL 74_1_1.pdf
著者 Chen, Yuehua| Ohara, Toshiaki| Xing, Boyi| Qi, Jiping| Noma, Kazuhiro| Matsukawa, Akihiro|
抄録 Iron is a trace but vital element in the human body and is necessary for a multitude of crucial processes in life. However, iron overload is known to induce carcinogenesis via oxidative stress. Cancer cells require large amounts of iron for their rapid division and cell growth. Iron was recently found to play a role in cancer stem cells (CSCs); it maintains stemness during development. Iron also plays an important role in stemness by moderating reactive oxygen species. Thus, iron metabolism in CSCs is a promising therapeutic target. In this review, we summarize the roles of iron in cancer cells and CSCs. We also summarize anti-cancer therapeutic studies with iron chelators and describe our expectation of a new therapeutic strategy for CSCs on the basis of our findings.
キーワード cancer stem cell stemness iron chelation chemotherapy
Amo Type Review
発行日 2020-02
出版物タイトル Acta Medica Okayama
74巻
1号
出版者 Okayama University Medical School
開始ページ 1
終了ページ 6
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
著作権者 CopyrightⒸ 2020 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 32099242
フルテキストURL FI_10_17.pdf
著者 Ohkura, Takahiro| Yoshimura, Teizo| Fujisawa, Masayoshi| Ohara, Toshiaki| Marutani, Rie| Usami, Kaya| Matsukawa, Akihiro|
キーワード Ras/Raf/ERK/MAPK Spred2 adipocyte inflammation macrophage obesity
発行日 2019-01-22
出版物タイトル Frontiers in Immunology
10巻
出版者 Frontiers Media S.A
開始ページ 17
ISSN 1664-3224
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
著作権者 Copyright © 2019 Authors
論文のバージョン publisher
PubMed ID 30723473
DOI 10.3389/fimmu.2019.00017
Web of Science KeyUT 000456196900002
関連URL isVersionOf https://doi.org/10.3389/fimmu.2019.00017
フルテキストURL cancers_11_2_177.pdf
著者 Katsura, Yuki| Ohara, Toshiaki| Noma, Kazuhiro| Ninomiya, Takayuki| Kashima, Hajime| Kato, Takuya| Sato, Hiroaki| Komoto, Satoshi| Narusaka, Toru| Tomono, Yasuko| Xing, Boyi| Chen, Yuehua| Tazawa, Hiroshi| Kagawa, Shunsuke| Shirakawa, Yasuhiro| Kasai , Tomonari| Seno, Masaharu| Matsukawa, Akihiro| Fujiwara, Toshiyoshi|
キーワード cancer stem cells combination therapy iron stemness
発行日 2019-02-03
出版物タイトル Cancers
11巻
2号
出版者 MDPI
開始ページ 177
ISSN 2072-6694
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
著作権者 © 2019 by the authors
論文のバージョン publisher
PubMed ID 30717462
DOI 10.3390/cancers11020177
Web of Science KeyUT 000460747200051
関連URL isVersionOf https://doi.org/10.3390/cancers11020177
フルテキストURL JGastroenterol_54_11_1019.pdf Table.pdf Figure 1.jpg Figure 2.jpg Figure 3A.tif Figure 3B.tif supplemental figure 1.jpg
著者 Matsumoto, Kazuyuki| Ohara, Toshiaki| Fujisawa, Masayoshi| Takaki, Akinobu| Takahara, Masahiro| Tanaka, Noriyuki| Kato, Hironari| Horiguchi, Shigeru| Yoshida, Ryuichi| Umeda, Yuzo| Fushimi, Soichiro| Yagi, Takahito| Matsukawa, Akihiro| Okada, Hiroyuki|
キーワード Immunohistochemistry PD-L1 Pancreatic cancer
備考 This fulltext will be available in Apr 2020|
発行日 2019-04-29
出版物タイトル Journal of Gastroenterology
54巻
11号
開始ページ 1019
終了ページ 1028
ISSN 09441174
NCID AA10988015
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
論文のバージョン author
PubMed ID 31032528
DOI 10.1007/s00535-019-01586-6
Web of Science KeyUT 000492169400008
関連URL isVersionOf https://doi.org/10.1007/s00535-019-01586-6
著者 Yoshimura, Teizo| Howard, O. M. Zack| Ito, Toshihiro| Kuwabara, Masaki| Matsukawa, Akihiro| Chen, Keqiang| Liu, Ying| Liu, Mingyong| Oppenheim, Joost J.| Wang, Ji Ming|
発行日 2013-03-18
出版物タイトル PLOS ONE
8巻
3号
資料タイプ 学術雑誌論文
著者 Mazaki, Tetsuro| Shiozaki, Yasuyuki| Yamane, Kentaro| Yoshida, Aki| Nakamura, Mariko| Yoshida, Yasuhiro| Zhou, Di| Kitajima, Takashi| Tanaka, Masato| Ito, Yoshihiro| Ozaki, Toshifumi| Matsukawa, Akihiro|
発行日 2014-03-25
出版物タイトル Scientific Reports
4巻
資料タイプ 学術雑誌論文
著者 Shiozaki, Yasuyuki| Kitajima, Takashi| Mazaki, Tetsuro| Yoshida, Aki| Tanaka, Masato| Umezawa, Akihiro| Nakamura, Mariko| Yoshida, Yasuhiro| Ito, Yoshihiro| Ozaki, Toshifumi| Matsukawa, Akihiro|
発行日 2013-04
出版物タイトル International Journal of Nanomedicine
8巻
1号
資料タイプ 学術雑誌論文
JaLCDOI 10.18926/AMO/51867
フルテキストURL 67_5_311.pdf
著者 Nishida, Keiichiro| Hashizume, Hiroyuki| Matsukawa, Akihiro| Hashizume, Kenzo| Shimamura, Yasunori| Torigoe, Yasuyuki| Ozaki, Toshifumi|
抄録 We report a case of 4th metacarpal head collapse of a 19-year-old healthy man. MRI revealed T1 low and T2 high regions in the collapsed 4th metacarpal head, as well as in the right 3rd and left 4th metacarpal head. Our initial diagnosis was occult compression fracture due to avascular necrosis, known as Dieterich's disease. However, pathological findings of surgically resected right 4th metacarpal head were compatible with transient osteoporosis and metacarpal head fracture followed by active tissue repair. The autologous osteochondral transplants from costchondral junction survived and maintained their size and shape even at 10-year follow-up.
キーワード occult compression fracture metacarpal head avascular necrosis osteochondral autograft
Amo Type Case Report
発行日 2013-10
出版物タイトル Acta Medica Okayama
67巻
5号
出版者 Okayama University Medical School
開始ページ 311
終了ページ 317
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
著作権者 CopyrightⒸ 2013 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 24145731
Web of Science KeyUT 000325836100005
著者 Wakabayashi, Hiroshi| Ito, Toshihiro| Fushimi, Soichiro| Nakashima, Yuki| Itakura, Jyunya| Liu, Qiuying| Win, Min Min| Sun, Cuiming| Chen, Cao| Sato, Miwa| Mino, Megumi| Ogino, Tetsuya| Makino, Hirofumi| Yoshimura, Akihiko| Matsukawa, Akihiro|
発行日 2012-09
出版物タイトル Clinical Immunology
144巻
3号
資料タイプ 学術雑誌論文
著者 八代 将登| 塚原 宏一| 松川 昭博| 山田 睦子| 藤井 洋輔| 長岡 義晴| 津下 充| 山下 信子| 伊藤 利洋| 山田 雅夫| 増谷 弘| 淀井 淳司| 森島 恒雄|
発行日 2013-08-01
出版物タイトル 岡山医学会雑誌
125巻
2号
資料タイプ 学術雑誌論文
著者 Yashiro, Masato| Tsukahara, Hirokazu| Matsukawa, Akihiro| Yamada, Mutsuko| Fujii, Yosuke| Nagaoka, Yoshiharu| Tsuge, Mitsuru| Yamashita, Nobuko| Ito, Toshihiro| Yamada, Masao| Masutani, Hiroshi|
発行日 2013-01
出版物タイトル Critical Care Medicine
41巻
1号
資料タイプ 学術雑誌論文
著者 樅木 勝巳| 高嶋 留美| 松川 昭博|
発行日 2011-05
出版物タイトル 岡山実験動物研究会報
27巻
資料タイプ 一般雑誌記事
JaLCDOI 10.18926/AMO/32897
フルテキストURL fulltext.pdf
著者 Matsukawa, Akihiro|
抄録 The innate immune system provides immediate defense against infection and serves as the first line of host defense during infection. In innate immunity, leukocytes such as neutrophils and macrophages recognize and respond to pathogens in a non-specific manner. Therefore, the recruitment and activation of leukocytes are essential in innate immunity, and are governed by a variety of chemical mediators including cytokines. Cytokines are generally divided into 2 types, termed type-1 and type-2 cytokines. Type-1 cytokines are important in local host defense, while type-2 cytokines play a protective role when inflammatory response spreads to the body. These cytokines exert their biological functions through the janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway. STAT1/3/4/6 are transcription factors that mediate IFNgamma/IL-10/IL-12/IL-13 cytokine signaling, respectively. Evidence indicates that STAT proteins have a significant impact on innate immunity during sepsis. This review focuses on recent understandings in the regulation of innate immunity by STAT proteins during sepsis and septic shock. The suppressor of cytokine signaling (SOCS) proteins are a family of SH2 domain-containing cytoplasmic proteins that complete a negative feedback loop to attenuate signal transduction from cytokines that act through the JAK/STAT pathway. The participation of SOCS proteins in sepsis is also discussed.
キーワード cytokines innate immunity sepsis SOCS STAT
Amo Type Review
発行日 2007-10
出版物タイトル Acta Medica Okayama
61巻
5号
出版者 Okayama University Medical School
開始ページ 239
終了ページ 245
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 17971840
Web of Science KeyUT 000250431700001
著者 松川 昭博|
発行日 2006-09-01
出版物タイトル 岡山医学会雑誌
118巻
2号
資料タイプ 学術雑誌論文