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ID 58287
フルテキストURL
著者
Katayama, Norihisa Department of Radiology, Okayama University Hospital Kaken ID researchmap
Sato, Shuhei Department of Radiology, Okayama University Hospital
Katsui, Kuniaki Department of Radiology, Okayama University Hospital ORCID Kaken ID
Takemoto, Mitsuhiro Department of Radiology, Okayama University Hospital
Tsuda, Toshihide Department of Radiology, Okayama University Hospital Kaken ID researchmap
Yoshida, Atsushi Department of Radiology, Okayama University Hospital
Morito, Tsuneharu Department of Radiology, Okayama University Hospital
Nakagawa, Tomio Department of Radiology, Okayama University Hospital
Mizutani, Akifumi Department of Radiology, Okayama University Hospital Kaken ID
Waki, Takahiro Department of Radiology, Okayama University Hospital ORCID
Niiya, Harutaka Department of Radiology, Okayama University Hospital
Kanazawa, Susumu Department of Radiology, Okayama University Hospital Kaken ID
抄録
Purpose: To evaluate factors associated with radiation-induced bronchiolitis obliterans organizing pneumonia (BOOP) syndrome after breast-conserving therapy.
Methods and materials: A total of 702 women with breast cancer who received radiotherapy after breast-conserving surgery at seven institutions between July 1995 and December 2006 were analyzed. In all patients, the whole breast was irradiated with two tangential photon beams. The criteria used for the diagnosis of radiation-induced BOOP syndrome were as follows: (1) radiotherapy to the breast within 12 months, (2) general and/or respiratory symptoms lasting for >or=2 weeks, (3) radiographs showing lung infiltration outside the radiation port, and (4) no evidence of a specific cause.
Results: Radiation-induced BOOP syndrome was seen in 16 patients (2.3%). Eleven patients (68.8%) were administered steroids. The duration of steroid administration ranged from 1 week to 3.7 years (median, 1.1 years). Multivariate analysis revealed that age (>or=50 years; odds ratio [OR] 8.88; 95% confidence interval [CI] 1.16-67.76; p = 0.04) and concurrent endocrine therapy (OR 3.05; 95% CI 1.09-8.54; p = 0.03) were significantly associated with BOOP syndrome. Of the 161 patients whose age was >or=50 years and who received concurrent endocrine therapy, 10 (6.2%) developed BOOP syndrome.
Conclusions: Age (>or=50 years) and concurrent endocrine therapy can promote the development of radiation-induced BOOP syndrome after breast-conserving therapy. Physicians should carefully follow patients who received breast-conserving therapy, especially those who are older than 50 years and received concurrent endocrine therapy during radiotherapy.
キーワード
Breast cancer
Breast-conserving surgery
Radiotherapy
Radiation-induced BOOP syndrome
Endocrine therapy
発行日
2009-03-15
出版物タイトル
International journal of radiation oncology, biology, physics
73巻
4号
出版者
Elsevier
開始ページ
1049
終了ページ
1054
ISSN
0360-3016
NCID
AA00680920
資料タイプ
学術雑誌論文
言語
English
OAI-PMH Set
岡山大学
論文のバージョン
author
PubMed ID
DOI
Web of Science KeyUT
関連URL
isVersionOf https://doi.org/10.1016/j.ijrobp.2008.05.050
ライセンス
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
Citation
Katayama N, Sato S, Katsui K, et al. Analysis of factors associated with radiation-induced bronchiolitis obliterans organizing pneumonia syndrome after breast-conserving therapy. Int J Radiat Oncol Biol Phys. 2009;73(4):1049‐1054. doi:10.1016/j.ijrobp.2008.05.050