香川俊輔

Extracellular vesicles shed from gastric cancer mediate protumor macrophage differentiation

フルテキストURL	fulltext.pdf
著者	Ito, Atene\| Kagawa, Shunsuke\| Sakamoto, Shuichi\| Kuwada, Kazuya\| Kajioka, Hiroki\| Yoshimoto, Masashi\| Kikuchi, Satoru\| Kuroda, Shinji\| Yoshida, Ryuichi\| Tazawa, Hiroshi\| Fujiwara, Toshiyoshi\|
キーワード	Extracellular vesicles Gastric cancer Tumor-associated macrophages Tumor microenvironment
発行日	2021-01-28
出版物タイトル	BMC Cancer
巻	21巻
号	1号
出版者	BMC
開始ページ	102
ISSN	1471-2407
NCID	AA12034763
資料タイプ	学術雑誌論文
言語	English
OAI-PMH Set	岡山大学
著作権者	© The Author(s). 2021
論文のバージョン	publisher
PubMed ID	33509150
DOI	10.1186/s12885-021-07816-6
Web of Science KeyUT	000615987400002
関連URL	isVersionOf https://doi.org/10.1186/s12885-021-07816-6

Fibroblast activation protein targeted near infrared photoimmunotherapy (NIR PIT) overcomes therapeutic resistance in human esophageal cancer

フルテキストURL	fulltext.pdf
著者	Katsube, Ryoichi\| Noma, Kazuhiro\| Ohara, Toshiaki\| Nishiwaki, Noriyuki\| Kobayashi, Teruki\| Komoto, Satoshi\| Sato, Hiroaki\| Kashima, Hajime\| Kato, Takuya\| Kikuchi, Satoru\| Tazawa, Hiroshi\| Kagawa, Shunsuke\| Shirakawa, Yasuhiro\| Kobayashi, Hisataka\| Fujiwara, Toshiyoshi\|
発行日	2021-01-18
出版物タイトル	Scientific Reports
巻	11巻
号	1号
出版者	Nature Research
開始ページ	1693
ISSN	2045-2322
資料タイプ	学術雑誌論文
言語	English
OAI-PMH Set	岡山大学
著作権者	© The Author(s) 2021
論文のバージョン	publisher
PubMed ID	33462372
DOI	10.1038/s41598-021-81465-4
Web of Science KeyUT	000612156600008
関連URL	isVersionOf https://doi.org/10.1038/s41598-021-81465-4

Real-Time Fluorescence Image-Guided Oncolytic Virotherapy for Precise Cancer Treatment

フルテキストURL	fulltext.pdf
著者	Yano, Shuya\| Tazawa, Hiroshi\| Kishimoto, Hiroyuki\| Kagawa, Shunsuke\| Fujiwara, Toshiyoshi\| Hoffman, Robert M.\|
キーワード	cancer cell cycle fluorescent proteins FUCCI imaging adenovirus oncolytic virotherapy cancer stem cell mouse model orthotopic
発行日	2021-01-17
出版物タイトル	International Journal of Molecular Sciences
巻	22巻
号	2号
出版者	MDPI
開始ページ	879
ISSN	1422-0067
NCID	AA12038549
資料タイプ	学術雑誌論文
言語	English
OAI-PMH Set	岡山大学
著作権者	© 2021 by the authors.
論文のバージョン	publisher
PubMed ID	33477279
DOI	10.3390/ijms22020879
Web of Science KeyUT	000611296000001
関連URL	isVersionOf https://doi.org/10.3390/ijms22020879

Targeting neutrophil extracellular traps with thrombomodulin prevents pancreatic cancer metastasis

著者	Kajioka, Hiroki\| Kagawa, Shunsuke\| Ito, Atene\| Yoshimoto, Masashi\| Sakamoto, Shuichi\| Kikuchi, Satoru\| Kuroda, Shinji\| Yoshida, Ryuichi\| Umeda, Yuzo\| Noma, Kazuhiro\| Tazawa, Hiroshi\| Fujiwara, Toshiyoshi\|
キーワード	HMGB1 Epithelial to mesenchymal transition Phorbol 12-myristate 13-acetate Ischemia-reperfusion model
備考	This fulltext is available in October, 2021.\|
発行日	2021-01-28
出版物タイトル	Cancer Letters
巻	497巻
出版者	Elsevier
開始ページ	1
終了ページ	3
ISSN	0304-3835
NCID	AA00598513
資料タイプ	学術雑誌論文
言語	English
OAI-PMH Set	岡山大学
論文のバージョン	author
PubMed ID	33065249
DOI	10.1016/j.canlet.2020.10.015
Web of Science KeyUT	000596072900001
関連URL	isVersionOf https://doi.org/10.1016/j.canlet.2020.10.015

Short-term and long-term comparisons of laparoscopy-assisted proximal gastrectomy with esophagogastrostomy by the double-flap technique and laparoscopy-assisted total gastrectomy for proximal gastric cancer

フルテキストURL	fulltext.pdf
著者	Tsumura, Tomoko\| Kuroda, Shinji\| Nishizaki, Masahiko\| Kikuchi, Satoru\| Kakiuchi, Yoshihiko\| Takata, Nobuo\| Ito, Atene\| Watanabe, Megumi\| Kuwada, Kazuya\| Kagawa, Shunsuke\| Fujiwara, Toshiyoshi\|
発行日	2020-11-12
出版物タイトル	PLoS ONE
巻	15巻
号	11号
出版者	Public Library of Science
開始ページ	e0242223
ISSN	1932-6203
資料タイプ	学術雑誌論文
言語	English
OAI-PMH Set	岡山大学
著作権者	© 2020 Tsumura et al.
論文のバージョン	publisher
PubMed ID	33180871
DOI	10.1371/journal.pone.0242223
Web of Science KeyUT	000593948000022
関連URL	isVersionOf https://doi.org/10.1371/journal.pone.0242223

Telomerase-specific oncolytic immunotherapy for promoting efficacy of PD-1 blockade in osteosarcoma

著者	Mochizuki, Yusuke\| Tazawa, Hiroshi\| Demiya, Koji\| Kure, Miho\| Kondo, Hiroya\| Komatsubara, Tadashi\| Sugiu, Kazuhisa\| Hasei, Joe\| Yoshida, Aki\| Kunisada, Toshiyuki\| Urata, Yasuo\| Kagawa, Shunsuke\| Ozaki, Toshifumi\| Fujiwara, Toshiyoshi\|
キーワード	Oncolytic adenovirus hTERT Immunogenic cell death ATP CD8
備考	This is a post-peer-review, pre-copyedit version of an article published in Cancer Immunology, Immunotherapy. The final authenticated version is available online at: http://dx.doi.org/10.1007/s00262-020-02774-7. </br>This fulltext is available in Nov. 2021.\|
発行日	2020-11-05
出版物タイトル	Cancer Immunology, Immunotherapy
出版者	Springer
開始ページ	0340-7004
NCID	AA00598499
資料タイプ	学術雑誌論文
言語	English
OAI-PMH Set	岡山大学
論文のバージョン	author
PubMed ID	33151368
DOI	10.1007/s00262-020-02774-7
Web of Science KeyUT	000586350500002
関連URL	isVersionOf https://doi.org/10.1007/s00262-020-02774-7

Intracorporeal semi‐hand‐sewn Billroth I reconstruction in total laparoscopic distal gastrectomy

著者	Kikuchi, Satoru\| Kuroda, Shinji\| Nishizaki, Masahiko\| Kuwada, Kazuya\| Takata, Nobuo\| Kakiuchi, Yoshihiko\| Yano, Shuya\| Noma , Kazuhiro\| Kagawa, Shunsuke\| Fujiwara, Toshiyoshi\|
キーワード	Billroth I reconstruction gastric cancer laparoscopic distal gastrectomy
備考	This is the peer reviewed version of the following article: Satoru Kikuchi et. al. Intracorporeal semi‐hand‐sewn Billroth I reconstruction in total laparoscopic distal gastrectomy. Asian Journal of Endoscopic Surgery (2020), which has been published in final form at https://doi.org/10.1111/ases.12887. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. </br>This fulltext is available on Oct. 2021.\|
発行日	2020-10-27
出版物タイトル	Asian Journal of Endoscopic Surgery
出版者	Wiley
ISSN	1758-5902
NCID	AA12488501
資料タイプ	学術雑誌論文
言語	English
OAI-PMH Set	岡山大学
論文のバージョン	author
PubMed ID	33111451
DOI	10.1111/ases.12887
Web of Science KeyUT	000583948100001
関連URL	isVersionOf https://doi.org/10.1111/ases.12887

FUCCI Real-Time Cell-Cycle Imaging as a Guide for Designing Improved Cancer Therapy: A Review of Innovative Strategies to Target Quiescent Chemo-Resistant Cancer Cells

フルテキストURL	fulltext.pdf
著者	Yano, Shuya\| Tazawa, Hiroshi\| Kagawa, Shunsuke\| Fujiwara, Toshiyoshi\| Hoffman, Robert M.\|
キーワード	cell cycle fluorescent proteins FUCCI imaging targeted cancer therapy quiescent cancer cells decoy chemotherapy
発行日	2020-09-17
出版物タイトル	Cancers
巻	12巻
号	9号
出版者	MDPI
開始ページ	2655
ISSN	2072-6694
資料タイプ	学術雑誌論文
言語	English
OAI-PMH Set	岡山大学
著作権者	© 2020 by the authors.
論文のバージョン	publisher
PubMed ID	32957652
DOI	10.3390/cancers12092655
Web of Science KeyUT	000580315800001
関連URL	isVersionOf https://doi.org/10.3390/cancers12092655

Elimination of MYCN-Amplified Neuroblastoma Cells by Telomerase-Targeted Oncolytic Virus via MYCN Suppression

フルテキストURL	fulltext.pdf
著者	Tanimoto, Terutaka\| Tazawa, Hiroshi\| Ieda, Takeshi\| Nouso, Hiroshi\| Tani, Morimichi\| Oyama, Takanori\| Urata, Yasuo\| Kagawa, Shunsuke\| Noda, Takuo\| Fujiwara, Toshiyoshi\|
キーワード	neuroblastoma MYCN hTERT adenovirus E2F1
発行日	2020-09-25
出版物タイトル	Molecular Therapy - Oncolytics
巻	18巻
出版者	Cell Press
開始ページ	14
終了ページ	23
ISSN	2372-7705
資料タイプ	学術雑誌論文
言語	English
OAI-PMH Set	岡山大学
著作権者	© 2020 The Author(s).
論文のバージョン	publisher
PubMed ID	32637577
DOI	10.1016/j.omto.2020.05.015
Web of Science KeyUT	000575168700002
関連URL	isVersionOf https://doi.org/10.1016/j.omto.2020.05.015

Boosting Replication and Penetration of Oncolytic Adenovirus by Paclitaxel Eradicate Peritoneal Metastasis of Gastric Cancer

フルテキストURL	fulltext.pdf
著者	Ishikawa, Wataru\| Kikuchi, Satoru\| Ogawa, Toshihiro\| Tabuchi, Motoyasu\| Tazawa, Hiroshi\| Kuroda, Shinji\| Noma, Kazuhiro\| Nishizaki, Masahiko\| Kagawa, Shunsuke\| Urata, Yasuo\| Fujiwara, Toshiyoshi\|
キーワード	peritoneal metastasis adenovirus gastric cancer intraperitoneal chemotherapy paclitaxel oncolytic virus
発行日	2020-09-25
出版物タイトル	Molecular Therapy - Oncolytics
巻	18巻
出版者	Cell Press
開始ページ	262
終了ページ	271
ISSN	2372-7705
資料タイプ	学術雑誌論文
言語	English
OAI-PMH Set	岡山大学
著作権者	© 2020 The Author(s).
論文のバージョン	publisher
PubMed ID	32728614
DOI	10.1016/j.omto.2020.06.021
Web of Science KeyUT	000575168700023
関連URL	isVersionOf https://doi.org/10.1016/j.omto.2020.06.021

Bone and Soft-Tissue Sarcoma: A New Target for Telomerase-Specific Oncolytic Virotherapy

フルテキストURL	fulltext.pdf
著者	Tazawa, Hiroshi\| Hasei, Joe\| Yano, Shuya\| Kagawa, Shunsuke\| Ozaki, Toshifumi\| Fujiwara, Toshiyoshi\|
キーワード	oncolytic adenovirus hTERT autophagy GFP p53
発行日	2020-02-18
出版物タイトル	Cancers
巻	12巻
号	2号
出版者	MDPI
ISSN	2072-6694
資料タイプ	学術雑誌論文
言語	English
OAI-PMH Set	岡山大学
著作権者	© 2020 by the authors.
論文のバージョン	publisher
PubMed ID	32085583
DOI	10.3390/cancers12020478
Web of Science KeyUT	000522477300224
関連URL	isVersionOf https://doi.org/10.3390/cancers12020478

Immune Modulation by Telomerase-Specific Oncolytic Adenovirus Synergistically Enhances Antitumor Efficacy with Anti-PD1 Antibody

フルテキストURL	fulltext.pdf Graphical_Abstract.pptx Figure1-6.pdf Supp_Info.pdf
著者	Kanaya, Nobuhiko\| Kuroda, Shinji\| Kakiuchi, Yoshihiko\| Kumon, Kento\| Tsumura, Tomoko\| Hashimoto, Masashi\| Morihiro, Toshiaki\| Kubota, Tetsushi\| Aoyama, Katsuyuki\| Kikuchi, Satoru\| Nishizaki, Masahiko\| Kagawa, Shunsuke\| Tazawa, Hiroshi\| Mizuguchi, Hiroyuki\| Urata, Yasuo\| Fujiwara, Toshiyoshi\|
キーワード	immune checkpoint programmed death-1 oncolytic adenovirus combined immunotherapy immunogenic cell death tumor infiltrating lymphocytes CD8 abscopal effect
発行日	2020-01-10
出版物タイトル	Molecular Therapy
巻	28巻
号	3号
出版者	Cell Press
開始ページ	794
終了ページ	804
ISSN	15250016
NCID	AA11475060
資料タイプ	学術雑誌論文
言語	English
OAI-PMH Set	岡山大学
論文のバージョン	author
PubMed ID	31991110
DOI	10.1016/j.ymthe.2020.01.003
Web of Science KeyUT	000518887200012
関連URL	isVersionOf https://doi.org/10.1016/j.ymthe.2020.01.003

Visualization of epithelial-mesenchymal transition in an inflammatory microenvironment-colorectal cancer network

著者	Ieda, Takeshi\| Tazawa, Hiroshi\| Okabayashi, Hiroki\| Yano, Shuya\| Shigeyasu, Kunitoshi\| Kuroda, Shinji\| Ohara, Toshiaki\| Noma, Kazuhiro\| Kishimoto, Hiroyuki\| Nishizaki, Masahiko\| Kagawa, Shunsuke\| Shirakawa, Yasuhiro\| Saitou, Takashi\| Imamura, Takeshi\| Fujiwara, Toshiyoshi\|
発行日	2019-11-8
出版物タイトル	Scientific Reports
巻	9巻
出版者	Nature Publishing Group
開始ページ	16378
ISSN	2045-2322
資料タイプ	学術雑誌論文
言語	English
OAI-PMH Set	岡山大学
著作権者	© The Author(s) 2019
論文のバージョン	publisher
PubMed ID	31705021
DOI	10.1038/s41598-019-52816-z
Web of Science KeyUT	000495372900001
関連URL	isVersionOf https://doi.org/10.1038/s41598-019-52816-z

PD-L1 expression combined with microsatellite instability/CD8+tumor infiltrating lymphocytes as a useful prognostic biomarker in gastric cancer

フルテキストURL	SR9_1_4633.pdf
著者	Morihiro, Toshiaki\| Kuroda, Shinji\| Kanaya, Nobuhiko\| Kakiuchi, Yoshihiko\| Kubota, Tetsushi\| Aoyama, Katsuyuki\| Tanaka, Takehiro\| Kikuch, Satoru\| Nagasaka, Takeshi\| Nishizaki, Masahiko\| Kagawa, Shunsuke\| Tazawa, Hiroshi\| Fujiwara, Toshiyoshi\|
発行日	2019-3-15
出版物タイトル	Scientific Reports
巻	9巻
出版者	Nature Publishing Group
開始ページ	4633
ISSN	2045-2322
資料タイプ	学術雑誌論文
言語	English
OAI-PMH Set	岡山大学
著作権者	© The Author(s) 2019
論文のバージョン	publisher
PubMed ID	30874607
DOI	10.1038/s41598-019-41177-2
Web of Science KeyUT	000461303000015
関連URL	isVersionOf https://doi.org/10.1038/s41598-019-41177-2

Multicenter retrospective study to evaluate the efficacy and safety of the double-flap technique as antireflux esophagogastrostomy after proximal gastrectomy (rD-FLAP Study)

フルテキストURL	AGS3_1_96.pdf SI.pdf
著者	Kuroda, Shinji\| Choda, Yasuhiro\| Otsuka, Shinya\| Ueyama, Satoshi\| Tanaka, Norimitsu\| Muraoka, Atsushi\| Hato, Shinji\| Kimura, Toshikazu\| Tanakaya, Kohji\| Kikuchi, Satoru\| Tanabe, Shunsuke\| Noma, Kazuhiro\| Nishizaki, Masahiko\| Kagawa, Shunsuke\| Shirakawa, Yasuhiro\| Kamikawa, Yasuaki\| Fujiwara, Toshiyoshi\|
キーワード	Kamikawa procedure antireflux surgery double‐flap technique esophagogastrostomy proximal gastrectomy
発行日	2018-10-11
出版物タイトル	Annals of Gastroenterological Surgery
巻	3巻
号	1号
出版者	Woley
開始ページ	96
終了ページ	103
ISSN	2475-0328
資料タイプ	学術雑誌論文
言語	English
OAI-PMH Set	岡山大学
著作権者	© 2018 The Authors
論文のバージョン	publisher
PubMed ID	30697614
DOI	10.1002/ags3.12216
Web of Science KeyUT	000456643500012
関連URL	isVersionOf https://doi.org/10.1002/ags3.12216

A Novel Combination Cancer Therapy with Iron Chelator Targeting Cancer Stem Cells via Suppressing Stemness

フルテキストURL	cancers_11_2_177.pdf
著者	Katsura, Yuki\| Ohara, Toshiaki\| Noma, Kazuhiro\| Ninomiya, Takayuki\| Kashima, Hajime\| Kato, Takuya\| Sato, Hiroaki\| Komoto, Satoshi\| Narusaka, Toru\| Tomono, Yasuko\| Xing, Boyi\| Chen, Yuehua\| Tazawa, Hiroshi\| Kagawa, Shunsuke\| Shirakawa, Yasuhiro\| Kasai , Tomonari\| Seno, Masaharu\| Matsukawa, Akihiro\| Fujiwara, Toshiyoshi\|
キーワード	cancer stem cells combination therapy iron stemness
発行日	2019-02-03
出版物タイトル	Cancers
巻	11巻
号	2号
出版者	MDPI
開始ページ	177
ISSN	2072-6694
資料タイプ	学術雑誌論文
言語	English
OAI-PMH Set	岡山大学
著作権者	© 2019 by the authors
論文のバージョン	publisher
PubMed ID	30717462
DOI	10.3390/cancers11020177
Web of Science KeyUT	000460747200051
関連URL	isVersionOf https://doi.org/10.3390/cancers11020177

Intraperitoneal cancer-immune microenvironment promotes peritoneal dissemination of gastric cancer

フルテキストURL	OncoImmunol_8_12_1671760.pdf
著者	Sakamoto, Shuichi\| Kagawa, Shunsuke\| Kuwada, Kazuya\| Ito, Atene\| Kajioka, Hiroki\| Kakiuchi, Yoshihiko\| Watanabe, Megumi\| Kagawa, Tetsuya\| Yoshida, Ryuichi\| Kikuchi, Satoru\| Kuroda, Shinji\| Tazawa, Hiroshi\| Fujiwara, Toshiyoshi\|
キーワード	Gastric cancer tumor-associated macrophages tumor microenvironment peritoneal dissemination
発行日	2019-10-22
出版物タイトル	OncoImmunology
巻	8巻
号	12号
出版者	TAYLOR & FRANCIS
開始ページ	e1671760
ISSN	2162402X
資料タイプ	学術雑誌論文
言語	English
OAI-PMH Set	岡山大学
著作権者	© 2019 The Author(s).
論文のバージョン	publisher
DOI	10.1080/2162402X.2019.1671760
Web of Science KeyUT	000494085400001
関連URL	isVersionOf https://doi.org/10.1080/2162402X.2019.1671760

Outcome of Radiation Monotherapy for High-risk Patients with Stage I Esophageal Cancer

JaLCDOI	10.18926/AMO/54981
フルテキストURL	71_2_127.pdf
著者	Shirakawa, Yasuhiro\| Noma, Kazuhiro\| Maeda, Naoaki\| Tanabe, Shunsuke\| Kuroda, Shinji\| Kagawa, Shunsuke\| Katsui, Kuniaki\| Katayama, Norihisa\| Kanazawa, Susumu\| Fujiwara, Toshiyoshi\|
抄録	Currently, chemoradiation is the most widely used nonsurgical treatment for esophageal cancer. However, some patients, particularly the very elderly or those with severe vital organ dysfunction, face difficulty with the chemotherapy component. We therefore examined the outcome of radiation therapy (RT) alone for patients with esophageal cancer at our facility. Between January 2005 and December 2014, 84 patients underwent RT at our hospital, and 78 of these patients received concomitant chemotherapy. The remaining 6 patients underwent RT alone; these patients were considered to be high-risk and to have no lymph node metastasis (stage I). Five of them received irradiation up to a curative dose: 4 showed a complete response (CR) and 1 showed a partial response (PR). Of the patients exhibiting CR, 3 are currently living recurrence-free, whereas 1 patient underwent endoscopic submucosal dissection (ESD) as salvage therapy for local recurrence, with no subsequent recurrence. High-risk stage I esophageal cancer patients can be treated radically with RT alone under certain conditions. In the future, to broaden the indications for RT monotherapy to include some degree of advanced cancers, a novel concurrent therapy should be identified.
キーワード	esophageal cancer radiation therapy high-risk patient
Amo Type	Original Article
発行日	2017-04
出版物タイトル	Acta Medica Okayama
巻	71巻
号	2号
出版者	Okayama University Medical School
開始ページ	127
終了ページ	133
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	English
著作権者	CopyrightⒸ 2017 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	28420894

A Phase II Clinical Trial of the Efficacy and Safety of Short-term (3 days) Enoxaparin for the Prevention of Venous Thromboembolism after Gastric Cancer Surgery

JaLCDOI	10.18926/AMO/54601
フルテキストURL	70_5_401.pdf
著者	Kuroda, Shinji\| Kikuchi, Satoru\| Nishizaki, Masahiko\| Kagawa, Shunsuke\| Hinotsu, Shiro\| Fujiwara, Toshiyoshi\|
抄録	Although intermittent pneumatic compression (IPC) has become common as perioperative prophylaxis for venous thromboembolism (VTE) consisting of pulmonary thromboembolism (PE) and deep vein thrombosis (DVT), the prophylactic effect against VTE, especially lethal PE, is not yet satisfactory. Therefore, pharmacologic prophylaxis, such as with enoxaparin, is desirable. While the efficacy and safety of enoxaparin have been proven in several clinical trials, concern about bleeding with longterm (at least 7 days) use have potentially decreased its widespread adoption. We have launched a phase II study to evaluate the efficacy and safety of short-term (3 days) enoxaparin, in which a total of 70 gastric cancer patients undergoing gastrectomy will be recruited, and the primary endpoint is the incidence of DVT. This study could contribute to making pharmacologic prophylaxis for VTE more common.
キーワード	venous thromboembolism enoxaparin short-term use gastric cancer surgery
Amo Type	Clinical Study Protocols
発行日	2016-10
出版物タイトル	Acta Medica Okayama
巻	70巻
号	5号
出版者	Okayama University Medical School
開始ページ	401
終了ページ	404
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	English
著作権者	CopyrightⒸ 2016 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	27777435
Web of Science KeyUT	000388098700012

Recurrence after Endoscopic Curative Resection of Mucosal Gastric Cancer Associated with an Adjacent Neoplastic Precursor Lesion

JaLCDOI	10.18926/AMO/54421
フルテキストURL	70_3_213.pdf
著者	Kikuchi, Satoru\| Kagawa, Shunsuke\| Ohara, Toshiaki\| Kubota, Tetsushi\| Kuwada, Kazuya\| Kagawa, Tetsuya\| Kuroda, Shinji\| Shirakawa, Yasuhiro\| Nishizaki, Masahiko\| Fujiwara, Toshiyoshi\|
抄録	A 69-year-old man underwent endoscopic submucosal dissection (ESD) for early gastric cancer (EGC) at the lesser curvature in the angle of stomach. Histological examination revealed tub1, pM, ly0, v0, pLM(-), pVM(-), and the resection was considered curative. The scar after ESD was followed by esophagogastroduodenoscopy (EGD) and biopsy. Twenty months later, EGD showed an ulcerative lesion in the vicinity of the ESD scar, and histological examination of the biopsy specimen showed adenocarcinoma. A distal gastrectomy with lymph node dissection was then performed. Postoperative pathology showed tub1, pM, pN0, ly0, v0, and Stage 1A. Skip lesions were seen in the specimen resected by ESD, and the histological review confirmed so-called “dysplasia-like atypia” (DLA) between the lesions. It has been reported recently that in DLA, the dysplasia-like change involves only the bases of the pits, without upper pit or surface epithelium involvement, and it is said that the rate of DLA is higher in gastric cancer patients. We speculated that a precancerous lesion close to the resected cancer developed into a local recurrence.
キーワード	dysplasia-like atypia early gastric cancer endoscopic submucosal dissection local recurrence
Amo Type	Case Report
発行日	2016-06
出版物タイトル	Acta Medica Okayama
巻	70巻
号	3号
出版者	Okayama University Medical School
開始ページ	213
終了ページ	216
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	English
著作権者	CopyrightⒸ 2016 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	27339211
Web of Science KeyUT	000379406100009

香川 俊輔