このエントリーをはてなブックマークに追加
ID 10576
Eprint ID
10576
フルテキストURL
Thumnail 93_45_49.pdf 1.75 MB
タイトル(別表記)
Induction of Atherosclerosis in Aorta and Coronary Artery of Chicken by Orally Administered Cholesterol
著者
近藤 康博 岡山大学 Kaken ID researchmap
本條 幸香 岡山大学
大月 寿栄 岡山大学
阿部 浅樹 岡山大学
抄録
Hypercholesterolemia and hyperlipidemia have been important in human health as factors that induce atherosclerotic lesions in brain and heart blood vessel. Various experimental studies have been done to prevent and treat atherosclerotic lesions in animals. In the present study, we assessed the suitability of chickens as experimental animal for atherosclerosis. Newly hatched chicks were fed on 1.0%-or 0.1%-cholesterol(CHO) containing feed. After 3 and 6 months, total cholesterol levels in the sera and histological changes in the aorta and coronary artery of chicks fed on 1.0%-CHO-containing feed for 3 and 6 months, intimal thickening and marked accumulation of foam cells were observed. Endothelial cells had disappeared in the aorta of these chicks. A slight accumulation of foam cells was observed in the aortic intima of chicks fed on 0.1%-CHO-containing feed. In the coronary artery, a remarkable thickening of intima with accumulation of foam cells and a marked stenosis of coronary space were observed in chicks fed on 1.0%-CHO-containing feed. The results of present study indicate that the chicken can be a useful experimental animal in the study of hypercholesterolemia, hyperlipidemia and atherosclerosis.
キーワード
experimental atherosclerosis
cholrsterol
chicks
発行日
2004-02
出版物タイトル
岡山大学農学部学術報告
出版物タイトル(別表記)
Scientific reports of the Faculty of Agriculture, Okayama University
93巻
1号
出版者
岡山大学農学部
出版者(別表記)
Faculty of Agriculture,Okayama University
開始ページ
45
終了ページ
49
ISSN
0474-0254
NCID
AN00033029
資料タイプ
紀要論文
言語
Japanese
論文のバージョン
publisher
査読
無し
Eprints Journal Name
srfa