このエントリーをはてなブックマークに追加
ID 32840
JaLCDOI
フルテキストURL
著者
Abe, Asaki Okayama University
Kawasoe, Chiaki Okayama University
Kondo, Yasuhiro Okayama University Kaken ID researchmap
Sato, Katsunori Okayama University
抄録

Changes in norepinephrine-induced transient contractions in Ca2+-deficient solution were investigated in the aortic smooth muscles of diabetic ALS (alloxan-induced diabetes susceptible) mice. The transient contractions in diabetic mice were significantly larger than those in normal mice. The longer incubation of the muscle preparations in Ca2+-deficient solution made the transient contractions smaller, probably due to the leakage and decrease in norepinephrine-releasable stored Ca2+. The rate of this reduction in contraction was slower in diabetic mice. These results suggest that the leakage of intracellular stored Ca2+ caused by extracellular Ca2+ deficiency is attenuated in diabetic mice, contributing to enhanced norepinephrine-induced transient contractions.

キーワード
diabetes mellitus
vascular smooth muscle
norepinephrine
Amo Type
Article
発行日
2003-02
出版物タイトル
Acta Medica Okayama
57巻
1号
出版者
Okayama University Medical School
開始ページ
45
終了ページ
48
ISSN
0386-300X
NCID
AA00508441
資料タイプ
学術雑誌論文
言語
English
論文のバージョン
publisher
査読
有り
PubMed ID
Web of Science KeyUT