ST49_3_254.pdf 1.18 MB
Sugimoto, Seiichiro Department of General Thoracic SurgeryOkayama University Hospital ORCID Kaken ID
Kurosaki, Takeshi Department of Organ Transplant CenterOkayama University Hospital Kaken ID
Otani, Shinji Department of Organ Transplant CenterOkayama University Hospital
Tanaka, Shin Department of General Thoracic SurgeryOkayama University Hospital
Hikasa, Yukiko Department of Anesthesiology and ResuscitologyOkayama University Hospital
Yamane, Masaomi Department of General Thoracic SurgeryOkayama University Hospital Kaken ID researchmap
Toyooka, Shinichi Department of General Thoracic SurgeryOkayama University Hospital ORCID Kaken ID publons researchmap
Kobayashi, Motomu Department of Anesthesiology and ResuscitologyOkayama University Hospital Kaken ID publons
When patients are mechanically ventilated for more than 5 days, they are usually declined as donors for lung transplantation (LTx); thus, the long-term outcomes of LTx from such donors remain unclear. We investigated the feasibility of LTx from donors that had been mechanically ventilated for prolonged periods.
The subjects of this retrospective comparative investigation were 31 recipients of LTx from donors who had been mechanically ventilated for < 5 days (short-term group) and 50 recipients of LTx from donors who had been mechanically ventilated for ≥ 5 days (long-term group).
The median duration of donor mechanical ventilation was 3 days in the short-term group and 8.5 days in the long-term group. However, other than the difference in the duration of donor ventilation, there were no significant differences in the clinical characteristics of the donors or recipients between the groups. The overall survival rate after LTx was comparable between the long-term group and short-term group (5-year survival rate, 66.6% vs. 75.2%).
The potential inclusion of donors who have been on mechanical ventilation for more than 5 days could be a feasible strategy to alleviate donor organ shortage.
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